吲哚美辛和卡介苗对小鼠移植瘤生长的影响。

Eksperimental'naia onkologiia Pub Date : 1990-01-01

Iu N Kurunov, V I Kaledin

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引用次数: 0

摘要

在饮水中持续给予吲哚美辛(indomethacin, IM)(20微克/毫升)对对照小鼠可移植肿瘤的生长有中度抑制作用，但与移植肿瘤细胞联合接种卡介苗的抗肿瘤作用明显增强。对疫苗不敏感的29号肝癌在注射IM后变得高度敏感。

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[Effects of indomethacin and BCG vaccine on growth of transplanted tumors in mice].

Continuous administration of indomethacin (IM) in drinking water (20 micrograms/ml) causes moderate inhibition of the growth of transplantable tumors in control mice but significantly increases the antitumor effect of BCG vaccine inoculated in combination with transplanted tumor cells. Hepatoma 29, insensitive to the vaccine becomes highly sensitivity to it under IM administration.

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Eksperimental'naia onkologiia

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