内毒素休克的多器官血小板隔离、血流动力学和气体交换及阿斯匹林-特布他林治疗的影响。

G H Sigurdsson, H A Youssef, S Stephen
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引用次数: 0

摘要

我们研究了两种不同药物对内毒素休克时多器官血小板隔离、血流动力学和呼吸功能的影响。28只羊(4组)麻醉并通气。AT-E组在大肠杆菌内毒素感染前30 min给予阿司匹林和特布他林,E-AT组在大肠杆菌内毒素感染后30 min给予阿司匹林和特布他林。E组同样给予内毒素治疗,但不给予药物治疗(休克对照组),C组既不给予内毒素治疗,也不给予药物治疗。内毒素给药后,E组和E- at组肺脏和肝脏内均有明显的血小板滞留,但4 h后E- at组血小板滞留较内毒素对照组明显(P < 0.05)。在预处理动物(at - e组)中,直到肺脏和肝脏内毒素暴露后近2小时,血小板隔离才增加,但在研究结束时(240分钟),预处理组和后处理组之间没有差异。两组小鼠肾脏和脾脏均未见明显变化。在E组和E- at组,内毒素输注导致肺动脉压(PAP)升高200%,平均动脉压(MAP)急剧下降;25-30%),呼吸顺应性(CT;50%),动脉氧张力(PaO2;70%)以及氧气输送指数(DO2;4小时后,E-AT组PAP明显下降,但E组仍保持较高水平(比C组高> 100%)。MAP、PaO2、DO2和CT在E-AT组略有改善,而E组仍保持较低水平。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Multiple organ platelet sequestration, hemodynamics, and gas exchange in endotoxin shock and the effects of aspirin-terbutaline treatment.

We studied the effects of two different drugs on multiple organ platelet sequestration, hemodynamics, and respiratory function during endotoxin shock. Twenty-eight sheep (four groups) were anesthetized and ventilated. Group AT-E received aspirin and terbutaline 30 min before and group E-AT 30 min after Escherichia coli endotoxin. Group E also received endotoxin but no drug treatment (shock controls), and group C received neither endotoxin nor drug treatment. There was a marked platelet trapping in the lungs and in the liver immediately after administration of endotoxin in groups E and E-AT, but after 4 hr it was less pronounced in group E-AT than in the endotoxin controls (P < 0.05). In the pretreated animals (group AT-E) there was no increase in platelet sequestration until almost 2 hr after endotoxin both in the lungs and the liver, but at the end of the study (240 min) there was no difference between the pre- and posttreated groups. No significant changes occurred in the kidneys and spleen in any of the groups. In groups E and E-AT the endotoxin infusion resulted in 200% rise in pulmonary artery pressure (PAP) and a sharp decrease in mean arterial pressure (MAP; 25-30%), respiratory compliance (CT; 50%), arterial oxygen tension (PaO2; 70%) as well as in oxygen delivery index (DO2; 30-40%) within 30 min. After 4 hr the PAP had decreased significantly in group E-AT, but remained high in group E (> 100% higher than in group C). Also MAP, PaO2, DO2 and CT improved slightly in group E-AT, while they remained low in group E.(ABSTRACT TRUNCATED AT 250 WORDS)

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