{"title":"Response to Dell'Unto et al.","authors":"Andre Jove, Robert J Huang","doi":"10.14309/ajg.0000000000003578","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003578","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144504471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor.","authors":"Cong Dai, Yu-Hong Huang, Min Jiang","doi":"10.14309/ajg.0000000000003556","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003556","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144482794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Griffith B Perkins, Amanda H Lim, Pravin B Hissaria, Nam Q Nguyen
{"title":"Response to Macias et al.","authors":"Griffith B Perkins, Amanda H Lim, Pravin B Hissaria, Nam Q Nguyen","doi":"10.14309/ajg.0000000000003553","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003553","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Zhang and Fang.","authors":"Gian Paolo Caviglia, Elisabetta Bugianesi","doi":"10.14309/ajg.0000000000003566","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003566","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor.","authors":"Kuan-Fu Liao, Shih-Wei Lai","doi":"10.14309/ajg.0000000000003527","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003527","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor.","authors":"Li Huang, Jiajie Lu","doi":"10.14309/ajg.0000000000003547","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003547","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to Sah et al.","authors":"Ashish Kumar, Shiv Kumar Sarin","doi":"10.14309/ajg.0000000000003550","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003550","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the Editor.","authors":"Yan Zhang, Yunda Fang","doi":"10.14309/ajg.0000000000003554","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003554","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144301013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Akari Miki, Megha Tandon, Dina Murad, Julia Loughman, Jodi Gilman, Sushrut Jangi
{"title":"Increasing Prevalence of Cannabinoid Hyperemesis Syndrome in Young Adults and Minority Populations.","authors":"Akari Miki, Megha Tandon, Dina Murad, Julia Loughman, Jodi Gilman, Sushrut Jangi","doi":"10.14309/ajg.0000000000003591","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003591","url":null,"abstract":"<p><strong>Introduction: </strong>Prevalence rates for cannabinoid hyperemesis syndrome (CHS) across demographic groups remain unclear.</p><p><strong>Methods: </strong>We used data from the Massachusetts Center for Health Information and Analysis to estimate the rates of CHS from 2012 - 2021, across > 15 million emergency department (ED) visits and demographic groups.</p><p><strong>Results: </strong>CHS cases per 10,000 ED visits increased from 0.729 to 10.6 in Massachusetts (2012-2021). Individuals aged 18-34 experienced the fastest rise in CHS prevalence, with young adults, Hispanic individuals, Black individuals, and males having the overall highest 10-year prevalence.</p><p><strong>Discussion: </strong>Younger adults, Hispanic individuals and Black individuals may be at higher risk for presenting with CHS.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sahand Rahnama-Moghadam, Nitin Arora, Raj Vuppalanchi, Yi Ju Li, Jiezhun Gu, Huiman Barnhart, Elizabeth Phillips, Naga Chalasani
{"title":"DRESS syndrome in patients with drug-induced liver injury: Characteristics and HLA risk factors.","authors":"Sahand Rahnama-Moghadam, Nitin Arora, Raj Vuppalanchi, Yi Ju Li, Jiezhun Gu, Huiman Barnhart, Elizabeth Phillips, Naga Chalasani","doi":"10.14309/ajg.0000000000003590","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003590","url":null,"abstract":"<p><strong>Introduction: </strong>Drug reaction with eosinophilia and systemic symptoms (DRESS) can sometimes occur in patients with drug-induced liver injury (DILI). However, detailed studies of DRESS in patients with DILI from the US are lacking. We investigated the characteristics and HLA risks for DILI who also developed DRESS.</p><p><strong>Methods: </strong>Patients with definite, highly likely, or probable DILI enrolled into US DILI Network studies between September 2004 and August 2023 were included. DRESS was defined based on modified RegiSCAR criteria. HLA alleles were compared between DILI-DRESS cases and two control groups (DILI with non-DRESS rash [n=244] and DILI without rash [n=1637).</p><p><strong>Results: </strong>Of 2,121 participants with DILI during the study period, 128 participants had DRESS (6%). The most frequently implicated drugs causing DRESS were trimethoprim/sulfamethoxazole, lamotrigine, phenytoin, allopurinol, and vancomycin. Compared to 1993 DILI patients without DRESS, patients with DILI + DRESS were younger (mean age 42.3 yrs vs 50.6 years), more likely to be Black (26% vs 12%), had shorter latency (median 31 days vs 47 days), higher frequency of rash (100% vs 13%), eosinophilia (55% vs 13%), and fever (76% vs 16%) (P<0.001 for all). Compared to DILI without DRESS, DILI + DRESS had more severe liver injury (severe/fatal: 45% vs 21.5%, p<0.001) and higher overall (15.6% vs 6.3%, P<0.001) and liver-related (9% vs 2.3%, p < 0.001) mortality. HLA A*32:01, HLA B*53:01 and HLA B*58:01 were significantly enriched in DILI-DRESS cases, compared to control groups.</p><p><strong>Conclusions: </strong>Patients with DILI and DRESS are younger, more likely to be Black, had shorter time to DILI onset with more severe liver injury and higher overall and liver-related mortality. HLA A*32:01, HLA B*53:01 and HLA B*58:01 are risk factors for DILI-DRESS.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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