{"title":"Reply to: “Coagulase-negative Staphylococcus bacteremia in ECMO: Examining key influencing factors”","authors":"Christian B. Wells MD , Joseph E. Marcus MD","doi":"10.1016/j.ajic.2025.03.016","DOIUrl":"10.1016/j.ajic.2025.03.016","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"53 7","pages":"Pages 806-807"},"PeriodicalIF":3.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jacob M Garrigues, Hannah K Gray, Ricardo P Ison, Daniel Z Uslan, Amorce Lima, Shekina Gonzalez-Ferrer, Marisol Trejo, Ran Zhuo, Colette J Matysiak Match, Erlinda R Ulloa, Sandeep Bhaurla, Vanessa Lewis, Urvashi Parti, Tessa Sandoval, Sebora Turay, Shaunté Walton, Kavitha Prabaker, Omai B Garner, Sukantha Chandrasekaran, Nicole M Green, Shangxin Yang
{"title":"Outbreak of New Delhi metallo-β-lactamase carbapenemase-producing Pseudomonas aeruginosa infections in a Southern California hospital.","authors":"Jacob M Garrigues, Hannah K Gray, Ricardo P Ison, Daniel Z Uslan, Amorce Lima, Shekina Gonzalez-Ferrer, Marisol Trejo, Ran Zhuo, Colette J Matysiak Match, Erlinda R Ulloa, Sandeep Bhaurla, Vanessa Lewis, Urvashi Parti, Tessa Sandoval, Sebora Turay, Shaunté Walton, Kavitha Prabaker, Omai B Garner, Sukantha Chandrasekaran, Nicole M Green, Shangxin Yang","doi":"10.1016/j.ajic.2025.06.005","DOIUrl":"10.1016/j.ajic.2025.06.005","url":null,"abstract":"<p><strong>Background: </strong>Carbapenemase-producing carbapenem-resistant Pseudomonas aeruginosa (CP-CRPA) is a major public health threat due to limited treatment options and high transmissibility. Though widespread globally, few instances of locally transmitted New Delhi metallo-β-lactamase (NDM)-producing CP-CRPA have been documented in the United States. Here, a cluster of locally transmitted NDM-1 CP-CRPA infections in Southern California is reported.</p><p><strong>Methods: </strong>Epidemiologic investigations involving both patient screening and environmental surveillance by microbiological culture, carbapenemase testing, and bacterial whole-genome sequencing were conducted.</p><p><strong>Results: </strong>Through extensive epidemiologic investigations, a sink environmental reservoir was identified. A genetically unique strain of NDM-CRPA was identified to be transmitted among seven patients in a single hospital over the course of 1.5 years. Changes in antimicrobial resistance genes harbored by a mobile genetic element were identified between the index and later cases, and the gene encoding NDM-1 resided within a mobile genetic element on the chromosome displaying evidence of widespread transmission between different species. Several interventions were implemented, including sink P-trap replacement and disinfectant against Pseudomonas biofilms. No additional cases were identified after the interventions.</p><p><strong>Conclusions: </strong>Implementation of real-time pathogen surveillance enabled effective response to an ongoing outbreak that involved environmental sampling, microbiological testing, whole-genome sequencing, facility management, and updated infection prevention policies.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for Authors","authors":"","doi":"10.1016/S0196-6553(25)00382-7","DOIUrl":"10.1016/S0196-6553(25)00382-7","url":null,"abstract":"","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":"53 7","pages":"Pages A9-A10"},"PeriodicalIF":3.8,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
George P Drewett, Mani Suleiman, Anthony Gust, Adam King, Saliya Hewagama, Craig Aboltins
{"title":"Hospital-acquired COVID-19 is associated with increased length and cost of stay in an Australian health care setting.","authors":"George P Drewett, Mani Suleiman, Anthony Gust, Adam King, Saliya Hewagama, Craig Aboltins","doi":"10.1016/j.ajic.2025.06.004","DOIUrl":"10.1016/j.ajic.2025.06.004","url":null,"abstract":"<p><p>The effect of hospital-acquired COVID-19 (HAI-COVID) on length- and cost- of hospital stay is incompletely understood. We performed a propensity-score matched, case-control study comparing inpatients with HAI-COVID versus non-HAI-COVID. For HAI-COVID, both length (15.0 vs 6.0 days) and cost (AUD$25,984 vs AUD$13,454) of stay were significantly increased (P<.001). Multistate modeling correcting for time-dependency bias demonstrated increased LOS of 4.6 days (95% CI 3.5-5.8 days). Minimizing HAI-COVID will lead to better patient and institutional outcomes.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144293204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Provincial PPE Safety Coach Program evaluation in continuing care settings in Alberta.","authors":"Kaethel Decker, Heather Gagnon, Abram Gutscher, Meaghan Brierley, Sara Mallinson, Jenine Leal","doi":"10.1016/j.ajic.2025.06.002","DOIUrl":"10.1016/j.ajic.2025.06.002","url":null,"abstract":"<p><strong>Background: </strong>Alberta Health Services (AHS) offered the Provincial Personal Protective Equipment (PPE) Safety Coach Program to continuing care homes to provide support to staff regarding the safe and appropriate use of PPE.</p><p><strong>Methods: </strong>A mixed-methods approach was used to evaluate staff experiences of training, adoption, and perceived impact of the program. Data were gathered using an online survey and semistructured qualitative interviews. The evaluation drew on implementation science frameworks to review implementation processes and contextual factors influencing program uptake and participant experiences.</p><p><strong>Results: </strong>A total of 283 surveys and 22 qualitative interviews were completed. Key findings are grouped into the following categories: program uptake, program content and delivery, skills and knowledge, the program's perceived impact, and feedback from nonadopting sites.</p><p><strong>Conclusions: </strong>Trained staff were largely satisfied with the delivery and content of the modules and other staff indicated it was beneficial to have support from trained staff. Sites that did not adopt the program indicated that the timing of the launch, ongoing staffing challenges, and the use of alternative PPE training were barriers to uptake.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fabio Borgonovo, Marta Colaneri, Federico Fassio, Giovanni Scaglione, Lucia Galli, Martina Offer, Camilla Genovese, Rebecca Fattore, Monica Schiavini, Giovanni De Capitani, Maria Calloni, Arianna Bartoli, Francesco Casella, Alba Taino, Antonio Gidaro, Chiara Cogliati, Valentina Breschi, Jessica Leoni, Andrea Gori, Antonella Foschi
{"title":"The CONSIDER study: Assessing the risk of catheter-associated bloodstream infections beyond the intensive care setting.","authors":"Fabio Borgonovo, Marta Colaneri, Federico Fassio, Giovanni Scaglione, Lucia Galli, Martina Offer, Camilla Genovese, Rebecca Fattore, Monica Schiavini, Giovanni De Capitani, Maria Calloni, Arianna Bartoli, Francesco Casella, Alba Taino, Antonio Gidaro, Chiara Cogliati, Valentina Breschi, Jessica Leoni, Andrea Gori, Antonella Foschi","doi":"10.1016/j.ajic.2025.05.020","DOIUrl":"10.1016/j.ajic.2025.05.020","url":null,"abstract":"<p><strong>Background: </strong>Catheter-associated and related bloodstream infection (CABSI and CRBSI) are major causes of hospital-acquired infections. However, their incidence and risk factors in non-intensive care unit (ICU) patients with vascular access devices (VADs) remain unclear.</p><p><strong>Methods: </strong>This retrospective study evaluated CABSI and CRBSI incidence and risk factors in non-ICU hospitalized adults with VADs. Hazard ratios (HR) were estimated with gamma frailty models and random survival forest analysis. Key variables were identified and validated in multivariable models.</p><p><strong>Results: </strong>Among 2,326 VAD insertions (1,892 patients), 153 with CRBSI or CABSI were identified. The incidence was 1.80 per 1,000 catheter-days for CABSI, 1.24 for CRBSI, and 2.97 overall. Coagulase-negative Staphylococci were the most isolated pathogens (43.9%). Infections were associated with parenteral nutrition (PN) (HR = 4.12) and multilumen catheters (HR = 2.56). Random survival forest models identified PN, intravenous drug use, and in-patient regimen as top variables. CRBSI was strongly associated with PN (HR = 7.42), while CABSI was linked to intravenous drug use (HR = 7.20).</p><p><strong>Conclusions: </strong>Our study showed a high incidence of CABSI and CRBSI in non-ICU adult patients. Identifying risk factors highlights the settings where stringent infection prevention strategies are needed.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Environmental detection and genetic profiling of Acanthamoeba in high-risk medical facilities.","authors":"Sara Sareminejad, Farnaz Kheirandish, Amirreza Javadi Mamaghani, Maryam Niyyati, Farzad Ebrahimzadeh, Mohammad Yarahmadi, Azadeh Karimi, Syedeh Fatemeh Moosavi, Nozhat Zebardast, Shirzad Fallahi","doi":"10.1016/j.ajic.2025.05.022","DOIUrl":"10.1016/j.ajic.2025.05.022","url":null,"abstract":"<p><strong>Background: </strong>Acanthamoeba parasite, one of the most common environmental protozoans, can be isolated from contact lenses, cleaning solutions, ventilation systems, dental treatment units, dialysis units, and emergency showers. Since the genus Acanthamoeba can lead to dangerous infectious diseases in immunocompromised patients, monitoring medical centers and hospitals admitting these patients, is of great importance.</p><p><strong>Methods: </strong>In this study, 53 dust samples were collected from 4 high-risk health care facilities in Khorramabad City, Western Iran. The samples were cultured in a non-nutritive agar culture medium, and samples with positive cultures were selected for molecular analysis. PCR and LAMP targeting 18srRNA gene-specific primers were used to analyze the samples.</p><p><strong>Results: </strong>The culture and microscopic examination showed that 31 out of 53 samples (58.5%) collected were positive for the Acanthamoeba parasite. All the positive samples by the culture method were also positive in the PCR assay. Out of 53 examined samples, 26 were positive by the LAMP technique regarding the presence of the Acanthamoeba parasite. Sequencing results of 4 sequenced samples showed T4 genotypes, Acanthamoeba sp, and Acanthamoeba culbertsoni.</p><p><strong>Conclusions: </strong>The present study showed that the environment of high-risk health care facilities in Khorramabad city is contaminated with Acanthamoeba, and the pathogenic T4 genotype is present among the positive samples.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Claire M Rickard, Andrew J Stewardson, Sally M Havers, Niccolo Buetti, Kevan R Polkinghorne, Aleece MacPhail, Zoe McQuilten, Benjamin Lazarus, Karina R Charles, Jessica A Schults
{"title":"Interventions to prevent bloodstream infections associated with central venous access devices: Priorities for an adaptive platform trial.","authors":"Claire M Rickard, Andrew J Stewardson, Sally M Havers, Niccolo Buetti, Kevan R Polkinghorne, Aleece MacPhail, Zoe McQuilten, Benjamin Lazarus, Karina R Charles, Jessica A Schults","doi":"10.1016/j.ajic.2025.06.003","DOIUrl":"10.1016/j.ajic.2025.06.003","url":null,"abstract":"<p><p>Health care-associated bloodstream infections are serious complications of central venous access devices. Numerous preventative interventions exist, but without high-level evidence. The IVCare adaptive platform trial will provide multiple answers for infection prevention. A prioritization study with infection preventionists using the Society for Healthcare Epidemiology of America central line-associated bloodstream infection prevention framework identified priorities for IVCare intervention testing as: vascular access teams, education/competency for central venous access device insertion/postinsertion care, sutureless securement, connector type and decontamination method.</p>","PeriodicalId":7621,"journal":{"name":"American journal of infection control","volume":" ","pages":""},"PeriodicalIF":3.8,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}