Measurement of Allostatic Load in Caregivers of Older Hispanic People With Alzheimer Disease and Related Disorders.

IF 1.8 4区医学 Q3 CLINICAL NEUROLOGY

Alzheimer Disease & Associated Disorders Pub Date : 2024-04-01 Epub Date: 2024-05-16 DOI:10.1097/WAD.0000000000000625

Jeanne A Teresi, Katja Ocepek-Welikson, Joseph P Eimicke, Mildred Ramirez, Shelley Liu, Stephanie Silver, Jose A Luchsinger

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引用次数: 0

Abstract

Background: Allostatic load (AL) has been studied in the context of biomarkers that may be affected by environmental and contextual stressors, including social determinants of health. The specific stressor studied here is the provision of caregiving to older persons with Alzheimer disease and related disorders. The aims were to examine the factor structure of stress and nonstress biomarkers, different methods for calculating AL, and the relationship of AL with other variables.

Methods: Latent variable models were used to examine biomarkers. Regression analyses were performed with the outcomes: AL calculated as percentile-based and clinically-based for both stress and nonstress components. The sample was 187 Hispanic caregivers to individuals with dementia.

Results: The results of the confirmatory factor analyses (CFAs) suggested defining 2 factors: nonstress and stress-related. Performance was better for the CFA results and the associations with covariates when stress and nonstress components were examined separately. Despite some limitations, this is one of the first studies of biomarkers in Hispanic caregivers to patients with dementia. It was possible to explain almost 30% of the variance in the nonstress AL component.

Conclusion: It may be important to differentiate among biomarkers indicative of cardiovascular, metabolic, and immune response as contrasted with the more stress-related biomarkers.

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测量患有阿尔茨海默病及相关疾病的西班牙裔老年人的护理人员的代谢负荷。

背景：在研究可能受环境和背景压力因素（包括健康的社会决定因素）影响的生物标志物时，对静态负荷（AL）进行了研究。本文研究的特定压力源是为患有阿尔茨海默病和相关疾病的老年人提供护理服务。目的是研究压力和非压力生物标志物的因子结构、计算AL的不同方法以及AL与其他变量的关系：方法：采用潜变量模型研究生物标志物。对结果进行回归分析：AL以百分位数为基础计算，压力和非压力部分以临床为基础计算。样本为 187 名西班牙裔痴呆症患者的照顾者：确证因子分析（CFA）的结果表明定义了两个因子：非压力因子和压力相关因子。当分别研究压力和非压力成分时，CFA 结果以及与协变量的关联性表现更好。尽管存在一些局限性，但这是对西班牙裔痴呆症患者护理者的生物标志物进行的首批研究之一。结论：在非压力AL成分中，有可能解释近30%的变异：区分心血管、新陈代谢和免疫反应生物标志物与压力相关生物标志物可能很重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer Disease & Associated Disorders 医学-病理学

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： Alzheimer Disease & Associated Disorders is a peer-reviewed, multidisciplinary journal directed to an audience of clinicians and researchers, with primary emphasis on Alzheimer disease and associated disorders. The journal publishes original articles emphasizing research in humans including epidemiologic studies, clinical trials and experimental studies, studies of diagnosis and biomarkers, as well as research on the health of persons with dementia and their caregivers. The scientific portion of the journal is augmented by reviews of the current literature, concepts, conjectures, and hypotheses in dementia, brief reports, and letters to the editor.