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American Journal of Gastroenterology最新文献

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Guidelines in Practice: Focal Liver Lesions. 实践指南：肝脏病灶
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-21 DOI: 10.14309/ajg.0000000000003152
Rahul Sandella, Yael Wollstein, Anjana Pillai
{"title":"Guidelines in Practice: Focal Liver Lesions.","authors":"Rahul Sandella, Yael Wollstein, Anjana Pillai","doi":"10.14309/ajg.0000000000003152","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003152","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Incidence of thiopurine induced severe myelosuppression in a nationwide cohort of inflammatory bowel disease patients. 全国炎症性肠病患者队列中硫嘌呤诱发严重骨髓抑制的发生率。
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-18 DOI: 10.14309/ajg.0000000000003141
Nabeel Khan, Dhruvan Patel, Ramaswamy Sundararajan
{"title":"Incidence of thiopurine induced severe myelosuppression in a nationwide cohort of inflammatory bowel disease patients.","authors":"Nabeel Khan, Dhruvan Patel, Ramaswamy Sundararajan","doi":"10.14309/ajg.0000000000003141","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003141","url":null,"abstract":"<p><strong>Introduction: </strong>There is paucity of data on the incidence of severe thiopurine (TP)-induced myelosuppression (TIM) among inflammatory bowel disease (IBD) patients.</p><p><strong>Methods: </strong>Utilizing the Veterans Affairs Healthcare system we identified IBD patients with normal pre-treatment thiopurine S-methyltransferase(TPMT) levels who received TPs for 6 months and developed severe TIM.</p><p><strong>Results: </strong>Among 73,392 IBD patients, 14,760 had received TPs, and 2823 had a normal TPMT level. The incidence rate of severe TIM was 1.25 per 1000 patient-years.</p><p><strong>Discussion: </strong>The incidence of severe TIM was very low, calling into question the necessity of frequent long-term CBC monitoring among IBD patients on TPs.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Should We Rest on a Rest? A Well-Differentiated Neuroendocrine Tumor Arising From Pancreatic Heterotopia. 我们应该休息吗？胰腺异位症引起的分化良好的神经内分泌肿瘤
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-17 DOI: 10.14309/ajg.0000000000003139
Donna E Leet, Kwun Wah Wen, Abdul Kouanda
{"title":"Should We Rest on a Rest? A Well-Differentiated Neuroendocrine Tumor Arising From Pancreatic Heterotopia.","authors":"Donna E Leet, Kwun Wah Wen, Abdul Kouanda","doi":"10.14309/ajg.0000000000003139","DOIUrl":"10.14309/ajg.0000000000003139","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of P-CABs in GERD. P-CAB 在胃食管反流病中的作用。
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-17 DOI: 10.14309/ajg.0000000000003140
Colin W Howden
{"title":"The role of P-CABs in GERD.","authors":"Colin W Howden","doi":"10.14309/ajg.0000000000003140","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003140","url":null,"abstract":"<p><p>Potassium-competitive acid blockers (P-CABs) constitute a relatively new class of gastric acid-suppressing drugs. Among this class, vonoprazan is the first to have been approved in the United States. However, some P-CABs including vonoprazan, tegoprazan and fexuprazan have been available in other countries since at least 2014. The first aim of this article is to review pharmacological differences between P-CABs that are currently approved or in development with proton pump inhibitors (PPIs). The specific focus thereafter is on the likely role of P-CABs in the treatment of different manifestations of gastroesophageal reflux disease (GERD). Multiple clinical trials have compared P-CABs with PPIs in erosive esophagitis. Additional trials have compared P-CABs with placebo in non-erosive reflux disease. Relevant results are reviewed and inferences drawn for their use in the US. Lastly, consideration is given to additional, potential uses of P-CABs in the broader spectrum of GERD and some suggestions made for future research initiatives.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gastrointestinal Xanthomas and Ichthyosis: A Mild Phenotype of CHILD Syndrome (NSDHL Gene Mutation). 胃肠道黄瘤和鱼鳞病：CHILD 综合征（NSDHL 基因突变）的轻度表型。
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-17 DOI: 10.14309/ajg.0000000000003138
Do Han Kim, Michael Marble, Juan E Corral
{"title":"Gastrointestinal Xanthomas and Ichthyosis: A Mild Phenotype of CHILD Syndrome (NSDHL Gene Mutation).","authors":"Do Han Kim, Michael Marble, Juan E Corral","doi":"10.14309/ajg.0000000000003138","DOIUrl":"10.14309/ajg.0000000000003138","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical Therapies for Prevention and Treatment of Inflammatory Pouch Disorders-A Systematic Review and Meta-Analysis. 预防和治疗炎症性眼袋疾病的医学疗法 - 系统回顾和元分析。
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-16 DOI: 10.14309/ajg.0000000000003136
Gaurav Syal, Edward Barnes, Laura Raffals, Elie Al Kazzi, John Haydek, Manasi Agarwal, Siddharth Singh
{"title":"Medical Therapies for Prevention and Treatment of Inflammatory Pouch Disorders-A Systematic Review and Meta-Analysis.","authors":"Gaurav Syal, Edward Barnes, Laura Raffals, Elie Al Kazzi, John Haydek, Manasi Agarwal, Siddharth Singh","doi":"10.14309/ajg.0000000000003136","DOIUrl":"10.14309/ajg.0000000000003136","url":null,"abstract":"<p><strong>Introduction: </strong>Pouchitis and Crohn's-like disease of the pouch (CLDP) are common in patients who undergo ileal pouch anal anastomosis for ulcerative colitis. We conducted separate systematic reviews to evaluate the effectiveness of available interventions to prevent and treat pouchitis and CLDP.</p><p><strong>Methods: </strong>Through systematic literature reviews, we identified studies that evaluated the effectiveness of probiotics, antibiotics, 5-aminosalicylates, nonsystemic oral corticosteroids, and advanced therapies for prevention and treatment of pouchitis and CLDP for meta-analysis. Primary outcomes were occurrence of pouchitis for pouchitis prevention and clinical response for pouchitis and CLDP treatment. We estimated the relative effectiveness of these interventions using the existing placebo response rates or hypothetical spontaneous improvement rates derived from clinical trials of pouchitis, ulcerative colitis, and Crohn's disease.</p><p><strong>Results: </strong>Probiotics were effective for primary (relative risk [RR] 0.18; 95% confidence interval [CI] 0.05-0.62) and secondary prevention (RR 0.17; 95% CI 0.09-0.34) of pouchitis. Antibiotics were effective for treatment of acute and chronic pouchitis (12 cohorts; RR 1.67; 95% CI 1.34-2.01; response rate 65%; 95% CI 52-75) with ciprofloxacin and metronidazole-based regimens being more effective than rifaximin. Advanced therapies were effective for treatment of chronic antibiotic-refractory pouchitis (31 cohorts; RR 1.71; 95% CI 1.28-2.56; response rate 50%; 95% CI 43-57) and CLDP (10 cohorts; RR 2.49; 95% CI 1.87-3.73; response rate 74%; 95% CI 68-79) without significant difference between classes.</p><p><strong>Discussion: </strong>Multiple medical interventions are effective for prevention and treatment of pouchitis and CLDP. Given the overall low quality of data, further research is needed to confirm these findings.</p>","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to El-Dallal et al. 对 El-Dallal 等人的回应
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-15 DOI: 10.14309/ajg.0000000000003064
Thomas Ka-Luen Lui, Wai K Leung
{"title":"Response to El-Dallal et al.","authors":"Thomas Ka-Luen Lui, Wai K Leung","doi":"10.14309/ajg.0000000000003064","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003064","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Intrapancreatic Fat Deposition and Pancreatitis Research With Additional Considerations. 加强胰内脂肪沉积和胰腺炎研究的其他考虑因素
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-14 DOI: 10.14309/ajg.0000000000003095
Qing Zhou
{"title":"Enhancing Intrapancreatic Fat Deposition and Pancreatitis Research With Additional Considerations.","authors":"Qing Zhou","doi":"10.14309/ajg.0000000000003095","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003095","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Shiratori et al. 对 Shiratori 等人的回应
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-14 DOI: 10.14309/ajg.0000000000003097
Reinier G S Meester, Sidney J Winawer, Ann G Zauber
{"title":"Response to Shiratori et al.","authors":"Reinier G S Meester, Sidney J Winawer, Ann G Zauber","doi":"10.14309/ajg.0000000000003097","DOIUrl":"10.14309/ajg.0000000000003097","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing the Management of Alcohol-Related Liver Disease: Addressing Socioeconomic Disparities and the Role of Social Work in Intervention Strategies. 加强酒精相关肝病的管理：解决社会经济差异和社会工作在干预策略中的作用。
IF 8 1区 医学
American Journal of Gastroenterology Pub Date : 2024-10-14 DOI: 10.14309/ajg.0000000000003089
Zhangbing Zhou, Liu Wang, Yunfeng Chen
{"title":"Enhancing the Management of Alcohol-Related Liver Disease: Addressing Socioeconomic Disparities and the Role of Social Work in Intervention Strategies.","authors":"Zhangbing Zhou, Liu Wang, Yunfeng Chen","doi":"10.14309/ajg.0000000000003089","DOIUrl":"https://doi.org/10.14309/ajg.0000000000003089","url":null,"abstract":"","PeriodicalId":7608,"journal":{"name":"American Journal of Gastroenterology","volume":" ","pages":""},"PeriodicalIF":8.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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