Nonendoscopic Detection of Barrett's Esophagus on Patients Without Gastroesophageal Reflux Disease Symptoms.

IF 7.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-08-01 DOI:10.14309/ajg.0000000000003669

Amitabh Chak, Komal Keerthy, Gi-Ming Wang, Wendy Brock, Beth Bednarchik, Rajesh Guptha, Suman Verma, Helen Moinova, Curtis Tatsuoka, John Dumot, Sapna Thomas, Joseph E Willis, Sanford Markowitz

引用次数: 0

Abstract

Introduction: Upper endoscopy (EGD) is generally recommended in those with chronic gastroesophageal reflux disease (GERD). To evaluate nonendoscopic screening in those without GERD symptoms.

Methods: EsoCheck/Esoguard (LucidDx) was performed in recruited patients without chronic GERD who had ≥3 other BE risk factors.

Results: The EsoGuard assay was positive in 34 of 120 patients. BE was identified in 9 of 27 who had follow-up EGD, positive predictive value = 33% (17%-54%). EGD performed in 22 of 86 subjects with negative assays found no BE, negative predictive value = 100% (85%-100%).

Discussion: Nonendoscopic BE detection is effective in patients without chronic GERD.

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无gerd症状患者barrett食管的非内镜检查。

背景：慢性胃食管反流病（GERD）患者通常推荐采用上内镜检查（EGD）。目的：评价无胃反流症状患者的非内镜筛查效果。方法：在招募的无慢性胃食管反流且有≥3个其他BE危险因素的患者中使用EsoCheck/Esoguard （LucidDx）。结果：120例患者中有34例EsoGuard检测呈阳性。27例随访EGD患者中有9例确诊BE， PPV = 33%[17%, 54%]。86例阴性受试者中22例EGD未发现BE， NPV = 100%[85%, 100%]。结论：非内镜BE检测对无慢性胃食管反流的患者是有效的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.