Alzheimer Disease & Associated Disorders最新文献_第6页

Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment: A Single Clinic-based Study in South Korea. 早发和晚发阿尔茨海默病相关认知障碍患者血管周围空间扩大的比较：韩国单一诊所研究

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-02 DOI: 10.1097/WAD.0000000000000614

Na-Yeon Jung, Yuri Je, Hong-Gi Ham, Yu Hyun Park, Tae-Yun Kim, Min-Su Go, Hye-In Lee, Da Eun Kim, Myung Jun Lee, Sang Won Seo, Eun-Joo Kim

{"title":"Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment: A Single Clinic-based Study in South Korea.","authors":"Na-Yeon Jung, Yuri Je, Hong-Gi Ham, Yu Hyun Park, Tae-Yun Kim, Min-Su Go, Hye-In Lee, Da Eun Kim, Myung Jun Lee, Sang Won Seo, Eun-Joo Kim","doi":"10.1097/WAD.0000000000000614","DOIUrl":"10.1097/WAD.0000000000000614","url":null,"abstract":"We examined whether there were differences in the presence of centrum semiovale-enlarged perivascular spaces (CSO-ePVS) and basal ganglia-ePVS (BG-ePVS) among patients with Alzheimer disease-related cognitive impairment (ADCI) based on their age of onset. Out of a total of 239 patients with cognitive impairment, 155 with positive amyloid-PET results were included. Among these, 43 had early-onset ADCI (EOADCI) and 112 had late-onset ADCI (LOADCI). Patients with LOADCI exhibited a higher prevalence of hypertension, lacunes, white matter hyperintensities, and BG-ePVS than those with EOADCI. BG-ePVS showed a significant correlation with age at the onset and the number of lacunes, whereas CSO-ePVS did not exhibit any association. The higher prevalence of BG-ePVS in patients with LOADCI might be attributable to vascular risk factors (hypertension) and cerebral small vessel disease (CSVD). These findings support the hypothesis that BG-ePVS is associated with CSVD and vascular risk factors, whereas CSO-ePVS is associated with cerebral amyloid angiopathy.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"201-204"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Delphi Approach to Define Lucid Episodes in People Living With Dementia. 用德尔菲法定义痴呆症患者的 "清醒发作"。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI: 10.1097/WAD.0000000000000621

Lauren R Bangerter, Joan M Griffin, Kyungmin Kim, Dawn M Finnie, Maria I Lapid, Joseph E Gaugler, Virginia S Biggar, Theresa Frangiosa

{"title":"A Delphi Approach to Define Lucid Episodes in People Living With Dementia.","authors":"Lauren R Bangerter, Joan M Griffin, Kyungmin Kim, Dawn M Finnie, Maria I Lapid, Joseph E Gaugler, Virginia S Biggar, Theresa Frangiosa","doi":"10.1097/WAD.0000000000000621","DOIUrl":"10.1097/WAD.0000000000000621","url":null,"abstract":"Purpose: Lucid episodes (LEs: unexpected episodes of spontaneous, meaningful, and relevant communication or behavior) in Alzheimer disease and related dementias are a new area of scientific inquiry that lacks clinical consensus and require more conceptual attention.Methods: We aimed to measure consensus from an expert group on: (1) potential medical or clinical explanations for LEs; (2) necessary medical and clinical context to LEs; and (3) interpretation of LEs.Patients: We convened 13 experts from different disciplines (neurology, psychiatry, psychology, pharmacy, palliative care, hospice, nursing, social work, primary care, geriatrics, and professional home caregivers) to identify elements of LEs.Results: Experts provided a range of opinions on medical and clinical explanations and questions to understand LEs. Consensus on LEs when presented with clinical vignettes was not reached. Panelists highlighted key medical and contextual factors needed to make a definitive judgement about LEs.Conclusion: There is variability in how LEs are interpreted by clinical experts, which complicates the identification of LEs in Alzheimer disease and related dementias.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"147-151"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Transformer Approach for Cognitive Impairment Classification and Prediction. 用于认知障碍分类和预测的变换器方法。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI: 10.1097/WAD.0000000000000619

Houjun Liu, Alyssa M Weakley, Jiawei Zhang, Xin Liu

{"title":"A Transformer Approach for Cognitive Impairment Classification and Prediction.","authors":"Houjun Liu, Alyssa M Weakley, Jiawei Zhang, Xin Liu","doi":"10.1097/WAD.0000000000000619","DOIUrl":"10.1097/WAD.0000000000000619","url":null,"abstract":"Introduction: Early classification and prediction of Alzheimer disease (AD) and amnestic mild cognitive impairment (aMCI) with noninvasive approaches is a long-standing challenge. This challenge is further exacerbated by the sparsity of data needed for modeling. Deep learning methods offer a novel method to help address these challenging multiclass classification and prediction problems.Methods: We analyzed 3 target feature-sets from the National Alzheimer Coordinating Center (NACC) dataset: (1) neuropsychological (cognitive) data; (2) patient health history data; and (3) the combination of both sets. We used a masked Transformer-encoder without further feature selection to classify the samples on cognitive status (no cognitive impairment, aMCI, AD)-dynamically ignoring unavailable features. We then fine-tuned the model to predict the participants' future diagnosis in 1 to 3 years. We analyzed the sensitivity of the model to input features via Feature Permutation Importance.Results: We demonstrated (1) the masked Transformer-encoder was able to perform prediction with sparse input data; (2) high multiclass current cognitive status classification accuracy (87% control, 79% aMCI, 89% AD); (3) acceptable results for 1- to 3-year multiclass future cognitive status prediction (83% control, 77% aMCI, 91% AD).Conclusion: The flexibility of our methods in handling inconsistent data provides a new venue for the analysis of cognitive status data.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"189-194"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and Temporal Relationships Between Atrophy and Hypometabolism in Behavioral-Variant Frontotemporal Dementia. 行为变异型额颞叶痴呆症患者脑萎缩与代谢低下之间的空间和时间关系

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-15 DOI: 10.1097/WAD.0000000000000611

Jane Stocks, Erin Gibson, Karteek Popuri, Mirza F Beg, Howard Rosen, Lei Wang

{"title":"Spatial and Temporal Relationships Between Atrophy and Hypometabolism in Behavioral-Variant Frontotemporal Dementia.","authors":"Jane Stocks, Erin Gibson, Karteek Popuri, Mirza F Beg, Howard Rosen, Lei Wang","doi":"10.1097/WAD.0000000000000611","DOIUrl":"10.1097/WAD.0000000000000611","url":null,"abstract":"Purpose: Individuals with behavioral-variant frontotemporal dementia (bvFTD) show changes in brain structure as assessed by MRI and brain function assessed by 18FDG-PET hypometabolism. However, current understanding of the spatial and temporal interplay between these measures remains limited.Methods: Here, we examined longitudinal atrophy and hypometabolism relationships in 15 bvFTD subjects with 2 to 4 follow-up MRI and PET scans (56 visits total). Subject-specific slopes of atrophy and hypometabolism over time were extracted across brain regions and correlated with baseline measures both locally, via Pearson correlations, and nonlocally, via sparse canonical correlation analyses (SCCA).Results: Notably, we identified a robust link between initial hypometabolism and subsequent cortical atrophy rate changes in bvFTD subjects. Network-level exploration unveiled alignment between baseline hypometabolism and ensuing atrophy rates in the dorsal attention, language, and default mode networks. SCCA identified 2 significant and highly localized components depicting the connection between baseline hypometabolism and atrophy slope over time. The first centered around bilateral orbitofrontal, frontopolar, and medial prefrontal lobes, whereas the second concentrated in the left temporal lobe and precuneus.Conclusions: This study highlights 18FDG-PET as a dependable predictor of forthcoming atrophy in spatially adjacent brain regions for individuals with bvFTD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 2","pages":"112-119"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Triadic Communication in Medical Encounters Including Individuals With Dementia: A Scoping Review. 包括痴呆症患者在内的医疗接触中的三方沟通：范围审查。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-30 DOI: 10.1097/WAD.0000000000000626

Easton N Wollney, Melissa J Armstrong, Chelsea N Hampton, Patti McCall-Junkin, Noheli Bedenfield, Carla L Fisher, Carma L Bylund

{"title":"Triadic Communication in Medical Encounters Including Individuals With Dementia: A Scoping Review.","authors":"Easton N Wollney, Melissa J Armstrong, Chelsea N Hampton, Patti McCall-Junkin, Noheli Bedenfield, Carla L Fisher, Carma L Bylund","doi":"10.1097/WAD.0000000000000626","DOIUrl":"10.1097/WAD.0000000000000626","url":null,"abstract":"Purpose: The overall goal of this review was to identify what is known about triadic (clinician-patient-caregiver) communication in mild cognitive impairment (MCI) and dementia care settings throughout the care continuum.Methods: Using a structured search, we conducted a systematic scoping review of relevant published journal articles across 5 databases. Study titles/abstracts and selected full-text articles were screened by 2 investigators in Covidence systematic review software. Articles were excluded if they were not about clinical communication, focused only on caregiver-patient communication or communication in residential care, were interventional, lacked empirical data, or were not in English. Extracted data were documented using Google Forms.Results: The study team screened 3426 article titles and abstracts and 112 full-text articles. Forty-four articles were included in the final review. Results were categorized by 3 communication scenarios: diagnostic communication (n=22), general communication (n=16), and advanced care planning communication (n=6).Conclusions and relevance: Across the included articles, the conceptualization and assessment of communication lacked homogeneity. Future directions include addressing these research gaps, establishing recommendations for clinicians to effectively communicate with individuals with dementia and caregivers, and creating and testing communication skills trainings for caregivers/family members, clinicians, and/or individuals with dementia to facilitate effective communication.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 2","pages":"213-225"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11977097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement of Allostatic Load in Caregivers of Older Hispanic People With Alzheimer Disease and Related Disorders. 测量患有阿尔茨海默病及相关疾病的西班牙裔老年人的护理人员的代谢负荷。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-16 DOI: 10.1097/WAD.0000000000000625

Jeanne A Teresi, Katja Ocepek-Welikson, Joseph P Eimicke, Mildred Ramirez, Shelley Liu, Stephanie Silver, Jose A Luchsinger

{"title":"Measurement of Allostatic Load in Caregivers of Older Hispanic People With Alzheimer Disease and Related Disorders.","authors":"Jeanne A Teresi, Katja Ocepek-Welikson, Joseph P Eimicke, Mildred Ramirez, Shelley Liu, Stephanie Silver, Jose A Luchsinger","doi":"10.1097/WAD.0000000000000625","DOIUrl":"10.1097/WAD.0000000000000625","url":null,"abstract":"Background: Allostatic load (AL) has been studied in the context of biomarkers that may be affected by environmental and contextual stressors, including social determinants of health. The specific stressor studied here is the provision of caregiving to older persons with Alzheimer disease and related disorders. The aims were to examine the factor structure of stress and nonstress biomarkers, different methods for calculating AL, and the relationship of AL with other variables.Methods: Latent variable models were used to examine biomarkers. Regression analyses were performed with the outcomes: AL calculated as percentile-based and clinically-based for both stress and nonstress components. The sample was 187 Hispanic caregivers to individuals with dementia.Results: The results of the confirmatory factor analyses (CFAs) suggested defining 2 factors: nonstress and stress-related. Performance was better for the CFA results and the associations with covariates when stress and nonstress components were examined separately. Despite some limitations, this is one of the first studies of biomarkers in Hispanic caregivers to patients with dementia. It was possible to explain almost 30% of the variance in the nonstress AL component.Conclusion: It may be important to differentiate among biomarkers indicative of cardiovascular, metabolic, and immune response as contrasted with the more stress-related biomarkers.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"178-188"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis of White Matter Hyperintensity Volume Differences Between APOE ε4 Carriers and Noncarriers. APOE ε4携带者与非携带者白质高密度体积差异的Meta分析。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1097/WAD.0000000000000620

Faissal Stipho, Michael Malek-Ahmadi

{"title":"Meta-Analysis of White Matter Hyperintensity Volume Differences Between APOE ε4 Carriers and Noncarriers.","authors":"Faissal Stipho, Michael Malek-Ahmadi","doi":"10.1097/WAD.0000000000000620","DOIUrl":"10.1097/WAD.0000000000000620","url":null,"abstract":"Several studies have suggested that white matter hyperintensity volume (WMHV) is increased among apolipoprotein E (APOE) ε4 carriers while others have reported contradictory findings. Although APOE ε4 carriage is associated with greater AD pathology, it remains unclear whether cerebrovascular damage is also associated with APOE ε4 carriage. The aim of this meta-analysis was to determine whether WMHV is associated with APOE ε4 carrier status. 12 studies that were included yielded a total sample size of 16,738 adult subjects (ε4 carrier n = 4,721; ε4 noncarrier n = 12,017). There were no significant differences in WMHV between ε4 carriers and noncarriers (Hedge's g = 0.07; 95% CI (-0.01 to 0.15), P = 0.09). Subgroup analysis of community-based studies (n = 8) indicated a small effect size where ε4 carriers had greater WMHV relative to noncarriers (Hedge's g = 0.09 95% CI (0.02 to 0.16), P = 0.008). Among clinic-based studies (n = 3) there was no significant difference in WMHV by APOE ε4 carrier status (Hedge's g = -0.09, 95% CI (-0.60 to 0.41), P = 0.70). Observed APOE ε4-associated WMHV differences may be context-dependent and may also be confounded by a lack of standardization for WMHV segmentation.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"208-212"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness. 阿尔茨海默病和脑外伤对皮质厚度的相互作用

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI: 10.1097/WAD.0000000000000607

Gina M D'Souza, Nathan W Churchill, Dylan X Guan, Marc A Khoury, Simon J Graham, Sanjeev Kumar, Corinne E Fischer, Tom A Schweizer

{"title":"Interaction of Alzheimer Disease and Traumatic Brain Injury on Cortical Thickness.","authors":"Gina M D'Souza, Nathan W Churchill, Dylan X Guan, Marc A Khoury, Simon J Graham, Sanjeev Kumar, Corinne E Fischer, Tom A Schweizer","doi":"10.1097/WAD.0000000000000607","DOIUrl":"10.1097/WAD.0000000000000607","url":null,"abstract":"Introduction: Traumatic brain injury (TBI) is associated with an accelerated course of dementia, although biological relationships are incompletely understood.Methods: The study examined 1124 participants, including 343 with Alzheimer disease (AD), 127 with AD with TBI, 266 cognitively normal adults with TBI, and 388 cognitively normal adults without TBI. Cortical thickness was quantified from T1-weighted magnetic resonance imaging data. Multiple linear regression was used to determine the interaction between AD and TBI on cortical thickness.Results: Among those with AD, TBI was associated with an earlier age of AD onset but, counterintuitively, less cortical thinning in frontotemporal regions relative to non-AD controls.Discussion: AD with TBI represents a distinct group from AD, likely with distinct pathologic contributions beyond gray matter loss. This finding has important implications for the diagnosis and treatment of AD in the presence of TBI and indicates that models of AD, aging, and neural loss should account for TBI history.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"14-21"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139574848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Traffic Lights Presentation of Dementia Risk Screening Information on Older Adults' Motivations for Risk Reduction in Primary Care Settings. 在初级医疗机构中，痴呆症风险筛查信息的红绿灯显示对老年人降低风险动机的影响》（The Influence of Traffic Lights Presentation of Dementia Risk Screening Information on Older Adults' Motivations for Risk Reduction in Primary Care Settings）。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI: 10.1097/WAD.0000000000000598

Diana Matovic, Malene Ahern, Xiaojing Lei, Viviana M Wuthrich

{"title":"The Influence of Traffic Lights Presentation of Dementia Risk Screening Information on Older Adults' Motivations for Risk Reduction in Primary Care Settings.","authors":"Diana Matovic, Malene Ahern, Xiaojing Lei, Viviana M Wuthrich","doi":"10.1097/WAD.0000000000000598","DOIUrl":"10.1097/WAD.0000000000000598","url":null,"abstract":"Objective: This study assessed older adults' preferences for how to communicate dementia risk information to maximize motivation for behavior change.Method: Eighty-nine community-dwelling older adults (aged 61 to 92 years, M=72.93, SD=6.36, 76% women) received dementia risk factor information in 2 formats: \"traffic lights\" (green=risk absent, amber=risk emerging, and red=risk present) or red/risk-only. Participants reported motivation to change risk-related behaviors, motivation to maintain good health behaviors, liking of the formats, categorical preference for traffic lights versus risk-only formats, reasons for preferences (open-ended), total applicable risks, and Motivation to Change Lifestyle and Health Behaviour for Dementia Risk Reduction.Results: Traffic lights presentation was more motivating ( Z =4.16, P <0.001), more liked ( Z =4.80, P <0.001), and preferred, N Traffic =71, N Red =14, χ 2 (1)=38.22, P <0.001, over risk-only. Self-efficacy and motivation to maintain good health behaviors were significant unique predictors of motivation to change risk-related behaviors following traffic lights presentation over age, sex, education, total applicable risks, perceived susceptibility, cues to action, and liking of the traffic lights presentation format. Themes indicated (1) traffic light presentation is informative and clear, and (2) green-light information increases self-efficacy.Conclusions: Traffic light presentation increases patient motivation to reduce dementia risk. Green-light information increases self-efficacy. Maximizing motivation through information presentation can decrease dementia prevalence.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"70-76"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Focusing on Earlier Management of Alzheimer Disease: Expert Opinion Based on a Modified Nominal Group Technique. 关注阿尔茨海默病的早期管理：基于改良名义小组技术的专家意见。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-01-01 Epub Date: 2024-01-29 DOI: 10.1097/WAD.0000000000000600

Kristian Steen Frederiksen, Xavier Morató, Henrik Zetterberg, Serge Gauthier, Mercè Boada, Vanesa Pytel, Soeren Mattke

{"title":"Focusing on Earlier Management of Alzheimer Disease: Expert Opinion Based on a Modified Nominal Group Technique.","authors":"Kristian Steen Frederiksen, Xavier Morató, Henrik Zetterberg, Serge Gauthier, Mercè Boada, Vanesa Pytel, Soeren Mattke","doi":"10.1097/WAD.0000000000000600","DOIUrl":"10.1097/WAD.0000000000000600","url":null,"abstract":"Background: Despite the number of people living with Alzheimer disease (AD), awareness of the early stages of this condition, including mild cognitive impairment due to AD-which poses management challenges-continues to be low. To identify areas for improvement in early AD management, dementia specialists convened in a virtual roundtable meeting.Methodology: A modified version of the nominal group technique was followed to prioritize specific topics and allow experts to provide their opinions. The overarching topics prioritized and discussed were (1) education and support for primary care physicians on cognitive assessment, detection of mild cognitive impairment, and patient monitoring; (2) nonpharmacological interventions; (3) and the introduction of disease-modifying therapies.Conclusions: Consensus was achieved regarding the need for educating primary care physicians on identifying people with cognitive impairment and for better diagnostic tools for its detection and early management. Management of mild cognitive impairment due to AD should encompass an adequate follow-up schedule aiming to maintain function for as long as possible, and primary care physicians and patients should be aware of the benefits of nonpharmacological interventions.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"1-7"},"PeriodicalIF":1.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139671085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0