{"title":"Bulbourethral (Cowper's) gland abnormalities in inbred laboratory mice","authors":"Matti Kiupel , Kathy S. Brown , John P. Sundberg","doi":"10.1016/S0939-8600(00)80010-3","DOIUrl":"10.1016/S0939-8600(00)80010-3","url":null,"abstract":"<div><p>Abnormalities of the bulbourethral (Cowper's) glands are rare in most strains of inbred laboratory mice. Since the glands are covered with striated muscle and because of their small size, the bulbourethral glands are often overlooked at necropsy. We review the gross and microscopic anatomy of the bulbourethral glands in laboratory mice and report in SJL/J and RBF/DnJ mice a series of anomalies of this gland that appear to be common in these strains and relatively strain specific. From 14 different inbred strains of mice that had been submitted for necropsy over a period of 4.5 years for various clinical complaints, including enlargement of the perianal region, 23.8% of SJL/J mice (27/113) and 51.2% of RBF/DnJ mice (21/41) had cystic hyperplasia of the bulbourethal glands. Furthermore 7.3% of BALB/cByJ mice (3/41) had cystic glands and 6.7% of DBA/2J mice (4/60) had enlarged bulbourethal glands, three of which (5.0%) were abscessed. All selected mice were active male breeders older than 6 months of age from production colonies at The Jackson Laboratory. Detailed examination of bulbourethral glands of retired SJL/J breeders revealed cystic glands in 83.8% (109/130) of mice. No abnormalities were found in the other inbred strains of mice investigated.</p></div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 4","pages":"Pages 178-188"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80010-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56855980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anja Kracke , Thomas Tschernig , Annette Hoffmann , Norbert Krug , Frank Fliegert , Reinhard Pabst
{"title":"Anatomy of a pulmonary immune response: Kinetics in different leukocyte pools","authors":"Anja Kracke , Thomas Tschernig , Annette Hoffmann , Norbert Krug , Frank Fliegert , Reinhard Pabst","doi":"10.1016/S0939-8600(00)80011-5","DOIUrl":"10.1016/S0939-8600(00)80011-5","url":null,"abstract":"<div><p>In pulmonary immune reactions the cells which can be obtained by bronchoalveolar lavage (BAL) are only one part of the picture. In this study the kinetics of an experimental pulmonary immune response were investigated simultaneously in different lung compartments in the same rat. On days 0, 1, 2, 3, 4, 5 and 11 after intratracheal challenge with sheep red blood cells, leukocytes were taken from the bronchoalveolar, the interstitial and the marginal lung vascular pool as well as from the peripheral blood. Total numbers of granulocytes, NK cells, B and T cells, CD4<sup>+</sup> and CD8<sup>+</sup> cells were determined. Histology and in vivo labeling of proliferating cells was performed. On day 1 after challenge an increase of granulocytes in the BAL was found. In the BAL the total number of T lymphocytes increased on day 1 and day 2 and the CD4/CD8 ratio increased from day 1 to day 5, indicating an influx of CD4<sup>+</sup> T cells. Changes in the lung interstitium showed a similar tendency, but were not found in the marginal pool or blood. Histologically cellular infiltrates were seen around the pulmonary small vessels. Little local proliferation occurred in the different lung compartments, indicating mainly immigration of cells. Further studies will focus on the expression of adhesion molecules during an immune response, to learn more about the mechanisms responsible for the increase of lymphocytes.</p></div>","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 4","pages":"Pages 189-200"},"PeriodicalIF":0.0,"publicationDate":"2000-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(00)80011-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56856159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Report on rat chromosome 14","authors":"Svetlana V. Dracheva, Elaine F. Remmers","doi":"10.1016/S0939-8600(99)80015-7","DOIUrl":"10.1016/S0939-8600(99)80015-7","url":null,"abstract":"","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 1","pages":"Pages 111-115"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(99)80015-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56258698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Dominique Gauguier, Pamela J. Kaisaki, Marie Thérese Bihoreau
{"title":"Report on rat chromosome 4","authors":"Dominique Gauguier, Pamela J. Kaisaki, Marie Thérese Bihoreau","doi":"10.1016/S0939-8600(99)80005-4","DOIUrl":"10.1016/S0939-8600(99)80005-4","url":null,"abstract":"","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 1","pages":"Pages 37-46"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(99)80005-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56258273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Report on rat chromosome 11","authors":"Elaine F. Remmers, Ronald L. Wilder","doi":"10.1016/S0939-8600(99)80012-1","DOIUrl":"10.1016/S0939-8600(99)80012-1","url":null,"abstract":"","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 1","pages":"Pages 93-95"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(99)80012-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56258562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"International symposium for life-sciences and computertechnology","authors":"","doi":"10.1016/S0939-8600(99)80025-X","DOIUrl":"https://doi.org/10.1016/S0939-8600(99)80025-X","url":null,"abstract":"","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 1","pages":"Page 164"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(99)80025-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138256588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Report on rat chromosome 15","authors":"M.T. Bihoreau, D. Gauguier","doi":"10.1016/S0939-8600(99)80016-9","DOIUrl":"10.1016/S0939-8600(99)80016-9","url":null,"abstract":"","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 1","pages":"Pages 117-120"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(99)80016-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56258844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H.A. van Lith (Chair of Committee for Rat Chromosome 16) , M. den Bieman , G. Levan , K. Matsumoto , C. Szpirer , L.F.M. van Zupthen
{"title":"Report on rat chromosome 16","authors":"H.A. van Lith (Chair of Committee for Rat Chromosome 16) , M. den Bieman , G. Levan , K. Matsumoto , C. Szpirer , L.F.M. van Zupthen","doi":"10.1016/S0939-8600(99)80017-0","DOIUrl":"10.1016/S0939-8600(99)80017-0","url":null,"abstract":"","PeriodicalId":77206,"journal":{"name":"Journal of experimental animal science","volume":"40 1","pages":"Pages 121-127"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0939-8600(99)80017-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"56258964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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