American Journal of Gastroenterology最新文献

{"title":"Accurately Predicting Recurrent Primary Sclerosing Cholangitis After Liver Transplantation.","authors":"Ming Gao, Xuefeng Ma","doi":"10.14309/ajg.0000000000003423","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003423","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Suggestions to Strengthen a Systematic Review.","authors":"Nosaibah Razaqi, Rachana Mehta, Shubham Kumar, Ranjana Sah","doi":"10.14309/ajg.0000000000003387","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003387","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of multiple gastrointestinal ulcers caused by dental floss used for endoscopic submucosal dissection defect closure.","authors":"Jiayao Zheng, Shijie Yang, Wanyin Deng","doi":"10.14309/ajg.0000000000003472","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003472","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LONG-TERM SUSTAINED IMPROVEMENT IN UNPLANNED HEALTHCARE UTILIZATION IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE.","authors":"Gil Y Melmed, Brant Oliver, Alice Kennedy, Jason K Hou, Donald Lum, Siddharth Singh, Welmoed K van Deen, Ridhima Oberai, S Alandra Weaver, James Testaverde, Corey A Siegel","doi":"10.14309/ajg.0000000000003454","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003454","url":null,"abstract":"<p><strong>Methods: </strong>After the QI initiative, we developed an \"urgent care toolkit\" for sites to implement. We measured patient- and provider-reported outcomes at clinical visits.</p><p><strong>Results: </strong>Improvements in ED utilization and hospitalization were sustained for over 3 years following completion of the initiative.</p><p><strong>Conclusions: </strong>Efforts to sustain improvements after a QI initiative can result in long-term improvement in patient outcomes.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Polysaccharide Hemostatic Powder on blood oozing among patients with Post-Endoscopic Sphincterotomy Bleeding: A Randomized Controlled Trial.","authors":"Hengcun Li, Jiaxuan Zuo, Wenhai Wang, Shanshan Wu, Yu Zhao, Yongqiu Wei, Jiugang Song, Zheng Zhang, Weilong Yao, Junxiong Wang, Chuntao Liu, Hongtao Wei, Zheng Liang, Xiaohan Yang, Kaiqi Yang, Fujing Lv, Yongjun Wang, Peng Li, Shutian Zhang","doi":"10.14309/ajg.0000000000003468","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003468","url":null,"abstract":"<p><strong>Background and aims: </strong>Post-endoscopic sphincterotomy (EST) bleeding presents challenges for endoscopists using side-viewing duodenoscopes. Recently, polysaccharide hemostatic powder (PHP) has shown promising results in managing gastrointestinal hemorrhage. Given the established efficacy of endoscopic clips in addressing post-EST bleeding, we aim to evaluate the efficacy of PHP and its non-inferiority to endoscopic clips in patients with non-pulsatile post-EST bleeding.</p><p><strong>Methods: </strong>Patients with non-pulsatile post-EST bleeding were randomized to receive either PHP or endoscopic clips. The primary endpoint was the immediate hemostasis rate, with secondary endpoints including delayed bleeding rate, overall treatment success rate, mean hemostasis time, and other major complications.</p><p><strong>Results: </strong>A total of 104 patients with non-pulsatile post-EST bleeding were included. Immediate hemostasis was achieved in 100% of the PHP group and 92.3% in the endoscopic clip group (risk difference, 7.7%, 95% CI = 0.5 - 15.0%, P = 0.022). Four patients in the endoscopic clip group experienced immediate hemostasis failure. Hemostasis time was shorter in the PHP group (50.77s vs. 62.81s, P = 0.011). One delayed bleeding case (2.1%) occurred in the clip group, while none were observed in the PHP group. The overall treatment success rate was higher in the PHP group compared to the endoscopic clip group (100% vs. 90.4%; P = 0.022). No differences were observed in adverse events.</p><p><strong>Conclusions: </strong>PHP is not inferior to endoscopic clip and could be of use in immediate hemostasis for non-pulsatile post-EST bleeding, with the added advantage of ease of use. Further research is needed to assess its efficacy in preventing delayed bleeding. (chictr.org.cn, ChiCTR2400092280).</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794559","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Barrett's Esophagus in Time and Space: A Methylation Panel for Tracking Esophageal Cancer.","authors":"Daniel H Jacobson, Rebecca C Fitzgerald","doi":"10.14309/ajg.0000000000003378","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003378","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Wei.","authors":"Nora Vladimirova, Jakob M Møller, Johan Burisch, Mikkel Østergaard","doi":"10.14309/ajg.0000000000003380","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003380","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PATIENT REPORTED OUTCOME MEASURES IN BENIGN ESOPHAGEAL DISORDERS.","authors":"John E Pandolfino, Ronnie Fass, Walter W Chan, C Prakash Gyawali","doi":"10.14309/ajg.0000000000003467","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003467","url":null,"abstract":"<p><p>Patient-reported outcome (PRO) measures are essential tools for assessing a patient's subjective experience related to disease and health. PROs measure symptom severity and evaluate treatment efficacy across a range of conditions at a particular point in time. While PROs focusing on esophageal symptoms and esophageal hypervigilance exist, disease-specific PROs for commonly encountered benign esophageal disorders such as gastroesophageal reflux disease (GERD), eosinophilic esophagitis (EoE), and achalasia are limited. Most GERD-specific PROs fail to address the complete spectrum of GERD presentations, and those that provide daily assessment are more suited for research. Similarly, many EoE-specific PROs were designed for clinical trials. Comprehensive instruments incorporating EoE symptoms, as well as endoscopic and histologic features of active inflammation and fibrostenotic changes are needed. The psychometric properties of the Eckardt Score used for achalasia has significant limitations, stemming primarily from the dominance of dysphagia in scoring. Newer achalasia-specific PROs attempt to overcome this by capturing nuanced patient experiences. Broader symptom PROs are often used assess esophageal symptoms across the spectrum of benign esophageal disorders, including a PRO that assesses esophageal hypervigilance and symptom specific anxiety (EHAS). Future efforts should focus on creating user-friendly PROs that comprehensively evaluate not just clinical presentation but also the disease state, which will enhance clinical symptom follow-up, quality of life assessment and research applications. Assessments of hypervigilance and visceral anxiety will complement these applications as these measures are both a PRO and an important moderator of symptom severity and quality of life.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Existential Reflections by Older Adults with Inflammatory Bowel Diseases on Medical and Surgical Treatments.","authors":"Alison Rusher, Alexandra Fuss, Elizabeth Araka, Christy Cauley, Sevdenur Cizginer, Christine Ritchie, Ashwin N Ananthakrishnan, Bharati Kochar","doi":"10.14309/ajg.0000000000003475","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003475","url":null,"abstract":"<p><strong>Objectives: </strong>Current treatment guidelines do not address the unique health risks or life priorities of the aging population with inflammatory bowel diseases (IBD). Patient priority-directed care approaches can facilitate better clinical management for this population. We aimed to explore the experiences of older adults with IBD in relation to medical and surgical treatments by investigating the factors that influence their decision-making.</p><p><strong>Methods: </strong>We conducted qualitative in-depth interviews with 22 patients ≥60 years who spoke English and received treatment for IBD at our center. We designed the interview guide using the Patient Priorities Care conceptual model to evaluate motives behind treatment decisions and goals. We used qualitative description and reflexive theoretical analysis to identify underlying themes specific to the lived experience of older adults with IBD.</p><p><strong>Results: </strong>Responses fit into three domains: (A) Treatment Decisions, (B) Treatment Reflections, and (C) Treatment Goals. Themes featured importance of trust in shared decision-making, resignation, acceptance, impact of treatments, anticipatory anxiety, finding meaningful life through treatment, maintaining remission, de-escalating medical therapy, and restoring normalcy. We found that having IBD at an older age creates a unique identify conflict. We learned that the most commonly identified treatment outcome is to feel \"normal.\" Participants felt resigned and anxious when making treatment decisions, yet grateful for the chance of remission.</p><p><strong>Conclusions: </strong>Supporting older adults with IBD to feel less resigned with their disease is critical. Providers should consider redefining what \"feeling normal\" means to facilitate disease acceptance and present treatment information with minimal bias.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overweight and Obesity-Associated Gastric Cancer Among Non-Asians.","authors":"Yong Zhou, Yan Sun","doi":"10.14309/ajg.0000000000003072","DOIUrl":"10.14309/ajg.0000000000003072","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":"930"},"PeriodicalIF":8.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142339344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}