Alzheimer Disease & Associated Disorders最新文献_第5页

Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus. 特发性正常压力脑积水患者肠道微生物组的变化

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-11 DOI: 10.1097/WAD.0000000000000613

Emilia Brandt, Anne Koivisto, Pedro Pereira, Ella Mustanoja, Petri Auvinen, Toni Saari, Juha-Matti Lehtola, Sanna Hannonen, Minna Rusanen, Ville Leinonen, Filip Scheperjans, Virve Kärkkäinen

{"title":"Gut Microbiome Changes in Patients With Idiopathic Normal Pressure Hydrocephalus.","authors":"Emilia Brandt, Anne Koivisto, Pedro Pereira, Ella Mustanoja, Petri Auvinen, Toni Saari, Juha-Matti Lehtola, Sanna Hannonen, Minna Rusanen, Ville Leinonen, Filip Scheperjans, Virve Kärkkäinen","doi":"10.1097/WAD.0000000000000613","DOIUrl":"10.1097/WAD.0000000000000613","url":null,"abstract":"Background: The gut microbiome is a complex system within the human gastrointestinal tract. The bacteria play a significant role in human health, and some can promote inflammation and pathologic processes through chemical interactions or metabolites. Gut microbiome dysbiosis has been linked to some neurological and other diseases. Here we aimed to examine microbiome differences between patients with a progressive neurological disorder, idiopathic normal pressure hydrocephalus (iNPH), compared with healthy controls (CO).Methods: We recruited 37 neurologically healthy CO and 10 patients with shunted iNPH. We evaluated these participants' cognition using the CERAD-NB test battery and CDR test, and collected a variety of information, including about dietary habits and health. We also collected fecal samples, which were subjected to 16S amplicon sequencing to analyze differences in gut microbiome composition.Results: We found that the iNPH group exhibited significantly different abundances of 10 bacterial genera compared with the CO group. The Escherichia/Shigella and Anaeromassilibacillus genera were most remarkably increased. Other increased genera were Butyrivibrio , Duncaniella , and an unidentified genus. The decreased genera were Agathobaculum , Paramuribaculum , Catenibacterium , and 2 unidentified genera.Conclusions: Here we report the first identified microbiome differences in iNPH patients compared with healthy controls.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"133-139"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recruitment of a Diverse Community-based Older Adult Cohort for a Longitudinal Aging Study: The 15104 Seniors Project. 为纵向老龄化研究招募多样化社区老年人队列：15104 老人项目。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1097/WAD.0000000000000618

Erin Jacobsen, Heather Lucas, Catherine Moran, Reverend Gloria Dixon, Mary Ganguli

{"title":"Recruitment of a Diverse Community-based Older Adult Cohort for a Longitudinal Aging Study: The 15104 Seniors Project.","authors":"Erin Jacobsen, Heather Lucas, Catherine Moran, Reverend Gloria Dixon, Mary Ganguli","doi":"10.1097/WAD.0000000000000618","DOIUrl":"10.1097/WAD.0000000000000618","url":null,"abstract":"Introduction: Enrolling individuals from underrepresented ethnoracial groups in aging research is often a challenge.Methods: We sought a diverse sample of older adults from a small-town area for a longitudinal aging study. We employed an intensive community engagement approach encompassing a range of recruitment strategies.Results: Over 4 years a steady trickle of individuals, 66% self-identifying as Black, signed up for study information; the proportion of those who eventually enroll in the study has been rising each year, from 68% to 94%. Community events, word-of-mouth referrals, and mailed postcards brought in the most contacts. The highest percentage of contacts who ultimately enrolled were from postcards, flyers, and word-of-mouth. Significantly more word-of-mouth referrals were endorsed by Black individuals than White and by Black men than other race/sex groups.Conclusions: We have had some success in building relationships and trust with the local community, enrolling Black study participants in a proportion equal to their representation in the target community using a variety of recruitment methods. Patience, immersion in the community, and partnerships with key community members alongside traditional advertisements, and the utilization of study participants as recruiters are critical to designing optimal, targeted, recruitment strategies.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"160-167"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11178142/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

" I'm not a risk taker " : Risk Perceptions of Nursing Home Residents With Dementia. "我不喜欢冒险"：养老院痴呆症患者的风险意识。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-23 DOI: 10.1097/WAD.0000000000000616

Liza L Behrens, Hannah L Anderson, Kaléi H Kowalchik, Jacqueline Mogle, Joanne Roman Jones, Kimberly Van Haitsma, Nancy Hodgson, Marie Boltz

{"title":"\" I'm not a risk taker \" : Risk Perceptions of Nursing Home Residents With Dementia.","authors":"Liza L Behrens, Hannah L Anderson, Kaléi H Kowalchik, Jacqueline Mogle, Joanne Roman Jones, Kimberly Van Haitsma, Nancy Hodgson, Marie Boltz","doi":"10.1097/WAD.0000000000000616","DOIUrl":"10.1097/WAD.0000000000000616","url":null,"abstract":"Background: Persons living with Alzheimer disease and related dementia (ADRD) in nursing homes (NH) are often excluded from conversations about their health/safety. These omissions impinge on personhood and the rights to have care preferences heard and honored. While persons with ADRD maintain the ability to communicate their preferences long after their decision-making abilities are affected, little is known about how persons with ADRD understand the risks associated with their preferences.Methods: As part of a larger focused ethnography, in-depth interviews and an adapted risk propensity questionnaire explored the risk perceptions of NH residents with ADRD (N=7) associated with their preferences for care and activities of daily living.Results: Residents generally self-identified as risk avoiders ( M =3.2±1.84) on the risk propensity scale and were able to rate risk associated with preferences described within 5 thematic categories: 1) participation in decision-making, 2) risk awareness, 3) paying attention to safety, 4) reliance on nursing home staff and family, and 5) impacts on quality of life and quality of care.Discussion: Results suggest NH residents with ADRD can express risk surrounding their preferences and should be encouraged to participate in discussions about their health and safety.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"168-177"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140846860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not All Days Were Created Equal-Better Day Orientation Following the Weekend on Mini-Mental State Examination (MMSE). 并非所有的日子都是平等的--周末后的日间定向对小型精神状态检查（MMSE）更有帮助。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-16 DOI: 10.1097/WAD.0000000000000624

Daphna Shefet, Ido Lurie

{"title":"Not All Days Were Created Equal-Better Day Orientation Following the Weekend on Mini-Mental State Examination (MMSE).","authors":"Daphna Shefet, Ido Lurie","doi":"10.1097/WAD.0000000000000624","DOIUrl":"10.1097/WAD.0000000000000624","url":null,"abstract":"Objective: The aim of this study was to test whether patients are better oriented to the day on the first working day following the weekend (in Israel-Sunday), compared with other weekdays, on the Mini-Mental Score Examination (MMSE).Methods: All MMSE scores from November 2016 until December 2022 in our mental health center's computerized system were collected. The proportion of correct answers to orientation to the day was compared between weekdays.Results: The cohort consisted of 2049 MMSEs taken by 1376 patients [average age 80.3 (SD=9.3), 56.4% female]. The difference between the proportion of correct and incorrect answers was statistically significant between the days, of which Sundays showed a larger difference (53.4%) compared with the other days (χ 2 =20.77, P <0.001, Cramer V =0.104). A statistically significant odds ratio (OR) for providing a correct response was found for Sundays (OR=1.55, P =0.001) and, to a lesser extent, on Thursdays (OR=1.29, P =0.01). The difference between Sundays and other weekdays disappears as the total MMSE decreases.Conclusion: Day orientation on the MMSE may be better on the first day following the weekend, especially in early cognitive decline.Clinical implications: The weekday in which the MMSE is performed may influence its results.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"205-207"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment: A Single Clinic-based Study in South Korea. 早发和晚发阿尔茨海默病相关认知障碍患者血管周围空间扩大的比较：韩国单一诊所研究

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-02 DOI: 10.1097/WAD.0000000000000614

Na-Yeon Jung, Yuri Je, Hong-Gi Ham, Yu Hyun Park, Tae-Yun Kim, Min-Su Go, Hye-In Lee, Da Eun Kim, Myung Jun Lee, Sang Won Seo, Eun-Joo Kim

{"title":"Comparison of Enlarged Perivascular Spaces in Early-Onset and Late-Onset Alzheimer Disease-related Cognitive Impairment: A Single Clinic-based Study in South Korea.","authors":"Na-Yeon Jung, Yuri Je, Hong-Gi Ham, Yu Hyun Park, Tae-Yun Kim, Min-Su Go, Hye-In Lee, Da Eun Kim, Myung Jun Lee, Sang Won Seo, Eun-Joo Kim","doi":"10.1097/WAD.0000000000000614","DOIUrl":"10.1097/WAD.0000000000000614","url":null,"abstract":"We examined whether there were differences in the presence of centrum semiovale-enlarged perivascular spaces (CSO-ePVS) and basal ganglia-ePVS (BG-ePVS) among patients with Alzheimer disease-related cognitive impairment (ADCI) based on their age of onset. Out of a total of 239 patients with cognitive impairment, 155 with positive amyloid-PET results were included. Among these, 43 had early-onset ADCI (EOADCI) and 112 had late-onset ADCI (LOADCI). Patients with LOADCI exhibited a higher prevalence of hypertension, lacunes, white matter hyperintensities, and BG-ePVS than those with EOADCI. BG-ePVS showed a significant correlation with age at the onset and the number of lacunes, whereas CSO-ePVS did not exhibit any association. The higher prevalence of BG-ePVS in patients with LOADCI might be attributable to vascular risk factors (hypertension) and cerebral small vessel disease (CSVD). These findings support the hypothesis that BG-ePVS is associated with CSVD and vascular risk factors, whereas CSO-ePVS is associated with cerebral amyloid angiopathy.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"201-204"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140334385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Delphi Approach to Define Lucid Episodes in People Living With Dementia. 用德尔菲法定义痴呆症患者的 "清醒发作"。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI: 10.1097/WAD.0000000000000621

Lauren R Bangerter, Joan M Griffin, Kyungmin Kim, Dawn M Finnie, Maria I Lapid, Joseph E Gaugler, Virginia S Biggar, Theresa Frangiosa

{"title":"A Delphi Approach to Define Lucid Episodes in People Living With Dementia.","authors":"Lauren R Bangerter, Joan M Griffin, Kyungmin Kim, Dawn M Finnie, Maria I Lapid, Joseph E Gaugler, Virginia S Biggar, Theresa Frangiosa","doi":"10.1097/WAD.0000000000000621","DOIUrl":"10.1097/WAD.0000000000000621","url":null,"abstract":"Purpose: Lucid episodes (LEs: unexpected episodes of spontaneous, meaningful, and relevant communication or behavior) in Alzheimer disease and related dementias are a new area of scientific inquiry that lacks clinical consensus and require more conceptual attention.Methods: We aimed to measure consensus from an expert group on: (1) potential medical or clinical explanations for LEs; (2) necessary medical and clinical context to LEs; and (3) interpretation of LEs.Patients: We convened 13 experts from different disciplines (neurology, psychiatry, psychology, pharmacy, palliative care, hospice, nursing, social work, primary care, geriatrics, and professional home caregivers) to identify elements of LEs.Results: Experts provided a range of opinions on medical and clinical explanations and questions to understand LEs. Consensus on LEs when presented with clinical vignettes was not reached. Panelists highlighted key medical and contextual factors needed to make a definitive judgement about LEs.Conclusion: There is variability in how LEs are interpreted by clinical experts, which complicates the identification of LEs in Alzheimer disease and related dementias.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"147-151"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Transformer Approach for Cognitive Impairment Classification and Prediction. 用于认知障碍分类和预测的变换器方法。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI: 10.1097/WAD.0000000000000619

Houjun Liu, Alyssa M Weakley, Jiawei Zhang, Xin Liu

{"title":"A Transformer Approach for Cognitive Impairment Classification and Prediction.","authors":"Houjun Liu, Alyssa M Weakley, Jiawei Zhang, Xin Liu","doi":"10.1097/WAD.0000000000000619","DOIUrl":"10.1097/WAD.0000000000000619","url":null,"abstract":"Introduction: Early classification and prediction of Alzheimer disease (AD) and amnestic mild cognitive impairment (aMCI) with noninvasive approaches is a long-standing challenge. This challenge is further exacerbated by the sparsity of data needed for modeling. Deep learning methods offer a novel method to help address these challenging multiclass classification and prediction problems.Methods: We analyzed 3 target feature-sets from the National Alzheimer Coordinating Center (NACC) dataset: (1) neuropsychological (cognitive) data; (2) patient health history data; and (3) the combination of both sets. We used a masked Transformer-encoder without further feature selection to classify the samples on cognitive status (no cognitive impairment, aMCI, AD)-dynamically ignoring unavailable features. We then fine-tuned the model to predict the participants' future diagnosis in 1 to 3 years. We analyzed the sensitivity of the model to input features via Feature Permutation Importance.Results: We demonstrated (1) the masked Transformer-encoder was able to perform prediction with sparse input data; (2) high multiclass current cognitive status classification accuracy (87% control, 79% aMCI, 89% AD); (3) acceptable results for 1- to 3-year multiclass future cognitive status prediction (83% control, 77% aMCI, 91% AD).Conclusion: The flexibility of our methods in handling inconsistent data provides a new venue for the analysis of cognitive status data.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"189-194"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial and Temporal Relationships Between Atrophy and Hypometabolism in Behavioral-Variant Frontotemporal Dementia. 行为变异型额颞叶痴呆症患者脑萎缩与代谢低下之间的空间和时间关系

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-15 DOI: 10.1097/WAD.0000000000000611

Jane Stocks, Erin Gibson, Karteek Popuri, Mirza F Beg, Howard Rosen, Lei Wang

{"title":"Spatial and Temporal Relationships Between Atrophy and Hypometabolism in Behavioral-Variant Frontotemporal Dementia.","authors":"Jane Stocks, Erin Gibson, Karteek Popuri, Mirza F Beg, Howard Rosen, Lei Wang","doi":"10.1097/WAD.0000000000000611","DOIUrl":"10.1097/WAD.0000000000000611","url":null,"abstract":"Purpose: Individuals with behavioral-variant frontotemporal dementia (bvFTD) show changes in brain structure as assessed by MRI and brain function assessed by 18FDG-PET hypometabolism. However, current understanding of the spatial and temporal interplay between these measures remains limited.Methods: Here, we examined longitudinal atrophy and hypometabolism relationships in 15 bvFTD subjects with 2 to 4 follow-up MRI and PET scans (56 visits total). Subject-specific slopes of atrophy and hypometabolism over time were extracted across brain regions and correlated with baseline measures both locally, via Pearson correlations, and nonlocally, via sparse canonical correlation analyses (SCCA).Results: Notably, we identified a robust link between initial hypometabolism and subsequent cortical atrophy rate changes in bvFTD subjects. Network-level exploration unveiled alignment between baseline hypometabolism and ensuing atrophy rates in the dorsal attention, language, and default mode networks. SCCA identified 2 significant and highly localized components depicting the connection between baseline hypometabolism and atrophy slope over time. The first centered around bilateral orbitofrontal, frontopolar, and medial prefrontal lobes, whereas the second concentrated in the left temporal lobe and precuneus.Conclusions: This study highlights 18FDG-PET as a dependable predictor of forthcoming atrophy in spatially adjacent brain regions for individuals with bvFTD.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 2","pages":"112-119"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141174035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Measurement of Allostatic Load in Caregivers of Older Hispanic People With Alzheimer Disease and Related Disorders. 测量患有阿尔茨海默病及相关疾病的西班牙裔老年人的护理人员的代谢负荷。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-16 DOI: 10.1097/WAD.0000000000000625

Jeanne A Teresi, Katja Ocepek-Welikson, Joseph P Eimicke, Mildred Ramirez, Shelley Liu, Stephanie Silver, Jose A Luchsinger

{"title":"Measurement of Allostatic Load in Caregivers of Older Hispanic People With Alzheimer Disease and Related Disorders.","authors":"Jeanne A Teresi, Katja Ocepek-Welikson, Joseph P Eimicke, Mildred Ramirez, Shelley Liu, Stephanie Silver, Jose A Luchsinger","doi":"10.1097/WAD.0000000000000625","DOIUrl":"10.1097/WAD.0000000000000625","url":null,"abstract":"Background: Allostatic load (AL) has been studied in the context of biomarkers that may be affected by environmental and contextual stressors, including social determinants of health. The specific stressor studied here is the provision of caregiving to older persons with Alzheimer disease and related disorders. The aims were to examine the factor structure of stress and nonstress biomarkers, different methods for calculating AL, and the relationship of AL with other variables.Methods: Latent variable models were used to examine biomarkers. Regression analyses were performed with the outcomes: AL calculated as percentile-based and clinically-based for both stress and nonstress components. The sample was 187 Hispanic caregivers to individuals with dementia.Results: The results of the confirmatory factor analyses (CFAs) suggested defining 2 factors: nonstress and stress-related. Performance was better for the CFA results and the associations with covariates when stress and nonstress components were examined separately. Despite some limitations, this is one of the first studies of biomarkers in Hispanic caregivers to patients with dementia. It was possible to explain almost 30% of the variance in the nonstress AL component.Conclusion: It may be important to differentiate among biomarkers indicative of cardiovascular, metabolic, and immune response as contrasted with the more stress-related biomarkers.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"178-188"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11149728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis of White Matter Hyperintensity Volume Differences Between APOE ε4 Carriers and Noncarriers. APOE ε4携带者与非携带者白质高密度体积差异的Meta分析。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-14 DOI: 10.1097/WAD.0000000000000620

Faissal Stipho, Michael Malek-Ahmadi

{"title":"Meta-Analysis of White Matter Hyperintensity Volume Differences Between APOE ε4 Carriers and Noncarriers.","authors":"Faissal Stipho, Michael Malek-Ahmadi","doi":"10.1097/WAD.0000000000000620","DOIUrl":"10.1097/WAD.0000000000000620","url":null,"abstract":"Several studies have suggested that white matter hyperintensity volume (WMHV) is increased among apolipoprotein E (APOE) ε4 carriers while others have reported contradictory findings. Although APOE ε4 carriage is associated with greater AD pathology, it remains unclear whether cerebrovascular damage is also associated with APOE ε4 carriage. The aim of this meta-analysis was to determine whether WMHV is associated with APOE ε4 carrier status. 12 studies that were included yielded a total sample size of 16,738 adult subjects (ε4 carrier n = 4,721; ε4 noncarrier n = 12,017). There were no significant differences in WMHV between ε4 carriers and noncarriers (Hedge's g = 0.07; 95% CI (-0.01 to 0.15), P = 0.09). Subgroup analysis of community-based studies (n = 8) indicated a small effect size where ε4 carriers had greater WMHV relative to noncarriers (Hedge's g = 0.09 95% CI (0.02 to 0.16), P = 0.008). Among clinic-based studies (n = 3) there was no significant difference in WMHV by APOE ε4 carrier status (Hedge's g = -0.09, 95% CI (-0.60 to 0.41), P = 0.70). Observed APOE ε4-associated WMHV differences may be context-dependent and may also be confounded by a lack of standardization for WMHV segmentation.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"208-212"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0