Serum Gastrin Levels Are Associated With Prevalent Neuroendocrine Tumors in Autoimmune Metaplastic Atrophic Gastritis.

IF 8 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-05-01 Epub Date: 2024-11-26 DOI:10.14309/ajg.0000000000003235

Andre Jove, Christina Lin, Joo Ha Hwang, Vidhya Balasubramanian, Nielsen Q Fernandez-Becker, Robert J Huang

引用次数: 0

Abstract

Introduction: Autoimmune metaplastic atrophic gastritis (AMAG) is a precancerous condition that predisposes to gastric neuroendocrine tumors (gNETs). There exist no methods to stratify patients with AMAG for gNET risk.

Methods: We identified a cohort of patients with AMAG within a university health system using histopathologic and serologic criteria. We analyzed features predictive of prevalent gNET.

Results: We identified 181 patients with AMAG and 41 (22.7%) with prevalent gNET. Gastrin levels were elevated in gNET (1,859.8 vs 679.5 pg/mL, P < 0.001), and gastrin titers demonstrated good discrimination (c = 0.799, 95% CI 0.707-0.892) for gNET.

Discussion: Gastrin levels differ significantly between patients with AMAG with and without gNET.

查看原文本刊更多论文

血清胃泌素水平与自身免疫性变性萎缩性胃炎中流行的神经内分泌肿瘤有关。

背景/目的：自身免疫性变性萎缩性胃炎（AMAG）是一种癌前病变，容易诱发胃神经内分泌肿瘤（gNET）。目前还没有对 AMAG 患者进行 gNET 风险分层的方法：我们采用组织病理学和血清学标准，在一所大学的医疗系统内确定了一组 AMAG 患者。我们分析了预测 gNET 流行的特征：我们发现了 181 名 AMAG 患者，其中 41 人（22.7%）患有流行性 gNET。胃泌素水平在 gNET 中升高（1859.8 对 679.5 pg/mL，p结论：患有和未患有 gNET 的 AMAG 患者的胃泌素水平差异很大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.