American journal of perinatology最新文献

筛选
英文 中文
Risk Factors, Trends, and Outcomes Associated with Rural Delivery Hospitalizations Complicated by Hypertensive Disorders of Pregnancy.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-27 DOI: 10.1055/a-2547-4267
Mary M Carmack, Joel Agarwal, Timothy Wen, Yongmei Huang, Alexander M Friedman
{"title":"Risk Factors, Trends, and Outcomes Associated with Rural Delivery Hospitalizations Complicated by Hypertensive Disorders of Pregnancy.","authors":"Mary M Carmack, Joel Agarwal, Timothy Wen, Yongmei Huang, Alexander M Friedman","doi":"10.1055/a-2547-4267","DOIUrl":"10.1055/a-2547-4267","url":null,"abstract":"<p><p>Hypertensive disorders of pregnancy (HDP) may account for a considerable and growing clinical burden at rural hospitals which have been providing fewer obstetric services over the past two decades. The objectives of this analysis were to evaluate trends, risk factors, and outcomes associated with HDP during delivery hospitalizations at rural hospitals in the United States.The 2000 to 2020 National Inpatient Sample was used for this repeated-cross sectional analysis. Delivery hospitalizations at rural hospitals to women 15 to 54 years of age with and without HDP (including preeclampsia and gestational hypertension) were identified. Trends in HDP were characterized with joinpoint regression and estimated as the average annual percent change (AAPC) with 95% confidence intervals (CIs). The associations between (i) HDP risk factors and HDP and (ii) HDP and adverse maternal outcomes were estimated with adjusted logistic regression models.Among 8,885,683 deliveries that occurred at rural hospitals, the proportion with a HDP diagnosis increased significantly from 6.0% in 2000 to 11.1% in 2020 (AAPC: 3.1%; 95% CI: 2.8 and 3.4%). Preeclampsia with severe features (AAPC: 5.5%; 95% CI: 4.8 and 6.2%) and superimposed preeclampsia (AAPC: 6.5%; 95% CI: 5.6 and 7.5%) underwent the largest relative increases over the study period. Obesity, pregestational diabetes, chronic hypertension, multiple gestation, and chronic kidney disease were all associated with increased adjusted odds of HDP. HDP diagnoses were significantly associated with severe maternal morbidity (SMM), transfusion, stroke, and disseminated intravascular coagulation. The proportion of overall delivery SMM associated with HDP more than doubled from 11.3% in 2000 to 24.7% in 2020.Among delivery hospitalizations at rural hospitals, HDP, and associated risk factors increased significantly over the study period. Deliveries with HDP accounted for an increasing proportion of population-level SMM. HDP is a major, growing contributor to maternal risk and adverse outcomes during deliveries at rural hospitals. · Hypertensive disorders accounted for an increasing proportion of population-level severe morbidity.. · Hypertensive disorders increased among rural delivery hospitalizations.. · Risk factors associated with hypertensive disorders increased among rural delivery hospitalizations..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Infants Discharged from Birth Hospitalization with Gastrostomy versus Nasogastric Feeding Tube.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-27 DOI: 10.1055/a-2550-5510
Hartlee Lidsky, Emily Anderson, Neal A deJong, Adriana Herrera, Ashley G Sutton
{"title":"Comparison of Infants Discharged from Birth Hospitalization with Gastrostomy versus Nasogastric Feeding Tube.","authors":"Hartlee Lidsky, Emily Anderson, Neal A deJong, Adriana Herrera, Ashley G Sutton","doi":"10.1055/a-2550-5510","DOIUrl":"10.1055/a-2550-5510","url":null,"abstract":"<p><p>Many infants, particularly those born premature or with medical complexity, require supplemental enteral nutrition upon discharge from birth hospitalization. Recent literature supports the safety of discharging infants with nasogastric tube (NG) feeding. However, further evidence is needed to characterize populations suited for home NG feeding compared to gastrostomy tube (GT) placement. This study aimed to describe demographic and clinical differences between infants discharged from birth hospitalization with NG versus GT feeding.This retrospective cohort study included infants discharged from birth hospitalization with NG or GT feeding between April 2014 and December 2022 at a single quaternary care hospital with a neonatal intensive care unit (NICU). Routinely collected health data were used to investigate associations between patient characteristics and discharge feeding modality, as well as assess feeding outcomes 12 months after discharge.Of 346 infants, 72 (20.8%) were discharged with NG and 274 (79.2%) with GT. Infants with GT were more often discharged from the NICU (71.2 vs. 26.4%) with lower birth weights (median 2.40 vs. 2.92 kg) and longer hospitalizations (median 84 vs. 51.5 days). Twelve months after discharge, 77.4% of NG infants achieved full oral feeding compared to 16.6% of GT infants with earlier tube discontinuation in NG infants (19 vs. 236 days).Home NG feeding is a viable, less invasive alternative to GT for selected infants, particularly those with less medical complexity. Prospective studies are needed to further delineate optimal discharge feeding modalities for various infant subpopulations. · Infants discharged with gastrostomies had lower birth weights.. · More NG tube infants achieved oral feeding than gastrostomy infants.. · NG tubes were removed much sooner than GT.. · Home NG feeding is an alternative to gastrostomy for less medically complex infants..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early versus Late Brain Magnetic Resonance Imaging and Spectroscopy in Infants with Neonatal Encephalopathy following Therapeutic Hypothermia.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-27 DOI: 10.1055/a-2540-2956
Tatiana A Nuzum, Pradeep Mally, Elena V Wachtel
{"title":"Early versus Late Brain Magnetic Resonance Imaging and Spectroscopy in Infants with Neonatal Encephalopathy following Therapeutic Hypothermia.","authors":"Tatiana A Nuzum, Pradeep Mally, Elena V Wachtel","doi":"10.1055/a-2540-2956","DOIUrl":"https://doi.org/10.1055/a-2540-2956","url":null,"abstract":"<p><p>This study aimed to evaluate the utility of early and late magnetic resonance imaging (MRI) in infants with neonatal encephalopathy (NE) after therapeutic hypothermia (TH), and to determine the concordance between magnetic resonance spectroscopy (MRS) and early MRI findings.We conducted a retrospective, observational study including encephalopathic neonates born between 2017 and 2023 at two regional perinatal centers. All subjects underwent early diffusion-weighted MRI (DWI) with or without MRS (day: 4-5), and late conventional T1/T2-weighted MRI (day: 12-14). Both MRIs were assigned an injury severity score based on the National Institute of Child Health and Human Development (NICHD) neonatal research network (NRN) pattern of injury, reflecting the injury apparent on the MR modality obtained. MRS injury was defined as the presence of a lactate peak.The majority of the cohort (<i>n</i> = 98) was moderately encephalopathic (78%). Early and late MR imaging was performed at an average of 5.7 and 13.6 days, respectively. Fifteen percent of infants had evidence of hypoxic-ischemic (HI) injury on early imaging only, and 6% on late imaging only. Forty percent of infants exhibited a change in NICHD score severity between early and late MRI. Twenty-three infants (24%) were found to have a milder injury and 16 (16%) were found to have more severe injury on late imaging, when scores were compared with early imaging scores. The concordance of injury between early MRS and MRI was 62.5%. Among the cases of discordant MRI/MRS, MRS detected additional injury in 70% of cases, and MRI detected additional injury in 30% of cases.Both early and late imaging are important to fully define injury and provide accurate neurodevelopmental prognoses in cases of encephalopathic infants following TH. Failure to perform imaging at two intervals would have potentially resulted in missed diagnoses in 6 to 15% of cases and misestimation of injury in up to 40% of cases. · Early and late neuroimaging is important for accurate neurodevelopmental prognostication of encephalopathic neonates.. · The NICHD NRN MRI scoring system is a helpful tool for clinical practice.. · MR spectroscopy shows promise for HI injury but requires more validation..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143727446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mode of Delivery Outcomes of Induced versus Spontaneous Labor in Individuals with Dichorionic Twins.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-27 DOI: 10.1055/a-2547-4074
Manasa G Rao, Chelsea A DeBolt, Kelly Wang, Alexandra Mills, Sonia G Khurana, Isabelle Band, Elianna Kaplowitz, Andrei Rebarber, Nathan S Fox, Joanne Stone
{"title":"Mode of Delivery Outcomes of Induced versus Spontaneous Labor in Individuals with Dichorionic Twins.","authors":"Manasa G Rao, Chelsea A DeBolt, Kelly Wang, Alexandra Mills, Sonia G Khurana, Isabelle Band, Elianna Kaplowitz, Andrei Rebarber, Nathan S Fox, Joanne Stone","doi":"10.1055/a-2547-4074","DOIUrl":"10.1055/a-2547-4074","url":null,"abstract":"<p><p>This study aimed to investigate odds of vaginal delivery comparing induced versus spontaneous labor in nulliparas and multiparas with dichorionic twins.A retrospective review of dichorionic twin pregnancies from 2008 to 2021. Those with scheduled or elective cesarean, malpresentation, prior uterine surgery, fetal anomaly, gestational age (GA) at delivery <34 weeks, and multifetal reduction were excluded. Nulliparas and multiparas were analyzed separately. The primary outcome was vaginal delivery of both twins. Secondary outcomes included preterm delivery, postpartum hemorrhage, and hypertensive disorders of pregnancy (HDP). Outcomes were compared among induced versus spontaneous labor and assessed using univariable and multivariable logistic regression.Among 258 nulliparas, 176 (68.2%) were induced, and 82 (31.8%) spontaneously labored. Induced patients were older (<i>p</i> = 0.048), had a higher proportion of intrahepatic cholestasis of pregnancy (IHCP; <i>p</i> = 0.04), HDP (<i>p</i> < 0.0001), and later GA at delivery (<i>p</i> < 0.0001). Patients who spontaneously labored had a higher proportion of preterm delivery at <37 weeks (<i>p</i> < 0.0001) and a higher proportion of at least one twin admitted to the neonatal intensive care unit (<i>p</i> = 0.01). On univariable analysis, induction was associated with decreased likelihood of vaginal delivery of both twins (<i>p</i> = 0.01). However, after adjusting for augmentation, GA at delivery, gestational diabetes, and HDP/chronic hypertension, this was no longer statistically significant (<i>p</i> = 0.14). Among 239 multiparas, 108 (45.2%) were induced, and 131 (54.8%) spontaneously labored. Induced patients had a higher proportion of IHCP (<i>p</i> = 0.02), chronic hypertension (<i>p</i> = 0.02), HDP (<i>p</i> < 0.0001), and later GA at delivery (<i>p</i> < 0.0001). Spontaneous labor patients had higher proportion of preterm delivery at <37 weeks (<i>p</i> < 0.0001). There was no significant difference in odds of vaginal delivery between spontaneous versus induced labor on univariate (<i>p</i> = 0.74) or adjusted analysis after controlling for augmentation, GA at delivery, gestational diabetes and HDP/chronic hypertension (<i>p</i> = 0.40) among multiparas.Among nulliparas and multiparas with dichorionic twins, induction of labor does not appear to be associated with decreased odds of vaginal delivery. · Spontaneous labor patients had a higher proportion of preterm delivery <37 weeks.. · Induction of labor and spontaneous labor had similar odds of vaginal delivery.. · Induction of labor may be offered as a safe option in delivery counseling of DCDA twins..</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522407","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association of pre-pregnancy obesity versus excessive gestational weight gain with adverse neonatal outcomes in the United States.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-25 DOI: 10.1055/a-2565-1687
Rodney McLaren, Deepa Rastogi, Shantanu Rastogi
{"title":"Association of pre-pregnancy obesity versus excessive gestational weight gain with adverse neonatal outcomes in the United States.","authors":"Rodney McLaren, Deepa Rastogi, Shantanu Rastogi","doi":"10.1055/a-2565-1687","DOIUrl":"https://doi.org/10.1055/a-2565-1687","url":null,"abstract":"<p><strong>Objective: </strong>Pre-pregnancy obesity (PPO) and excessive gestational weight gain (eGWG) during pregnancy, both are associated with adverse neonatal outcomes. The objective of this study was to compare the independent associations of PPO and eGWG with adverse neonatal outcomes.</p><p><strong>Methods: </strong>This was a retrospective cohort study of singleton, live births in the United States in 2018 using National Vital Statistics System data. These were divided into four groups: 1) normal pre-pregnancy BMI and normal GWG, 2) normal pre-pregnancy BMI and eGWG, 3) pre-pregnancy BMI >30 kg/m2 (PPO) and normal GWG and 4) PPO and eGWG. The adverse neonatal outcomes, including preterm delivery, large for gestational age (LGA) infants, assisted neonatal ventilation, low 5-minute Apgar scores, neonatal intensive care unit (NICU) admissions, and surfactant use were studied. These outcomes were compared among groups using ANOVA and multivariable analyses.</p><p><strong>Results: </strong>Of the 1,477,062 births included, 21.8%, 41.6%, 10.4% and 26.3% were in Groups 1-4 respectively. With Group 1 as the reference group after correcting for significant factors, groups 2-4 had higher risk (aOR with 95% CI), for preterm delivery of <37 weeks 1.17 (1.14-1.20), 1.05 (1.02-1.09) and 1.14 (1.11-1.18) and for LGA infants 2.38 (2.31-2.44), 2.37 (2.29-2.45), 3.91 (3.80-4.02) in groups 2-4 respectively. Further, patients with PPO with and without eGWG also had increased risk of immediate assisted neonatal ventilation 1.07 (1.02-1.12) and 1.16 (1.12-1.218), for 5-minute Apgar score <3 1.40 (1.19-1.65), 1.38 (1.20-1.58), and for NICU admission in 1.04, (1.01-1.08), 1.12 (1.09-1.15) for Groups 3 and 4 respectively.</p><p><strong>Conclusion: </strong>Both PPO and eGWG were independently associated with preterm delivery and LGA infants. PPO with or without excessive GWG was also associated with low Apgar scores, more NICU admission and higher need for immediate ventilatory support. This data supports the importance of pre-pregnancy weight loss to prevent or decrease adverse neonatal outcomes.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improving Understanding of Macrosomia with a Graphics-Based Educational Tool: A Randomized Controlled Trial (MATE).
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-25 DOI: 10.1055/a-2565-1836
Kristen Cagino, Myra Kurjee, Emily Hyde, Han-Yang Chen, Hector Mendez-Figueroa, Suneet P Chauhan
{"title":"Improving Understanding of Macrosomia with a Graphics-Based Educational Tool: A Randomized Controlled Trial (MATE).","authors":"Kristen Cagino, Myra Kurjee, Emily Hyde, Han-Yang Chen, Hector Mendez-Figueroa, Suneet P Chauhan","doi":"10.1055/a-2565-1836","DOIUrl":"https://doi.org/10.1055/a-2565-1836","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to determine if a graphics-based education tool (GBET) leads to improved macrosomia knowledge on risk factors/complications (RF/C) and management options (MO) for macrosomia among pregnant individuals compared to routine care.</p><p><strong>Study design: </strong>We conducted a randomized control trial (NCTO6281301). Inclusion criteria were individuals at 18-55 years, with singleton pregnancy delivering at > 36 weeks. After consent, participants were randomized to either routine care or GBET. To assess knowledge of macrosomia, a questionnaire consisting of 17 questions relating to the RF/C (11 questions) and MO (6 questions) of suspected macrosomic fetuses was administered to participants one time either directly after consent (if routine care) or directly following review of GBET. The primary outcome was the overall score on the questionnaire. Secondary outcomes were summary scores on the RF/C and MO. Descriptive statistics were used for baseline characteristics and outcomes. Chi-squared test or Fisher's exact test was used to compare categorical variables and Student's t-test for continuous variables.</p><p><strong>Results: </strong>From January to July 2023, 232 eligible individuals were approached and 196 (84%) agreed to participate; of them, 98 received the GBET, while 98 received routine care. Baseline demographics were similar. The majority (42%) of respondents were non-Hispanic Black, 60% were employed, 56% had some level of college education, and 30% lived below the poverty line. There were 41% nulliparous, 67% with a BMI > 30 kg/m2 and 16% with diabetes. The primary outcome was significantly higher in those who received the GBET (70% versus 64%, p <0.001). The RF/C scores were also higher in the GBET group (72% versus 63%, p = 0.001); however, the MO scores were similar between groups (65% versus 68%, p=0.084).</p><p><strong>Conclusion: </strong>In our population, a graphics-based education tool improved participant knowledge on the risk factors / complications for macrosomia, but not their management options.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Universalizing Aspirin Prophylaxis on Treatment Provision for High-Risk Pregnant Patients.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-25 DOI: 10.1055/a-2565-9272
Adina Rachel Kern-Goldberger, Kirat Sandhu, Cara D Dolin, Antonio Bajan, Elizabeth Raiff, Justin R Lappen
{"title":"The Impact of Universalizing Aspirin Prophylaxis on Treatment Provision for High-Risk Pregnant Patients.","authors":"Adina Rachel Kern-Goldberger, Kirat Sandhu, Cara D Dolin, Antonio Bajan, Elizabeth Raiff, Justin R Lappen","doi":"10.1055/a-2565-9272","DOIUrl":"https://doi.org/10.1055/a-2565-9272","url":null,"abstract":"<p><p>Low-dose aspirin is an established preventive strategy for reducing risk of preeclampsia in patients with designated risk factors. This prospective observational study evaluated trends in aspirin prescription rates in a multi-hospital health system over a 10-month period during which a policy to offer low dose aspirin universally was instituted. 11,382 patients were included and interrupted time series was used to analyze rates of aspirin prescriptions ordered by 16w0d before and after implementation of the universal policy. There were statistically significant increases in aspirin prescription rates for the entire cohort (incidence rate ratio [IRR] of 2.93, 95% CI 2.13-4.04) and for a high-risk sub-cohort including patients with chronic hypertension, pre-gestational diabetes, and/or multiple gestation (IRR 1.48, 95% CI 1.26-1.76).</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut-Brain Axis in Preterm Infants with Surgical Necrotizing Enterocolitis.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-20 DOI: 10.1055/a-2563-0878
Parvesh Mohan Garg, Jeffrey Shenberger, Mckenzie Ostrander, Terrie Inder, Padma Parvesh Garg
{"title":"Gut-Brain Axis in Preterm Infants with Surgical Necrotizing Enterocolitis.","authors":"Parvesh Mohan Garg, Jeffrey Shenberger, Mckenzie Ostrander, Terrie Inder, Padma Parvesh Garg","doi":"10.1055/a-2563-0878","DOIUrl":"10.1055/a-2563-0878","url":null,"abstract":"<p><p>Necrotizing enterocolitis (NEC) affects 5-10% of very-low-birth-weight infants and remains a leading cause of mortality and long-term morbidity. Preterm infants with NEC, especially those requiring surgery, have higher inflammatory markers in the blood, severe white matter abnormalities on brain imaging, and adverse neurodevelopmental outcomes. This review presents current evidence regarding the clinical factors associated with brain injury in preterm infants with necrotizing enterocolitis needing surgical intervention. Studies that evaluate neuroprotective strategies to prevent brain injury are greatly needed to improve neurodevelopmental outcomes in high-risk preterm infants with NEC.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
FETAL TEI INDEX IN PREGNANCIES WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY: A CASE-CONTROL STUDY.
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-20 DOI: 10.1055/a-2555-3684
Manuel Guerra, Maria Haye, Ignacio Montaño, Victoria Toro, Nerea Maiz
{"title":"FETAL TEI INDEX IN PREGNANCIES WITH INTRAHEPATIC CHOLESTASIS OF PREGNANCY: A CASE-CONTROL STUDY.","authors":"Manuel Guerra, Maria Haye, Ignacio Montaño, Victoria Toro, Nerea Maiz","doi":"10.1055/a-2555-3684","DOIUrl":"10.1055/a-2555-3684","url":null,"abstract":"<p><strong>Objectives: </strong>First, to explore differences in fetal cardiac function in patients with and without intrahepatic cholestasis of pregnancy (ICP) based on the TEI index. Second, to explore a potential correlation between TEI index and bile acid levels in pregnant women with ICP. Thirdly, to study changes in the TEI index of fetuses from pregnant women with ICP after administration of ursodeoxycholic acid (UDCA).</p><p><strong>Methods: </strong>This is a prospective observational case-control study conducted at Hospital Clínico San José and Clínica RedSalud Vitacura, both in Santiago, Chile, between April 2018 and October 2020. ICP was defined as palmar-plantar pruritus of nocturnal predominance for more than one week associated with a total bile acid level above 10 μmol/L. Control cases were women with pregnancies scheduled for induction or elective cesarean section between 37 and 40 weeks of gestation according to current protocols. Differences in the TEI index between cases and controls were assessed by the Wilcoxon test. The correlation between the TEI index and bile acid levels was assessed by the Spearman correlation test. Changes in TEI index before and after administration of UDCA were analyzed by the paired samples Wilcoxon test.</p><p><strong>Results: </strong>One hundred and ten women with ICP and 72 controls were included in the Sstudy. Median gestational age at inclusion was 35.9 weeks. Median TEI index was 0.31 (IQR, 0.29-0.36),; this was significantly longer in fetuses of women with ICP ((0.34 vs 0.30, p<0.001). There was a significant correlation between bile acid levels and TEI index (0.584, p<0.001). In 21 fetuses the median TEI index decreased significantly following UDCA administration ((0.40 ms before treatment vs 0.33 after treatment, p=0.001).</p><p><strong>Conclusions: </strong>The TEI index is increased in fetuses of women with ICP. TEI index was significantly correlated with bile acid levels, and administration of UDCA significantly reduced the TEI index.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Sound of Comfort - Neonatal Healthcare Professionals' Perspectives on Music and Other Comfort Measures during Targeted Neonatal Echocardiography. 舒适之音--新生儿医护人员对新生儿超声心动图检查过程中音乐和其他舒适措施的看法。
IF 1.5 4区 医学
American journal of perinatology Pub Date : 2025-03-20 DOI: 10.1055/a-2562-1538
Joshua Hazan Mea, Daniela Villegas Martinez, Stephanie Mardakis, Elissa Remmer, Tíscar Cavallé-Garrido, Gabriel Altit
{"title":"The Sound of Comfort - Neonatal Healthcare Professionals' Perspectives on Music and Other Comfort Measures during Targeted Neonatal Echocardiography.","authors":"Joshua Hazan Mea, Daniela Villegas Martinez, Stephanie Mardakis, Elissa Remmer, Tíscar Cavallé-Garrido, Gabriel Altit","doi":"10.1055/a-2562-1538","DOIUrl":"10.1055/a-2562-1538","url":null,"abstract":"<p><strong>Objective: </strong>Assess healthcare professionals' perspectives on how implemented measures impact patient comfort during targeted neonatal echocardiography (TNE).</p><p><strong>Study design: </strong>Survey distributed to neonatal healthcare professionals at the Montreal Children's Hospital NICU. Responses were collected for four weeks, anonymized and analyzed using descriptive statistics.</p><p><strong>Results: </strong>Of 110 respondents, most believed that scans in general disturbed infants (71%) by increasing the risk of hypothermia (75%) and lability (67%). Key comfort measures identified were warm gel (85%), bundling (80%), and a focused exam (<30 minutes) (80%). Neoclassical music recordings were valued for their calming effect on the infant (73%), parent (44%), and sonographer (39%). Respondents preferred recorded music over other forms of music delivery (53%).</p><p><strong>Conclusion: </strong>Healthcare workers generally agree that scans disturb newborns and that implementing comfort measures, such as music and the cost-efficient bundle used in our NICU, may enhance patient comfort. Further objective studies are needed to validate these findings and assess their impact on neonatal care outcomes Keywords: music, targeted neonatal echocardiography, ultrasound, comfort, neonatology.</p>","PeriodicalId":7584,"journal":{"name":"American journal of perinatology","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信