Drivers of Memory Loss Underreport in Mild Cognitive Impairment Due to Alzheimer Versus Vascular Disease.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-17 DOI:10.1097/WAD.0000000000000627

Anthony Q Briggs, Sakina Ouedraogo Tall, Carolina Boza-Calvo, Mark A Bernard, Omonigho M Bubu, Arjun V Masurkar

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引用次数: 0

Abstract

Background: We examined drivers of self and study partner reports of memory loss in mild cognitive impairment (MCI) from Alzheimer (AD-MCI) and vascular disease (Va-MCI).

Methods: We performed retrospective cross-sectional analyses of participants with AD-MCI (n=2874) and Va-MCI (n=376) from the National Alzheimer Coordinating Center data set. Statistical analysis utilized 2-sided t test or the Fisher exact test.

Results: Compared with AD-MCI, Va-MCI subjects (24.5% vs. 19.7%, P =0.031) and study partners (31.4% vs. 21.6%, P <0.0001) were more likely to deny memory loss. Black/African Americans were disproportionately represented in the group denying memory loss in AD-MCI (20.0% vs. 13.2%, P <0.0001) and Va-MCI (33.7% vs. 18.0%, P =0.0022). Study partners of participants with these features also disproportionately denied memory loss: female (AD-MCI: 60.1% vs. 51.7%, P =0.0002; Va-MCI: 70.3% vs. 52.3%, P =0.0011), Black/African American (AD-MCI: 23.5% vs. 11.98%, P <0.0001; Va-MCI: 48.8% vs. 26.5%, P =0.0002), and <16 years of education (AD-MCI only: 33.9% vs. 16.3%, P =0.0262). In AD-MCI and Va-MCI, participants with anxiety were disproportionately represented in the group endorsing memory loss (AD: 28.2% vs. 17.4%, P <0.0001; Va: 31.5% vs. 16.1%, P =0.0071), with analogous results with depression.

Conclusion: The findings would suggest extra vigilance in interview-based MCI detection of persons at-risk for self-based or informant-based misreport.

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阿尔茨海默病与血管性疾病导致的轻度认知功能障碍中记忆力丧失少报的驱动因素。

背景：我们研究了阿尔茨海默病（AD-MCI）和血管性疾病（Va-MCI）轻度认知障碍（MCI）患者自己和研究伙伴报告记忆力减退的驱动因素：我们研究了阿尔茨海默病（AD-MCI）和血管性疾病（Va-MCI）引起的轻度认知障碍（MCI）中自我和研究伙伴报告记忆力减退的驱动因素：我们对国家阿尔茨海默氏症协调中心数据集中的AD-MCI（n=2874）和Va-MCI（n=376）参与者进行了回顾性横断面分析。统计分析采用双侧 t 检验或费雪精确检验：结果：与AD-MCI相比，Va-MCI受试者（24.5% vs. 19.7%，P=0.031）和研究伙伴（31.4% vs. 21.6%，P=0.031）的警惕性更高：研究结果表明，在基于访谈的 MCI 检测中，应格外警惕自我或信息提供者的误报风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.