{"title":"[Skin infections due to Staphylococcus aureus and Streptococcus pyogenes].","authors":"J Arata","doi":"10.5025/hansen.65.83","DOIUrl":"https://doi.org/10.5025/hansen.65.83","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"83-7"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.65.83","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19780112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The road to the abolition of the leprosy prevention law.","authors":"K Nakatani","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"128-35"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19779375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H Nomaguchi, Y Yogi, M Matsuoka, Y Fukotomi, H Okamura, K Nagata, S Nagai, N Ohara, T Yamada
{"title":"[BCG vaccination to Mycobacterium leprae infection in mice].","authors":"H Nomaguchi, Y Yogi, M Matsuoka, Y Fukotomi, H Okamura, K Nagata, S Nagai, N Ohara, T Yamada","doi":"10.5025/hansen.65.106","DOIUrl":"https://doi.org/10.5025/hansen.65.106","url":null,"abstract":"<p><p>BCG vaccine (Tokyo strain) was given in BALB/cA mice intradermally 1 or 3 months before Mycobacterium leprae (M. leprae) challenge as modified Shepard's method. The vaccine dosage was 10(7-8) or 10(6). The BCG gave good protection in both dosages and both challenges against M. leprae infection. Lymphocytes proliferations of BCG-vaccinated splenocyte cultures in response to M. leprae lysate or BCG components (hsp65, 38 kD, 30 kD or 12 kD protein) were tested, and potent proliferative responses were seen in the cultures with M. leprae lysate and hsp65. Furthermore, gamma-IFN productions were positive in the cultures with M. leprae lysate or hsp65, but negative with other antigens. The production of gamma-IFN with hsp65 was never inhibited with polymyxin B, but inhibited with IL-10. These results show that BCG (Tokyo strain) is a useful vaccine for M. leprae infection in mice, and one of the components of BCG, hsp65, may be a effective antigen component for protection of M. leprae infection inducing Th1 type cytokine.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"106-12"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19779372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[HLA class II alleles and leprosy (Hansen's disease) classified by WHO-MDT criteria].","authors":"S Joko, J Numaga, K Masuda, M Namisato, H Maeda","doi":"10.5025/hansen.65.121","DOIUrl":"https://doi.org/10.5025/hansen.65.121","url":null,"abstract":"<p><p>Human leukocyte antigens (HLA) class II alleles were analyzed in Japanese leprosy patients to ascertain whether immunogenetic differences exist among the forms of leprosy in classification of World Health Organization-recommended multidrug therapy (WHO-MDT). The subjects were 86 unrelated Japanese leprosy patients, including 62 multibacillary leprosy (MBL), 24 paucibacillary leprosy (PBL). Controls were 114 unrelated healthy subjects. Genotyping of HLA class II alleles was performed by using the polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) and PCR-restriction fragment length polymorphism (RFLP) methods. The frequencies of HLA-DRB1* 1501, * 1502 and DRB5* 0101,* 0102 and DQA1* 0102 and DQB1* 0602 were significantly increased in the whole patients (44.2%, 34.9%, 44.2%, 34.9%, 53.4% and 41.9%, respectively) as compared with the control subjects (14.0%, 21.1%, 14.0%, 21.1%, 27.2% and 13.2%, respectively). On the other hand, the frequencies of HLA-DRB1* 0405, * 0803, * 0901 and DQA1* 03 and DQB1* 0401 were significantly decreased in the whole patients (10.5%, 5.8%, 16.3%, 41.9% and 9.3%, respectively) as compared with the control subjects (29.8%, 17.5%, 30.7%, 78.1% and 29.8%, respectively). When MBL and PBL patients were compared, the frequencies of HLA-DRB1* 1501, DRB5* 0101 and DQB1* 0602 were significantly increased in the MBL patients (51.6%, 51.6% and 48.4%, respectively) as compared with the PBL patients (25.0%, respectively). Our results suggest that HLA-DRB1* 1501, DRB5* 0101 and DQB1* 0602 contribute to the susceptibility to the Japanese MBL.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"121-7"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19779374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A serologic Mycobacteria leprae gelatin particle agglutination (MLPA) in the diagnosis of leprosy: comparison with conventional enzyme-linked immunoassay and bacterial index.","authors":"A T Agdamag, M Endoh, K Kawatsu, S Izumi","doi":"10.5025/hansen.65.100","DOIUrl":"https://doi.org/10.5025/hansen.65.100","url":null,"abstract":"<p><p>A gelatin particle agglutination test (MLPA) for the detection of anti-phenolic glycolipid-1 (PGL-1) antibodies was compared with the slit skin smear method in the diagnosis of leprosy. MLPA and BI tests showed a good agreement rate of 88.1% and MLPA and ELISA tests showed an excellent agreement rate 96.2%. This MLPA test is simple and reliable, it will be very convenient for the medical practitioners, it would be of great benefit for leprosy patient as well because this test would look like a routine blood examination compared with slit skin smear method which is widely known diagnostic tool for leprosy.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"100-5"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.5025/hansen.65.100","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19779371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Effects of glycerin and dextran on maintenance of the activity of Mycobacterium leprae in a cell-free liquid medium].","authors":"M Nakamura","doi":"10.5025/hansen.65.94","DOIUrl":"https://doi.org/10.5025/hansen.65.94","url":null,"abstract":"<p><p>In the previous paper, it was indicated that the activity (ATP values extracted from collected cells) of Mycobacterium leprae could be maintained in the phosphate buffer (pH 7.0) containing fetal calf serum (10%) for more than 4 weeks under the incubation at 30 degrees C. The present paper describes that the activity of cells of M.leprae is prolonged and somewhat stimulated when glycerin and dextran are added to the buffer serum system. The optimal concentrations for glycerin and dextran are 2% and 1%, respectively. In addition, it is found that the dextran of MW. 200,000-300,000 is much more effective than that of MW. 100,000-200,000.</p>","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"94-9"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19780114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Leprosy control program in Thailand.","authors":"P Duangajna","doi":"10.5025/hansen.65.88","DOIUrl":"https://doi.org/10.5025/hansen.65.88","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 2","pages":"88-93"},"PeriodicalIF":0.0,"publicationDate":"1996-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19780113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[The 69th general meeting of Japanese Leprosy Association. Okayama, Japan. April 25-27, 1996. Abstracts].","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"65 1","pages":"1-78"},"PeriodicalIF":0.0,"publicationDate":"1996-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19945722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Heat shock protein and immunity].","authors":"H Nomaguchi","doi":"10.5025/hansen1977.64.188","DOIUrl":"https://doi.org/10.5025/hansen1977.64.188","url":null,"abstract":"","PeriodicalId":76236,"journal":{"name":"Nihon Rai Gakkai zasshi","volume":"64 3","pages":"188-99"},"PeriodicalIF":0.0,"publicationDate":"1995-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19562440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}