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American journal of physiologic imaging最新文献

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The captopril renogram in percutaneous transluminal angioplasty of the renal arteries. 卡托普利重图在经皮腔内肾动脉血管成形术中的应用。
American journal of physiologic imaging Pub Date : 1992-01-01
A J Meholic, M C Saddler, G W Hallin, P S Avasthi, A H Tzamaloukas
{"title":"The captopril renogram in percutaneous transluminal angioplasty of the renal arteries.","authors":"A J Meholic,&nbsp;M C Saddler,&nbsp;G W Hallin,&nbsp;P S Avasthi,&nbsp;A H Tzamaloukas","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Technetium-99m DTPA renograms were performed before and after angioplasty in a 63-year-old man with bilateral renal artery stenosis (RAS), hypertension, and renal insufficiency. Decreased isotope uptake after captopril by the right kidney assisted in the selection of the right renal artery for angioplasty. Post-angioplasty improvement in both blood pressure control and renal function was accompanied by an absence of effect of captopril on the isotope uptake by the right kidney. In bilateral RAS, the captopril renogram is a useful tool for selecting the site for angioplasty, for assessing the adequacy of the procedure, and for long-term follow-up.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"36-41"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12560246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dynamic human glycogen and glucose metabolism detection utilizing in vivo 13C NMR. 利用体内13C核磁共振动态检测人体糖原和葡萄糖代谢。
American journal of physiologic imaging Pub Date : 1992-01-01
M Ishihara, H Ikehira, S Nishikawa, T Hashimoto, K Yamada, F Shishido, T Ogino, K Cho, S Kobayashi, M Kawana
{"title":"Dynamic human glycogen and glucose metabolism detection utilizing in vivo 13C NMR.","authors":"M Ishihara,&nbsp;H Ikehira,&nbsp;S Nishikawa,&nbsp;T Hashimoto,&nbsp;K Yamada,&nbsp;F Shishido,&nbsp;T Ogino,&nbsp;K Cho,&nbsp;S Kobayashi,&nbsp;M Kawana","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The dynamic detection studies of glucose-glycogen metabolism of the human liver were performed with normal volunteers. A single tuned surface coil of 20-cm diameter was used for 13C (at 16.04 MHz). Natural glucose 100 g was administered for the natural abundance 13C MR dynamic study and 13C enriched (99%) 1-13C-D-glucose 1 g mixed 75 g glucose was administered to study the 13C enrichment effect. The total scan time of this dynamic study was 1 hr and each single scan time was 20 min. We did not use proton decoupling for the human 13C MR study. Localized (PRIME) proton shimming was performed and the shim value was less than 20 Hz. Glucose and glycogen spectra were clearly visible at 120 to 80 ppm and about 3 hr later both peaks almost disappeared. These data demonstrate that dynamic hepatic glucose-glycogen metabolism should be possible to detect which should allow for the direct diagnosis of hepatic glucose-glycogen metabolic disorders.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"32-5"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12689090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiac function and Fourier phase data from simulated Wolff-Parkinson-White syndrome in a baboon model. 狒狒模型中模拟沃尔夫-帕金森-怀特综合征的心功能和傅立叶相位数据。
American journal of physiologic imaging Pub Date : 1992-01-01
I C Dormehl, A L van Gelder, N Hugo, J J Stanton, I F Redelinghuys
{"title":"Cardiac function and Fourier phase data from simulated Wolff-Parkinson-White syndrome in a baboon model.","authors":"I C Dormehl,&nbsp;A L van Gelder,&nbsp;N Hugo,&nbsp;J J Stanton,&nbsp;I F Redelinghuys","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The diagnostic value of Fourier phase analysis and planar scintigraphy in Wolff-Parkinson-White (WPW) syndrome has been suspect. This study investigates phase analytical data from planar radionuclide ventriculography of six baboons with simulated WPW syndrome by means of implanted electrodes. An electrode in the atrium controlled the heart rate and a subsequent stimulation was delivered by electrodes placed at different sites on the ventricles, delayed to cause the characteristic delta wave of the WPW syndrome. Sensitivity for accurately-localizing variously-situated first points of activation (FPAs) from the Fourier phase images was found highest for premature right ventricular (RV) activation, and for atrioventricular (AV) delays around 125 msec. Other sites were subject to artifacts. Changes in cardiac function, phase delay, and histogram parameters were not statistically meaningful.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"12-9"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12689084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Detecting coronary artery disease using SPECT imaging: a comparison of thallium-201 and teboroxime. 用SPECT显像检测冠状动脉疾病:铊-201和替博肟的比较。
American journal of physiologic imaging Pub Date : 1992-01-01
R M Fleming
{"title":"Detecting coronary artery disease using SPECT imaging: a comparison of thallium-201 and teboroxime.","authors":"R M Fleming","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Thirty subjects underwent single photon emission computed tomography (SPECT) imaging with technetium-99m teboroxime (TEBO). Of these, 26 underwent thallium SPECT imaging and 25 underwent quantitative coronary arteriography (QCA). Twenty-one of the subjects underwent all three studies. SPECT images were reviewed by two independent observers blinded to the clinical data. Stenoses were considered significant if there was a greater than or equal to 50% diameter narrowing as defined by QCA analysis of the coronary arteriograms. The overall sensitivity and specificity was 78% and 78%, respectively, for thallium-201. The overall sensitivity and specificity for teboroxime was 72% and 80%, respectively. The results obtained for these two tracers were not statistically different. Some of the false-positive results obtained from teboroxime imaging appear to have been due to the 10-min acquisition protocol and can be reduced with the use of new software programs using a continuous 3-min acquisition and dipyridamole. Teboroxime's rapid biologic half-life allows completion of SPECT imaging within 60-90 min, compared with the minimum of 4 h required for thallium SPECT imaging.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"20-3"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12689088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor and organ biochemical profiles determined in vivo following uptake of a combination of radiolabeled substrates: potential applications for PET. 肿瘤和器官的生化特征确定在体内后的放射性标记底物的组合摄取:PET的潜在应用。
American journal of physiologic imaging Pub Date : 1992-01-01
B Schmall, P S Conti, D J Schaeffer, E L Kleinert
{"title":"Tumor and organ biochemical profiles determined in vivo following uptake of a combination of radiolabeled substrates: potential applications for PET.","authors":"B Schmall,&nbsp;P S Conti,&nbsp;D J Schaeffer,&nbsp;E L Kleinert","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>This paper describes a method which generates an in vivo metabolic profile of tumors and organ tissues derived from the tissue uptake of a combination of radiotracers. Metabolic substrates labeled with carbon-11, a positron-emitting radionuclide (T1/2 = 20.4 min) have been used to probe tumor metabolism in vivo using positron emission tomography (PET). Carbon-11 labeled radiotracers which have been used include alpha-aminoisobutyric acid (AIB), 2-deoxy-D-glucose (2-DG), and thymidine (TdR). This paper reports data on the tissue distribution of carbon-14 labeled analogues of AIB, 2-DG, and TdR. Tissue distribution studies were carried out in normal male Copenhagen rats, in rats bearing Dunning R3327G or R3327H prostatic adenocarcinomas, and in tumor rats that have been treated with difluoromethylornithine and methylglyoxal-bisguanylhydrazone, or with diethylstilbestrol. A combination of the tissue distribution data of these radiolabeled agents is used to provide a metabolic description of the state of a tumor or tissue in vivo. This approach to defining a tissue's biochemical profile may be useful for the assessment and prediction of a therapeutic response, even at low tracer concentrations in a tumor, and may be useful in relating the biochemical characteristics of one tissue to that of another.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"2-11"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12689086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Hilbert transform to radionuclide-gated cardiac studies: analysis of asynchronous emptying and filling in various heart diseases. 希尔伯特变换在放射性核素门控心脏研究中的应用:各种心脏疾病的非同步排空和充血分析。
American journal of physiologic imaging Pub Date : 1992-01-01
K Murase, T Mochizuki, Y Fujiwara, S Tanada, K Hamamoto
{"title":"Application of Hilbert transform to radionuclide-gated cardiac studies: analysis of asynchronous emptying and filling in various heart diseases.","authors":"K Murase,&nbsp;T Mochizuki,&nbsp;Y Fujiwara,&nbsp;S Tanada,&nbsp;K Hamamoto","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Fourier phase analysis has generally been used to investigate asynchronous emptying and filling in various heart diseases. A potential limitation of this form of analysis is curve fitting error, since a truncated Fourier series may not adequately describe the shape of a time-volume curve (TVC) and thus may produce errors in indices calculated from the fit. To overcome this problem, we developed a new method using Hilbert transform. Using Hilbert transform, the instantaneous phase (IP) curve was calculated directly from the TVC obtained from multigated cardiac blood pool images. Four parameters [time to maximum IP [T(max)], time to 0 in IP[T(0)], time to minimum IP[T(min)], and time from 0 to minimum IP [T(min-0)]] were extracted from the IP curves for each pixel, and functional images were constructed in 40 patients with ischemic heart disease (IHD), 16 with hypertrophic cardiomyopathy (HCM), 3 with dilated cardiomyopathy (DCM), and 7 normal controls (N). The standard deviations (SD) of these parameters were then calculated for the left ventricle. In IHD patients with a left ventricle ejection fraction (LVEF) of less than 50% and in DCM, the SDs of all parameters were significantly higher than in group N. In IHD patients with an LVEF of greater than 50%, the SDs of T(min), T(0), and T(min-0) were significantly higher than in group N, but there was no significant difference in the SD of T(max). In HCM patients, the SDs of T(min) and T(min-0) were significantly higher than in group N, suggesting the presence of asynchronous filling. In conclusion, this method appears to be promising for the quantitative analysis of asynchronous emptying and filling in various heart diseases.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"24-31"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12688991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: diffuse gastrointestinal bleeding. 病例报告:弥漫性消化道出血。
American journal of physiologic imaging Pub Date : 1992-01-01
M L Goris, R Licho
{"title":"Case report: diffuse gastrointestinal bleeding.","authors":"M L Goris,&nbsp;R Licho","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Diffuse gastrointestinal bleeding in an immunodeficient patient is presented. Two hours after in vivo erythrocyte labeling, abnormal activity was observed in the wall of a distended colon. If this abnormal concentration had been luminal, a focal, surgically treatable lesion could not have been excluded. This pattern of hemorrhagic colonic lesions has been described pathologically, but not scintigraphically, in immune deficient patients.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 1","pages":"42-3"},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vicarious gastric excretion of intravenous contrast. 静脉造影剂替代胃排泄。
American journal of physiologic imaging Pub Date : 1991-10-01
A J Meholic, M Davis, C Bonmati
{"title":"Vicarious gastric excretion of intravenous contrast.","authors":"A J Meholic,&nbsp;M Davis,&nbsp;C Bonmati","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Radiographic identification of vicarious excretion of intravenous contrast into the stomach has not previously been cited in the literature. We report here an instance of gastric excretion of iodinated intravenous contrast following excretory urography in a severely burned patient. The physiology and possible pathways of vicarious excretion of contrast are discussed.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"6 4","pages":"197-200"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12979190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in patients with malignant melanoma. 碳-11标记α -氨基异丁酸(AIB)在恶性黑色素瘤患者中的肿瘤成像。
American journal of physiologic imaging Pub Date : 1991-10-01
P P Sordillo, G R DiResta, J Fissekis, P Conti, R S Benua, S D Yeh, J S Laughlin
{"title":"Tumor imaging with carbon-11 labeled alpha-aminoisobutyric acid (AIB) in patients with malignant melanoma.","authors":"P P Sordillo,&nbsp;G R DiResta,&nbsp;J Fissekis,&nbsp;P Conti,&nbsp;R S Benua,&nbsp;S D Yeh,&nbsp;J S Laughlin","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The potential usefulness of [C-11]-labeled alpha-aminoisobutyric acid (AIB) for tumor imaging has been demonstrated previously in our findings of increased tumor uptake with C-14-labeled AIB in human melanoma heterotransplants in nude mice, and subsequently, in a single case study using C-11 AIB to demonstrate the extent of metastases in patient with widespread malignant melanoma. We report here on the use of C-11 AIB in ten patients with metastatic or unresectable malignant melanoma. Five patients had intense tracer uptake at all known sites of tumor involvement. A sixth patient had good uptake in metastatic lesions in the shoulder and the pelvis, but did not demonstrate uptake within metastatic lesions in the lungs. Two patients had only minimal uptake over the tumor lesions while the two other patients had essentially normal studies. Further studies with C-11 AIB in patients with melanoma and other tumors are warranted.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"6 4","pages":"172-5"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12979182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simplified radiolabeling and initial experimental studies of the in vivo kinetics of iodine-123 atrial natriuretic peptide. 碘-123心房利钠肽体内动力学的简化放射性标记和初步实验研究。
American journal of physiologic imaging Pub Date : 1991-10-01
N Scheffold, B Woesle, H Wolf, E Henze
{"title":"Simplified radiolabeling and initial experimental studies of the in vivo kinetics of iodine-123 atrial natriuretic peptide.","authors":"N Scheffold,&nbsp;B Woesle,&nbsp;H Wolf,&nbsp;E Henze","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Conventional methods regarding the iodination of atrial natriuretic factor (ANP) were associated with the use of high performance liquid chromatography in a linear elution technique. This chromatographic system is not standard in most radiochemical laboratories. The present study describes a method that allows labeling of ANP with 123I-iodide by using conventional isocratic HPLC equipment. First, the labeled protein was purified in a cascaded way. Then eight gradients with a ratio of acetonitrile/water of 5/95 up to 60/40 (v/v) and a time range of 5 min were applied. The iodinated ANP eluted at about 25 to 30% of acetonitrile. Centrifugation with a speedvac resulted in an injectable solution. Administration of about 20 MBq/kg [123I]iodo-ANP to a rabbit was performed in a pilot study to evaluate the in vivo kinetics of various organs by dynamic acquisition with a gamma camera. The kidneys showed an increasing uptake from 4.2 to 5.3% of total body activity after 75 min. An increasing tracer uptake was also observed in the skull region from 2.4% after 10 min to 3.6% at 75 min. The time activity curve of the liver showed a decrease from 6.6 to 5.1% and that of the heart from 3.7 to 2.9% at 75 min. Thus, labeling of ANP--and probably other peptides--is possible with a simplified cascade elution procedure without the use of gradient HPLC equipment.</p>","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"6 4","pages":"190-3"},"PeriodicalIF":0.0,"publicationDate":"1991-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13001320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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