[A/HeJ和CC67BR/Mv小鼠肝脏和血管肿瘤对邻氨基偶氮甲苯诱导敏感性的互易差异]。

Eksperimental'naia onkologiia Pub Date : 1990-01-01
V I Kaledin, L A Semenova
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引用次数: 0

摘要

皮下给药时,邻氨基偶氮甲苯在A/HeJ小鼠中主要诱导肝脏肿瘤,而在CC57BR/Mv小鼠中主要诱导血管肿瘤(主要位于肩胛间棕色脂肪垫)。肝脏肿瘤在女性中更常见,而血管肿瘤在男性中更常见。在杂交条件下,雄性F1杂种对诱导两种肿瘤的易感性是中间遗传的,而雌性对诱导血管肿瘤的抗性占主导地位。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Reciprocal differences in the susceptibility to induction by ortho-aminoazotoluene of liver and vascular tumors in A/HeJ and CC67BR/Mv mice].

When administered subcutaneously, ortho-aminoazotoluene induces predominantly liver tumours in A/HeJ mice but vascular tumours (located mainly in the interscapular brown fat pads) in CC57BR/Mv mice. Liver tumours are more frequent in females, while vascular tumours--in males. Under crossing, the susceptibility to induction of the both types of tumours in male F1 hybrids is inherited intermediately, whereas in females the resistance to induction of vascular tumours predominates.

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