Impact of Cannabis Legalization on Umbilical Cord Tetrahydrocannabinol (THC) Levels.

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2024-11-21 DOI:10.1055/a-2480-3163

Kimberly Spence, Sarah Milota, Paula Buchanan, Nirja Acharya, Amit Mathur

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引用次数: 0

Abstract

Title: Impact of Cannabis Legalization on Umbilical Cord Tissue Tetrahydrocannabinol (THC) levels Objective: To assess the impact of cannabis legalization on both qualitative and quantitative umbilical cord tissue tetrahydrocannabinol (THC) rates and concentrations as a proxy for fetal exposure.

Study design: This is a retrospective, observational study of umbilical cord tissue THC levels in a single center, comparing THC exposure rates and concentration levels before and after cannabis legalization in the state of Illinois, Epoch 1 (October 1,2018-June 30, 2019, pre-legalization) and Epoch 2 (July 1, 2019-August 31, 2021, post-legalization).

Results: 811 umbilical cords were analyzed during epoch 1 and 2170 during epoch 2. A higher percent of umbilical cord tissue tested positive for THC in Epoch 2 compared to Epoch 1 (46.2% vs. 40.6%; p<0.01). Mean THC levels were 51% higher in umbilical cord tissue in Epoch 2 vs. Epoch 1 (6.2ng/gm vs 4.1 ng/gm; p<0.001).

Conclusions: Legalization of recreational cannabis was associated with more fetuses exposed to THC and in higher concentrations.

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大麻合法化对脐带四氢大麻酚（THC）水平的影响。

标题：大麻合法化对脐带组织四氢大麻酚（THC）水平的影响大麻合法化对脐带组织四氢大麻酚（THC）水平的影响 Objective：评估大麻合法化对作为胎儿暴露替代物的脐带组织四氢大麻酚（THC）定性和定量比率和浓度的影响：这是一项在单一中心进行的脐带组织四氢大麻酚水平的回顾性观察研究，比较了伊利诺伊州大麻合法化前后的四氢大麻酚暴露率和浓度水平，第一纪元（2018 年 10 月 1 日至 2019 年 6 月 30 日，合法化前）和第二纪元（2019 年 7 月 1 日至 2021 年 8 月 31 日，合法化后）：第一纪元分析了 811 条脐带，第二纪元分析了 2170 条脐带。与纪元 1 相比，纪元 2 中四氢大麻酚检测呈阳性的脐带组织比例更高（46.2% 对 40.6%；p）：娱乐性大麻合法化与更多胎儿暴露于更高浓度的四氢大麻酚有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.