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Eksperimental'naia onkologiia最新文献

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[Changes in clonogenic properties of bone marrow and transplantable mice tumor cells during combined use of cyclophosphane and biological response modifiers of adaptogenic origin]. [联合使用环磷酰胺和适应源性生物反应调节剂对骨髓和可移植小鼠肿瘤细胞克隆特性的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
S N Udintsev, V P Shakhov
{"title":"[Changes in clonogenic properties of bone marrow and transplantable mice tumor cells during combined use of cyclophosphane and biological response modifiers of adaptogenic origin].","authors":"S N Udintsev,&nbsp;V P Shakhov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The clonogenic activity of tumors and blood marrow cells has been studied in experiments on CBA, BALB/C and C57B1/6 mice with the Ehrlich adenocarcinoma and Lewis lung carcinosarcoma treated with adaptogenic drugs of Rhodiola Rosea extract, a synthetic analog of Rhodiola phenol derivative, methyluracil and their combinations with cyclophosphamide. The extract and derivative are shown to protect the myelopoietic tissue from the toxic action of cyclophosphamide, retaining or increasing the suppressive effect of the latter towards clonogenic tumors cells. These data can be the reason for using the extract and derivative during the antitumor chemotherapy as biological response modifiers.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"55-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13412762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of indomethacin and BCG vaccine on growth of transplanted tumors in mice]. 吲哚美辛和卡介苗对小鼠移植瘤生长的影响。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
Iu N Kurunov, V I Kaledin
{"title":"[Effects of indomethacin and BCG vaccine on growth of transplanted tumors in mice].","authors":"Iu N Kurunov,&nbsp;V I Kaledin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Continuous administration of indomethacin (IM) in drinking water (20 micrograms/ml) causes moderate inhibition of the growth of transplantable tumors in control mice but significantly increases the antitumor effect of BCG vaccine inoculated in combination with transplanted tumor cells. Hepatoma 29, insensitive to the vaccine becomes highly sensitivity to it under IM administration.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"57-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13412763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The carcinogenic and genotoxic action of the substances in the exhaust gases from internal combustion engines]. [内燃机废气中物质的致癌和遗传毒性作用]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
M S Makhover, A Ia Khesina
{"title":"[The carcinogenic and genotoxic action of the substances in the exhaust gases from internal combustion engines].","authors":"M S Makhover,&nbsp;A Ia Khesina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The review presents physicochemical methods of the study of polycyclic aromatic hydrocarbons (PAH) and analysis of substances composing the exhausts of the internal combustion engines (ICE). High carcinogenic effect of the ICE exhausts due to the presence of nitro-PAHs was confirmed in the experiments with animals and the mutagenic effect was detected in the Ames test. A necessity to study carcinogenic and mutagenic effects of nitro-PAHs in a view to reveal their potential human health hazard is emphasized.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 5","pages":"11-4, 34"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12864089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Several parameters of growth of heterografts of human lung tumor in the subrenal capsule of CBA mice]. [人肺肿瘤异种移植物在CBA小鼠肾下被膜内生长的几个参数]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
O I Skotnikova, N S Sergeeva, I K Sviridova, I A Moroz, I I Pelevina
{"title":"[Several parameters of growth of heterografts of human lung tumor in the subrenal capsule of CBA mice].","authors":"O I Skotnikova,&nbsp;N S Sergeeva,&nbsp;I K Sviridova,&nbsp;I A Moroz,&nbsp;I I Pelevina","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>28 species of human lung cancer of the III-IV stages were investigated. The maximal growth of heterotransplants was found for them with the initial area of 1.2-1.5 mm2. The analysis of the data obtained has shown that the samples of lung adenocarcinomas grow more slowly than those of squamous cell and small-cell carcinomas and also of carcinoid.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"41-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13308003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Analysis of B-lymphotropic oncogenic herpesvirus of Macaca arctoides]. 猕猴b淋巴嗜癌疱疹病毒分析。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V V Kakubava, V Z Agrba, V V Timanovskaia, B Brzhikhachek
{"title":"[Analysis of B-lymphotropic oncogenic herpesvirus of Macaca arctoides].","authors":"V V Kakubava,&nbsp;V Z Agrba,&nbsp;V V Timanovskaia,&nbsp;B Brzhikhachek","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Some physico-chemical and molecular-biological parameters of B-lymphotropic herpes virus of Macaca arctoides (HVMA) have been analyzed. The buoyant density of virions and nucleocapsids in a gradient of the percoll density is 1.10 and 1.14 g/ml, respectively, while that of DNA in CsCl gradient is 1.717 g/ml, which is typical for herpes viruses of primates. At the same time the homology of DNA HVMA with DNA EBV and DNA HVP is 30-45%. Differences in restrictions sites between DNA HVMA, DNA HVP and DNA EBV are determined. The intraspecific heterogeneity of HVMA strains has been detected according to restriction sites of DNA. The HVMA genome size is about 170 kb. The DNA HVMA is colinear to the EBV genome, which is also typical of B-lymphotropic herpes viruses of primates.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"44-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13328679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Tissue specificity of monoclonal antibodies to cells of human pulmonary adenocarcinoma]. [单克隆抗体对人肺腺癌细胞的组织特异性]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I D Kokhanova, S G Egorova, N V Vial'tsev, K K Pugachev, G I Avdeev
{"title":"[Tissue specificity of monoclonal antibodies to cells of human pulmonary adenocarcinoma].","authors":"I D Kokhanova,&nbsp;S G Egorova,&nbsp;N V Vial'tsev,&nbsp;K K Pugachev,&nbsp;G I Avdeev","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Immunohistological localization of antigens revealed by 5 MoAbs to human lung adenocarcinoma cell line was studied by indirect immunoperoxidase technique. One of the MoAbs--A2F4--showed a relative specificity to epithelial tissues having a glandular differentiation. Except approximately 50% of normal cells of lungs and those of pulmonary tumours (mostly adenocarcinomas) they reacted with some other normal (stomach, oesophagus, breast) and tumoral (gastric, mammary and colonic) tissue cells. Other four MoAbs reacted with the much larger number of cells including some nonepithelial (granulocytes and histiocytes) ones.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"57-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13352060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Characteristics of blood neutrophil reactions to acute hypoxia in mice of low and high tumor incidence strains]. [低、高肿瘤株小鼠急性缺氧时血中性粒细胞反应特点]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
T I Koliada, V I Ogreba, L Ia Shevchenko, T G Konovalova
{"title":"[Characteristics of blood neutrophil reactions to acute hypoxia in mice of low and high tumor incidence strains].","authors":"T I Koliada,&nbsp;V I Ogreba,&nbsp;L Ia Shevchenko,&nbsp;T G Konovalova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The dependence of the neutrophil reaction of the low-tumour strain mice CBA/CaLacY, BALB/cLacY and C57B1/6J on acute hypoxia upon the value of the initial activity (the Wilder-Leites rule is shown. This dependence is disturbed in the high-tumour strain mice AKR/JY and A/SnY. The possible presence of latent immunodeficiency in AKR/JY and A/SnY mice is discussed.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"47-9"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Evaluation of the effectiveness of regional interleukin-2 dependent adoptive immunocytotherapy of mice with transplanted rhabdomyosarcoma]. [移植型横纹肌肉瘤小鼠局部白介素-2依赖性过继免疫细胞治疗的有效性评价]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
R A Semenova-Kobzar', V M Iudin, L Ia Kushko, L V Iakhimovich, N M Berezhnaia
{"title":"[Evaluation of the effectiveness of regional interleukin-2 dependent adoptive immunocytotherapy of mice with transplanted rhabdomyosarcoma].","authors":"R A Semenova-Kobzar',&nbsp;V M Iudin,&nbsp;L Ia Kushko,&nbsp;L V Iakhimovich,&nbsp;N M Berezhnaia","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Alternative principles of regional IL-2-dependent adoptive immunocytotherapy of malignant tumours are suggested. Regional adoptive immunocytotherapy consists in the administration of the short-term IL-2 treated lymphocytes of the lymph nodes removed from the tumour which have tumour-associated suppressor activity and spleen cells after elimination of cells with the immunosuppressive activity.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"50-2"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13494759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Action of carcinogenesis promoters on the adhesive force of cells in the liver, lung and thyroid gland in rats and mice]. 【致癌促进剂对大鼠、小鼠肝、肺、甲状腺细胞黏附力的影响】。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I M Kolotygina, E A Modianova, A G Malenkov
{"title":"[Action of carcinogenesis promoters on the adhesive force of cells in the liver, lung and thyroid gland in rats and mice].","authors":"I M Kolotygina,&nbsp;E A Modianova,&nbsp;A G Malenkov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The short-term effects of the carcinogenesis promoters on the adhesive force of cells are compared with the data from literature on their ability to exert a promoter action on the carcinogenesis development in the same organs during prolonged introduction after an initiator. The ability of substances to decrease the adhesive force in the tissue below the resistance threshold is established to correlate with its promoter activity. The coincidence of tissue specificity of both effects and active doses of substances is observed.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"22-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13529169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Ag-negative phenomenon of nucleolar organizers of bone marrow and blood cells in children with acute lymphoblastic leukemia]. [急性淋巴细胞白血病患儿骨髓和血细胞核仁组织者ag阴性现象]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
O A Ikonnikova, R V Lenskaia, O V Zatsepina, K L Kondratchik, V M Chernov
{"title":"[Ag-negative phenomenon of nucleolar organizers of bone marrow and blood cells in children with acute lymphoblastic leukemia].","authors":"O A Ikonnikova,&nbsp;R V Lenskaia,&nbsp;O V Zatsepina,&nbsp;K L Kondratchik,&nbsp;V M Chernov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The activity of nucleoli-organizing (NOR's) regions was studied in leukemic cells of 53 children with immunologically typical ALL. The Ag-negative type of ALL was found in 9 cases of IA-ALL and Comm(+)-ALL. Dominating cells were not argentaffin. Some cytological peculiarities of Ag-negative cases have been demonstrated: lower presence of E(+)-receptor on circulating lymphoid cells, the greater number of cells with smooth surface which was revealed by the scanning electron microscopic method. The cases when the product of Ag-philic reaction was impossible to be revealed are discussed.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"40-3"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12860130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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