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Synthesis of Macrocyclic Tetraoxadithiaspiroalkanes in the Presence of Lanthanide Catalysts 镧系催化剂催化合成大环四氧二硫代螺烷
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024603765
N. N. Makhmudiyarova, I. R. Ishmukhametova, U. M. Dzhemilev
{"title":"Synthesis of Macrocyclic Tetraoxadithiaspiroalkanes in the Presence of Lanthanide Catalysts","authors":"N. N. Makhmudiyarova,&nbsp;I. R. Ishmukhametova,&nbsp;U. M. Dzhemilev","doi":"10.1134/S1070428024603765","DOIUrl":"10.1134/S1070428024603765","url":null,"abstract":"<p>An efficient method has been developed for the synthesis of macrocyclic tetraoxadithiaspiroalkanes by the cyclocondensation of alkane-α,ω-dithiols (butane-1,4-dithiol, pentane-1,5-dithiol, and hexane-1,6-dithiol) with 1,1-dihydroperoxycycloalkanes and formaldehyde in the presence of lanthanide catalysts.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"367 - 373"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of Isosteviol-Based Bifunctional Thiourea Organocatalysts for Michael Addition of Aromatic Ketones and Nitroalkenes 基于异甜菊醇的双功能硫脲有机催化剂的研究进展
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024603662
Yuxia Liu, Zhaoyang Fan, Qi Liu, Mingyang Lv, Xinyu Dai
{"title":"Development of Isosteviol-Based Bifunctional Thiourea Organocatalysts for Michael Addition of Aromatic Ketones and Nitroalkenes","authors":"Yuxia Liu,&nbsp;Zhaoyang Fan,&nbsp;Qi Liu,&nbsp;Mingyang Lv,&nbsp;Xinyu Dai","doi":"10.1134/S1070428024603662","DOIUrl":"10.1134/S1070428024603662","url":null,"abstract":"<p>Chiral 1,2-diphenylethylenediamine (DPEN) was introduced into isosteviol-derived thiourea organo­catalyst to promote the Michael addition of aromatic ketones and nitroalkenes. Under neutral conditions, the new isosteviol-DPEN thiourea catalyst provides high yield (up to 98%) and enantioselectivity (up to 97%) of the Michael addition products with dual stereoselective control. Furthermore, the isosteviol-DPEN thiourea catalyst showed sufficient recyclability and maintained the stereoselectivity in five reuse cycles.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"484 - 491"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid 氟西地酸邻丙炔类似物的合成与转化
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024604618
E. V. Salimova, D. A. Golovnina, L. V. Parfenova
{"title":"Synthesis and Transformations of O-Propargyl Analogues of Fusidic Acid","authors":"E. V. Salimova,&nbsp;D. A. Golovnina,&nbsp;L. V. Parfenova","doi":"10.1134/S1070428024604618","DOIUrl":"10.1134/S1070428024604618","url":null,"abstract":"<p>In continuation of our studies of modification of fusidane triterpenoids, <i>O</i>-propargyl fragment has been introduced at C<sup>3</sup> of fusidic acid methyl ester, and the resulting <i>O</i>-propargyl ether was subjected to copper(I)-catalyzed transformations to obtain aminomethyl, phenylacetylene, and 1,2,3-triazole derivatives.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"412 - 418"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Three-Component Synthesis of Novel 3H-Pyrrolo[3,2-f]quinoline Derivatives 新型3h -吡咯[3,2-f]喹啉衍生物的三组分合成
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S107042802460414X
Huan-Huan Yan, Dong-Sheng Chen
{"title":"Three-Component Synthesis of Novel 3H-Pyrrolo[3,2-f]quinoline Derivatives","authors":"Huan-Huan Yan,&nbsp;Dong-Sheng Chen","doi":"10.1134/S107042802460414X","DOIUrl":"10.1134/S107042802460414X","url":null,"abstract":"<p>A one-pot three-component reaction of quinolin-6-amine, arylglyoxals, and cyclohexane-1,3-diones in the presence of acetic acid as a catalyst in ethanol under reflux conditions afforded a series of novel 3<i>H</i>-pyrrolo[3,2-<i>f</i>]quinoline derivatives in good yields.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"504 - 510"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spiro Heterocyclization of 1-Antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with Dimedone 1-安替吡基-4-芳基-5-甲氧羰基- 1h -吡咯-2,3-二酮与二酮的螺环杂环化
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428023602650
V. A. Lyadov, E. S. Denislamova, A. N. Maslivets
{"title":"Spiro Heterocyclization of 1-Antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with Dimedone","authors":"V. A. Lyadov,&nbsp;E. S. Denislamova,&nbsp;A. N. Maslivets","doi":"10.1134/S1070428023602650","DOIUrl":"10.1134/S1070428023602650","url":null,"abstract":"<p>1-Antipyryl-4-aroyl-5-methoxycarbonyl-1<i>H</i>-pyrrole-2,3-diones reacted with dimedone (5,5-di­methyl­cyclohexane-1,3-dione) to give 1′-antipyryl-3′-aroyl-4′-hydroxy-6,6-dimethyl-6,7-dihydrospiro­[benzo­furan-3,2′-pyrrole]-2,4,5′(1′<i>H</i>,5<i>H</i>)-triones.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"558 - 560"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Strategic Synthesis and Antimycobacterial Evaluation of Coumarin- and Quinoline-Substituted s-Triazine Derivatives via Palladium-Catalyzed Suzuki Coupling 香豆素和喹啉取代的s-三嗪衍生物的钯催化铃木偶联合成及抑菌评价
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024603534
J. B. Mahyavanshi, J. V. Pandya, M. R. Solanki
{"title":"Strategic Synthesis and Antimycobacterial Evaluation of Coumarin- and Quinoline-Substituted s-Triazine Derivatives via Palladium-Catalyzed Suzuki Coupling","authors":"J. B. Mahyavanshi,&nbsp;J. V. Pandya,&nbsp;M. R. Solanki","doi":"10.1134/S1070428024603534","DOIUrl":"10.1134/S1070428024603534","url":null,"abstract":"<p>A novel and efficient synthetic pathway was devised for the preparation of 4-{4-anilino-6-[(quino­lin-8-yl)oxy]-1,3,5-triazin-2-yl}benzonitriles and 4-{4-anilino-6-[(2-oxo-2<i>H</i>-1-benzopyran-8-yl)oxy]-1,3,5-triazin-2-yl}benzonitriles via palladium-catalyzed Suzuki coupling reaction. This approach allowed precise synthesis of <i>s</i>-triazine derivatives. In vitro antimycobacterial testing against <i>Mycobacterium tuberculosis</i> H37Rv demonstrated notable efficacy, especially of the coumarin derivatives. The structural identity and purity of the products were confirmed through IR, ¹H and ¹³C NMR, and mass spectrometry.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"456 - 461"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143918938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Antiproliferative Activity of 4-(1H-Benzimidazol-2-yl)-N-{3-[(pyrimidin-2-yl)amino]phenyl}benzamides as Potential Protein Kinase Inhibitors 作为潜在蛋白激酶抑制剂的4-（1h -苯并咪唑-2-基）- n-{3-[（嘧啶-2-基）氨基]苯基}苯酰胺的合成及抗增殖活性
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024604679
E. V. Koroleva, A. L. Ermolinskaya, Zh. V. Ignatovich, O. V. Panibrat, Thi-Kim-Dung Hoang, Thi-Kim-Chi Huynh, Thi-Cam-Thu Nguyen
{"title":"Synthesis and Antiproliferative Activity of 4-(1H-Benzimidazol-2-yl)-N-{3-[(pyrimidin-2-yl)amino]phenyl}benzamides as Potential Protein Kinase Inhibitors","authors":"E. V. Koroleva,&nbsp;A. L. Ermolinskaya,&nbsp;Zh. V. Ignatovich,&nbsp;O. V. Panibrat,&nbsp;Thi-Kim-Dung Hoang,&nbsp;Thi-Kim-Chi Huynh,&nbsp;Thi-Cam-Thu Nguyen","doi":"10.1134/S1070428024604679","DOIUrl":"10.1134/S1070428024604679","url":null,"abstract":"<p>The results of studying the synthesis and antiproliferative activity of new 4-(1<i>H</i>-benzimidazol-2-yl)­benzamides containing pharmacophoric 2aminopyrimidine and pyridine moieties are reported. The target com­pounds were obtained by the acylation of <i>N</i>-(pyrimidin-2-yl)-<i>m</i>-phenylenediamines with 4-(1<i>H</i>-benzimidazol-2-yl)benzoyl chloride or by the aminolysis 4-(1<i>H</i>-benzimidazol-2-yl)benzoic acid with the same amines. The synthesized compounds were evaluated for their in vitro antiproliferative activity against stable human tumor cell lines K562, HL-60, RPMI 1788, and HeLa.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"378 - 384"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reaction of 1-Antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with N-Substituted and N-Unsubstituted 3-Amino-5,5-dimethylcyclohex-2-en-1-ones 1-安替吡基-4-芳基-5-甲氧基羰基- 1h -吡咯-2,3-二酮与n-取代和n-未取代的3-氨基-5,5-二甲基环己基-2-烯-1的反应
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024603996
V. A. Lyadov, E. S. Denislamova, A. N. Maslivets
{"title":"Reaction of 1-Antipyryl-4-aroyl-5-methoxycarbonyl-1H-pyrrole-2,3-diones with N-Substituted and N-Unsubstituted 3-Amino-5,5-dimethylcyclohex-2-en-1-ones","authors":"V. A. Lyadov,&nbsp;E. S. Denislamova,&nbsp;A. N. Maslivets","doi":"10.1134/S1070428024603996","DOIUrl":"10.1134/S1070428024603996","url":null,"abstract":"<p>Nucleophilic transformations of <i>N</i>-antipyryl-substituted 1<i>H</i>-pyrrole-2,3-diones by the action of enamines derived from dimedone as 1,3-C,N-binucleophiles afforded 1′-antipyryl-3′-aroyl-4′-hydroxy-6,6-dimethyl-6,7-dihydrospiro[indole-3,2′-pyrrole]-2,4,5′(1<i>H</i>,1′<i>H</i>,5<i>H</i>)-triones and 1′-antipyryl-1-aryl-3′-aroyl-4′-hydroxy-6,6-dimethyl-6,7-dihydrospiro[indole-3,2′-pyrrole]-2,4,5′(1<i>H</i>,1′<i>H</i>,5<i>H</i>)-triones.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"374 - 377"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Sympatholytic and Adrenomimetic Activities of Amino Amides and Amino Esters Based on 1-(1,3-Benzodioxol-5-yl)cyclopentane- and 4-(1,3-Benzodioxol-5-yl)tetrahydro-2H-pyran-4-carboxylic Acids 基于1-（1,3-苯二酚-5-基）环戊烷和4-（1,3-苯二酚-5-基）四氢- 2h -吡喃-4羧酸的氨基酰胺和氨基酯的合成及其交感解和拟肾上腺素活性
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S107042802560010X
R. E. Margaryan, G. V. Stepanyan, A. A. Aghekyan, H. A. Panosyan, S. A. Arutyunyan, A. S. Tsatinyan, M. S. Grigoryan, G. G. Mkryan
{"title":"Synthesis and Sympatholytic and Adrenomimetic Activities of Amino Amides and Amino Esters Based on 1-(1,3-Benzodioxol-5-yl)cyclopentane- and 4-(1,3-Benzodioxol-5-yl)tetrahydro-2H-pyran-4-carboxylic Acids","authors":"R. E. Margaryan,&nbsp;G. V. Stepanyan,&nbsp;A. A. Aghekyan,&nbsp;H. A. Panosyan,&nbsp;S. A. Arutyunyan,&nbsp;A. S. Tsatinyan,&nbsp;M. S. Grigoryan,&nbsp;G. G. Mkryan","doi":"10.1134/S107042802560010X","DOIUrl":"10.1134/S107042802560010X","url":null,"abstract":"<p>The reactions of 2-(1,3-benzodioxol-5-yl)acetonitrile with 1,4-dibromobuthane and 2,2′-bis(2-chloro­ethyl) ether gave 1-(1,3-benzodioxol-5-yl)cyclopentane- and 4-(1,3-benzodioxol-5-yl)tetrahydro-2<i>H</i>-pyran-4-carbonitriles which were hydrolyzed in alkaline medium to the corresponding carboxylic acids, and the latter were converted to acid chlorides. 1-(1,3-Benzodioxol-5-yl)cyclopentane- and 4-(1,3-benzodioxol-5-yl)­tetrahydro-2<i>H</i>-pyran-4-carbonyl chlorides reacted with <i>N</i>,<i>N</i>-dialkylaminoalkyl- and hetarylalkylamines, as well as with <i>N</i>,<i>N</i>-dialkylaminoalkanols and hetarylalkanols, to afford the target (1,3-benzodioxol-5-yl)cyclo­pentane(tetrahydropyran)carboxamides and (1,3-benzodioxol-5-yl)cyclopentane(tetrahydropyran)carboxylates. The synthesized compounds were evaluated for their effects on the cardiovascular system and blood hemodynamics.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"403 - 411"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioautography and Synthesis of Ribavirin Analogues as Possible Nucleosidase Inhibitors 利巴韦林类似物作为核苷酶抑制剂的生物自传和合成
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-05-07 DOI: 10.1134/S1070428024604382
A. Srinivas
{"title":"Bioautography and Synthesis of Ribavirin Analogues as Possible Nucleosidase Inhibitors","authors":"A. Srinivas","doi":"10.1134/S1070428024604382","DOIUrl":"10.1134/S1070428024604382","url":null,"abstract":"<p>Ribavirin analogues were synthesized starting from D-glucose through a series of reactions. The structure of the synthesized compounds was confirmed by IR, NMR, and mass spectrometry. Their nucleosidase enzyme inhibitory activity was tested using TLC bioautography. Almost all of the compounds exhibited enzyme inhibitory activity.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 3","pages":"527 - 534"},"PeriodicalIF":0.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143919112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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