A Zelman, M White, K Acker, T Neal, R Parsons, D Gisser
{"title":"A simple method for incorporating single pass dialysate delivery and controlled ultrafiltration with the RP-6 high flux dialyzer.","authors":"A Zelman, M White, K Acker, T Neal, R Parsons, D Gisser","doi":"10.3109/08860227909063942","DOIUrl":"https://doi.org/10.3109/08860227909063942","url":null,"abstract":"<p><p>A simple hemodialysis protocol has been developed to permit significant \"middle molecule\" clearance, yet retain normal low molecular weight clearance. The high flux RP-6 dialyzer has been combined with a single pass dialysate delivery system to provide accurate control of ultrafiltration without resorting to specialized or expensive equipment. By operating the RP-6 in the co-current mode, a simple valve on the dialysate output can be used to regulate ultrafiltration. At QB = 200 ml/min and QD = 500 ml/min, CU = 127 ml/min and CB12 = 56 ml/min at zero ultrafiltration rate; these values increase considerably with ultrafiltration. This protocol offers dialysis centers with standard equipment the opportunity to use high flux membranes in a routine manner.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 2-3","pages":"219-35"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11716261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Osmotic ultrafiltration with dextran sodium sulfate potential for use in peritoneal dialysis.","authors":"J Rubin, K Nolph, T McGary","doi":"10.3109/08860227909063944","DOIUrl":"https://doi.org/10.3109/08860227909063944","url":null,"abstract":"<p><p>Dextran sodium sulfate was evaluated in vitro as a potential non-absorbable osmotic agent for peritoneal dialysis. It was compared to poly(sodium acrylate) which has been shown previously to be effective in rats, but probably toxic. Dextran sodium sulfate induced osmotic ultrafiltration rates as high as 20 ml/min in water but only 2 ml/min in solution containing non-polymer electrolytes presumably because of Gibbs-Donnan effects. Compared to acrylate the dextran polymer has less sodium per gram, lower osmotic activity of polymer sodium, and yields less ultrafiltration at given transmembrane osmolalities. A non-toxic polymer more like acrylate would seem more promising as an osmotic agent for peritoneal dialysis.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 2-3","pages":"251-64"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063944","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11716263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T Ikeda, Y Hirasawa, Y Aizawa, A Shibata, F Gejyo, K Ei
{"title":"Effect of acetate upon arterial gases.","authors":"T Ikeda, Y Hirasawa, Y Aizawa, A Shibata, F Gejyo, K Ei","doi":"10.3109/08860227909063935","DOIUrl":"https://doi.org/10.3109/08860227909063935","url":null,"abstract":"<p><p>Following infusion of sodium acetate, a significant fall in arterial oxygen tension (PO2) was observed (p less than 0.001). A rise in PCO2 or bicarbonate was also statistically significant. pH was however remained unchanged. Though a rise in PCO2, bicarbonate, pH was observed following infusion of sodium bicarbonate, no significant fall in PO2 was observed. These results suggest a role of acetate ion for the fall of arterial oxygen tension; the hemodialysis-induced hypoxemia.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 2-3","pages":"135-41"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063935","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11264871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The binding of theophylline to serum proteins of hemodialysis patients.","authors":"M M Reidenberg, K Restivo","doi":"10.3109/08860227909063955","DOIUrl":"https://doi.org/10.3109/08860227909063955","url":null,"abstract":"<p><p>The binding of theophylline to serum proteins was studied by 18 hour equilibrium dialysis at 37 degrees C in serum from 10 chronic dialysis patients and 6 healthy subjects. The healthy subjects had a mean (+/- S.D.) unbound fraction of 54 +/- 5% while the dialysis patients had 63 +/- 5% unbound (p less than 0.02). For dialysis patients to achieve the same theophylline concentration in plasma water that metabolically normal asthmatics achieve at the \"therapeutic\" serum theophylline levels of 10-20 micrograms/ml, their total serum theophylline levels should be 8.6-17.3 micrograms/ml.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 4","pages":"375-81"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063955","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11478294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N T Ott, W Kohnle, R Scheck, P Konstantin, H E Franz
{"title":"Effect of hemoperfusion with coated and uncoated charcoal on human blood in vitro.","authors":"N T Ott, W Kohnle, R Scheck, P Konstantin, H E Franz","doi":"10.3109/08860227909063947","DOIUrl":"https://doi.org/10.3109/08860227909063947","url":null,"abstract":"<p><p>During 4 hours, in-vitro hemoperfusion of human blood was performed in 4 series of experiments: control, cellulose coated charcoal, polyacrylohydrogel coated charcoal and uncoated charcoal. In the control series little change on corpuscular elements and electrolytes was observed. In all hemoperfusion series there was little change of RBC and uniformly a marked fall of the granulocyte count. Platelet- and lymphocyte counts were significantly less affected by cellulose coated charcoal than by the other preparations. Coated and uncoated charcoal absorbed avidly calcium and glucose from the blood. By contrast the potassium level decreased moderately with polyacrylohydrogel coated and uncoated charcoal, whereas the opposite was observed with cellulose coated charcoal.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 4","pages":"291-308"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063947","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11478432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Zelman, P Whittam, W Edleman, J Angell, M White, D Gisser
{"title":"Standards for accurate in vitro characterization of dialyzers: test case the Vivacell.","authors":"A Zelman, P Whittam, W Edleman, J Angell, M White, D Gisser","doi":"10.3109/08860227909064909","DOIUrl":"https://doi.org/10.3109/08860227909064909","url":null,"abstract":"<p><p>A standard format is proposed for cataloging dialyzer transport data in order to improve communication and understanding of published results. The need for such a format is obvious from the ambiguity and lack of uniformity in published data. This report for in vitro characterization also describes an adequate experimental set-up for proper dialyzer characterization and an improved means for reporting uncertainty where curve fitting techniques are employed. The Vivacell dialyzer has been evaluated by these means as the first test case.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 1","pages":"11-25"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909064909","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11675088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Eosinophilia in maintenance hemodialysis patients.","authors":"W E Hoy, R V Cestero","doi":"10.3109/08860227909064913","DOIUrl":"https://doi.org/10.3109/08860227909064913","url":null,"abstract":"<p><p>Peripheral blood eosinophilia was noted in 38% of a group of maintenance hemodialysis patients, and documented by bone marrow examination. The prevalence of eosinophilia rose with increasing time on hemodialysis. In 3 subjects the phenomenon appeared to be related to dialysis equipment, but the relationship was less clear in the group as a whole. Severe hypersensitivity reactions during dialysis occurred in 2 patients with marked eosinophilia. Possible causes of sensitization in maintenance hemodialysis patients are discussed.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 1","pages":"73-87"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909064913","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11775614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A note on the representation of the performance of hemodialyzers.","authors":"M Ataka, H Osada","doi":"10.3109/08860227909063936","DOIUrl":"https://doi.org/10.3109/08860227909063936","url":null,"abstract":"<p><p>The performance of hemodialyzers was expressed schematically using three dimensionless quantities. Compared with the usual representation in which the dialysance is plotted against the blood flow rate for each of the solutes of interest, this expression is considered to have the following advantages: (1) the function of a dialyzer to remove different solutes can be expressed by a single curve, (2) the effect of changing the membrane area, its permeability, and the flow rates on the performance can easily be understood, and (3) the effect of changing the blood flow rate on the ratio of the transport efficiency of two or more kinds of solutes can be evaluated. An estimate of the overall mass transfer coefficient is the only procedure necessary to move from the usual to the present expression. These analyses were applied to the performance of a commercial hemodialyzer, and it was verified that this representation could denote its operation fairly well.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 2-3","pages":"143-51"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063936","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11716258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemodynamics during hemodialysis, sequential ultrafiltration and hemofiltration.","authors":"H Hampl, H Paeprer, V Unger, M W Kessel","doi":"10.3109/08860227909064912","DOIUrl":"https://doi.org/10.3109/08860227909064912","url":null,"abstract":"<p><p>Circulatory parameters were determined by cardiac catheterization in patients on maintenance hemodialysis. They were studied in three groups during conventional hemodialysis, sequential ultrafiltration and hemofiltration. All three groups revealed significant reduction of cardiac output, stroke volume, pulmonary artery pressure and plasma volume. In the hemodialysis group hemodynamic parameters were unstable; specifically, hypotension, increased heart rate, and only minimal increase of peripheral resistance were observed. The other two groups showed only minor changes in circulatory parameters despite high ultrafiltration rates. Blood pressure and heart rate remained stable. On the other hand, peripheral vascular resistance increased remarkably. There is compelling evidence that during hemofiltration and sequential ultrafiltration, the patient's ability for vasoconstrictive counterregulation is better maintained than during conventional hemodialysis.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 1","pages":"51-71"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909064912","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11589321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H Inamoto, Y Ino, M Jinnouchi, K Sata, T Wada, N Inamoto, A Osawa
{"title":"Dialyzing room disinfection with ultra-violet irradiation.","authors":"H Inamoto, Y Ino, M Jinnouchi, K Sata, T Wada, N Inamoto, A Osawa","doi":"10.3109/08860227909063940","DOIUrl":"https://doi.org/10.3109/08860227909063940","url":null,"abstract":"<p><p>Infections represent a major problem in dialysis treatment, thus the dialyzing room should be kept abacterial as possible. We have installed 15-watt ultra-violet (U-V.) lamps for every 13.5 m2 on the ceiling for the purpose of the room disinfection and used them for 16 hours nightly after working hours. Bacteria were killed with over 10 hours irradiation even at the areas of low U-V. intensity where the irradiation may not be direct. This unexpected effectiveness might be from the influence of reflected rays and 03 produced. When half the lamps were turned on, the bacteriocidal effect was not sufficient in some areas. Any living organism with nucleic acids must be inactivated by this treatment, for the baceteriocidal effect is due to the nucleic acids injury. Furthermore, safety, readiness after the treatment, easy application and the negligible costs would make this method more advantageous to the other methods in room disinfection.</p>","PeriodicalId":75998,"journal":{"name":"Journal of dialysis","volume":"3 2-3","pages":"191-205"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3109/08860227909063940","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11264872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}