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碳酸铯促进的2-[（二苯基甲基）氨基]乙酸叔丁基与2-甲基-3-{[叔丁基（二甲基）硅基]氧}丙基和乙酰基氯化物反应的替代途径

IF 0.9 4区 化学 Q4 CHEMISTRY, ORGANIC
Russian Journal of Organic Chemistry Pub Date : 2025-08-18 DOI:10.1134/S1070428025602997
Z. R. Valiullina, G. R. Sunagatullina, M. S. Miftakhov
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引用次数: 0

摘要

在碳酸铯存在下，2-甲基-3-{[叔丁基-（二甲基）硅基]氧}丙酰氯在二氯甲烷中与2-丁基-3-{[叔丁基-（二甲基）硅基]氧}丙酰氯反应得到相应的β-内酰胺和乙酰甘氨酸衍生物。乙酰氯与2-[（二苯基甲基）氨基]乙酸叔丁酯反应生成2-（乙醯胺）乙酸叔丁酯是唯一具有高化学选择性的产物。
本文章由计算机程序翻译，如有差异，请以英文原文为准。

Alternative Pathways in Cesium Carbonate-Promoted Reactions of tert-Butyl 2-[(Diphenylmethylidene)amino]acetate with 2-Methyl-3-{[tert-butyl(dimethyl)silyl]oxy}propanoyl and Acetyl Chlorides

Alternative Pathways in Cesium Carbonate-Promoted Reactions of tert-Butyl 2-[(Diphenylmethylidene)amino]acetate with 2-Methyl-3-{[tert-butyl(dimethyl)silyl]oxy}propanoyl and Acetyl Chlorides

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Alternative Pathways in Cesium Carbonate-Promoted Reactions of tert-Butyl 2-[(Diphenylmethylidene)amino]acetate with 2-Methyl-3-{[tert-butyl(dimethyl)silyl]oxy}propanoyl and Acetyl Chlorides

The reaction of tert-butyl 2-[(diphenylmethylidene)amino]acetate with 2-methyl-3-{[tert-butyl­(dimethyl)silyl]oxy}propanoyl chloride in methylene chloride in the presence of cesium carbonate afforded the corresponding β-lactam and acetylglycine derivative. Acetyl chloride reacted with tert-butyl 2-[(diphenyl­methyli­dene)amino]acetate to produce tert-butyl 2-(acetamido)acetate as the only product with high chemo­selectivity.

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来源期刊
Russian Journal of Organic Chemistry
Russian Journal of Organic Chemistry 化学-有机化学
CiteScore
1.40
自引率
25.00%
发文量
139
审稿时长
3-6 weeks
期刊介绍： Russian Journal of Organic Chemistry is an international peer reviewed journal that covers all aspects of modern organic chemistry including organic synthesis, theoretical organic chemistry, structure and mechanism, and the application of organometallic compounds in organic synthesis.
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