American Journal of Gastroenterology最新文献

{"title":"Increased Mortality Associated With Sarcopenia in Inflammatory Bowel Disease: A Long-Term Prospective Cohort Study.","authors":"Qian Zhang, Haoxi Liu, Si Liu, Shengtao Zhu, Shutian Zhang, Zhirong Yang, Shanshan Wu","doi":"10.14309/ajg.0000000000003734","DOIUrl":"10.14309/ajg.0000000000003734","url":null,"abstract":"<p><strong>Introduction: </strong>With gradually increasing number of older patients with inflammatory bowel disease (IBD), a significant number of patients with IBD suffer from sarcopenia. Emerging evidence has demonstrated various adverse outcomes associated with sarcopenia; however, the impact of sarcopenia on long-term mortality risk among patients with IBD has not yet been explored.</p><p><strong>Methods: </strong>Overall, 4,966 patients with IBD (aged 56.9 ± 8.0 years, 51.6% female) were enrolled in the prospective cohort. Sarcopenia was assessed according to criteria of the European Working Group on Sarcopenia in Older People 2. The primary outcome was all-cause mortality. Multivariable Cox proportional hazard model was conducted to estimate related associations. Sensitivity analysis and subgroup analysis were used to validate the results.</p><p><strong>Results: </strong>Overall, 775 (14.6%) and 34 (0.7%) were considered probable sarcopenia and confirmed sarcopenia, respectively. During a median follow-up of 14.6 years, 564 all-cause deaths (11.4%) were identified. There were 136 deaths (17.5%) among those with probable sarcopenia and 10 deaths (29.4%) among those with confirmed sarcopenia. Compared with nonsarcopenia, those with probable sarcopenia and confirmed sarcopenia had a 47% (hazard ratio = 1.47, 95% confidence interval: 1.20-1.80, P < 0.001) and 140% (hazard ratio = 2.40, 95% confidence interval: 1.27-4.52, P = 0.007) excess risk of mortality, respectively. Similar results were observed in sensitivity analysis.</p><p><strong>Discussion: </strong>Probable and confirmed sarcopenia increase the risk of long-term mortality in patients with IBD. Sarcopenia assessment can help risk stratification for prognosis in older patients with IBD.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Unexpected Outcome of a Giant Hypopharyngeal Lipoma.","authors":"An-Yi Xiang, Ke-Yi Guo, Xin-Yue Li, Li-Yun Ma, Jian-Wei Hu, Xiao-Yue Xu, Ping-Hong Zhou","doi":"10.14309/ajg.0000000000003731","DOIUrl":"10.14309/ajg.0000000000003731","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Esophageal Dilation Procedures in Patients on Antithrombotic Therapy: A Propensity-Matched Cohort Study.","authors":"Khaled Elfert, Abdellatif Ismail, Mohammed Abusuliman, Mohamed Eldesouki, Khalid Aloum, Mohammad Kloub, Mahmoud Elghayesh, Karla Passalacqua, Hazem Abosheaishaa, Mahmoud Nassar, Justin Kupec, Matthew Krafft, Sherif E Elhanafi","doi":"10.14309/ajg.0000000000003732","DOIUrl":"10.14309/ajg.0000000000003732","url":null,"abstract":"<p><strong>Introduction: </strong>Esophageal dilation procedures are frequently performed on patients who are taking antithrombotic medications. The aim of this study was to evaluate whether patients on antithrombotic therapies have an increased risk of bleeding from esophageal dilation.</p><p><strong>Methods: </strong>A retrospective propensity-matched cohort study was conducted to evaluate patients in the TriNetX US Collaborative Network database who underwent esophageal dilation procedures. The primary outcome was to assess the effect of anticoagulants and dual-antiplatelet therapies (DAPTs) on the rate of postprocedural gastrointestinal bleeding within 30 days.</p><p><strong>Results: </strong>Patients on anticoagulants were found to be at higher risk of postprocedural gastrointestinal bleeding compared with patients not on anticoagulants (relative risk [RR], 1.43; 95% confidence interval [CI], 1.06-1.92; P  = 0.017). The anticoagulant group had higher rates of blood transfusion and intensive care unit admission. The DAPT group had a higher rate of gastrointestinal bleeding compared with no antiplatelet therapy, though this did not reach statistical significance (RR, 1.64; 95% CI, 0.97-2.75; P = 0.06). When compared with aspirin monotherapy, the difference in bleeding rates was also not statistically significant (RR, 1.36; 95% CI, 0.84-2.19; P = 0.2). There was no difference in the rates of blood transfusion or intensive care unit admission when DAPT was compared separately with aspirin and with no antiplatelet groups. In addition, early resumption of anticoagulation or antiplatelet therapy was not associated with increased postprocedural bleeding.</p><p><strong>Discussion: </strong>Patients on anticoagulants at the time of esophageal dilation were at higher risk of postprocedural bleeding. DAPT was numerically associated with a higher risk of bleeding, but this did not reach statistical significance. These findings aim to inform the clinical decision making in preprocedure and postprocedure management of esophageal dilation procedures.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Sagnik Biswas, Pranjal Singh, Shalimar","doi":"10.14309/ajg.0000000000003647","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003647","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to Fang et al.","authors":"Julian Prosenz, Sebastian Bernhofer, Christine Duller, David Venturi, Andreas Maieron","doi":"10.14309/ajg.0000000000003648","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003648","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144870873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: A Stool DNA-Based SDC2 Methylation Test for the Early Detection of Colorectal Cancer in an Asymptomatic, High-Risk Population: A Multicenter Prospective Randomized Trial.","authors":"Chang Woo Kim, Hyunjin Kim, Hyoung Rae Kim, Daeyeon David Won, Woo Jung Nam, Byung Soh Min, Tae Jeong Oh, Sungwhan An, Suk-Hwan Lee","doi":"10.14309/ajg.0000000000003549","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003549","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Persistence, Effectiveness, and Safety of Upadacitinib in Crohn's Disease and Ulcerative Colitis in Real Life: Results From a Spanish Nationwide Study (Ureal Study).","authors":"Joaquin Borras-Blasco, Alejandro Valcuende-Rosique, Silvia Cornejo-Uixeda","doi":"10.14309/ajg.0000000000003619","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003619","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Xueli Shangguan, Chuanchuan Tan","doi":"10.14309/ajg.0000000000003632","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003632","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor.","authors":"Yunda Fang, Jiang Liu, Yan Zhang","doi":"10.14309/ajg.0000000000003625","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003625","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonendoscopic Detection of Barrett's Esophagus on Patients Without Gastroesophageal Reflux Disease Symptoms.","authors":"Amitabh Chak, Komal Keerthy, Gi-Ming Wang, Wendy Brock, Beth Bednarchik, Rajesh Guptha, Suman Verma, Helen Moinova, Curtis Tatsuoka, John Dumot, Sapna Thomas, Joseph E Willis, Sanford Markowitz","doi":"10.14309/ajg.0000000000003669","DOIUrl":"10.14309/ajg.0000000000003669","url":null,"abstract":"<p><strong>Introduction: </strong>Upper endoscopy (EGD) is generally recommended in those with chronic gastroesophageal reflux disease (GERD). To evaluate nonendoscopic screening in those without GERD symptoms.</p><p><strong>Methods: </strong>EsoCheck/Esoguard (LucidDx) was performed in recruited patients without chronic GERD who had ≥3 other BE risk factors.</p><p><strong>Results: </strong>The EsoGuard assay was positive in 34 of 120 patients. BE was identified in 9 of 27 who had follow-up EGD, positive predictive value = 33% (17%-54%). EGD performed in 22 of 86 subjects with negative assays found no BE, negative predictive value = 100% (85%-100%).</p><p><strong>Discussion: </strong>Nonendoscopic BE detection is effective in patients without chronic GERD.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}