{"title":"Reaction of Aroylpyruvic Acids with 3- and 4-Nitrobenzohydrazides. Synthesis of Pyrazoline-5-carboxylic Acids","authors":"A. A. Andreeva, Yu. V. Shklyaev, A. N. Maslivets","doi":"10.1134/S1070428025602535","DOIUrl":null,"url":null,"abstract":"<p>4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1 : 2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-[2-(3-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1<i>H</i>-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-[2-(4-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1<i>H</i>-pyrazole-5-carboxylic acids. The structure of the products was confirmed by X-ray diffraction analysis. The reaction proceeds under mild, catalyst-free conditions to give high yields, and the products were isolated without column chromatography. The synthesized compounds exhibit potential for diverse biological activities.</p>","PeriodicalId":766,"journal":{"name":"Russian Journal of Organic Chemistry","volume":"61 8","pages":"1458 - 1464"},"PeriodicalIF":0.9000,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of Organic Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070428025602535","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1 : 2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-[2-(3-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-[2-(4-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acids. The structure of the products was confirmed by X-ray diffraction analysis. The reaction proceeds under mild, catalyst-free conditions to give high yields, and the products were isolated without column chromatography. The synthesized compounds exhibit potential for diverse biological activities.
期刊介绍:
Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.