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Design, Synthesis, and Molecular Docking Study of New Indole Derivatives as BRD4 Inhibitors
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024602036
Gang Jin, Zhangxu He, Feifei Yang, Jingyu Zhang
{"title":"Design, Synthesis, and Molecular Docking Study of New Indole Derivatives as BRD4 Inhibitors","authors":"Gang Jin,&nbsp;Zhangxu He,&nbsp;Feifei Yang,&nbsp;Jingyu Zhang","doi":"10.1134/S1070428024602036","DOIUrl":"10.1134/S1070428024602036","url":null,"abstract":"<p>Bromodomain-containing protein 4, an epigenetic reader, was considered as a promising drug target for human diseases, such as cancers and cardiac remodeling. This protein contains a pair of bromodomains (BD1 and BD2). Selective inhibition of bromodomains is critical for maintaining cell homeostasis. In the present work we made use of the molecular hybridization strategy to design and synthesize a novel series of indole derivatives, specifically (3-[5-(methylsulfanyl)-4-<i>m</i>-tolyl-4<i>H</i>-1,2,4-triazol-3-yl]-1<i>H</i>-indole, 5-(1<i>H</i>-indol-3-yl)-4-<i>p</i>-tolyl-4<i>H</i>-1,2,4-triazole-3-thiol; 5-(1<i>H</i>-indol-3-yl)-4-(<i>o</i>-tolyl)-4<i>H</i>-1,2,4-triazole-3-thiol, and 4-(3-chlorophenyl)-5-(1<i>H</i>-indol-3-yl)-4<i>H</i>-1,2,4-triazole-3-thiol), as well as 3-[5-(methylsulfanyl)-4-<i>m</i>-tolyl-4<i>H</i>-1,2,4-triazol-3-yl]-1<i>H</i>-indole as potential BRD4 inhibitors. 3-[5-(Methylsulfanyl)-4-(<i>m</i>-tolyl)-4<i>H</i>-1,2,4-triazol-3-yl]-1<i>H</i>-indole showed the highest inhibitory activity against BRD4 BD2 with an inhibition rate of 62% at 20 μM. In addition, this compound was found to work as a selective BD2 inhibitor: its inhibitory effect on BD2 is 8 times stronger than on BD1. The molecular docking study revealed critical interactions between 5-(methylsulfanyl)-4-(<i>m</i>-tolyl)-4<i>H</i>-1,2,4-triazol-3-yl]-1<i>H</i>-indole and Asn433, His437, and Pro375 and predicted good drug likeness for this derivative, which makes it a promising candidate for use as a lead compound for further drug design and development.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"280 - 287"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Cyclohex-3-en(ane)-, 1-Methylcyclohex-3-en(ane)-, and 5-Alkylphenyl-substituted Dodecacarboxylic Acids
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024604060
G. A. Mirzoyeva, Sh. M. Eyvazova
{"title":"Synthesis of Cyclohex-3-en(ane)-, 1-Methylcyclohex-3-en(ane)-, and 5-Alkylphenyl-substituted Dodecacarboxylic Acids","authors":"G. A. Mirzoyeva,&nbsp;Sh. M. Eyvazova","doi":"10.1134/S1070428024604060","DOIUrl":"10.1134/S1070428024604060","url":null,"abstract":"<p>The synthesis of heterocyclic and mono- and dicarboxamide compounds of various structures and functional substitutions was performed by electrophilic reactions, using chlorides of cyclohexane(ene)-, 1-methylcyclohexane(ene)-, and 5-phenyldodecacarboxylic and their isostructural aliphatic carboxylic acids as acylating reagents and aromatic mono- and difunctionally substituted mono- and aliphatic amines as substrates. <i>N</i>-Cycloacyl derivatives of benzimidazole were obtained for the first time by the acylation of benzimidazole with cyclohex-3-ene(an)-1-methylcyclohex-3-ene(an)carboxylic acid chlorides. The acylation of <i>o</i>-phenylenediamine with corresponding acid chrolides was used to prepare <i>N</i>-alkyl and <i>N</i>-acyl, as well as <i>C</i>-acyl benzimidazole derivatives. Saturated cyclohexane- and 1-methylcyclohexanecarboxylic acids and their chlorides were prepared by the hydrogenation of the corresponding unsaturated cyclohexane-3-ene- and 1-methylcyclohex-3-enecarboxylic acids.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"212 - 216"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthetic Approaches to 2-Aminopyridine-3-carbonitriles (A Review)
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428025600998
A. V. Khlus, D. M. Egorov
{"title":"Synthetic Approaches to 2-Aminopyridine-3-carbonitriles (A Review)","authors":"A. V. Khlus,&nbsp;D. M. Egorov","doi":"10.1134/S1070428025600998","DOIUrl":"10.1134/S1070428025600998","url":null,"abstract":"<p>The review describes the syntheses of substituted 2-aminopyridine-3-carbonitriles, reported over the period 1998–2024.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"195 - 211"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of New Pyrimidine-2,4,6(1H,3H,5H)-trione Derivatives
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024602620
A. V. Velikorodov, E. N. Kutlalieva, V. Yu. Kotova, E. A. Shustova
{"title":"Synthesis of New Pyrimidine-2,4,6(1H,3H,5H)-trione Derivatives","authors":"A. V. Velikorodov,&nbsp;E. N. Kutlalieva,&nbsp;V. Yu. Kotova,&nbsp;E. A. Shustova","doi":"10.1134/S1070428024602620","DOIUrl":"10.1134/S1070428024602620","url":null,"abstract":"<p>The condensation of 5-acetylpyrimidine-2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-trione with 3-fluoro-, 4-fluoro-, and 2-methoxy-3,5-dichlorobenzaldehydes and methyl (4-formyl-2- oxo-2<i>H</i>-chromen-7-yl)carbamate in BuOH in the presence of piperidine and acetic acid for 4 h under reflux gave 5-[(<i>E</i>)-3-aryl-2-propenoyl]pyrimidine--2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-triones) and methyl <i>N</i>-{2-oxo-4-[(<i>E</i>)-3-oxo-3-(2,4,6-trioxohexahydropyrimidin-5-yl)-1-propenyl]-2<i>H</i>-chromen-7-yl}carbamate. The reactions of 3-methoxy-4-hydroxy-, 3,5-dimethoxy-4-hydroxybenzaldehydes with 5-acetyl-pyrimidine-2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-trione in dioxane in the presence of boron trifluoride etherate at room temperature forms the corresponding chalcones within 48 h. The corresponding imines and 5-arylidene derivatives were prepared by the condensation of barbituric acid with alkyl <i>C</i>-nitroso phenylcarbamates in methanol and hydroxy-substituted benzaldehydes in water. The condensation of 5-[(4-hydroxy-3,5-dimethoxyphenyl)methylene]pyrimidine-2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-triones with aminoguanidine bicarbonate results in the formation of 7-hydrazinyl-5-(4-hydroxy-3,5-dimethoxyphenyl)pyrimido[4,5-<i>d</i>]pyrimidine-2,4(1<i>H</i>,3<i>H</i>)-dione. The cyclocondensation of pyrimidine-2,4,6(1<i>H</i>,3<i>H</i>,5<i>H</i>)-trione with methyl <i>N</i>-{3-[(<i>E</i>)-3-(4-methoxyphenyl)-2-propenoyl]phenyl}carbamate in acetic acid in the presence of P<sub>2</sub>O<sub>5</sub> provided methyl {3-[5-(4-methoxyphenyl)-2,4-dioxo-1,3,4,5-tetrahydro-2<i>H</i>-pyrano[2,3-<i>d</i>]pyrimidin-7-yl]phenyl}carbamate.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"225 - 234"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reaction of Substituted Dinitroacetonitriles with Isoquinoline in the Presence of Dimethyl But-2-yne-1,4-dioate
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024603790
A. G. Tyrkov, Е. А. Yurtaeva
{"title":"Reaction of Substituted Dinitroacetonitriles with Isoquinoline in the Presence of Dimethyl But-2-yne-1,4-dioate","authors":"A. G. Tyrkov,&nbsp;Е. А. Yurtaeva","doi":"10.1134/S1070428024603790","DOIUrl":"10.1134/S1070428024603790","url":null,"abstract":"<p>The reaction of substituted dinitroacetonitrile with isoquinoline in the presence of dimethyl but-2-yne-1,4-dioate involves 1,3-dipolar cycloaddition to form a mixture of diastereomeric dimethyl 2-(dinitromethyl)-1,1<i>bH</i>-pyrimido[2,1-<i>a</i>]isoquinoline-3,4-dicarboxylates. The synthesized compounds can be considered as promising synthons with potential antitubercular and fungicidal activity.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"235 - 238"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[BMIM]BF4-Mediated Multicomponent Synthesis of N-[(2-Hydroxynaphthalen-1-yl)(1H-pyrazol-5-yl)methyl]acetamides
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428025020186
Pullagura Siva Prakash, Vidavalur Siddhaiah, Arunkumar Thiriveedhi, A. Sajeli Begum, Lakshmi Soukya, Venkateswara Rao B, Akula Raghunadh, and Podugu Rajitha Lakshmi
{"title":"[BMIM]BF4-Mediated Multicomponent Synthesis of N-[(2-Hydroxynaphthalen-1-yl)(1H-pyrazol-5-yl)methyl]acetamides","authors":"Pullagura Siva Prakash,&nbsp;Vidavalur Siddhaiah,&nbsp;Arunkumar Thiriveedhi,&nbsp;A. Sajeli Begum,&nbsp;Lakshmi Soukya,&nbsp;Venkateswara Rao B,&nbsp;Akula Raghunadh,&nbsp;and Podugu Rajitha Lakshmi","doi":"10.1134/S1070428025020186","DOIUrl":"10.1134/S1070428025020186","url":null,"abstract":"<p>Naphthalene-bridged pyrazole scaffolds are important as fundamental components in numerous pharmacologically active novel chemical entities. The present study focuses on the synthesis of derivatives of <i>N</i>-((2-hydroxynaphthalen-1-yl)(1<i>H</i>-pyrazol-5-yl)methyl)acetamides (<b>4</b>). This synthesis was achieved through a one-pot three-component reaction involving naphthalen-2-ol (<b>1</b>), 1<i>H</i>-pyrazole-5-carbaldehydes (<b>2</b>), and acetamides (<b>3</b>). The reaction was conducted using [BMIM][BF<sub>4</sub>] as a green reaction medium, producing good yields of the desired products. The compounds <b>4b</b>, <b>4c</b>, and <b>4d</b> showed similar amino acid interaction with Thr 179 and docking scores of –7.839, –8.021, and –8.446 with 5LYJ.pdb. The compound <b>4f</b> showed interaction with Tyr 281 and a docking score of –7.293 with 6WV3.pdb.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"330 - 337"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Asymmetric Reductive Heck Cyclization of 3-(Adamantan-1-yl)-1-(2-bromophenyl)prop-2-en-1-one: Highly Enantioselective Synthesis of 3-(Adamantan-1-yl)indan-1-one 3-(金刚烷-1-基)-1-(2-溴苯基)丙-2-烯-1-酮的不对称还原 Heck 环化：3-(金刚烷-1-基)-1-(2-溴苯基)丙-2-烯-1-酮的高对映选择性合成
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024604023
A. N. Reznikov, S. Yu. Vostrukhina, M. A. Ashatkina, Yu. N. Klimochkin
{"title":"Asymmetric Reductive Heck Cyclization of 3-(Adamantan-1-yl)-1-(2-bromophenyl)prop-2-en-1-one: Highly Enantioselective Synthesis of 3-(Adamantan-1-yl)indan-1-one","authors":"A. N. Reznikov,&nbsp;S. Yu. Vostrukhina,&nbsp;M. A. Ashatkina,&nbsp;Yu. N. Klimochkin","doi":"10.1134/S1070428024604023","DOIUrl":"10.1134/S1070428024604023","url":null,"abstract":"<p>Intramolecular asymmetric Heck reaction of sterically hindered 3-(adamantan-1-yl)-1-(2-bromophenyl)prop-2-en-1-one, catalyzed by a semicorrin nickel complex and a bisphosphine palladium complex, was studied. The nickel-containing catalytic system offers the advantage that it provides that the enantiomeric excess for the resulting 3-(adamantan-1-yl)indan-1-one of 97%.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"361 - 365"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis, Characterization, and Pharmacokinetic Study of Novel 1,2,3-Triazolo/amido Hydroquinone Derivatives as Anticancer and Antibacterial Agents 作为抗癌和抗菌剂的新型 1,2,3-三唑并/氨基对苯二酚衍生物的合成、表征和药代动力学研究
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428025020216
Syed Nazreen
{"title":"Synthesis, Characterization, and Pharmacokinetic Study of Novel 1,2,3-Triazolo/amido Hydroquinone Derivatives as Anticancer and Antibacterial Agents","authors":"Syed Nazreen","doi":"10.1134/S1070428025020216","DOIUrl":"10.1134/S1070428025020216","url":null,"abstract":"<p>In the present study, novel 1,2,3-triazolo/amido derivatives of hydroquinone have been prepared and tested for the anticancer and antibacterial potential. The structures of the synthesized derivatives were established by various analytical techniques. One of the products, 2-(4-{[1-(4-bromophenyl)-1<i>H</i>-1,2,3-triazol-4-yl]methoxy}phenoxy)acetic acid, showed promising cytotoxicity (IC<sub>50</sub> 0.92, 1.72, and 3.56 μM against MCF-7, HepG2 and SKOV3 cells, respectively), close to that of the standard drug doxorubicin. In terms of the antibacterial activity, 2-(4-{[1-(4-nitrophenyl)-1<i>H</i>-1,2,3-triazol-4-yl]methoxy}phenoxy)acetic acidexhibited the highest activity against <i>S. aureus</i> (MIC 25 μg/mL) and <i>E. coli</i> (MIC 50 μg/mL), which was close to the inhibitory activity of amoxicillin. The in silico ADME study showed that all the synthesized hydroquinone derivatives followed the Lipinski’s rule with zero violations, are lipophilic and flexible and have good gastrointestinal absorption and poor permeability through the blood brain barrier.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"352 - 360"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of New 2,2':6',2''-Terpyridin Series with Directly Linked Benzimidazole Moieties
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024603984
E. N. Shepelenko, V. A. Podshibyakin, O. P. Demidov, D. Yu. Pobedinskaya, K. E. Shepelenko, V. M. Chernyshev
{"title":"Synthesis of New 2,2':6',2''-Terpyridin Series with Directly Linked Benzimidazole Moieties","authors":"E. N. Shepelenko,&nbsp;V. A. Podshibyakin,&nbsp;O. P. Demidov,&nbsp;D. Yu. Pobedinskaya,&nbsp;K. E. Shepelenko,&nbsp;V. M. Chernyshev","doi":"10.1134/S1070428024603984","DOIUrl":"10.1134/S1070428024603984","url":null,"abstract":"<p>Herein, we describe the synthesis of novel 2,2':6',2''-terpyridines with directly linked benzimidazole moieties. Owing to the unique structural and electronic properties, these compounds are of great interest as ligands for transition metals for wide range of applications. The structure of the synthesized terpyridines was characterized by <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, X-ray diffraction analysis, and high-resolution mass spectrometry.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"267 - 271"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis and Evaluation of Novel Dimethyltriazene Epoxide and 2-Thioxotetrahydropyrimidin-5(2H)-one Derivatives as Potential Anticancer Agents
IF 0.8 4区 化学
Russian Journal of Organic Chemistry Pub Date : 2025-04-15 DOI: 10.1134/S1070428024603224
Vidhya V. Jadvani, Yogesh T. Naliapara
{"title":"Synthesis and Evaluation of Novel Dimethyltriazene Epoxide and 2-Thioxotetrahydropyrimidin-5(2H)-one Derivatives as Potential Anticancer Agents","authors":"Vidhya V. Jadvani,&nbsp;Yogesh T. Naliapara","doi":"10.1134/S1070428024603224","DOIUrl":"10.1134/S1070428024603224","url":null,"abstract":"<p>A novel series of 3,3-dimethyltriazene-bearing chalcone epoxides and 2-thioxo-tetrahydropyrimidine-5(2<i>H</i>)-one derivatives have been designed and synthesized. The synthesized compounds were characterized by IR and <sup>1</sup>H and <sup>13</sup>C NMR spectroscopy, mass spectrometry, and elemental analysis and screened in vitro against MCF-7 breast cancer cell lines by the MTS assay with Tamoxifen as a reference drug. Out of the fourteen tested compounds, ten demonstrated a significant anticancer potential against MCF-7 carcinoma cells.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 2","pages":"272 - 279"},"PeriodicalIF":0.8,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143830797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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