American journal of physiologic imaging最新文献_第2页

Development of the scintillation camera. 闪烁照相机的研制。

American journal of physiologic imaging Pub Date : 1992-07-01

J J Erickson

引用次数: 0

A radioimaging technique for quantifying regional myocardial blood flow. 一种量化局部心肌血流的放射成像技术。

American journal of physiologic imaging Pub Date : 1992-07-01

G Arora, P M Mehta, P Paspa, S R Jolly, W C Reeves, A Movahed

{"title":"A radioimaging technique for quantifying regional myocardial blood flow.","authors":"G Arora, P M Mehta, P Paspa, S R Jolly, W C Reeves, A Movahed","doi":"","DOIUrl":"","url":null,"abstract":"We developed a radioimaging technique for measuring regional myocardial blood flow (rMBF) in 5 mm2 myocardial tissue using canine closed-chest models. RMBF was measured in three groups: (1) total occlusion of left anterior descending (LAD) coronary artery with microfibrillar collagen, (2) fixed stenosis of LAD with angioplasty balloon, and (3) comparison of clinical dose response of adenosine (AD) and dipyridamole (DP) on rMBF. In these studies, rMBF in every 5 mm2 tissue was measured throughout the epicardium and endocardium. In groups 1 and 2, rMBF was also measured during adenosine-induced coronary hyperemia (ADICH). In group 1 (n = 7), rMBF measured at 6 hours post-LAD occlusion in epicardial infarct center (IC), peri-infarct (PI) and normal zone (NZ) were 17 +/- 7, 55 +/- 8, and 132 +/- 12 ml/min/100 tissue, respectively. The area and location of infarct seen in TTC staining matched with rMBF images. During ADICH, the corresponding rMBF were 16.2 +/- 13.9, 98.3 +/- 53.0, and 226.0 +/- 103.6 ml/min/100 g tissue, respectively. RMBF measured during ADICH in group 2 (n = 4) in areas of LAD stenosis (LS), surrounding stenosis (SS), and no stenosis (NS) were 120 +/- 58, 249 +/- 123, and 432 +/- 181 ml/min/100 gm tissue, respectively. In group 3, rMBF measured during 3 min into 0.14 mg/kg/min adenosine infusion in areas perfused by LAD, circumflex (CX) and right coronary artery (RCA) were 244 +/- 22, 238 +/- 19, and 215 +/- 19 ml/min/100 g tissue, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 3-4","pages":"230-8"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12516063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SPECT instrumentation. SPECT仪表。

American journal of physiologic imaging Pub Date : 1992-07-01

W L Rogers, R J Ackermann

{"title":"SPECT instrumentation.","authors":"W L Rogers, R J Ackermann","doi":"","DOIUrl":"","url":null,"abstract":"The sensitivity of conventionally collimated SPECT systems is essentially fixed by the number of resolution elements desired. A variety of collimation methods are proposed or in use that distribute sensitivity and resolution differently among the various projection elements, but the effects on image quality have not really been documented. Of the many existing systems, the camera-based systems, which are useful for both head and body imaging, will be most useful in a clinical environment. For brain imaging, it is clear that fan beam collimation offers a large performance advantage over parallel collimation. However, comparison of the various instruments based on specifications alone is difficult if not impossible, and careful 3-dimensional imaging studies are an absolute necessity. In view of the fairly healthy price of dedicated brain instruments, it is interesting to speculate on their role in nuclear imaging. Their cost is from $50,000 to $200,000 less than a multi-headed general purpose system, and they have excellent resolution and sensitivity for brain imaging. They cost from $175,000 to $300,000 more than a single head camera-computer system yet offer 3 to 4 times the resolution-adjusted sensitivity. This suggests that a special purpose instrument would need to be heavily utilized or located (physically or politically) where the body imaging capability of a two or three-headed system would not be used. A good case might be made for locating a dedicated instrument in a neurological ICU in order to avoid transporting critically ill patients out of the unit. The various non-conventional imaging methods show promise for exceeding the sensitivity limit of regular collimators. At present it is speculative as to how much can be gained and whether it will be worth the added complexity and/or cost. Nevertheless, they are very interesting and certainly justify additional research.","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 3-4","pages":"105-20"},"PeriodicalIF":0.0,"publicationDate":"1992-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12516881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vivo magnetic resonance spectroscopy in humans: a brief review. 人体内磁共振波谱:简要回顾。

American journal of physiologic imaging Pub Date : 1992-07-01

E F Jackson

引用次数: 0

Topographic mapping of brain electromagnetic signals: a review of current technology. 脑电磁信号的地形图绘制:当前技术综述。

American journal of physiologic imaging Pub Date : 1992-07-01

M E Brandt

引用次数: 0

Sonographic evaluation of physiologic bolus volume in oral swallowing. 口服吞咽生理体积的超声评价。

American journal of physiologic imaging Pub Date : 1992-04-01

A Fanucci, P Cerro, E Fanucci

引用次数: 0

Pathophysiologic considerations in carotid artery imaging: current status and physiologic background. 颈动脉成像病理生理方面的考虑:现状和生理背景。

American journal of physiologic imaging Pub Date : 1992-04-01

T K Chaudhuri, S Fink, S Weinberg, A Farpour

引用次数: 0

Multiple organ platelet sequestration, hemodynamics, and gas exchange in endotoxin shock and the effects of aspirin-terbutaline treatment. 内毒素休克的多器官血小板隔离、血流动力学和气体交换及阿斯匹林-特布他林治疗的影响。

American journal of physiologic imaging Pub Date : 1992-04-01

G H Sigurdsson, H A Youssef, S Stephen

{"title":"Multiple organ platelet sequestration, hemodynamics, and gas exchange in endotoxin shock and the effects of aspirin-terbutaline treatment.","authors":"G H Sigurdsson, H A Youssef, S Stephen","doi":"","DOIUrl":"","url":null,"abstract":"We studied the effects of two different drugs on multiple organ platelet sequestration, hemodynamics, and respiratory function during endotoxin shock. Twenty-eight sheep (four groups) were anesthetized and ventilated. Group AT-E received aspirin and terbutaline 30 min before and group E-AT 30 min after Escherichia coli endotoxin. Group E also received endotoxin but no drug treatment (shock controls), and group C received neither endotoxin nor drug treatment. There was a marked platelet trapping in the lungs and in the liver immediately after administration of endotoxin in groups E and E-AT, but after 4 hr it was less pronounced in group E-AT than in the endotoxin controls (P < 0.05). In the pretreated animals (group AT-E) there was no increase in platelet sequestration until almost 2 hr after endotoxin both in the lungs and the liver, but at the end of the study (240 min) there was no difference between the pre- and posttreated groups. No significant changes occurred in the kidneys and spleen in any of the groups. In groups E and E-AT the endotoxin infusion resulted in 200% rise in pulmonary artery pressure (PAP) and a sharp decrease in mean arterial pressure (MAP; 25-30%), respiratory compliance (CT; 50%), arterial oxygen tension (PaO2; 70%) as well as in oxygen delivery index (DO2; 30-40%) within 30 min. After 4 hr the PAP had decreased significantly in group E-AT, but remained high in group E (> 100% higher than in group C). Also MAP, PaO2, DO2 and CT improved slightly in group E-AT, while they remained low in group E.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 2","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12590133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical experience with Tc-99m labeled (N2S2) anti-melanoma antibody fragments and single photon emission computed tomography. Tc-99m标记(N2S2)抗黑色素瘤抗体片段和单光子发射计算机断层扫描的临床经验。

American journal of physiologic imaging Pub Date : 1992-04-01

R L Wahl, N A Swanson, J W Johnson, R Natale, N A Petry, S Mallette, S Kasina, J Reno, K Sullivan, P Abrams

{"title":"Clinical experience with Tc-99m labeled (N2S2) anti-melanoma antibody fragments and single photon emission computed tomography.","authors":"R L Wahl, N A Swanson, J W Johnson, R Natale, N A Petry, S Mallette, S Kasina, J Reno, K Sullivan, P Abrams","doi":"","DOIUrl":"","url":null,"abstract":"We evaluated the imaging capability of murine Tc-99m-labeled antimelanoma Fab fragments in 12 patients with clinical stage II and III melanoma. Tc-99m-NRX118.7 antimelanoma Fab fragment, 10.0 to 27.2 mCi (370-1, 006 MBq), was injected IV 30 min after irrelevant nonspecific intact antibody and 5 min after intact specific antibody were given. In all patients, whole-body scans and spot views were obtained. Single photon emission computed tomography (SPECT) was additionally performed in eight of the patients. The procedure was well tolerated, and 31 of 38 known foci of melanoma were detected (sensitivity, 82%). SPECT aided in detecting and better localizing lesions in the head, neck, and chest. The specificity of the technique was satisfactory when interpretation was performed with a knowledge of normal sites of accretion and excretion of technetium-99m activity such as the kidneys and gut. In several instances, lesions were discovered by means of the antibody scan before detection by other methods, and in two instances, the lack of visualization on antibody scan of a palpable mass correctly indicated that no melanoma was present in the mass. Scan results in three patients led to alterations in patient care; including preventing aggressive surgical and nonsurgical treatments. Although these data are encouraging, evaluation in additional patients will be essential to determine the clinical utility of this antibody scan in the management of patients with melanoma.","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 2","pages":"48-58"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12590136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using quantitative coronary arteriography to redefine SPECT sensitivity and specificity. 定量冠状动脉造影重新定义SPECT的敏感性和特异性。

American journal of physiologic imaging Pub Date : 1992-04-01

R M Fleming, H R Gibbs, J Swafford

{"title":"Using quantitative coronary arteriography to redefine SPECT sensitivity and specificity.","authors":"R M Fleming, H R Gibbs, J Swafford","doi":"","DOIUrl":"","url":null,"abstract":"Previous studies looking at the sensitivity, specificity, and predictive accuracy of single photon emission computed tomography (SPECT) have been based upon the results obtained by visual interpretation of coronary arteriograms. Since the results of visual and quantitative determination of percent diameter stenosis have been shown to be statistically different, the results obtained from SPECT imaging when compared to quantitative methods for assessing coronary artery disease would be expected to provide a more correct assessment of sensitivity, specificity, and predictive accuracy. To determine the \"true\" sensitivity, specificity, and predictive accuracy of SPECT in diagnosing coronary artery disease, this study compared the results obtained in 44 SPECT images (20 thallium and 24 teboroxime) with the results obtained when quantitative coronary arteriography was used to analyze the coronary arteriograms. These 44 cases were then compared against 8 different definitions of significant coronary artery disease, varying from 30 to 80%, to yield 352 comparisons. The maximum specificity and predictive accuracy was found when 45% diameter stenosis was used to define the presence or absence of significant disease. At 45% diameter stenosis, SPECT imaging demonstrated an 86% sensitivity, 78% specificity, and 94% predictive accuracy with only 6% false positives. In 100% of the cases where 45% diameter stenosis was used to define the presence of disease and exercise failed to demonstrate ST segment changes or angina, when SPECT imaging demonstrated a perfusion defect(s), quantitative coronary arteriography agreed with SPECT imaging results.(ABSTRACT TRUNCATED AT 250 WORDS)","PeriodicalId":76992,"journal":{"name":"American journal of physiologic imaging","volume":"7 2","pages":"59-65"},"PeriodicalIF":0.0,"publicationDate":"1992-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12590899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0