Alzheimer Disease & Associated Disorders最新文献_第4页

Urinary AD7c-NTP is Associated With Cognitive Recovery After Ischemic Stroke. 尿液 AD7c -NTP 与缺血性脑卒中后的认知恢复有关

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-07 DOI: 10.1097/WAD.0000000000000634

Yuqin Wang, Huimin Tao, Maohong Cao, Kefu Cai

{"title":"Urinary AD7c-NTP is Associated With Cognitive Recovery After Ischemic Stroke.","authors":"Yuqin Wang, Huimin Tao, Maohong Cao, Kefu Cai","doi":"10.1097/WAD.0000000000000634","DOIUrl":"10.1097/WAD.0000000000000634","url":null,"abstract":"Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is regarded as a biomarker for β-amyloid protein deposition in Alzheimer disease (AD). The value of AD7c-NTP in predicting post-stroke cognitive recovery was worth exploring. In total, 224 patients with first-ever stroke were enrolled in this retrospective study. Cognitive assessment was evaluated by Mini-Mental State Examination (MMSE), and cognitive improvement was defined as MMSE scores ≥27 or 4-score elevation at 3-month follow-up after stroke. The AD7c-NTP level was 0.68±0.40 ng/mL in the 135 patients with cognitive improvement, while the AD7c-NTP level was 1.49±0.99 ng/mL in the 89 patients without improvement ( P <0.001). Those displaying better cognitive recovery also had younger ages, higher MMSE scores, and lower NIHSS scores on admission. In multivariable logistic regression analysis, AD7c-NTP concentration (OR=9.14, 95% CI: 4.52-18.49, P <0.001), age (OR=1.04, 95% CI: 1.01-1.08, P =0.012), and NIHSS score on admission (OR=1.17, 95% CI: 1.07-1.28, P <0.001) remained the independent risk factors affecting cognitive recovery. The area under the receiver operating characteristics curve for AD7c-NTP in predicting unfavorable cognitive function was 0.80 (sensitivity: 0.73 and specificity: 0.84). Urinary AD7c-NTP is a valuable biomarker associated with post-stroke cognitive recovery. It might be adopted to discriminate coexisting AD pathology from vascular cognitive impairment.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"292-294"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141896548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Personality Traits on Driving Behaviors in Preclinical Alzheimer Disease. 人格特征对临床前阿尔茨海默病患者驾驶行为的影响。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI: 10.1097/WAD.0000000000000632

Andrew J Aschenbrenner, David B Carr, Tammie L S Benzinger, John C Morris, Ganesh M Babulal

{"title":"The Influence of Personality Traits on Driving Behaviors in Preclinical Alzheimer Disease.","authors":"Andrew J Aschenbrenner, David B Carr, Tammie L S Benzinger, John C Morris, Ganesh M Babulal","doi":"10.1097/WAD.0000000000000632","DOIUrl":"10.1097/WAD.0000000000000632","url":null,"abstract":"Introduction: Alzheimer disease (AD) has a long preclinical phase in which AD pathology is accumulating without detectable clinical symptoms. It is critical to identify participants in this preclinical phase as early as possible since treatment plans may be more effective in this stage. Monitoring for changes in driving behavior, as measured with GPS sensors, has been explored as a low-burden, easy-to-administer method for detecting AD risk. However, driving is a complex, multifaceted process that is likely influenced by other factors, including personality traits, that may change in preclinical AD.Methods: We examine the moderating influence of neuroticism and conscientiousness on longitudinal changes in driving behavior in a sample of 203 clinically normal older adults who are at varying risk of developing AD.Results: Neuroticism moderated rates of change in the frequency of speeding as well as the number of trips taken at night. Conscientiousness moderated rates of change in typical driving space.Conclusions: Personality traits change in early AD and also influence driving behaviors. Studies that seek to utilize naturalistic driving behavior to establish AD risk need to accommodate interpersonal differences, of which personality traits are one of many possible factors. Future studies should explicitly establish how much benefit is provided by including personality traits in predictive models of AD progression.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 3","pages":"241-248"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142034972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factor Structure and Internal Consistency of the National Alzheimer Coordinating Center's Uniform Data Set Version 3 Neuropsychological Test Battery (UDSNB 3.0): The Nigeria Sample. 全国老年痴呆症协调中心统一数据集第三版神经心理测试库（UDSNB 3.0）的因子结构和内部一致性：尼日利亚样本。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1097/WAD.0000000000000630

Valentine Ucheagwu, Chiamaka Odilora, Rita Ugokwe-Joseph, Bruno Giordani

{"title":"Factor Structure and Internal Consistency of the National Alzheimer Coordinating Center's Uniform Data Set Version 3 Neuropsychological Test Battery (UDSNB 3.0): The Nigeria Sample.","authors":"Valentine Ucheagwu, Chiamaka Odilora, Rita Ugokwe-Joseph, Bruno Giordani","doi":"10.1097/WAD.0000000000000630","DOIUrl":"https://doi.org/10.1097/WAD.0000000000000630","url":null,"abstract":"Background: Construct validation of cognitive batteries across Africa is imperative to understanding dementia in the region. We examined construct validity and internal consistency of the neuropsychological battery of Uniform Data Set version 3 (UDSNB 3.0) of the Alzheimer Coordinating Center in Nigeria older adults.Method: Three hundred forty-nine (220 females; age: 65 to 85) community dwellers were recruited. UDSNB 3.0 with 12 subscales were used to measure cognition. Two sets of data were collected. First was for exploratory factor analysis (EFA) and second was confirmatory factor analysis (CFA). Four models were specified for CFA.Result: EFA principal axis factor with varimax rotation yielded 4 factors: Executive function, memory, visual-spatial ability, and processing speed. Four CFA were performed based on 4 specified models, with only model 3 showing good model fit: CMIN/DF=2.13; confirmatory fit index=0.94; root mean square error of approximation=0.07. Model 3 had 5 latent variables: working memory, language, verbal memory, visual-spatial ability, and processing speed. UDSNB 3.0 had an overall Cronbach alpha of 0.73, suggesting strong internal reliability with ANOVA model F134,1619=183.65 significant at P<0.001 level of testing.Conclusions: Our study showed that UDSNB 3.0 has construct validity and good internal consistency in our older adult population.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":"38 3","pages":"265-270"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142034899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Moderate and Vigorous Physical Activity With Cognitive Performance: Evidence From Brazil. 适度和剧烈运动与认知能力的关系：巴西的证据

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-02 DOI: 10.1097/WAD.0000000000000637

Ingryd Mayara Nascimento Martins de Pais, Wendell Lima Rabelo, Naomi Vidal Ferreira, Cleusa Pinheiro Ferri, Claudia Kimie Suemoto, Natalia Gomes Gonçalves

{"title":"Association of Moderate and Vigorous Physical Activity With Cognitive Performance: Evidence From Brazil.","authors":"Ingryd Mayara Nascimento Martins de Pais, Wendell Lima Rabelo, Naomi Vidal Ferreira, Cleusa Pinheiro Ferri, Claudia Kimie Suemoto, Natalia Gomes Gonçalves","doi":"10.1097/WAD.0000000000000637","DOIUrl":"10.1097/WAD.0000000000000637","url":null,"abstract":"Objective: It is estimated that 2% of dementia cases worldwide could be prevented with increases in physical activity. However, there is little evidence of the association between vigorous physical activity (VPA) and cognitive performance. This study aimed to investigate the association of moderate physical activity (MPA) and VPA with cognitive performance in older adults from the Brazilian Longitudinal Study of Aging (ELSI-Brasil).Patients and methods: Data from 7954 participants were analyzed. Mean age was 61.8 ± 9.2 years, 61.8% were women, and 44.3% were mixed races. Cognitive performance evaluated the memory, temporal orientation, and verbal fluency domains. A global composite z-score was derived from the tests. Physical activity was assessed by self-report. We used linear regression models to verify the association of MPA and VPA with cognitive performance.Results: Compared with participants who did not meet the guidelines for MPA (<150 min/wk), those who met the guidelines (150 to 299 min/wk) and those who performed more than 2x the recommended amount of MPA (300 min or more/wk) had better global cognitive performance (β = 0.163, 95% CI = 0.086, 0.241; P < 0.001; β = 0.180, 95% CI = 0.107, 0.253, P < 0.001, respectively). We found no association between VPA and cognitive performance.Conclusion: There was no additional benefit of VPA for cognitive performance.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"249-256"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141878169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Musculoskeletal Injuries Among Informal and Formal Carers of People With Dementia. 探索痴呆症患者非正式和正式照护者中的肌肉骨骼损伤。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1097/WAD.0000000000000635

Eleni Dimakopoulou, Theodoros M Bampouras, Georgia Katsardi, Georgios Tavoulareas, Maria Karydaki, Maria Theodorelou, Panagiota Zoi, Paraskevi Sakka

{"title":"Exploring Musculoskeletal Injuries Among Informal and Formal Carers of People With Dementia.","authors":"Eleni Dimakopoulou, Theodoros M Bampouras, Georgia Katsardi, Georgios Tavoulareas, Maria Karydaki, Maria Theodorelou, Panagiota Zoi, Paraskevi Sakka","doi":"10.1097/WAD.0000000000000635","DOIUrl":"10.1097/WAD.0000000000000635","url":null,"abstract":"Background: Carers of people with dementia manually handle the care recipients (eg, repetitive lifting, transferring, and pulling) as part of the care service, increasing the musculoskeletal injury risk to themselves.Objective: We aimed to determine the prevalence of musculoskeletal injuries among informal and formal carers of people with dementia and the perceived associated risk factors.Methods: Primary carers of people with dementia (26 males and 141 females) from Dementia Care Centers and Home Care programs completed a questionnaire providing information about (a) the carers' and their care recipients' characteristics, (b) musculoskeletal symptoms (via the Nordic Musculoskeletal Questionnaire) and related aspects, and (c) the caregiving activities exposing the carers to risk of musculoskeletal injury.Results: Our results showed that 69.7% of informal and 86.7% of formal carers reported having more than 1 musculoskeletal injury, while 63.1% and 61.5%, respectively, reported having a musculoskeletal injury in the last year. Lower back had the highest injury prevalence (>10% for both groups). The 2 carer groups were not different in any of the variables.Conclusions: Our results reinforce calls for education and support of carers, regardless of their formal status, to enable injury-free and prolonged service provision.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"271-276"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Quantitative Analysis of Factors of Attrition in a Double-blind rTMS Study for Alzheimer Treatment. 经颅磁刺激治疗老年痴呆症双盲研究中自然减员因素的定量分析

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1097/WAD.0000000000000633

Carly A Bretecher, Ashley Verot, James M Teschuk, Maria A Uehara, Paul B Fitzgerald, Lisa Koski, Brian J Lithgow, Zahra Moussavi

{"title":"Quantitative Analysis of Factors of Attrition in a Double-blind rTMS Study for Alzheimer Treatment.","authors":"Carly A Bretecher, Ashley Verot, James M Teschuk, Maria A Uehara, Paul B Fitzgerald, Lisa Koski, Brian J Lithgow, Zahra Moussavi","doi":"10.1097/WAD.0000000000000633","DOIUrl":"10.1097/WAD.0000000000000633","url":null,"abstract":"Attrition is a particular concern in studies examining the efficacy of a treatment for Alzheimer disease. Analyzing reasons for withdrawal in Alzheimer studies is crucial to ruling out attrition bias, which can undermine a study's validity. In contrast, attrition in studies using repetitive transcranial magnetic stimulation (rTMS) has received much less attention. Our goal was to identify any commonalities between participants who withdrew for the same reasons. Three independent coders rated each response concerning the reasons for withdrawal, and frequency tables were generated to characterize the participants within each category. This study was conducted on the 28 withdrawn cases from a 7-month study investigating the short-term and long-term therapeutic effects of rTMS for Alzheimer disease among 156 participants across 3 sites of the study. Seven reasons for withdrawal were identified, with health and medical changes being the most commonly reported reason (7 participants). Personal issues involving family or caregivers were the next most common (5 participants), and the remaining 5 categories consisted of 3 participants each. Although the limited sample size prevented the use of inferential statistics, our findings highlight the need for more transparent reporting of attrition rates and withdrawal reasons by rTMS researchers.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"288-291"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High School Curriculum and Cognitive Function in the Eighth Decade of Life. 高中课程与人生第八个十年的认知功能。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-08 DOI: 10.1097/WAD.0000000000000629

Sara M Moorman, Saber Khani

{"title":"High School Curriculum and Cognitive Function in the Eighth Decade of Life.","authors":"Sara M Moorman, Saber Khani","doi":"10.1097/WAD.0000000000000629","DOIUrl":"10.1097/WAD.0000000000000629","url":null,"abstract":"Introduction: Formal educational attainment, or years of schooling, has a well-established positive effect on cognitive health across the life course. We hypothesized that the content and difficulty of the curriculum influence this relationship, such that more challenging curricula in high school lead to higher levels of socioeconomic attainment in adulthood and, in turn, to better cognitive outcomes in older adulthood.Methods: We estimated multilevel structural equation models (MSEMs) in data from 2,405 individuals who attended one of 1,312 US high schools in 1960 and participated in the Project Talent Aging Study in 2018.Results: A college preparatory curriculum and a greater number of semesters of math and science in high school were positively related to word recall and verbal fluency at an average age of 75. Effects were robust to controlling for adolescent cognitive ability, academic performance, socioeconomic background, and school characteristics.Discussion: We discuss the implications of these findings for educational policy.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"235-240"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11849057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141900627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Improvement after Cognitive Training in Mild Cognitive Impairment: Insights from the Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Trial. 轻度认知障碍患者认知训练后病情改善的预测因素：轻度认知障碍认知训练和神经可塑性试验的启示》。

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-05 DOI: 10.1097/WAD.0000000000000639

Min Qian, Jeffrey Motter, Emily Deehan, Jamie Graff, Alisa Adhikari, P Murali Doraiswamy, Terry E Goldberg, Devangere P Devanand

{"title":"Predictors of Improvement after Cognitive Training in Mild Cognitive Impairment: Insights from the Cognitive Training and Neuroplasticity in Mild Cognitive Impairment Trial.","authors":"Min Qian, Jeffrey Motter, Emily Deehan, Jamie Graff, Alisa Adhikari, P Murali Doraiswamy, Terry E Goldberg, Devangere P Devanand","doi":"10.1097/WAD.0000000000000639","DOIUrl":"10.1097/WAD.0000000000000639","url":null,"abstract":"Objective: Cognitive training may benefit older adults with mild cognitive impairment (MCI), but the prognostic factors are not well-established.Methods: This study analyzed data from a 78-week trial with 107 participants with MCI, comparing computerized cognitive training (CCT) and computerized crossword puzzle training (CPT). Outcomes were changes in cognitive and functional measures from baseline. Linear mixed-effect models were used to identify prognostic factors for each intervention.Results: Baseline neuropsychological composite z-score was positively associated with cognitive and functional improvements for both interventions in univariable models, retaining significance in the final multivariable model for functional outcome in CPT ( P < 0.001). Apolipoprotein E e4 carriers had worse cognitive ( P = 0.023) and functional ( P = 0.001) outcomes than noncarriers for CPT but not CCT. African Americans showed greater functional improvements than non-African Americans in both CPT ( P = 0.001) and CCT ( P = 0.010). Better baseline odor identification was correlated with cognitive improvements in CPT ( P = 0.006) and functional improvements in CCT ( P < 0.001).Conclusion: Baseline cognitive test performance, African American background, and odor identification ability are potential prognostic factors for improved outcomes with cognitive interventions in older adults with MCI. Apolipoprotein E e4 is associated with poor outcomes. Replication of these findings may improve the selection of cognitive interventions for individuals with MCI.","PeriodicalId":7679,"journal":{"name":"Alzheimer Disease & Associated Disorders","volume":" ","pages":"227-234"},"PeriodicalIF":1.8,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141888263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Handedness in Alzheimer Disease: A Systematic Review. 阿尔茨海默病的手部特征：系统回顾

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI: 10.1097/WAD.0000000000000640

Giorgio Guido, Alberto Bonato, Samuele Bonomi, Simone Franceschini, John C Morris

引用次数: 0

Frequent Occurrence of Alzheimer Disease in Patients With IgE-mediated Allergies. IgE介导的过敏症患者常患阿尔茨海默病

IF 1.8 4区医学

Alzheimer Disease & Associated Disorders Pub Date : 2024-07-01 Epub Date: 2024-08-23 DOI: 10.1097/WAD.0000000000000636

Andrzej Bożek, Robert Pawłowicz, Aleksandra Spyra, Natalia Tekiela, Martyna Miodonska, Alicja Grzanka

引用次数: 0