Alzheimer Disease & Associated Disorders最新文献_第4页

High School Curriculum and Cognitive Function in the Eighth Decade of Life. 高中课程与人生第八个十年的认知功能。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1097/WAD.0000000000000629

Sara M Moorman, Saber Khani

{"title":"High School Curriculum and Cognitive Function in the Eighth Decade of Life.","authors":"Sara M Moorman, Saber Khani","doi":"10.1097/WAD.0000000000000629","DOIUrl":"10.1097/WAD.0000000000000629","url":null,"abstract":"Introduction: Formal educational attainment, or years of schooling, has a well-established positive effect on cognitive health across the life course. We hypothesized that the content and difficulty of the curriculum influence this relationship, such that more challenging curricula in high school lead to higher levels of socioeconomic attainment in adulthood and, in turn, to better cognitive outcomes in older adulthood.Methods: We estimated multilevel structural equation models (MSEMs) in data from 2,405 individuals who attended one of 1,312 US high schools in 1960 and participated in the Project Talent Aging Study in 2018.Results: A college preparatory curriculum and a greater number of semesters of math and science in high school were positively related to word recall and verbal fluency at an average age of 75. Effects were robust to controlling for adolescent cognitive ability, academic performance, socioeconomic background, and school characteristics.Discussion: We discuss the implications of these findings for educational policy.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"235-240"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Improvement after Cognitive Training in Mild Cognitive Impairment: Insights from the Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Trial. 轻度认知障碍患者认知训练后病情改善的预测因素：轻度认知障碍认知训练和神经可塑性试验的启示》。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-05 DOI: 10.1097/WAD.0000000000000639

Min Qian, Jeffrey Motter, Emily Deehan, Jamie Graff, Alisa Adhikari, P Murali Doraiswamy, Terry E Goldberg, Devangere P Devanand

{"title":"Predictors of Improvement after Cognitive Training in Mild Cognitive Impairment: Insights from the Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Trial.","authors":"Min Qian, Jeffrey Motter, Emily Deehan, Jamie Graff, Alisa Adhikari, P Murali Doraiswamy, Terry E Goldberg, Devangere P Devanand","doi":"10.1097/WAD.0000000000000639","DOIUrl":"10.1097/WAD.0000000000000639","url":null,"abstract":"Objective: Cognitive training may benefit older adults with mild cognitive impairment (MCI), but the prognostic factors are not well-established.Methods: This study analyzed data from a 78-week trial with 107 participants with MCI, comparing computerized cognitive training (CCT) and computerized crossword puzzle training (CPT). Outcomes were changes in cognitive and functional measures from baseline. Linear mixed-effect models were used to identify prognostic factors for each intervention.Results: Baseline neuropsychological composite z-score was positively associated with cognitive and functional improvements for both interventions in univariable models, retaining significance in the final multivariable model for functional outcome in CPT ( P < 0.001). Apolipoprotein E e4 carriers had worse cognitive ( P = 0.023) and functional ( P = 0.001) outcomes than noncarriers for CPT but not CCT. African Americans showed greater functional improvements than non-African Americans in both CPT ( P = 0.001) and CCT ( P = 0.010). Better baseline odor identification was correlated with cognitive improvements in CPT ( P = 0.006) and functional improvements in CCT ( P < 0.001).Conclusion: Baseline cognitive test performance, African American background, and odor identification ability are potential prognostic factors for improved outcomes with cognitive interventions in older adults with MCI. Apolipoprotein E e4 is associated with poor outcomes. Replication of these findings may improve the selection of cognitive interventions for individuals with MCI.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"227-234"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Handedness in Alzheimer Disease: A Systematic Review. 阿尔茨海默病的手部特征：系统回顾

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI: 10.1097/WAD.0000000000000640

Giorgio Guido, Alberto Bonato, Samuele Bonomi, Simone Franceschini, John C Morris

引用次数: 0

Frequent Occurrence of Alzheimer Disease in Patients With IgE-mediated Allergies. IgE介导的过敏症患者常患阿尔茨海默病

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI: 10.1097/WAD.0000000000000636

Andrzej Bożek, Robert Pawłowicz, Aleksandra Spyra, Natalia Tekiela, Martyna Miodonska, Alicja Grzanka

引用次数: 0

Feasibility and Acceptability of a Multifaceted Observational Protocol to Investigate Lucidity in Advanced Dementia. 调查晚期痴呆症患者清醒程度的多方面观察方案的可行性和可接受性。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-04-08 DOI: 10.1097/WAD.0000000000000615

Alison Coulson, Clark Benson, Jess Fehland, Kayla Dillon, Kimberly Mueller, Andrea Gilmore-Bykovskyi

{"title":"Feasibility and Acceptability of a Multifaceted Observational Protocol to Investigate Lucidity in Advanced Dementia.","authors":"Alison Coulson, Clark Benson, Jess Fehland, Kayla Dillon, Kimberly Mueller, Andrea Gilmore-Bykovskyi","doi":"10.1097/WAD.0000000000000615","DOIUrl":"10.1097/WAD.0000000000000615","url":null,"abstract":"Objective: Episodes of lucidity (ELs), characterized by spontaneous, transient recovery of abilities, are reported across neurological conditions, including advanced dementia. Despite the significance of these events, existing research is limited to retrospective reports. Approaches to prospectively capturing and characterizing ELs in dementia are lacking.Methods: This pilot study determined the feasibility and acceptability of a multifaceted observational protocol to capture, characterize, and validate ELs in individuals with advanced dementia in hospice. Feasibility was measured through enrollment/retention rates, workload/usability assessment of video observation, and data processing procedures to facilitate the measurement of verbal and nonverbal features for EL characterization. The acceptability of observation and informant validation procedures was qualitatively examined with clinician and family caregiver participants.Results: Study procedures were endorsed as highly acceptable among clinician (N = 49) and caregiver (N = 16) participants, demonstrating higher than anticipated thresholds for observation duration. Enrollment and retention rates for patient participants (N = 6) were 100% and 84%, respectively. Workload and usability measures demonstrated low disruptiveness and high ease of use after training.Discussion: Longitudinal video observation among individuals with advanced dementia in hospice care for the detection of lucidity was feasible and highly acceptable. Multidimensional, temporal coding of features of ELs is feasible but time-intensive.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"140-146"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141205/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140861596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease. 认知正常队列中的包膜损伤证据：与 CSF 和 PET 阿尔茨海默病生物标记物的关联

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-16 DOI: 10.1097/WAD.0000000000000623

Arsalan Haghdel, Natasha Smith, Lidia Glodzik, Yi Li, Xiuyuan Wang, Tamara Crowder, Yuan-Shan Zhu, Tracy Butler, Kaj Blennow, Laura Beth McIntire, Silky Pahlajani, Joseph Osborne, Gloria Chiang, Mony de Leon, Jana Ivanidze

{"title":"Evidence of Pericyte Damage in a Cognitively Normal Cohort: Association With CSF and PET Biomarkers of Alzheimer Disease.","authors":"Arsalan Haghdel, Natasha Smith, Lidia Glodzik, Yi Li, Xiuyuan Wang, Tamara Crowder, Yuan-Shan Zhu, Tracy Butler, Kaj Blennow, Laura Beth McIntire, Silky Pahlajani, Joseph Osborne, Gloria Chiang, Mony de Leon, Jana Ivanidze","doi":"10.1097/WAD.0000000000000623","DOIUrl":"10.1097/WAD.0000000000000623","url":null,"abstract":"Background: Blood-brain barrier (BBB) dysfunction is emerging as an important pathophysiologic factor in Alzheimer disease (AD). Cerebrospinal fluid (CSF) platelet-derived growth factor receptor-β (PDGFRβ) is a biomarker of BBB pericyte injury and has been implicated in cognitive impairment and AD.Methods: We aimed to study CSF PDGFRβ protein levels, along with CSF biomarkers of brain amyloidosis and tau pathology in a well-characterized population of cognitively unimpaired individuals and correlated CSF findings with amyloid-PET positivity. We performed an institutional review board (IRB)-approved cross-sectional analysis of a prospectively enrolled cohort of 36 cognitively normal volunteers with available CSF, Pittsburgh compound B PET/CT, Mini-Mental State Exam score, Global Deterioration Scale, and known apolipoprotein E ( APOE ) ε4 status.Results: Thirty-six subjects were included. Mean age was 63.3 years; 31 of 36 were female, 6 of 36 were amyloid-PET-positive and 12 of 36 were APOE ε4 carriers. We found a moderate positive correlation between CSF PDGFRβ and both total Tau (r=0.45, P =0.006) and phosphorylated Tau 181 (r=0.51, P =0.002). CSF PDGFRβ levels were not associated with either the CSF Aβ42 or the amyloid-PET.Conclusions: We demonstrated a moderate positive correlation between PDGFRβ and both total Tau and phosphorylated Tau 181 in cognitively normal individuals. Our data support the hypothesis that BBB dysfunction represents an important early pathophysiologic step in AD, warranting larger prospective studies.Trial registration: ClinicalTrials.gov Identifier: NCT00094939.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"107-111"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11132093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943497","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Characterization of Veterans With Alzheimer Disease by Disease Severity in the United States. 按疾病严重程度划分的美国退伍军人阿尔茨海默病临床特征。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI: 10.1097/WAD.0000000000000622

Peter Morin, Byron J Aguilar, Dan Berlowitz, Raymond Zhang, Amir Abbas Tahami Monfared, Quanwu Zhang, Weiming Xia

{"title":"Clinical Characterization of Veterans With Alzheimer Disease by Disease Severity in the United States.","authors":"Peter Morin, Byron J Aguilar, Dan Berlowitz, Raymond Zhang, Amir Abbas Tahami Monfared, Quanwu Zhang, Weiming Xia","doi":"10.1097/WAD.0000000000000622","DOIUrl":"10.1097/WAD.0000000000000622","url":null,"abstract":"Purpose: We aimed to examine the clinical characteristics of US veterans who underwent neurocognitive test score-based assessments of Alzheimer disease (AD) stage in the Veterans Affairs Healthcare System (VAHS).Methods: Test dates for specific stages of AD were referenced as index dates to study behavioral and psychological symptoms of dementia (BPSD) and other patient characteristics related to utilization/work-up and time to death.Patients: We identified veterans with AD and neurocognitive evaluations using the VAHS Electronic Health Record (EHR).Results: Anxiety and sleep disorders/disturbances were the most documented BPSDs across all AD severity stages. Magnetic resonance imaging, neurology and psychiatry consultations, and neuropsychiatric evaluations were slightly higher in veterans with mild AD than in those at later stages. The overall average time to death from the first AD severity record was 5 years for mild and 4 years for moderate/severe AD.Conclusion: We found differences in clinical symptoms, healthcare utilization, and survival among the mild, moderate, and severe stages of AD. These differences are limited by the low documentation of BPSDs among veterans with test score-based AD stages. These data support the hypothesis that our cohorts represent coherent subgroups of patients with AD based on disease severity.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"195-200"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethnoracial Identity and Cognitive Impairment: A Community Study. 种族认同与认知障碍：一项社区研究。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-15 DOI: 10.1097/WAD.0000000000000617

Isabella Wood, Ruopu Song, Yingjin Zhang, Erin Jacobsen, Tiffany Hughes, Chung-Chou H Chang, Mary Ganguli

{"title":"Ethnoracial Identity and Cognitive Impairment: A Community Study.","authors":"Isabella Wood, Ruopu Song, Yingjin Zhang, Erin Jacobsen, Tiffany Hughes, Chung-Chou H Chang, Mary Ganguli","doi":"10.1097/WAD.0000000000000617","DOIUrl":"10.1097/WAD.0000000000000617","url":null,"abstract":"Background: Identifying potentially modifiable risk factors associated with MCI in different ethnoracial groups could reduce MCI burden and health inequity in the population.Methods: Among 2845 adults aged 65+ years, we investigated potential risk exposures including education, physical and mental health, lifestyle, and sensory function, and their cross-sectional associations with MCI. We compared proportions of exposures between Black and White participants and explored relationships among race, MCI, and exposures. Logistic regression modeled MCI as a function of each exposure in the overall sample adjusting for age, sex, educational level, and race, and investigating race*exposure interactions.Results: Compared with White participants, Black participants had greater odds of MCI (OR 1.53; 95% CI, 1.13 to 2.06) and were more likely to report depressive symptoms, diabetes, and stroke, to have high blood pressure and BMI, and to be APOE - 4 carriers. Exposures associated with higher odds of MCI were diabetes, stroke, lifetime smoking, sleep disturbances, social isolation, loneliness, depression and anxiety symptoms, and vision and hearing loss. There were no significant interactions between race and any exposure.Conclusions: Black participants had 53% higher odds of MCI adjusting for age, sex, and education. The same exposures were associated with MCI in Black and White participants.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"152-159"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140943495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Drivers of Memory Loss Underreport in Mild Cognitive Impairment Due to Alzheimer Versus Vascular Disease. 阿尔茨海默病与血管性疾病导致的轻度认知功能障碍中记忆力丧失少报的驱动因素。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI: 10.1097/WAD.0000000000000627

Anthony Q Briggs, Sakina Ouedraogo Tall, Carolina Boza-Calvo, Mark A Bernard, Omonigho M Bubu, Arjun V Masurkar

{"title":"Drivers of Memory Loss Underreport in Mild Cognitive Impairment Due to Alzheimer Versus Vascular Disease.","authors":"Anthony Q Briggs, Sakina Ouedraogo Tall, Carolina Boza-Calvo, Mark A Bernard, Omonigho M Bubu, Arjun V Masurkar","doi":"10.1097/WAD.0000000000000627","DOIUrl":"10.1097/WAD.0000000000000627","url":null,"abstract":"Background: We examined drivers of self and study partner reports of memory loss in mild cognitive impairment (MCI) from Alzheimer (AD-MCI) and vascular disease (Va-MCI).Methods: We performed retrospective cross-sectional analyses of participants with AD-MCI (n=2874) and Va-MCI (n=376) from the National Alzheimer Coordinating Center data set. Statistical analysis utilized 2-sided t test or the Fisher exact test.Results: Compared with AD-MCI, Va-MCI subjects (24.5% vs. 19.7%, P =0.031) and study partners (31.4% vs. 21.6%, P <0.0001) were more likely to deny memory loss. Black/African Americans were disproportionately represented in the group denying memory loss in AD-MCI (20.0% vs. 13.2%, P <0.0001) and Va-MCI (33.7% vs. 18.0%, P =0.0022). Study partners of participants with these features also disproportionately denied memory loss: female (AD-MCI: 60.1% vs. 51.7%, P =0.0002; Va-MCI: 70.3% vs. 52.3%, P =0.0011), Black/African American (AD-MCI: 23.5% vs. 11.98%, P <0.0001; Va-MCI: 48.8% vs. 26.5%, P =0.0002), and <16 years of education (AD-MCI only: 33.9% vs. 16.3%, P =0.0262). In AD-MCI and Va-MCI, participants with anxiety were disproportionately represented in the group endorsing memory loss (AD: 28.2% vs. 17.4%, P <0.0001; Va: 31.5% vs. 16.1%, P =0.0071), with analogous results with depression.Conclusion: The findings would suggest extra vigilance in interview-based MCI detection of persons at-risk for self-based or informant-based misreport.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"128-132"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141209/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140955796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Association Between Physical Activity and Cognition in a Racially/Ethnically Diverse Cohort of Older Adults: Results From the Kaiser Healthy Aging and Diverse Life Experiences Study. 不同种族/族裔老年人群中体育活动与认知之间的关系：凯撒健康老龄化和多元化生活经历研究》的结果。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-03-27 DOI: 10.1097/WAD.0000000000000612

Mariana L Almeida, Anna M Pederson, Scott C Zimmerman, Ruijia Chen, Sarah Ackley, Alicia Riley, Chloe W Eng, Rachel A Whitmer, Kristen M George, Rachel L Peterson, Elizabeth Rose Mayeda, Paola Gilsanz, Dan M Mungas, Sarah Tomaszewski Farias, M Maria Glymour

{"title":"The Association Between Physical Activity and Cognition in a Racially/Ethnically Diverse Cohort of Older Adults: Results From the Kaiser Healthy Aging and Diverse Life Experiences Study.","authors":"Mariana L Almeida, Anna M Pederson, Scott C Zimmerman, Ruijia Chen, Sarah Ackley, Alicia Riley, Chloe W Eng, Rachel A Whitmer, Kristen M George, Rachel L Peterson, Elizabeth Rose Mayeda, Paola Gilsanz, Dan M Mungas, Sarah Tomaszewski Farias, M Maria Glymour","doi":"10.1097/WAD.0000000000000612","DOIUrl":"10.1097/WAD.0000000000000612","url":null,"abstract":"Objective: Most prior research on physical activity (PA) and cognition is based on predominantly white cohorts and focused on associations of PA with mean (average) cognition versus the distribution of cognition. Quantile regression offers a novel way to quantify how PA affects cognition across the entire distribution.Methods: The Kaiser Healthy Aging and Diverse Life Experiences study includes 30% white, 19% black, 25% Asian, and 26% Latinx adults age 65+ living in Northern California (n = 1600). The frequency of light or heavy PA was summarized as 2 continuous variables. Outcomes were z-scored executive function, semantic memory, and verbal episodic memory. We tested associations of PA with mean cognition using linear regression and used quantile regression to estimate the association of PA with the 10th-90th percentiles of cognitive scores.Results: Higher levels of PA were associated with higher mean semantic memory (b = 0.10; 95% CI: 0.06, 0.14) and executive function (b = 0.05; 95% CI: 0.01, 0.09). Associations of PA across all 3 cognitive domains were stronger at low quantiles of cognition.Conclusion: PA is associated with cognition in this racially/ethnically diverse sample and may have larger benefits for individuals with low cognitive scores, who are most vulnerable to dementia.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"120-127"},"PeriodicalIF":1.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11141342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0