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IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

American journal of perinatology Pub Date : 2024-12-24 DOI:10.1055/a-2480-5329

Mullapudi V Surekha, Gargi Meur, Nadimpalli Suneetha, Nagalla Balakrishna, Putcha U Kumar, Bhukya Tulja, K Suryam Reddy, Ahmed Ibrahim, Pratha Sunitha

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引用次数: 0

摘要

目的：有关冠状病毒病 2019（COVID-19）对孕妇及其新生儿的影响，特别是对其微量营养素状态、脂肪酸（FA）和炎症状态的影响的研究很少。我们假设 COVID-19 感染会对母亲通过脐带向胎儿输送营养物质和脂肪酸以及炎症细胞的母胎分布产生不利影响。本研究旨在确定 COVID-19 对孕妇及其新生儿脐带血中的微量营养素、炎症标志物和脂肪酸的影响：这是一项横断面研究，研究对象是212名怀孕三个月的孕产妇及其新生儿，这些孕产妇是在接受严重急性呼吸系统综合征冠状病毒2（SARS-CoV-2）血清检验后被招募的。在新生儿出生时收集母亲的外周血和脐带血，并分析维生素 B12（Vit B12）、叶酸、25(OH)D3、FAs 和外周血单核细胞。统计显著性采用学生 t 检验或方差分析（ANOVA）。非正态分布数据采用 Mann-Whitney U 检验和 Kruskal-Wallis 检验，比例比较采用卡方检验：结果：COVID-19血清反应呈阳性的母亲体内维生素B12水平明显偏低，肾上腺素水平明显偏高，而血清反应呈阳性的脐带血中25（OH）D3水平明显偏低。无论 COVID-19 血清状态如何，脐带血中叶酸、维生素 B12 和饱和脂肪酸水平都明显偏高，这表明它们从母亲向胎儿的转移增加。然而，脐带血中单不饱和脂肪酸（MUFA）和多不饱和脂肪酸（PUFA）的含量明显较低。无论 COVID-19 血清状态如何，脐带血中的 CD4+ T 辅助细胞（占淋巴细胞的百分比）都明显高于母血，而脐带血中的 NK 细胞、NK-T 细胞和 CD8+ T 淋巴细胞（占淋巴细胞的百分比）则明显低于母血：结果表明，虽然COVID-19不会阻碍MUFA和PUFA等必需营养素从母体向胎儿的转移，也不会影响母胎免疫细胞反应，但它似乎会影响维生素B12、维生素D和肾上腺酸的水平：- COVID-19不会阻碍必需脂肪酸通过脐带血的转移。- COVID-19影响母胎免疫反应- COVID-19影响维生素B12、维生素D和肾上腺素水平

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COVID-19 Serostatus Does Not Affect the Intrauterine Transfer of Micronutrients and Fatty Acids or Maternal-fetal Lymphocyte Cell Composition: An Observational Study.

Objective: Studies on the effects of coronavirus disease 2019 (COVID-19) on pregnant mothers and their newborns, specifically in relation to their micronutrient status, fatty acids (FAs), and inflammatory status are sparse. We hypothesized that COVID-19 infection would adversely affect the transfer of nutrients, and FAs from mothers to their fetuses via the umbilical cord and maternal-fetal distribution of inflammatory cells. This study aimed to determine the effect of COVID-19 on micronutrients, inflammatory markers, and FAs profiles in pregnant mothers and their newborns' cord blood.

Study design: This was a cross-sectional study of 212 pregnant mothers in the third trimester and their newborns, recruited after testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) serostatus. Peripheral blood of mothers and cord blood were collected at birth and analyzed for vitamin B12 (Vit B12), folic acid, 25(OH)D3, FAs, and peripheral blood mononuclear cells. Student's t-test or analysis of variance (ANOVA) was used to express statistical significance. Non-normal data were tested using the Mann-Whitney U test and Kruskal-Wallis test, with proportions compared with the chi-square test.

Results: Vit B12 levels were significantly low and adrenic acid levels significantly high in COVID-19 seropositive mothers while 25(OH)D3 was significantly low in seropositive cord blood. Irrespective of COVID-19 serostatus, folate, vit B12, saturated FA levels were significantly high in cord blood indicating their increased transfer from mothers to the fetus. However, monounsaturated (MUFA) and polyunsaturated fatty acid (PUFA) levels were significantly lower in cord blood. Irrespective of COVID-19 serostatus, CD4⁺ T helper cells (percentage of lymphocytes) were significantly higher in cord blood, while NK cells, NK-T cells, and CD8⁺ T-cytotoxic cells-percentage of lymphocytes-were significantly lower in cord blood when compared with corresponding mother's blood.

Conclusion: The results indicate that while COVID-19 did not impede the transfer of essential nutrients such as MUFA and PUFA from mother to fetus, or affect maternal-fetal immune cell responses, it did appear to affect the levels of vit B12, vitamin D, and adrenic acid.

Key points: · COVID-19 did not impede essential fatty acids transfer through cord blood.. · COVID-19 affected maternal-fetal immune responses.. · COVID-19 affected vitB12, vitamin D and adrenic acid levels..

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来源期刊

American journal of perinatology 医学-妇产科学

CiteScore

5.90

自引率

0.00%

发文量

302

审稿时长

4-8 weeks

期刊介绍： The American Journal of Perinatology is an international, peer-reviewed, and indexed journal publishing 14 issues a year dealing with original research and topical reviews. It is the definitive forum for specialists in obstetrics, neonatology, perinatology, and maternal/fetal medicine, with emphasis on bridging the different fields. The focus is primarily on clinical and translational research, clinical and technical advances in diagnosis, monitoring, and treatment as well as evidence-based reviews. Topics of interest include epidemiology, diagnosis, prevention, and management of maternal, fetal, and neonatal diseases. Manuscripts on new technology, NICU set-ups, and nursing topics are published to provide a broad survey of important issues in this field. All articles undergo rigorous peer review, with web-based submission, expedited turn-around, and availability of electronic publication. The American Journal of Perinatology is accompanied by AJP Reports - an Open Access journal for case reports in neonatology and maternal/fetal medicine.