American journal of physiology. Regulatory, integrative and comparative physiology最新文献

{"title":"The influence of aortic compliance on pulsatile cerebral blood flow in young healthy men: insight from endurance training intervention.","authors":"Tsubasa Tomoto, Hiroshi Kumagai, Takashi Tarumi, Jun Sugawara","doi":"10.1152/ajpregu.00038.2025","DOIUrl":"10.1152/ajpregu.00038.2025","url":null,"abstract":"<p><p>Aortic compliance reflects the ability to buffer arterial pulsations generated by the left ventricle (LV) and attenuate pulsatile cerebral blood flow (CBF). Endurance training is associated with increased stroke volume (SV) and enhanced LV systolic function, potentially increasing arterial pulsations to the brain. This study investigated the contribution of aortic compliance to the heart-brain hemodynamic interaction, providing insights from endurance training intervention and lower body negative pressure (LBNP) stimulus. Ten male collegiate tennis players underwent an 8-mo endurance training program to improve cardiac function. SV and LV systolic functions were measured using echocardiography and applanation tonometry. Pulsatile cerebral blood velocity in the middle cerebral artery was assessed by transcranial Doppler. Aortic compliance was calculated as the ratio between estimated SV via Modelflow and aortic pulse pressure via transfer function from radial arterial pressure. The release of -30 mmHg LBNP was used to initiate a rapid recovery of limited venous return and consequent increases in SV and CBF to assess dynamic recovery slopes. Endurance training increased SV, LV systolic function, and aortic compliance at rest, whereas pulsatile CBF was unchanged. The recovery slopes of SV and aortic compliance were steeper after endurance training, whereas the slopes of pulsatile CBF remained similar. The change in the slope of aortic compliance was negatively correlated with the change in the slope of pulsatile CBF (<i>r</i> = -0.758, <i>P</i> = 0.011). These results suggest that improved aortic compliance after endurance training may accommodate increased SV and LV systolic function and buffer potential increases in arterial pulsations to the brain.<b>NEW & NOTEWORTHY</b> Eight months of progressive moderate-to-vigorous endurance training increased stroke volume (SV), left ventricular (LV) systolic performance, and aortic compliance, whereas pulsatile cerebral blood flow (CBF) remained unchanged in young, healthy men. The increase in aortic compliance was associated with decreased pulsatile CBF. These findings suggest that the improved aortic compliance after endurance training may offset the expected increases in pulsatile CBF induced by the increased SV and enhanced LV systolic function.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R204-R215"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"G tolerance and vascular sympathetic reflex responses as affected by repeated prolonged exposures to increased force field.","authors":"Ola Eiken, Michail E Keramidas, Antonis Elia, Heather M Bowes, Roger Kölegård","doi":"10.1152/ajpregu.00036.2025","DOIUrl":"10.1152/ajpregu.00036.2025","url":null,"abstract":"<p><p>The capacity to tolerate high G loads in the head-to-seat direction (+Gz tolerance) is critical for pilots flying high-performance aircraft. The adaptive effects of repeated +Gz loading on relaxed +Gz tolerance and G-protective sympathetic reflex pressor responses were investigated. Twelve men were exposed to increased +Gz loads in a relaxed state, during 15 × 40 min sessions across 5 wk. Before and after the training regimen, relaxed +Gz tolerance was investigated during rapid onset-rate (ROR) and gradual onset-rate (GOR) G exposures, and cardiovascular responses were investigated during exposures to 2.5 G in the belly-to-back direction (+Gx) as well as during orthostatic provocations and pressure manipulations of the carotid baroreceptors. The G training increased (<i>P</i> = 0.04) the ROR G tolerance by 17% but did not affect GOR G tolerance, orthostatic tolerance, or the sensitivity and operational pressure range of the carotid baroreflex pressor response. The training reduced (<i>P</i> < 0.001) the arterial pressure response to +Gx exposure. The results suggest that repeated high +Gz exposures do not improve the overall vascular sympathetic response to high +Gz nor the responsiveness of the vascular branch of the carotid baroreflex, but, judging by the arterial pressure responses to +Gx loads, reduces the responsiveness of the vestibulosympathetic reflex. That the G training improved the ROR +Gz tolerance is attributable to local vascular adaptation, in terms of increased stiffness in dependent precapillary vessels resulting from the iterative increments in local transmural pressures.<b>NEW & NOTEWORTHY</b> Five weeks of repeated exposures to head-to-seat directed G load in the relaxed state increased the capacity to tolerate rapid but not gradual G elevations, suggesting unaffected overall vascular sympathetic responses to high G. The G training did not affect the responsiveness of the vascular branch of the carotid baroreflex but reduced the vestibulosympathetic reflex response. The improved tolerance to rapid G elevations is attributable to increased stiffness in dependent precapillary vessels.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R86-R97"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of sex on the cardiopulmonary and neuromuscular response to high-intensity interval exercise.","authors":"Hannah K Wilson, Lina Bernert, Padraig Spillane, Emma Squires, Lorna Crawford, Jessica Piasecki, Ross Julian, Eurico N Wilhelm, Kirsty M Hicks, Paul Ansdell","doi":"10.1152/ajpregu.00306.2024","DOIUrl":"10.1152/ajpregu.00306.2024","url":null,"abstract":"<p><p>Sex differences exist in the integrative response to exercise; however, these are typically researched during incremental and constant-load exercise. Interval exercise involves high-intensity efforts interspersed with recovery periods to repeatedly stress physiological systems, and it is currently unknown whether the response to this form of exercise differs between sexes. Ten males and 10 females (age: 25 ± 3 yr) completed two experimental visits. First, an incremental treadmill exercise test was performed to obtain submaximal (lactate threshold) and maximal (V̇o_2peak) data. Thereafter, visit two involved 4 × 3-min running intervals at 90% of the final incremental test velocity (vV̇o_2peak), with 90-s rest between intervals. Before exercise and after each interval, maximal voluntary contraction (MVC), quadriceps potentiated twitch (<i>Q</i>_tw.pot), and voluntary activation (VA) were recorded. The rates of oxygen uptake (V̇o₂), carbon dioxide production (V̇co₂), and ventilation (V̇e) were continuously recorded throughout. There was no sex difference in relative V̇o_2peak (males: 47.2 ± 6.0 vs. females: 44.4 ± 5.8 mL·kg^-1·min^-1, <i>P</i> = 0.292). When expressed relative to peak values, there were no sex differences in the V̇o₂ or V̇co₂ response to the interval task (<i>P</i> ≥ 0.781). Females had greater V̇e/V̇o₂, and V̇e/V̇co₂ values during the first (<i>P</i> ≤ 0.034) and second (V̇e/V̇co₂, <i>P</i> = 0.006) intervals, with a sex × time interaction effect (<i>P</i> ≤ 0.046). There were no sex differences in the reductions in MVC, <i>Q</i>_tw.pot, and VA during the interval task (<i>P</i> ≥ 0.150); however, females had lesser reductions in <i>Q</i>_tw.pot values postexercise (-24 ± 9 vs. -15 ± 8%, <i>P</i> = 0.044). Sex differences exist in the physiological response to interval exercise. Compared with males, females experienced greater hyperpnea during the initial stages, and had lesser decreases in contractile function postexercise.<b>NEW & NOTEWORTHY</b> This study determined that males and females differ in the physiological response to high-intensity interval exercise. Specifically, females had poorer ventilatory efficiency during the first half of the task, but greater knee-extensor fatigue resistance following the task. These data build upon previous observations from constant-load exercise, demonstrating that physiological sex differences are observed during an ecologically valid exercise task commonly prescribed by practitioners in clinical and athletic populations.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R123-R133"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between heart rate fragmentation and kidney function decline in MESA: evidence consistent with parasympathetic degradation.","authors":"Madalena D Costa, Susan Redline, Nisha Bansal, Susan R Heckbert, Ary L Goldberger","doi":"10.1152/ajpregu.00091.2025","DOIUrl":"10.1152/ajpregu.00091.2025","url":null,"abstract":"<p><p>The contribution of sympathetic overactivity to the pathogenesis of chronic kidney disease (CKD) is well established; in contrast, the role of the parasympathetic system in renal homeostasis remains less well understood. Studies in animal models suggest that parasympathetic activity may influence kidney function by buffering sympathetic tone, activating the cholinergic anti-inflammatory pathway, and modulating cardiovascular (CV) function. We investigated whether a novel noninvasive marker of parasympathetic function, heart rate fragmentation (HRF), was associated with <i>1</i>) the likelihood of prevalent CKD and <i>2</i>) longitudinal changes in estimated glomerular filtration rate (eGFR) over ∼5 yr. The analytical cohort included 1,388 participants in the Multi-Ethnic Study of Atherosclerosis (MESA) (mean age: 66.8 ± 8.5 yr; 44.5% male) with polysomnographic ECG recordings. Higher HRF, indicative of reduced parasympathetic function, was associated with <i>1</i>) an increased likelihood of prevalent CKD (rate ratio: 1.15 [95% confidence interval (CI): 1.04; 1.27], per 1-SD increase in HRF) and <i>2</i>) a steeper decline in eGFR (-0.86 [95% CI: -1.43; -0.28] mL/min/1.73 m², per 1-SD increase in HRF), independent of major comorbidities, including age, hypertension, diabetes, and baseline CKD status. Stratified analyses in lower- and higher-risk subgroups yielded consistent results. These findings support a role for parasympathetic activity in renal homeostasis and suggest that HRF may serve as a noninvasive biomarker of risk for <i>1</i>) early renal function decline in lower-risk populations and <i>2</i>) accelerated decline in the general and higher-risk populations. HRF may also be useful for evaluating interventions targeting renal neuroautonomics, such as vagal stimulation or renal sympathetic denervation.<b>NEW & NOTEWORTHY</b> This study identifies reduced cardiac parasympathetic activity, measured by heart rate fragmentation (HRF), as a potential contributor to accelerated renal function decline in a community-based population. The findings suggest a mechanistic link between vagal dysfunction and kidney deterioration. From a translational perspective, the results support the utility of HRF-a noninvasive, repeatable measure-for renal disease risk stratification and monitoring of autonomic-targeted interventions.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R186-R194"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12236214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence for potentiation in sympathetic neurovascular transduction following exercise in normotensive adults.","authors":"Massimo Nardone, Julian C Bommarito, Kathryn N Pfundt, Samuel Amanual, Yeshale Chetty, Philip J Millar","doi":"10.1152/ajpregu.00084.2025","DOIUrl":"10.1152/ajpregu.00084.2025","url":null,"abstract":"<p><p>Vascular conductance increases following a single bout of dynamic exercise, whereas sympathetic nerve traffic commonly appears unchanged. Discordance between vascular and sympathetic responses may reflect modulation in vasoconstrictor responsiveness. The primary study objective was to evaluate sympathetic neurovascular transduction following cycling exercise. The secondary objective was to explore mechanisms contributing to altered sympathetic neurovascular transduction by manipulating limb vascular conductance using local heating of the foot. We hypothesized that sympathetic neurovascular transduction would decrease following cycling exercise but would be unchanged by lower limb heating. Sixteen adults (22 ± 3 yr; 43 ± 8 mL·kg^-1·min^-1; 8 females) underwent measurements of heart rate (electrocardiography), mean arterial pressure (photoplethysmography), muscle sympathetic nerve activity (MSNA; microneurography), and femoral vascular conductance (FVC; duplex ultrasound) across three interventions: cycling exercise [60 min, 60% peak oxygen consumption (V̇O_2peak), <i>n</i> = 16], time control (60 min, <i>n</i> = 16), and lower limb heating (foot submersion into 40°C water, <i>n</i> = 9). MSNA-FVC transduction was quantified using signal averaging. Compared with control, exercise did not alter MSNA (<i>P</i> = 0.72) but increased FVC (<i>P</i> < 0.01) and MSNA-FVC transduction (-8.6 ± 4.5 vs. -15.1 ± 5.7 mL/min/100 mmHg; <i>P</i> < 0.01). Compared with exercise, heating did not alter MSNA (<i>P</i> = 0.71) and tended to increases FVC (<i>P</i> = 0.09). However, increases in MSNA-FVC transduction following exercise tended to persist when compared with heating (-8.7 ± 8.0 vs. -15.1 ± 5.9 mL/min/100 mmHg; <i>P</i> = 0.06). Contrary to our hypothesis, these findings provide evidence for potentiated sympathetic neurovascular transduction following acute cycling exercise in healthy adults. The observed increase in neurovascular transduction appears independent of resting vasomotor tone.<b>NEW & NOTEWORTHY</b> Following cycling exercise, leg vascular conductance increases, whereas sympathetic nerve traffic is unchanged in young healthy adults. Discordant vascular and sympathetic responses may reflect modulation in vasoconstrictor responsiveness. The current study demonstrated that signal-averaged sympathetic neurovascular transduction was increased by ∼75% following a single bout of cycling exercise. Secondary experiments using local heating suggest that potentiation in sympathetic neurovascular transduction after exercise may occur independent of changes in resting vascular conductance.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R195-R203"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of thermoregulatory, cardiovascular, and immune responses to different passive heat therapy modalities.","authors":"Jessica K Atencio, Emma L Reed, Karen Wiedenfeld Needham, Kathryn M Lucernoni, Lindan N Comrada, John R Halliwill, Christopher T Minson","doi":"10.1152/ajpregu.00012.2025","DOIUrl":"10.1152/ajpregu.00012.2025","url":null,"abstract":"<p><p>This study compared thermoregulatory, cardiovascular, and immune responses to acute hot water immersion (HWI), traditional sauna (TRAD), and far infrared sauna (FIR). Twenty healthy adults (10 F; age 24 ± 4 yr) completed three bouts of passive heating: HWI (45 min at 40.5°C), TRAD (3 × 10 min at 80°C), and FIR (45 min at 45-65°C) separated by at least 1 wk. Core temperature (T_c) was measured at baseline and every 5-min during heating. Cardiac output (Q_c) was measured before, halfway, and at the end of heating using the open-circuit acetylene wash-in method. Venous blood was collected at baseline and ∼20-min, 24-, and 48-h postheating for measurement of inflammatory cytokines and immune cell populations. The overall change in T_c from baseline to end of heating was greater in HWI [+1.1°C (0.9, 1.3)] vs. TRAD [+0.4°C (0.2, 0.6), <i>P</i> < 0.01], HWI vs. FIR [+0.0°C (-0.1, 0.2), <i>P</i> < 0.01], and TRAD vs. FIR (<i>P</i> = 0.02). Q_c increased to the greatest extent in HWI [+3.7 L/min (2.9, 4.4)] vs. TRAD [+2.3 L/min (1.8, 2.8), <i>P</i> < 0.01] and HWI vs. FIR [+1.6 L/min (1.2, 2.1), <i>P</i> < 0.01], with no difference between TRAD vs. FIR (<i>P</i> = 0.06). HWI was the only heating modality to elicit inflammatory and immune responses as evidenced by increased interleukin-6 (IL-6) concentration postheating [+0.386 pg/mL (0.093, 0.680), <i>P</i> = 0.04], NK cells 24-h postheating (<i>P</i> = 0.03), and CD8⁺ T cells at 24 (<i>P</i> = 0.02) and 48 h postheating (<i>P</i> = 0.03). A single bout of hot water immersion elicits the greatest thermoregulatory, cardiovascular, and immune responses compared with both sauna modalities.<b>NEW & NOTEWORTHY</b> Our goal was to compare three widely utilized modalities of passive heating in the manner that they are most commonly used for heat therapy. We have demonstrated that hot water immersion leads to the greatest thermoregulatory, cardiovascular, and immune responses compared with both traditional and far infrared saunas in young, healthy adults. Far infrared sauna heating was the least impactful on raising body core temperature and the resulting cardiovascular and immune responses.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R20-R35"},"PeriodicalIF":2.3,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the organum vasculosum of the lamina terminalis in the physiopathology of 2-kidney-1-clip hypertension in rats.","authors":"Camila F Roncari, Richard B David","doi":"10.1152/ajpregu.00039.2025","DOIUrl":"10.1152/ajpregu.00039.2025","url":null,"abstract":"","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R184-R185"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of sex on fiber-specific indices of oxidative capacity in human skeletal muscle.","authors":"Celine Bailleul, Nathan Hodson, Sidney Abou Sawan, Dinesh Kumbhare, Daniel R Moore, Jenna B Gillen","doi":"10.1152/ajpregu.00298.2024","DOIUrl":"10.1152/ajpregu.00298.2024","url":null,"abstract":"<p><p>There are reports that females compared to males display increased skeletal muscle oxidative capacity in resting mixed-muscle fiber samples from the <i>vastus lateralis</i>, including markers of mitochondrial content and capillarization. Given that sex comparisons at the mixed-fiber level may be explained by differences in muscle fiber type between males and females, it remains unclear whether the oxidative capacity of type I and/or II fibers differs between sexes. The purpose of this study was to evaluate the influence of sex on fiber-specific indices of mitochondrial content and capillarization in healthy untrained males and females. Resting skeletal muscle samples from eumenorrheic females (<i>n</i> = 14; 23 ± 5 yr; 23.3 ± 3.2 kg/m²) and males (<i>n</i> = 13; 23 ± 4 yr; 23.1 ± 2.4 kg/m²) were analyzed via immunofluorescence staining. There were no sex differences in indices of capillarization (all <i>P</i> > 0.05) or mitochondrial content (all <i>P</i> > 0.05) in type I or type II muscle fibers. However, we observed lower capillary density in type II vs. type I muscle fibers in males (280 ± 66 vs. 364 ± 88 capillaries/mm²; <i>P</i> < 0.001) but not females (335 ± 77 vs. 329 ± 48 capillaries/mm²; <i>P</i> = 0.76), owing to greater cross-sectional area (CSA) of type II vs. type I fibers in males only (males <i>P</i> = 0.03; females <i>P</i> = 0.44). Females compared to males also displayed greater proportionate area of type I fibers (44 ± 12% vs. 31 ± 14%; <i>P</i> = 0.03) and smaller CSA of type IIx fibers (3,033 ± 902 vs. 5,573 ± 1,352 μm²; <i>P</i> = 0.002). Our results suggest that while muscle fiber type composition and size differ between males and females, there are no sex differences in mitochondrial content and capillarization of type I or II muscle fibers in untrained adults.<b>NEW & NOTEWORTHY</b> Research suggests that skeletal muscle oxidative capacity in mixed-fiber muscle homogenates is greater in females than in males. In healthy, untrained individuals, we demonstrate by fiber-specific immunofluorescence that females have a greater proportionate area of type I muscle fibers but no difference in mitochondrial content or capillarization of type I or II fibers compared to males. These findings suggest that although females display a more oxidative fiber type composition, sex does not influence muscle fiber-specific oxidative capacity.</p>","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R70-R80"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144132105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Isolating the effects of iterative cold exposure on metabolic heat production and hypothermia risk.","authors":"Billie K Alba, Afton D Seeley","doi":"10.1152/ajpregu.00095.2025","DOIUrl":"10.1152/ajpregu.00095.2025","url":null,"abstract":"","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R152-R153"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it the heat or the strain? Understanding risk and resilience in heat-exposed laborers.","authors":"Kevin O Murray, Orlando Laitano","doi":"10.1152/ajpregu.00137.2025","DOIUrl":"10.1152/ajpregu.00137.2025","url":null,"abstract":"","PeriodicalId":7630,"journal":{"name":"American journal of physiology. Regulatory, integrative and comparative physiology","volume":" ","pages":"R182-R183"},"PeriodicalIF":2.2,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}