Journal of experimental animal science最新文献_第9页

A new set of recombinant inbred strains complementary to HXB and BXH sets 与HXB和BXH组合互补的一组新的重组自交系

Journal of experimental animal science Pub Date : 2000-03-01 DOI: 10.1016/S0939-8600(00)80030-9

Vladimír Křen, Vlasta Bílá, Rudolf Kašparek, Drahomíra Křenová

{"title":"A new set of recombinant inbred strains complementary to HXB and BXH sets","authors":"Vladimír Křen, Vlasta Bílá, Rudolf Kašparek, Drahomíra Křenová","doi":"10.1016/S0939-8600(00)80030-9","DOIUrl":"10.1016/S0939-8600(00)80030-9","url":null,"abstract":"<div>A new set of recombinant inbred [RI]strains has been developed complementary to the original RI strains BXH/HXB using the BXH2 RI strain and the SHR-Lx congenic strain as progenitors, both homozygous in Lx locus. The reason behind the production of this lies in a special SHR/BN gene combination in the BXH2 strain which is increasing the expressivity of the Lx gene and sensitizes this strain to teratogenic effects. On the contrary, the SHR genetic background minimizes the Lx gene expression as well as the teratogenic action of retinoic acid.There are 10 PXO strains in 17th up to 21st generation of inbreeding. The variability of leg malformation on PXO strains is similar to that in BXH/HXB polydactylous RI strains. The genotyping of PXO RI set has been started showing relatively high degree of homozygosity [over 90%] in individual RI strains. After inbreeding is accomplished the PXO will have become a useful complement to the original RI strain system. In preliminary teratologic testing, variable sensitivity to retinoic acid has been shown in 3 PXO strains.</div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"41 1","pages":"Pages 54-56"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80030-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56856973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Search for chromosomal regions carrying uterine cancer susceptibility genes in rats 寻找大鼠携带子宫癌易感基因的染色体区域

Journal of experimental animal science Pub Date : 2000-03-01 DOI: 10.1016/S0939-8600(00)80033-4

B. Beckmann , C.-M. Prokop , D. Wedekind , G. Levan , C. Szpirer , H.J. Hedrich

{"title":"Search for chromosomal regions carrying uterine cancer susceptibility genes in rats","authors":"B. Beckmann , C.-M. Prokop , D. Wedekind , G. Levan , C. Szpirer , H.J. Hedrich","doi":"10.1016/S0939-8600(00)80033-4","DOIUrl":"10.1016/S0939-8600(00)80033-4","url":null,"abstract":"<div>Uterine cancer is the fourth most frequent cancer in women. Therefore, a suitable animal model is needed. The BDII rat appears to be a good model since there are similarities in the uterine tumors in man and rat. These similarities refer to the estrogen dependent growth, the age related occurrence, the histological pattern and the inheritance.Virgin BDII rats develop these tumors with an incidence >90%. F1 and F2 offspring of a cross between BDII and SPRD-Cu3 (resistant) as well as BN (low incidence) are informative for the genetics of this heritable, the following number of malignant uterine tumors occured:F1-population: BDII × SPRD-Cu3 (n = 16): 1 (6,25%) BDII × BN (n = 18): 8 (44%)F2-population: BDII × SPRD-Cu3 (n = 53): 10 (18,5%) BDII × BN (n = 59): 16 (27%)Together with teams from Gothenburg and Brussel we have started a whole genome scan in both F2 populations. Our group examined RNO 4, 7, 11, 12, 13, 15, 18, 19, 20. RNO11 and RNO13 turned out to be interesting regarding the uterine tumors. Upon fine mapping it should be possible to identify the relevant genes and to use this information to identify the respective chromosomal regions in man.</div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"41 1","pages":"Pages 64-67"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80033-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56857049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Partial cloning of the class I gene-encompassing regions in the rat major histocompatibility complex 大鼠主要组织相容性复合体中I类基因包围区域的部分克隆

Journal of experimental animal science Pub Date : 2000-03-01 DOI: 10.1016/S0939-8600(00)80038-3

Lutz Walter, Sofia Ioannidu, Eberhard Günther

引用次数: 0

Cyclosporine A-induced autoimmunity: an animal model for human scleroderma 环孢素a诱导的自身免疫:人类硬皮病的动物模型

Journal of experimental animal science Pub Date : 2000-03-01 DOI: 10.1016/S0939-8600(00)80021-8

J. Damoiseaux, H. van der Heijden, J. van de Gaar, P. van Breda Vriesman

{"title":"Cyclosporine A-induced autoimmunity: an animal model for human scleroderma","authors":"J. Damoiseaux, H. van der Heijden, J. van de Gaar, P. van Breda Vriesman","doi":"10.1016/S0939-8600(00)80021-8","DOIUrl":"10.1016/S0939-8600(00)80021-8","url":null,"abstract":"<div>Animal models have been shown to be very valuable in the elucidation of pathologic mechanisms in complex human diseases. However, conscientious comparison with the human disease is required to define to what extend the respective model is relevant for the human situation. In this study we have compared Cyclosporine A-induced autoimmunity in the rat with human scleroderma and hereby we have taken into account the histo- and immunopathology, the presence of vascular abnormalities, and the occurrence of circulating autoantibodies. Altogether, the macroscopical and histopathological similarities are the most important characteristics for considering Cyclosporine A-induced autoimmunity as an experimental model for human scleroderma. Furthermore, the presence of T cells and macrophages in the lesions, as well as the peripheral immune deviation within the CD4 T cell compartment are two other common factors and they justify the use of the animal model Cyclosporine A-induced autoimmunity in further studies on the role of T cells in the pathogenesis of scleroderma.</div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"41 1","pages":"Pages 22-26"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80021-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56856628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Putative candidate genes for blood pressure control in the SHR.BN-RNO8 congenic substrains SHR中可能控制血压的候选基因。BN-RNO8同源亚株

Journal of experimental animal science Pub Date : 2000-03-01 DOI: 10.1016/S0939-8600(00)80029-2

Drahomíra Křenová , Lucie Šoltysová , Michal Pravenec , Marie-Pierre Moisan , W. Theodore Kurtz , Vladimír Křen

{"title":"Putative candidate genes for blood pressure control in the SHR.BN-RNO8 congenic substrains","authors":"Drahomíra Křenová , Lucie Šoltysová , Michal Pravenec , Marie-Pierre Moisan , W. Theodore Kurtz , Vladimír Křen","doi":"10.1016/S0939-8600(00)80029-2","DOIUrl":"10.1016/S0939-8600(00)80029-2","url":null,"abstract":"<div>The SHR-Lx congenic strain carrying a differential segment of chromosome 8 of BN and PD origin was recently shown to exhibit a significant decrease in blood pressure as compared to the SHR strain. There were two positional candidate genes for blood pressure control mapped to the differential segment: the rat kidney epithelial potassium channel gene (Kcnj1) and brain dopamine receptor 2 gene (Drd2). Bot these genes were separated into SHR.BN-RNO8 congenic substrains. In this communication, we are presenting the assignment of two further putative candidate genes, which might be involved in blood pressure control to the BN/PD differential segment of the SHR-Lx congenic strain. These are: the gene coding for smooth muscle cell specific protein 22 (Sm22) defined by the D8Mcw1 marker and neuronal nicotinic acetylcholine receptor gene cluster, defined by the D8Bord1 marker. Moreover, the glutamate receptor gene Grik4 which also maps to the differential segment of the SHR-Lx should be taken into account. The genetic separation of all these putative candidate genes of blood pressure control is being performed by recombinations and subsequent selection using (SHR×SHR-Lx) intercross population.</div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"41 1","pages":"Pages 51-53"},"PeriodicalIF":0.0,"publicationDate":"2000-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80029-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56856957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Modern genetic mapping approaches in laboratory animals/rats 实验动物/大鼠的现代基因作图方法

Journal of experimental animal science Pub Date : 2000-03-01 DOI: 10.1016/S0939-8600(00)80023-1

Howard J. Jacob

引用次数: 1

A retrospective study of the microbiological and parasitological status of laboratory rodents in France 法国实验室啮齿动物微生物学和寄生虫学现状回顾性研究

Journal of experimental animal science Pub Date : 2000-01-01 DOI: 10.1016/S0939-8600(00)80013-9

Lionel Zenner, Jean-Pierre Regnault

{"title":"A retrospective study of the microbiological and parasitological status of laboratory rodents in France","authors":"Lionel Zenner, Jean-Pierre Regnault","doi":"10.1016/S0939-8600(00)80013-9","DOIUrl":"10.1016/S0939-8600(00)80013-9","url":null,"abstract":"<div>Between 1988 and 1997, 72 mouse colonies and 38 rat colonies were examined for the presence of bacteria parasite infections. Among mouse and rat bacteria, high positive rates were observed with Proteus species (sp.), Pasteurella pneumotropica, Mycoplasma sp. and Pseudomonas aeruginosa. Concerning murine colonies, parasites frequently detected were Tritrichomonas sp., Syphacia sp., Aspiculuris tetraptera, Entamoeba muris, Spironucleus muris, Myobia musculi, Chilomastix sp. and Myocoptes musculinus. In rats, high rates were obtained with Syphacia sp., Tritrichomonas sp., Spironucleus muris, Entamoeba muris and Chilomastix sp. During the first part of the last decade, some agents such as Clostridium piliforme, Citrobacter sp., Mycoplasma sp., Pseudomonas aeruginosa, Myobia musculi, Radfordia ensifera, Spironucleus muris and Giardia muris were often found among rodents, and most of them were still present in 1997. At the time of our study, results point out that some agents are still persistent, even increasing during the same period. It is particularly the case for parasites such as Entamoeba muris and the oxyurids, but also for bacteria like Proteus sp. and Klebsiella pneumoniae. We can thus conclude that only very limited success has been achieved in preventing microbial and parasitic infections in mice and rats colonies.</div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 4","pages":"Pages 211-222"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80013-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56856119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Development of neutralizing antibodies correlates with resolution of interstitial pneumonia after measles virus infection in cotton rats 中和抗体的产生与棉大鼠麻疹病毒感染后间质性肺炎的消退相关

Journal of experimental animal science Pub Date : 2000-01-01 DOI: 10.1016/S0939-8600(00)80012-7

Stefan Niewiesk , Paul-Georg Germann

引用次数: 8

High resolution genetic and physical mapping of the mouse asebia locus: A key gene locus for sebaceous gland differentiation 小鼠asebia基因座的高分辨率遗传和物理定位:皮脂腺分化的关键基因座

Journal of experimental animal science Pub Date : 2000-01-01 DOI: 10.1016/S0939-8600(00)80008-5

Kenneth J. Eilertsen , Tai Tran , John P. Sundberg , Kurt S. Stenn , Satish Parimoo

{"title":"High resolution genetic and physical mapping of the mouse asebia locus: A key gene locus for sebaceous gland differentiation","authors":"Kenneth J. Eilertsen , Tai Tran , John P. Sundberg , Kurt S. Stenn , Satish Parimoo","doi":"10.1016/S0939-8600(00)80008-5","DOIUrl":"10.1016/S0939-8600(00)80008-5","url":null,"abstract":"<div>The asebia (ab) mutation in the mouse is an autosomal recessive trait with hypoplastic sebaceous glands. As a first step toward cloning the ab gene, we report here the genetic mapping of the ab locus with respect to Chromosome 19 microsatellite markers. 644 backcross progeny were generated by mating (CAST/EiJ × DBA/1LacJ-ab2J/ab2J) F1 heterozygous females and parental ab2J/ab2J mutant males. Our results located the ab gene to an interval of 1.6 cM on mouse Chromosome 19 defined by flanking markers D19Mit11 and D19Mit53/D19Mit27, and identified a tightly linked polymorphic marker, D19Mit67, that co-segregates with the mutation in the backcross progeny examined. This places ab locus 4 cM distal to its present position as indicated in Mouse Genome Database at The Jackson Laboratory. We have also mapped a yeast artificial chromosome (YAC) contig in this locus interval which suggests the ab interval to be less than one megabase of DNA.</div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 4","pages":"Pages 165-170"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80008-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56855929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Nicotine consumption of several mouse strains using a two bottle choice paradigm 使用两瓶选择范式的几种小鼠品系的尼古丁消耗

Journal of experimental animal science Pub Date : 2000-01-01 DOI: 10.1016/S0939-8600(00)80009-7

Susanne Aschhoff , Karl-Christian Schroff , Dieter B. Wildenauer , Elmar Richter

引用次数: 26