American Journal of Gastroenterology最新文献

{"title":"Esophageal Clear Cell Carcinoma Treated by Endoscopic Submucosal Dissection.","authors":"Yanhui Mao, Yong Yan, Liming Wen, Jiamin Qin","doi":"10.14309/ajg.0000000000003364","DOIUrl":"10.14309/ajg.0000000000003364","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Barrett's Esophagus After Sleeve Gastrectomy.","authors":"Samuel Tanner, Joel H Rubenstein","doi":"10.14309/ajg.0000000000003358","DOIUrl":"10.14309/ajg.0000000000003358","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Triple Modality Triumph: Novel Endoscopic Treatment of Complex Ileorectal Anastomotic Stricture.","authors":"Zehra Naseem, Aun Muhammad, Hassan Siddiki","doi":"10.14309/ajg.0000000000003357","DOIUrl":"10.14309/ajg.0000000000003357","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143405155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spray and Forced Coagulation Mode Endoscopic Submucosal Dissection for Early Gastric Neoplasms: A Multicenter Randomized Controlled Trial.","authors":"Mitsuru Esaki, Yorinobu Sumida, Kosuke Maehara, Daisuke Yamaguchi, Kei Nishioka, Hitoshi Homma, Taisuke Inada, Kazuo Shiotsuki, Shin-Ichiro Fukuda, Hirotada Akiho, Tadahiro Nomura, Yumi Mizuta, Satoshi Ishida, Shun Fujimoto, Shunichiro Kimura, Yuichiro Tanaka, Kaori Hata, Noriko Shiga, Tsutomu Iwasa, Yusuke Kimura, Norimoto Nakamura, Yusuke Suzuki, Yosuke Minoda, Xiaopeng Bai, Yoshimasa Tanaka, Yoshitaka Hata, Haruei Ogino, Takatoshi Chinen, Eikichi Ihara, Koshiro Tagawa, Yoshihiro Ogawa","doi":"10.14309/ajg.0000000000003360","DOIUrl":"10.14309/ajg.0000000000003360","url":null,"abstract":"<p><strong>Introduction: </strong>Controlling intraoperative bleeding during endoscopic submucosal dissection (ESD) is essential to ensure the safety and reliability of the procedure. ESD in spray coagulation mode (SCM-ESD) is expected to ensure more effective bleeding control. The aim of this study was to investigate the superiority of SCM-ESD over conventional forced coagulation mode ESD (FCM-ESD) in hemostatic ability for treating early gastric neoplasms (EGNs).</p><p><strong>Methods: </strong>This multicenter randomized controlled trial (Spray-G Trial) was conducted at 5 Japanese institutions. Patients with intramucosal EGNs were enrolled and randomly assigned to either the SCM-ESD or FCM-ESD group. The primary outcome was ESD completion with an electrosurgical knife alone, that is, without the use of hemostatic forceps. The number and duration of hemostatic procedures using hemostatic forceps, procedure time, curability, and adverse events were also evaluated.</p><p><strong>Results: </strong>Each group included 65 patients. The rate of ESD completion without using hemostatic forceps was significantly higher for SCM-ESD than for FCM-ESD (83.1% vs 13.8%, P < 0.0001). SCM-ESD and FCM-ESD did not differ significantly in procedure time (48.3 minutes vs 56.0 minutes, P = 0.1071), R0 resection (100% vs 95.4%, P = 0.2442), and rate of adverse events (3.1% vs 6.2%, P = 0.6801).</p><p><strong>Discussion: </strong>SCM-ESD significantly improved ESD completion rates for intramucosal EGNs without using hemostatic forceps. SCM-ESD is a promising technique that may streamline ESD by eliminating the need to exchange devices and reducing costs (UMIN Clinical Trials Registry, Numbers: UMIN000047353).</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Glucagon-Like Peptide-1 Receptor Agonists on Bowel Preparation for Colonoscopy: A Systematic Review and Meta-Analysis.","authors":"Azizullah Beran, Tarek Nayfeh, Aya Akhras, Daryl Ramai, Mouhand Mohamed, John J Guardiola, Mohammad Al-Haddad, Douglas K Rex","doi":"10.14309/ajg.0000000000003362","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003362","url":null,"abstract":"<p><strong>Introduction: </strong>The impact of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on colonoscopy bowel preparation is unclear.</p><p><strong>Methods: </strong>We searched multiple databases for studies comparing bowel preparation quality between GLP-1RA users and control group. Using a random-effects model, we calculated pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CIs). Inadequate bowel preparation (IBP) rate was the primary outcome and Boston Bowel Preparation Scale (BBPS) mean score was the secondary outcome.</p><p><strong>Results: </strong>Five studies with 10,833 subjects (n=5,434 GLP-1RAs vs. n=5,399 control) were included. The IBP rate was higher in the GLP-1RAs group compared to the control group (OR 2.10, 95% CI 1.41-3.13, p=0.0003). Furthermore, the mean BBPS score was lower in the GLP1-RAs group compared to the control group (MD -0.34; 95% CI -0.51, -0.17; p=0.0001).</p><p><strong>Conclusions: </strong>Our findings suggest that using GLP-1RA increases the risk of inadequate bowel preparation.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video Violence: Navigating a New Frontier in Workplace Violence Amidst the Surge in Telehealth Adoption.","authors":"B Houge, R M Elias, S V Kane","doi":"10.14309/ajg.0000000000003361","DOIUrl":"10.14309/ajg.0000000000003361","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spatiotemporal Study of a Risk-Stratification Epigenetic-Based Biomarker Assay in Barrett's Esophagus Patients.","authors":"Sarah E Laun, Lisa Kann, Jerome Braun, Francia Pierre, Suji Kim, Stacey Gilbert, Daniel Lunz, Andrew Kalra, Ke Ma, Yulan Cheng, Cadman L Leggett, Ali H Zaidi, Ashten N Omstead, Louis Korman, Blair Jobe, Lorrie Perpetua, Bruce D Greenwald, Tara Maddala, Stephen J Meltzer","doi":"10.14309/ajg.0000000000003367","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003367","url":null,"abstract":"<p><strong>Background: </strong>Barrett's esophagus (BE) is the strongest known risk factor for developing esophageal adenocarcinoma (EAC), the second-most lethal cancer in the United States. Esopredict is a novel validated methylation-based biomarker assay that provides precise quantification of neoplastic progression risk in BE patients. Inherit challenges, including tissue heterogeneity, sampling error, interobserver variability, and inconsistent adherence to surveillance biopsy guidelines may impact Esopredicts' predictive value results obtained at different anatomic locations or different sampling time points.</p><p><strong>Methods: </strong>To investigate the spatiotemporal performance of Esopredict across multiple spatiotemporal sampling points, we profiled 220 biopsies obtained from 58 BE patients, including 11 patients with overlapping spatial and temporal biopsies. We focused on spatial profiling (i.e., multiple biopsies obtained at several anatomic locations during a single endoscopy and temporal profiling (i.e., biopsies obtained from multiple endoscopies performed at different time points). Each patient had an initial histologic diagnosis of nondysplastic Barrett's esophagus (NDBE), indefinite for dysplasia (IND), or low-grade dysplasia (LGD). Final follow-up (endpoint) biopsies showed either HGD or EAC (progressors); or NDBE, IND, or LGD (non-progressors). Biopsies were analyzed with Esopredict to compute a progression risk score, which quantified the likelihood of future progression to HGD or EAC within 5 years.</p><p><strong>Results: </strong>In 52 spatially profiled patients, Esopredict demonstrated a sensitivity of 81% (17/21 progressor patients), based on the highest-scoring biopsy from each patient; sensitivity increased to 100% (12/12) when endpoint biopsies occurred within 5 years of the index (initial) biopsy. In 28 temporally profiled patients, sensitivity was 100% (8/8 patients), based on the biopsy performed at the timepoint closest to the endpoint biopsy.</p><p><strong>Conclusion: </strong>Esopredict showed high predictive performance in multiple spatiotemporal samples in BE patients. These data further support the use of Esopredict as a robust test to distinguish high-risk BE patients, who may benefit from endoscopic eradication therapy or increased surveillance frequency, from low-risk patients, who may be candidates for less frequent surveillance and non-interventive observation.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143397766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Cholestasis on Primary Sclerosing Cholangitis in Patients Following Liver Transplantation: Insights From Mixed Censoring Outcomes.","authors":"Lingyu Xu, Xuefei Shen, Yan Xu","doi":"10.14309/ajg.0000000000003313","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003313","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is It Time to Scale Down the Bristol?","authors":"Peter L Lu","doi":"10.14309/ajg.0000000000003283","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003283","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143187940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Melton et al.","authors":"Varol Tunali, Beyza Hilal Ermiş, Özkan Ufuk Nalbantoğlu","doi":"10.14309/ajg.0000000000003309","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003309","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}