北美地区22年来甲型肝炎相关急性肝衰竭的演变

IF 7.6 1区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

American Journal of Gastroenterology Pub Date : 2025-08-22 DOI:10.14309/ajg.0000000000003743

Usamah Chaudhary, Ahmad Anouti, Jody A Rule, William M Lee

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引用次数: 0

摘要

甲型肝炎病毒（HAV）是一种罕见的急性肝衰竭（ALF）的原因，它具有相对良好的康复预后。近年来，甲型肝炎病例总数有所下降，这可能是由于甲型肝炎疫苗接种率的提高。我们回顾了急性肝衰竭研究组24年来与甲型肝炎相关的ALF病例的数量。总的来说，登记的HAV - ALF病例数量急剧下降。2010年后，当我们开始记录急性肝损伤（ALI: INR≥2但无脑病）时，尽管几乎没有ALF病例，但我们注意到ALI发生率明显增加。

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Evolution of Hepatitis A-Related Acute Liver Failure in North America Over 22 years.

Introduction: Hepatitis A virus (HAV) is a rare cause of acute liver failure (ALF) that carries a relatively good prognosis for recovery. In recent years, overall numbers of HAV cases have declined, likely because of increased hepatitis A vaccination rates.

Methods and results: We reviewed the Acute Liver Failure Study Group registry for the number HAV-related ALF cases over 24 years.

Discussion: Overall, the number of HAV ALF cases enrolled steeply declined. After 2010, when we began recording acute liver injury (ALI: International normalized ratio ≥ 2 but no encephalopathy), an apparent increase in ALI incidence was noted, despite a near absence of ALF cases.

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来源期刊

American Journal of Gastroenterology 医学-胃肠肝病学

CiteScore

11.40

自引率

5.10%

发文量

458

审稿时长

12 months

期刊介绍： Published on behalf of the American College of Gastroenterology (ACG), The American Journal of Gastroenterology (AJG) stands as the foremost clinical journal in the fields of gastroenterology and hepatology. AJG offers practical and professional support to clinicians addressing the most prevalent gastroenterological disorders in patients.