Reaction of Aroylpyruvic Acids with 3- and 4-Nitrobenzohydrazides. Synthesis of Pyrazoline-5-carboxylic Acids

IF 0.9 4区 化学 Q4 CHEMISTRY, ORGANIC
A. A. Andreeva, Yu. V. Shklyaev, A. N. Maslivets
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引用次数: 0

Abstract

4-Aryl-2,4-dioxobutanoic acids react with 3-nitro- and 4-nitrobenzohydrazides in a 1 : 2 ratio to form the corresponding 3-aryl-1-(3-nitrobenzoyl)-5-[2-(3-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acids and 3-aryl-1-(4-nitrobenzoyl)-5-[2-(4-nitrobenzoyl)hydrazinyl]-4,5-dihydro-1H-pyrazole-5-carboxylic acids. The structure of the products was confirmed by X-ray diffraction analysis. The reaction proceeds under mild, catalyst-free conditions to give high yields, and the products were isolated without column chromatography. The synthesized compounds exhibit potential for diverse biological activities.

Abstract Image

芳基丙酮酸与3-和4-硝基苯并肼的反应。吡唑啉-5-羧酸的合成
4-芳基-2,4-二氧丁酸与3-硝基和4-硝基苯并肼以1:2的比例反应,生成相应的3-芳基-1-(3-硝基苯甲酰)-5-[2-(3-硝基苯甲酰)肼基]-4,5-二氢1h -吡唑-5-羧酸和3-芳基-1-(4-硝基苯甲酰)-5-[2-(4-硝基苯甲酰)肼基]-4,5-二氢1h -吡唑-5-羧酸。通过x射线衍射分析证实了产物的结构。该反应在温和、无催化剂的条件下进行,产率高,产物无需柱层析分离。合成的化合物具有多种生物活性。
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来源期刊
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍: Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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