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[Heat shock proteins and proliferative activity of cultured hepatocytes after hyperthermia]. [热休克蛋白与热疗后培养肝细胞的增殖活性]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
L A Osipova, A N Mukvich, N I Nemliĭ
{"title":"[Heat shock proteins and proliferative activity of cultured hepatocytes after hyperthermia].","authors":"L A Osipova,&nbsp;A N Mukvich,&nbsp;N I Nemliĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Hepatocytes in cell culture have been studied for their sensitivity to mitogenic effect of the epidermal growth factor, epidermal growth factor and insulin, 10% of cattle blood serum after hyperthermia. It is established that heat shock (43 degrees C, 90 min) induces hypersensitivity of hepatocytes to the mentioned mitogens, its maximum being observed 20-24 h after hyperthermia and coinciding in time with the development of thermotolerance and intensification of protein biosynthesis after the heat shock 68, 70, 94 kD.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"61-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13412765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reciprocal differences in the susceptibility to induction by ortho-aminoazotoluene of liver and vascular tumors in A/HeJ and CC67BR/Mv mice]. [A/HeJ和CC67BR/Mv小鼠肝脏和血管肿瘤对邻氨基偶氮甲苯诱导敏感性的互易差异]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V I Kaledin, L A Semenova
{"title":"[Reciprocal differences in the susceptibility to induction by ortho-aminoazotoluene of liver and vascular tumors in A/HeJ and CC67BR/Mv mice].","authors":"V I Kaledin,&nbsp;L A Semenova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When administered subcutaneously, ortho-aminoazotoluene induces predominantly liver tumours in A/HeJ mice but vascular tumours (located mainly in the interscapular brown fat pads) in CC57BR/Mv mice. Liver tumours are more frequent in females, while vascular tumours--in males. Under crossing, the susceptibility to induction of the both types of tumours in male F1 hybrids is inherited intermediately, whereas in females the resistance to induction of vascular tumours predominates.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"16-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13450407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A possible role of phosphoprotein p53 in the mechanism of autostimulation of tumor cell proliferation]. [磷酸化蛋白p53在自身刺激肿瘤细胞增殖机制中的可能作用]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
A I Ageenko, V S Erkhov, L V Cherniaev, L Iu Volkova
{"title":"[A possible role of phosphoprotein p53 in the mechanism of autostimulation of tumor cell proliferation].","authors":"A I Ageenko,&nbsp;V S Erkhov,&nbsp;L V Cherniaev,&nbsp;L Iu Volkova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been shown that phosphoprotein p53 may participate in the DNA-synthesis stimulation in the mixed culture of tumour cells and syngeneic embryonic mouse cells (10 days of pregnancy). This effect has been eliminated by the preliminary treatment of embryonic cells in vitro by the monoclonal antibodies to p53 (pAb421) in the model system. A conclusion is drawn that p53-epitopes of embryonic cell surface membrane take part in the formation of the determinant which is recognized by receptors of tumour cells. The stimulation of DNA-synthesis in tumour cells is resulted by this process.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"35-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12853483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Monoclonal antibodies IGR to nuclear antigens of neutrophilic granulocytes of human blood]. [人血嗜中性粒细胞核抗原单克隆抗体IGR]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
S O Ingerpuu, A O Piĭrsoo, A E Siunter, S Iu Kivi
{"title":"[Monoclonal antibodies IGR to nuclear antigens of neutrophilic granulocytes of human blood].","authors":"S O Ingerpuu,&nbsp;A O Piĭrsoo,&nbsp;A E Siunter,&nbsp;S Iu Kivi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four monoclonal antibodies (Mabs) of series IGR-1 and IGR-2 to nuclear antigens of neutrophilic granulocytes of human peripheral blood were obtained. Mabs IGR-1 2B8 and IGR-1 6B5 are bound to their specific antigens in the nuclei of all the investigated human cell lines. These Mabs were also specific for metaphase chromosomes of cell lines HL-60 and U-937. Investigations on the ultrastructural level showed that Mabs IGR-1 6B5 reacted with the HL-60 nuclear heterochromatin region. Mabs IGR-1 3D3 and IGR-2 2F1 manifested high specificity only for the nuclei of mature neutrophils and of plasma cells.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"24-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12857488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of proto-oncogenes in fundamental manifestations of life]. 原癌基因在生命基本表现中的作用。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I F Seĭts
{"title":"[The role of proto-oncogenes in fundamental manifestations of life].","authors":"I F Seĭts","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Problems of the origin, structure and functions, in the cells and tissues, of the so-called proto-oncogenes (c-onc)--cell genes, homologues and oncogene foreparents (v-onc)--are considered in the review. Up-to-date data are given to show the participation of the main groups of proto-oncogenes in the processes of cell division, proliferation and differentiation. The role of c-onc genes is found to be important for fundamental manifestations of the cell life activity. Special attention is paid to the problem of interrelation of the proto-oncogenes with growth factors and their receptors.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of At-211 alpha irradiation on Ehrlich ascites tumor cells]. [At-211 α辐照对埃利希腹水肿瘤细胞的影响]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
N L Shmakova, Iu V Norseev, A A Waĭnson, Z Siuch, T A Fadeeva, T E Fomenkova, V A Khalkin, A P Cherebatenko
{"title":"[Effects of At-211 alpha irradiation on Ehrlich ascites tumor cells].","authors":"N L Shmakova,&nbsp;Iu V Norseev,&nbsp;A A Waĭnson,&nbsp;Z Siuch,&nbsp;T A Fadeeva,&nbsp;T E Fomenkova,&nbsp;V A Khalkin,&nbsp;A P Cherebatenko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The biological effect of 211At alpha-particles has been investigated using the Chinese hamster fibroblasts and Ehrlich carcinoma cells growth in vitro. The mean energy of 211At alpha-particles is 6.8 MeV, LET in tissue is 70-160 keV/microns; the half-life period of decomposition of 211At is 7.2 h. The end-points used were a decrease in the mitotic activity, an elevation of the number of degenerating cells, cell with chromosome aberrations and the cell survival. The RBE of alpha-particles in comparison with 60Co gamma-rays is close to 3.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"58-60"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13267117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The mutagenic action of the dust of natural zeolites and chrysotile asbestos]. [天然沸石和温石棉粉尘的诱变作用]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
A D Durnev, T B Suslova, Z P Cheremisina, O Iu Dubovskaia, E A Nigarova, L G Korkina, S B Seredenin, B T Velichkovskiĭ
{"title":"[The mutagenic action of the dust of natural zeolites and chrysotile asbestos].","authors":"A D Durnev,&nbsp;T B Suslova,&nbsp;Z P Cheremisina,&nbsp;O Iu Dubovskaia,&nbsp;E A Nigarova,&nbsp;L G Korkina,&nbsp;S B Seredenin,&nbsp;B T Velichkovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The cell chemiluminescence method was used to demonstrate the ability of asbest and zeolite dusts from 8 deposits of the USSR to induce generation of free oxygen radicals in the phagocytosing cells suspension. It has been found that asbest and zeolite (0.01 and 0.05 mg/ml) increase levels of cells with chromosome aberrations in human cell cultures. The cytogenetic effect of asbest was inhibited by superoxide dismutase (50 mg/ml). The damaging effect of zeolite was decreased by the pharmacological drug bemithyl (0.007-0.07 mM) and completely eliminated by catalase (20 mg/ml). The results obtained indicate that mutagenic effect of dust particles of asbest and zeolite is mediated by oxygen radicals.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 2","pages":"21-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13310713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Chromosomal changes in primary myelodysplasias]. [原发性骨髓增生异常的染色体改变]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
L I Iavorkovskiĭ, L Iu Riauzova, E Ia Soloveĭ, L L Iavorkovskiĭ
{"title":"[Chromosomal changes in primary myelodysplasias].","authors":"L I Iavorkovskiĭ,&nbsp;L Iu Riauzova,&nbsp;E Ia Soloveĭ,&nbsp;L L Iavorkovskiĭ","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The data from literature on chromosome abnormalities in various subgroups of the myelodysplastic syndrome (according to FAB-classification) are presented. Special attention is paid to information about changes in the number and structure of chromosomes during the disease and their prognostic significance. The relation of definite chromosome aberrations to the clinical course and prognosis of the disease, in particular to its transformation into acute leukosis is under discussion.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 2","pages":"10-6"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13334173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[14Co-dimetinur distribution in mice in relation to the stage of the development of tumor process]. [14] co -dimetinur在小鼠体内分布与肿瘤发展阶段的关系。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
L A Ostrovskaia, V A Rykova, A A Kondarov, L Etvesh, E Shimon-Trompler, I S Sokolova, D B Korman
{"title":"[14Co-dimetinur distribution in mice in relation to the stage of the development of tumor process].","authors":"L A Ostrovskaia,&nbsp;V A Rykova,&nbsp;A A Kondarov,&nbsp;L Etvesh,&nbsp;E Shimon-Trompler,&nbsp;I S Sokolova,&nbsp;D B Korman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Pharmacokinetics of the antitumour agent 14CO-dimetinur (100 mg/kg) after oral administration to the intact mice and those with solid leukemia P 388 is characterized by its rapid delivery to organs and tumours with the achievement of maximum radioactivity 5 hours later and the further gradually decline during 4 days. The increased accumulation of the 14CO-products in kidneys and their retarded output from the brain and lungs against a background of the relatively equal distribution of radioactivity between other tested organs have been established. The same level of carbamoylated products in large tumours (the 16th day after leukemia transplantation) as well as in small tumours (the 9th day after inoculation) is in agreement with the conservation of the initial marked inhibitory effect of the drug against advanced tumours.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"70-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13448132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cytochemical analysis of polyamines in Ehrlich ascitic carcinoma cells during different phases of mitotic cycle under the effects of difluoromethylornithine]. [二氟甲基鸟氨酸作用下不同有丝分裂周期埃利希腹水癌细胞多胺的细胞化学分析]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
M P Vinarchuk, V A Shliakhovenko, I N Danko
{"title":"[Cytochemical analysis of polyamines in Ehrlich ascitic carcinoma cells during different phases of mitotic cycle under the effects of difluoromethylornithine].","authors":"M P Vinarchuk,&nbsp;V A Shliakhovenko,&nbsp;I N Danko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Mice bearing Ehrlich carcinoma cells received one 80 mg/kg dose of DFMO. After 20 hours the cells were extracted from the peritoneal cavity and separated by means of sedimentation of 1 g in saccharose gradient into 9 fractions depending on the mitotic cycle phase. The content of polyamines in the cells of each fraction was detected by the fluorescent method using fluorescamine. It was shown that the tumor cells during G1 phase mitotic cycle (13-15% cells blocked) and especially cells in the 1st half of S-phase (19-23% cells blocked) were most sensitive to inhibitory effect of DFMO.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"53-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13412761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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