Nihon Rai Gakkai zasshi最新文献

{"title":"[Cutaneous or subcutaneous calcinosis observed in leprosy patients. 1. Clinical observations].","authors":"M Maeda,&nbsp;M Narita","doi":"10.5025/hansen1977.62.89","DOIUrl":"https://doi.org/10.5025/hansen1977.62.89","url":null,"abstract":"<p><p>A roentgenographic examination was made for the limbs of leprosy patients with calcinosis in whom atrophic cutaneous sclerosis and subcutaneous induration or infiltration were observed. The observation results are summarized as follows. 1. Atrophic cutaneous sclerosis was one of a sequela in lepromatous lesion, especially in case of ENL, and it was observed to occur frequently at the extended sides of 1/3distal part from the forearm and the crus mainly. The atrophied cutaneous surface was tinged with lustrous red. It was able to observe calcium deposition directly just under the skin and/or in the shallow subcutaneous region from the roentgenogram of the site. The roentgenographic patterns were demonstrated as if many granules were scattered, and also the dendric and reticular platy-expansions were detected in some cases. The enucleated parts seemed to be similar to the cancellous bone. It might be said that dystrophic calcinosis cutis developed by inducing histological disorder is one of the origin of such a calcinosis, because the skin in these regions is deficient in the mobility and tends to provoke the circulatory disorder in case of chronic inflammation as discerned in lepromatous lesion. 2. An induration in subcutaneous tissue is lipid lump being as it was when chaulmoogra oil was injected and not undergo absorption of the oil. The lipid lumps enveloped in the tunic were observed in the site of lateral upperarm and the front of femur. They seemed to be remained almost all as it was. It was observed that the lipid lumps, as such, were adjacent to the outer layer of fascia, but not in the muscle. And there are some cases where the oil flowed from the injection site through the hypodermis and got the lipid lumps formed in the forearm and/or the crus. Roentgenogram of that showed the existence of calcinosis regardless of size which transmissivity of X-ray had an irregular pattern. The enucleated lipid lumps were easily cut to pieces by scalpel. 3. It may be said that the calcinosis observed in atrophic cutaneous sclerosis due to lepromatous lesion or lipid lump of unabsorbed chaulmoogra oil makes it necessary for its healing to be 10-20 years. 4. Roentgenogram at that time revealed no abnormality as to serum calcium, phosphorous and/or alkaline phosphatase values.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 3","pages":"89-98"},"PeriodicalIF":0.0,"publicationDate":"1993-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19179896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Immunohistochemical analysis of cell surface markers in leprosy patients].","authors":"N Ishii,&nbsp;Y Sugita,&nbsp;S Kim,&nbsp;K Sato,&nbsp;H Nakajima","doi":"10.5025/hansen1977.62.49","DOIUrl":"https://doi.org/10.5025/hansen1977.62.49","url":null,"abstract":"<p><p>Nine biopsy specimens from 3 tuberculoid (TT), 1 borderline tuberculoid (BT), 2 borderline (BB), 2 borderline lepromatous (BL), and 1 lepromatous (LL) patients were studied using immunoperoxidase procedures with monoclonal antibodies. In TT patients 4B4+, TCR alpha beta+, CD4+ T cells were dominant in dermal granulomas. In LL patient, dermal granulomas with 4B4+, TCR alpha beta+, CD4+ T cells and 2H4+, TCR alpha beta+, CD4+ T cells also had CD8+ T cells. The proportion of 4B4+ T cells increased in granulomas from LL to TT and 2H4+ T cells proportionately increased from TT to LL. TCR gamma delta+ T cells were detected only in BB and BL patients. However, there is no difference of staining pattern of ICAM-1 or LFA-1 antigen in any type of leprosy. These results indicate that the immunohistochemical pattern of T cells (CD4, CD8, 4B4, 2H4, TCR) may be useful in the diagnosis of the spectrum of leprosy.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 2","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19271425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current leprosy situation and control programme in Bangladesh.","authors":"E Faruque","doi":"10.5025/hansen1977.62.55","DOIUrl":"https://doi.org/10.5025/hansen1977.62.55","url":null,"abstract":"バングラデシュの近年のらい事情を疫学調査面からのらい患者の掌握現況,国のらい対策プログラム,らい専門家の養成,多剤併用療法の実施方法およびその進展等について概説した。らい撲滅のためのプログラムの疫学面およびその実施活動面からの評価結果は,必ずしも正確とは思われない情報収集と資料不足のため正しい評価が下せないというのが実情である。また,不適当な所見例,処方通りに薬を服用しない多くの患者達の存在,さらにはプログラムを遂行するのに十分でない予算,専門家不足等,今なお5千余名のらい新患発生数をみるバングラデシュのらい対策は多くの困難の中で行われている。願わくば,\"バングラデシュの結核とらい撲滅推進作戦\"という名の下に施行されているプロジェクトが,近い将来,これらの病気に病む全ての患者達に行き届くことを望むものである。","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 2","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19271426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Detection of MRSA in National Leprosarium of Ohshima Seisho-En].","authors":"R Kimura,&nbsp;N Kondo,&nbsp;T Nagai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 2","pages":"62-5"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19271427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[On the establishment of Fukusei Byoin--letter of father Germaine Testevuide, founder].","authors":"T Yukawa","doi":"10.5025/hansen1977.62.66","DOIUrl":"https://doi.org/10.5025/hansen1977.62.66","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 2","pages":"66-72"},"PeriodicalIF":0.0,"publicationDate":"1993-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19271428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative determination of PCR products by colorimetric method.","authors":"J A Dayanghirang,&nbsp;M Matsuoka","doi":"10.5025/hansen1977.62.21","DOIUrl":"https://doi.org/10.5025/hansen1977.62.21","url":null,"abstract":"PCRによって増幅された産物を,高感度かつ客観的に検出,定量するための方法として,非放射性プロープを用いた非色法の有用性が検討された。マイクロプレートウェルに一本鎖PCR増幅産物を吸着し,Digoxigenin (Dig.)をラベルしたプローブとハイブリダイゼーションを行なった後,パーオキシンダーゼ標識抗Dig抗体によるELISAを行なった。パーオキシダーゼ標識プローブは,Biotin標識プローブより10倍以上の感度を示し,ピコグラム単位での検出,定量が可能であった。未知材料の定量は,既知材料のO. D.値曲線に対して,ELESAの結果示されたO. D.値を外挿することにより求められた。この方法は同じく簡便な方法であるアガオースゲルによる定量に比し,客観性に優れ,10,000倍以上の感度を有し,アガロースゲルによる定量では,検出不能な低濃度材料に対しても有効であった。本法は,他の定量方法に比し,求められる条件即ち,客観性,感度,手技の簡便性に優れ,PCR産物の定量,あるいはPCRによる増幅の違いに基づくTempletの推量に有用な手段であると結論した。","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 1","pages":"21-7"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19216663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Reminiscences of my life in the field of leprosy (1)].","authors":"Y Yajima","doi":"10.5025/hansen1977.62.33","DOIUrl":"https://doi.org/10.5025/hansen1977.62.33","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 1","pages":"33-6"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19216665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunopathological stain of lipoarabinomannan-B (LAM-B) for diagnosis of leprosy.","authors":"K I Butt,&nbsp;K Kawatsu,&nbsp;T Wang,&nbsp;Y Maeda,&nbsp;S Izumi","doi":"10.5025/hansen1977.62.13","DOIUrl":"https://doi.org/10.5025/hansen1977.62.13","url":null,"abstract":"<p><p>We developed an immunopathological staining of LAM-B antigen in formalin-fixed paraffin-embedded tissues, and compared it with, PGL-I immunostaining, Fite Faraco's stain and periodic acid carbol pararosaniline (PACPR) stain. Out of the total 28 leprosy cases, 27 were positive to LAM-B immunostaining while 23 were positive to PGL-I stain. Fite's stain was positive in 21 cases while PACPR stain was positive in 24 cases. In scrofuloderma, LAM-B antigen was observed only in the granuloma while no other positive findings were noted with other stains. Normal skin did not give any positive findings with any of the stains. Other dermatoses showed no positive findings to any of the stains tested. LAM-B staining was observed in the nerve even in the absence of bacilli in leprosy tissues. Presence of LAM-B in the cutaneous nerves is helpful in discriminating leprosy from other mycobacterioses. Considering the high sensitivity of LAM-B and the predilection of M. leprae for the nerves, we concluded that LAM-B staining can be a useful new tool in the prompt diagnosis of leprosy, especially in suspected or early cases.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 1","pages":"13-20"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18696064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Changes and present status of a Japanese National Leprosarium--analysis of smear positive rate and relapse in Hoshizuka-Keiaien between 1972-1991].","authors":"M Goto,&nbsp;M Suzuki,&nbsp;S Kitajima,&nbsp;M Imaizumi","doi":"10.5025/hansen1977.62.1","DOIUrl":"https://doi.org/10.5025/hansen1977.62.1","url":null,"abstract":"<p><p>Change of clinical features of leprosy in a Japanese National Leprosarium Hoshizuka-Keiaien during 20 years (1972-91) was studied by analyzing clinical records. (1) Skin slit smear positive rate among lepromatous and borderline cases once increased from 16.3% (1972) to 28.8% (1981) and then declined to 3% (1991). (2) Relapse was 4.25 cases per annum among 817 patients (0.52% per annum). Relapse of lepromatous leprosy (0.42% per annum) is decreasing, and borderline or neuritic relapse (0.12% per annum) of previously lepromatous cases is the major feature in recent years. (3) In lepromatous relapse cases, it took 3.5 years in average to become smear negative again, but this duration is shortening in recently relapsed cases. (4) Number of erythema nodosum leprosum is remarkably decreased, but iridocyclitis is still observed. (5) 85% of inpatients in 1991 are classified as clinical cure (Japanese criteria 1989). By the advance of chemotherapy and aging of the inpatients (average age: 68 years), geriatric diseases, instead of leprosy, are becoming major problems in Japanese National Leprosaria.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19216662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction of genomic DNA library of Mycobacterium leprae Thai-53 strain, and detection of M. leprae specific genes in the library by polymerase chain reaction.","authors":"K Chaicumpar,&nbsp;K Kohsaka,&nbsp;M Matsuoka,&nbsp;H Nomaguchi","doi":"10.5025/hansen1977.62.28","DOIUrl":"https://doi.org/10.5025/hansen1977.62.28","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"62 1","pages":"28-32"},"PeriodicalIF":0.0,"publicationDate":"1993-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19216664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}