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[Characteristics of metastasis and antimetastatic activity of macrophages in mice after postoperative immunomodulation]. [术后免疫调节后小鼠巨噬细胞的转移特征及抗转移活性]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
N P Taraskina, V M Iunker, O Iu Surkova
{"title":"[Characteristics of metastasis and antimetastatic activity of macrophages in mice after postoperative immunomodulation].","authors":"N P Taraskina,&nbsp;V M Iunker,&nbsp;O Iu Surkova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Results of the treatment of spontaneous pulmonary metastases by immunocorrection after tumour resection in mice and the analysis of antimetastatic activity of spleen macrophages (SM) by the method of adoptive transfer are presented. The injection of cytotoxic SM, NK-cells or the use of the biological response (lipid A and MDP-PE) modifiers cause no decrease in the number of lung metastases. The SM of operated mice, as distinct from the SM of immunocorrected mice causes the metastatic spreading in lungs of recipient mice. This effect is supposed to be mediated by the suppressor macrophages secreting prostaglandin E2 (PgE2). The treatment of mice with indometacin (inhibitor of the PgE2-synthesis) in the drinking water resulted in the 7-8-fold decrease in the number of lung metastases in operated mice.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"67-70"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13526439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Inhibition of immune cytotoxic lymphocyte induction by antilymphocyte autoantibodies from the blood serum of patients with preleukemia and leukemia]. 白血病前期和白血病患者血清抗淋巴细胞自身抗体对免疫细胞毒性淋巴细胞诱导的抑制作用
Eksperimental'naia onkologiia Pub Date : 1990-01-01
A F Etkin, M M Gurevich
{"title":"[Inhibition of immune cytotoxic lymphocyte induction by antilymphocyte autoantibodies from the blood serum of patients with preleukemia and leukemia].","authors":"A F Etkin,&nbsp;M M Gurevich","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The influence of the presence of antilymphocyte IgG autoantibodies (ALA) from sera of haematologic patients and human retrovirus-infected ones was studied by determination of the cytotoxic lymphocyte (CTL) activity in mixed lymphocyte culture (MLC). Suppressive effects of ALA were shown at different levels. For initial 48 h of MLC in the presence of ALA the inhibition of antigen presentation by monocytes was identified and such ALA activity was adsorbed by stimulated lymphocytes. Moreover ALA induced production of soluble nondializable suppressive factors as well. The latest effects were linked to IL2-dependent lymphocyte proliferation as a result of the presence of anti-IL2R autoantibodies in the spectrum of ALA. No differences between effects of ALA from serum specimens of the used groups of patients and subjects have been detected.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"43-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13297234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The sensitivity of the blood lymphocytes in stomach cancer patients to met-enkephalin, dopamine and serotonin]. 胃癌患者外周血淋巴细胞对脑啡肽、多巴胺和血清素的敏感性。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
D D Kharkevich, G I Gubina, Z G Kadagidze
{"title":"[The sensitivity of the blood lymphocytes in stomach cancer patients to met-enkephalin, dopamine and serotonin].","authors":"D D Kharkevich,&nbsp;G I Gubina,&nbsp;Z G Kadagidze","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Sensitivity of blood lymphocytes to the stimulating effect of met-enkephalin and dopamine was shown to decrease at late stages of the gastric cancer (IIIB-IV) or in the case of metastases to other organs, while to the inhibitory effect of serotonin it increased as compared to early stages (I-IIA). Using specific blockers of opioid, dopamine and serotonin receptors it was shown that these effects were mediated through stimulation of respective type receptors.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 2","pages":"66-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13310714","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Effects of prostaglandins on the activity of natural killer cells during tumor growth]. 前列腺素对肿瘤生长过程中自然杀伤细胞活性的影响
Eksperimental'naia onkologiia Pub Date : 1990-01-01
Ia V Shparyk, B T Bilynskiĭ, T L Iuk
{"title":"[Effects of prostaglandins on the activity of natural killer cells during tumor growth].","authors":"Ia V Shparyk,&nbsp;B T Bilynskiĭ,&nbsp;T L Iuk","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Prostaglandins (PG) are studied for their effect on the activity of natural killer cells (NKC) under the tumour growth. The interaction of PG with other regulators of the NKC activity (interferons, interleukins) is considered.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"10-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13342737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Immunocytochemical detection of antigen associated with squamous cell cancer of the cervix uteri in women]. [妇女宫颈鳞状细胞癌相关抗原的免疫细胞化学检测]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
E S Ievleva, N V Marshutina, A I Ageenko, B G Tsukerman
{"title":"[Immunocytochemical detection of antigen associated with squamous cell cancer of the cervix uteri in women].","authors":"E S Ievleva,&nbsp;N V Marshutina,&nbsp;A I Ageenko,&nbsp;B G Tsukerman","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cervical preparations from 89 women were studied for antigen associated with squamous-cell cervical cancer (SCCC) by the indirect immunofluorescence method. The antigen was revealed specifically in 77.8% of samples of SCCC (stages Ib, II and III) in 64.3% of samples of cancer (in situ and stage Ia) in 55.5% of samples of displasia (stages II and III) and in 17.2% of samples from tumours of other organs. In samples of 9 healthy women the antigen was not revealed. Thus, the detection of antigen associated with SCCC may be useful in elaboration of adjuvant diagnostic and prognostic tests.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 4","pages":"65-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13351949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Initial morphological manifestations in experimental neuroleukemia]. 【实验性神经白血病的初步形态学表现】。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
S A Petrov
{"title":"[Initial morphological manifestations in experimental neuroleukemia].","authors":"S A Petrov","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The results of the study of primary morphological manifestation of neuroleukemia (MMN) by mice with transplanting leukemia strains L 1210, P-388, L 5178Y, and are presented. It is determined that the MMN development degree depends on the leukemia cells dissemination amplitude after their transplantation and, in particular, on the degree of the bone-marrow affection, from which the leukemia cells grow into the dura mater encephali and epidural fat of the vertebral canal from the side of skull bones and vertebral canal. The analogous dependence is assumed to be present in a man and, therefore, there appears the possibility of using it for the neuroleukemia development frequency prognosing.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"31-4"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13448273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reciprocal differences in the susceptibility to induction by ortho-aminoazotoluene of liver and vascular tumors in A/HeJ and CC67BR/Mv mice]. [A/HeJ和CC67BR/Mv小鼠肝脏和血管肿瘤对邻氨基偶氮甲苯诱导敏感性的互易差异]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
V I Kaledin, L A Semenova
{"title":"[Reciprocal differences in the susceptibility to induction by ortho-aminoazotoluene of liver and vascular tumors in A/HeJ and CC67BR/Mv mice].","authors":"V I Kaledin,&nbsp;L A Semenova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>When administered subcutaneously, ortho-aminoazotoluene induces predominantly liver tumours in A/HeJ mice but vascular tumours (located mainly in the interscapular brown fat pads) in CC57BR/Mv mice. Liver tumours are more frequent in females, while vascular tumours--in males. Under crossing, the susceptibility to induction of the both types of tumours in male F1 hybrids is inherited intermediately, whereas in females the resistance to induction of vascular tumours predominates.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"16-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13450407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[A possible role of phosphoprotein p53 in the mechanism of autostimulation of tumor cell proliferation]. [磷酸化蛋白p53在自身刺激肿瘤细胞增殖机制中的可能作用]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
A I Ageenko, V S Erkhov, L V Cherniaev, L Iu Volkova
{"title":"[A possible role of phosphoprotein p53 in the mechanism of autostimulation of tumor cell proliferation].","authors":"A I Ageenko,&nbsp;V S Erkhov,&nbsp;L V Cherniaev,&nbsp;L Iu Volkova","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It has been shown that phosphoprotein p53 may participate in the DNA-synthesis stimulation in the mixed culture of tumour cells and syngeneic embryonic mouse cells (10 days of pregnancy). This effect has been eliminated by the preliminary treatment of embryonic cells in vitro by the monoclonal antibodies to p53 (pAb421) in the model system. A conclusion is drawn that p53-epitopes of embryonic cell surface membrane take part in the formation of the determinant which is recognized by receptors of tumour cells. The stimulation of DNA-synthesis in tumour cells is resulted by this process.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 1","pages":"35-7"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12853483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Monoclonal antibodies IGR to nuclear antigens of neutrophilic granulocytes of human blood]. [人血嗜中性粒细胞核抗原单克隆抗体IGR]。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
S O Ingerpuu, A O Piĭrsoo, A E Siunter, S Iu Kivi
{"title":"[Monoclonal antibodies IGR to nuclear antigens of neutrophilic granulocytes of human blood].","authors":"S O Ingerpuu,&nbsp;A O Piĭrsoo,&nbsp;A E Siunter,&nbsp;S Iu Kivi","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Four monoclonal antibodies (Mabs) of series IGR-1 and IGR-2 to nuclear antigens of neutrophilic granulocytes of human peripheral blood were obtained. Mabs IGR-1 2B8 and IGR-1 6B5 are bound to their specific antigens in the nuclei of all the investigated human cell lines. These Mabs were also specific for metaphase chromosomes of cell lines HL-60 and U-937. Investigations on the ultrastructural level showed that Mabs IGR-1 6B5 reacted with the HL-60 nuclear heterochromatin region. Mabs IGR-1 3D3 and IGR-2 2F1 manifested high specificity only for the nuclei of mature neutrophils and of plasma cells.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 3","pages":"24-8"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12857488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[The role of proto-oncogenes in fundamental manifestations of life]. 原癌基因在生命基本表现中的作用。
Eksperimental'naia onkologiia Pub Date : 1990-01-01
I F Seĭts
{"title":"[The role of proto-oncogenes in fundamental manifestations of life].","authors":"I F Seĭts","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Problems of the origin, structure and functions, in the cells and tissues, of the so-called proto-oncogenes (c-onc)--cell genes, homologues and oncogene foreparents (v-onc)--are considered in the review. Up-to-date data are given to show the participation of the main groups of proto-oncogenes in the processes of cell division, proliferation and differentiation. The role of c-onc genes is found to be important for fundamental manifestations of the cell life activity. Special attention is paid to the problem of interrelation of the proto-oncogenes with growth factors and their receptors.</p>","PeriodicalId":77530,"journal":{"name":"Eksperimental'naia onkologiia","volume":"12 6","pages":"14-26"},"PeriodicalIF":0.0,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12867079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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