American Journal of Gastroenterology最新文献

{"title":"Endoscopic Approach to Palliation of Pancreatic Cancer.","authors":"Christina S Gainey, Todd H Baron","doi":"10.14309/ajg.0000000000003762","DOIUrl":"10.14309/ajg.0000000000003762","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Feed or Not to Feed: Is that the Question?","authors":"Rupjyoti Talukdar, Victoria Gómez","doi":"10.14309/ajg.0000000000003679","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003679","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Hiba Mikhael-Moussa, Guillaume Gourcerol, Chloé Melchior","doi":"10.14309/ajg.0000000000003683","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003683","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Increased Frailty in Elders With Celiac Disease.","authors":"Rohan Karkra","doi":"10.14309/ajg.0000000000003682","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003682","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor: Second sigmoid colon intubation for colonoscopy: Much Done, More to Be Considered.","authors":"Jianmei Wang, Xiaoli Ren","doi":"10.14309/ajg.0000000000003685","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003685","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Jue Tang, Jian Zhang, Ling Hang","doi":"10.14309/ajg.0000000000003698","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003698","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Novel Concepts on the Functional Neuroanatomy of the Anorectum: Implications for Anorectal Neuropathy and Neuromodulation Therapy.","authors":"Yun Yan, Busra Inal, Prasanna Kapavarapu, Keri Alber, Satish S C Rao","doi":"10.14309/ajg.0000000000003665","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003665","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Shangguan and Tan.","authors":"Marco Vincenzo Lenti, Emanuela Miceli, Antonio Di Sabatino","doi":"10.14309/ajg.0000000000003656","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003656","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-Life Clinical Validation of Artificial Intelligence-Assisted Detection and Differentiation of Pleomorphic Lesions in Capsule Endoscopy.","authors":"Miguel Mascarenhas Saraiva, João Ferreira, João Afonso, Francisco Mendes, William Preston Sonnier, Bruno Rosa, Tiago Ribeiro, Tiago Cúrdia Gonçalves, Miguel Martins, Pedro Campelo, Cláudia Macedo, Pedro Cardoso, Joana Mota, Maria João Almeida, António Pinto da Costa, Ana Pérez-Gonzalez, Jorge Mendoza, Thicianie Andrade Cavalcante, Erika Borges Fortes, Matheus de Carvalho, Marcos Eduardo Lera Dos Santos, Ana Patrícia Andrade, Hélder Cardoso, Eduardo Horneaux de Moura, Cecílio Santander, Jack di Palma, José Cotter, Guilherme Macedo","doi":"10.14309/ajg.0000000000003756","DOIUrl":"10.14309/ajg.0000000000003756","url":null,"abstract":"<p><strong>Introduction: </strong>Capsule endoscopy (CapE) is a minimally invasive procedure designed for small bowels' evaluation. However, prolonged reading times and a risk of missing clinically significant findings limit its potential. Prospective clinical validation studies of artificial intelligence (AI) for CapE remain scarce. Furthermore, existing studies focus on lesion detection, without addressing lesion differentiation.</p><p><strong>Methods: </strong>The aim of a multicenter prospective validation study was to compare AI-assisted reading with conventional CapE reading. Three hundred thirty CapE videos from 3 devices across 7 centers and 4 countries were included. After conventional reading reports, AI-assisted reading was performed by an independent expert using a deep learning model to detect and differentiate pleomorphic small bowel lesions. Both reports were reviewed by an expert from an independent center, which decided in discrepant cases. AI-assisted and standard readings were evaluated through their accuracy, sensitivity, specificity, positive and negative predictive value, and small bowel lesion detection rate.</p><p><strong>Results: </strong>AI-assisted reading detected 605 of 635 lesions identified by expert-based consensus, whereas standard reading identified 354 lesions. AI-assisted reading outperformed standard reading, with small bowel lesion detection rate of 96.1% vs 76.3% and sensitivity of 97.5% vs 78.2%. AI-assisted reading had a mean examination reading time of 203 seconds per examination.</p><p><strong>Discussion: </strong>This was the first multicentric study proving AI-assisted CapE reading superiority compared with conventional reading. The inclusion of videos from multiple devices addresses the interoperability challenge, whereas including patients from 4 countries and 2 different continents assures a diverse demographic context. AI achieved gastroenterologist-level identification of small-bowel lesions, surpassing conventional reading methods in both lesion detection and characterization.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sub-cutaneous infliximab for perianal Crohn's disease: the BioLap-Rem multicentre study from the GETAID.","authors":"M André, J Kirchgesner, D Laharie, L Guillo, P Seksik, L Abramowitz, M Fumery, P Wils, M Amil, S Nancey, C Le Berre, A Buisson, N Fathallah, C Giletta, M Uzzan, D Moussata, N Duveau, L Peyrin-Biroulet, S Nahon, N Richard, M Charkaoui, E Vicaut, L Vuitton","doi":"10.14309/ajg.0000000000003755","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003755","url":null,"abstract":"<p><strong>Background and aims: </strong>Intravenous infliximab (IFX) is the cornerstone for treating patients with perianal Crohn's disease (pCD). Data on the recently launched subcutaneous (SC) IFX for pCD are limited. The aim of our study was to evaluate the effectiveness and safety of SC IFX in pCD.</p><p><strong>Methods: </strong>We conducted a multicentre retrospective cohort study from the GETAID, including patients with either active (group 1) or inactive (group 2) pCD when they started SC IFX. Inclusion criteria were, for group 1: active pCD in the 6 months prior to initiation of SC IFX; for group 2: inactive pCD for > 6 months at the time of IV to SC switch. The primary endpoints were clinical remission at 6 months in group 1, and pCD relapse in group 2.</p><p><strong>Results: </strong>Of the 183 patients included in 24 centers, 66 were in group 1 and 117 in group 2. The median follow-up was 50.4 (27.0-64.6) and 53.4 (40.6-67) weeks, respectively. In group 1 at 6 months, clinical remission was observed in 44.6% of patients, clinical response in 87.7%. Clinical remission including seton removal occurred in 35.5% of patients. In multivariable analysis, high BMI was the only independent predictor of remission (OR 0.88-CI95 0.77-0.99). In group 2, rates of relapse free survival were 94.3 % and 87.9 % at 6 and 12 months. Sixteen (8.3%) cases of adverse events related to SC injection were observed.</p><p><strong>Conclusion: </strong>SC IFX was effective and safe for the treatment of active pCD and for maintaining remission after switching in this large multicentre cohort, thus supporting its use in routine practice in this indication.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}