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Contents of Volume 25 第25卷内容
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80010-X
{"title":"Contents of Volume 25","authors":"","doi":"10.1016/S0014-4908(80)80010-X","DOIUrl":"https://doi.org/10.1016/S0014-4908(80)80010-X","url":null,"abstract":"","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 9","pages":"Pages III-V"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80010-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136402740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of combined phenylbutazone and ethanol administration on rat liver 苯丁酮与乙醇联合给药对大鼠肝脏的影响
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80004-4
M. Beskid, J. Białek, J. Dzieniszewski, J. Sadowski, J. Tlałka
{"title":"Effect of combined phenylbutazone and ethanol administration on rat liver","authors":"M. Beskid,&nbsp;J. Białek,&nbsp;J. Dzieniszewski,&nbsp;J. Sadowski,&nbsp;J. Tlałka","doi":"10.1016/S0014-4908(80)80004-4","DOIUrl":"10.1016/S0014-4908(80)80004-4","url":null,"abstract":"<div><p>The effect of combined administration of phenylbutazone and ethanol on rat liver was studied by electron microscopy. The results of the experiments revealed strong hepatotoxic action of phenylbutazone combined with ethanol. Feeding with ethanol alone induces slight alterations in the liver, phenylbutazone alone affects the liver but slightly, whereas combined administration of phenylbutazone and ethanol revealed a strong toxic action leading to severe damage of the liver cells including focal necrosis.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 9","pages":"Pages 487-491"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80004-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55384132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 18
Macrophage electrophoretic mobility (MEM) test in immunodiagnostics of Papio hamadryas malignant lymphomas 巨噬细胞电泳迁移率(MEM)试验在乳头状瘤恶性淋巴瘤免疫诊断中的应用
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80006-8
L.V. Indzhiia , L.A. Yakovleva , B.A. Lapin (Director: Prof. Dr.) , T.N. Tsaturyan , M. Malkowsky , J. Bubenik
{"title":"Macrophage electrophoretic mobility (MEM) test in immunodiagnostics of Papio hamadryas malignant lymphomas","authors":"L.V. Indzhiia ,&nbsp;L.A. Yakovleva ,&nbsp;B.A. Lapin (Director: Prof. Dr.) ,&nbsp;T.N. Tsaturyan ,&nbsp;M. Malkowsky ,&nbsp;J. Bubenik","doi":"10.1016/S0014-4908(80)80006-8","DOIUrl":"10.1016/S0014-4908(80)80006-8","url":null,"abstract":"<div><p>Reactivity of lymphocytes from <em>P. hamadryas</em> monkeys carrying malignant lymphomas directed against soluble antigens from allogeneic lymphomas was investigated using macrophage electrophoretic mobility (MEM) test. Twenty-three monkeys have been examined. 14 of them carried malignant lymphoma including those with initial manifestations of malignant lymphoma, animals with generalized processes and those in the period of spontaneous remission, and 9 control animals (8 healthy baboons and one animal with hepatoma). The macrophage electrophoretic mobility reduction higher than 10% was considered as positive. Positive reaction was observed in 78% of monkeys with malignant lymphoma. The MEM-test was positive already in the initial stage of the disease and remained positive in the period of spontaneous remission.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 9","pages":"Pages 496-501"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80006-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55384161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural and biochemical studies of the brain and other organs in rats after chronic ethanol administration 慢性乙醇给药后大鼠脑及其他脏器超微结构及生化研究
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80061-5
H. Karwacka
{"title":"Ultrastructural and biochemical studies of the brain and other organs in rats after chronic ethanol administration","authors":"H. Karwacka","doi":"10.1016/S0014-4908(80)80061-5","DOIUrl":"10.1016/S0014-4908(80)80061-5","url":null,"abstract":"<div><p>The aim in view was to establish whether chronic administration of ethanol causes ultrastructura changes in the brain of rats, particularly in the structures through which alcohol penetrates to the brain, that is the cerebral cortex capillaries. The experiments were performed with 5 Wistar rats, three of which received ethanol according to <span>Ratcliffe</span>'s model for 8 weeks in increasing concentrations from 2.5 to 25 per cent. Two rats served as control. In the endothelium of some capillaries of the brain cortex in the rats ingesting ethanol an enlargement of the cell nuclei was observed.</p><p>The number of mitochondria in the cytoplasm and of micropinocytic vesicles was found to increase, and proliferation of the smooth endoplasmic reticulum and Golgi system were noted. Considerable oedema was observed in the astrocytic processes surrounding the vessels, with the presence of numerous mitochondria of abnormal shape and huge size. Oedema of perivascular astrocytic processes and enhanced pinocytosis seem to indicate an increased permeability of the blood-brain barrier as the result of the toxic effect of ethanol.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 2","pages":"Pages 118-126"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80061-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18392320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
The effect of methylnitrosourea intoxication on the fatty acid pattern of myelin lipids 甲基亚硝基脲中毒对髓磷脂脂肪酸模式的影响
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80046-9
M. Wender, Z. Adamczewska-Goncerzewicz, S. Żórawski
{"title":"The effect of methylnitrosourea intoxication on the fatty acid pattern of myelin lipids","authors":"M. Wender,&nbsp;Z. Adamczewska-Goncerzewicz,&nbsp;S. Żórawski","doi":"10.1016/S0014-4908(80)80046-9","DOIUrl":"10.1016/S0014-4908(80)80046-9","url":null,"abstract":"<div><p>The effect of intravenous administration of methylnitrosourea (MNU), 60 mg/kg body weight to adult BD IX rats for 6 consecutive days, on the fatty acid composition of myelin lipids has been examined.</p><p>The results of our investigations show that the fatty acid spectrum of all myelin lipid components was significantly altered after MNU treatment.</p><p>The comparison of the fatty acid composition of the myelin phospholipids and the cholesterol esters formed MNU intoxication did not speak in favour of the hypothesis that enhanced lipolysis and thus the fatty acids liberated mainly from phospholipids are responsible for the increased esterification of cholesterol observed in toxic myelinopathies. It rather confirms the thesis that enhanced esterification of cholesterol is one of the early, independent events occurring in the lipid layer of the myelin sheath in the course of demyelination.</p><p>The observed changes in the fatty acyl spectrum of various myelin lipids may weaken the stability of the myelin lipid layer, and thus constitute another factor in the pathomechanism of toxic myelinopathies.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 7","pages":"Pages 444-455"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80046-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18448446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ultrastructural morphometric studies of mitochondrial membranes in the rat heart after physical training 体育训练后大鼠心脏线粒体膜超微结构形态学研究
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80009-3
H. Guski, G. Wassilew, R. Meyer
{"title":"Ultrastructural morphometric studies of mitochondrial membranes in the rat heart after physical training","authors":"H. Guski,&nbsp;G. Wassilew,&nbsp;R. Meyer","doi":"10.1016/S0014-4908(80)80009-3","DOIUrl":"10.1016/S0014-4908(80)80009-3","url":null,"abstract":"<div><p>Myocardial mitochondria of the left ventricle of 16 adult, 6-month-old, male Wistar rats, 11 of which were trained animals which had undergone different periods of swimming (45, 180, 360 hours) of different load(½ up to a maximum of 5 hours per day) and 5 of which were coeval untrained controls, were subjected to a morphometric analysis. No significant differences were observed in the volume and surface density of the mitochondrial cristae between the former and the latter animals. This result is attributed to the dilution effect as a result of an increase in the proportion of the volume of the mitochondria. For this reason only the “specific” surface values in relation to the mitochondrial volume can be regarded as representative parameters for assessing the surface capacity of the inner membranes as a structural equivalent of mitochondrial metabolism. The specific volume and surface density of the mitochondrial cristae increases by 101% and 25% respectively after 45 hours of training. Given a uniform training load, the changes recede as a sign of the completed adaptation of the mitochondria. The surface of mitochondrial cristae per unit myofibrillar volume (cristae/myofibrils ratio) is statistically unchanged during 45–180 hours of exercise indicating a proportional increase of ATP-synthesizing structures in the hypertrophied heart. The significant reduction in respiratory membrane capacity after 360 hours of intensive physical load is interpreted as an effect of overadaptation.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 9","pages":"Pages 510-519"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80009-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55384197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Action of chronic peracetic acid (Wofasteril®) administration on the rabbit oral mucosa 慢性过氧乙酸(Wofasteril®)对家兔口腔黏膜的作用
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80074-3
P. Müller, G. Raabe, D. Schumann, E. Müller, L. Schwabe
{"title":"Action of chronic peracetic acid (Wofasteril®) administration on the rabbit oral mucosa","authors":"P. Müller,&nbsp;G. Raabe,&nbsp;D. Schumann,&nbsp;E. Müller,&nbsp;L. Schwabe","doi":"10.1016/S0014-4908(80)80074-3","DOIUrl":"10.1016/S0014-4908(80)80074-3","url":null,"abstract":"<div><p>Peracetic acid Wofasteril®) is increasingly made use of as a disinfecting fluid. Because of its high effectiveness it has found widespread use in medical practice.</p><p>The action of Wofasteril® on the oral mucosa during long-term action is studied by aid of an “oral tank”. After a test period of 11 months peracetic acid only caused a slight ballooning of the superficial layers and enhanced vascularization of the submucous tissue. The results of the experiment suggest the intraoral administration of peracetic acid in oral surgery and stomatology.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 1","pages":"Pages 80-84"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80074-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18392319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Quantitative data on the secretory granules in the normal mouse endocrine panreas 正常小鼠内分泌胰腺分泌颗粒的定量研究
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80059-7
R. Lorentzon, L. Boquist
{"title":"Quantitative data on the secretory granules in the normal mouse endocrine panreas","authors":"R. Lorentzon,&nbsp;L. Boquist","doi":"10.1016/S0014-4908(80)80059-7","DOIUrl":"10.1016/S0014-4908(80)80059-7","url":null,"abstract":"<div><p>In order to obtain basic information on different morphometrical parameters a semi-automatic image-analysis of the secretory granules of the B-, A-, D- and PP-cells of the normal adult mouse endocrine pancreas was carried out. The following results were obtained: Cross sectional area of whole secretory granules: A &gt; B &gt; D &gt; PP; cross sectional area of secretory granule cores: A &gt; B; ratio of cross sectional area of whole secretory granules to secretory granule cores: 2.35 for B-cells and 1.74 for A-cells; maximum diameter of whole secretory granules: A &gt; B &gt; D &gt; PP; maximum diameter of secretory granule cores A &gt; B; form factor for whole secretory granules: A &gt; B &gt; D and PP; form factor for secretory granule cores: A &gt; B. The findings show that the secretory granules of the parenchymal cells of the normal adult mouse endocrine pancreas differ from each other with respect to the size and form of both whole granules and cores.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 2","pages":"Pages 111-113"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80059-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18040809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Induction of extra-thymic lymphatic leukemias in nude mice by means of administration of N-methyl-N-nitrosourea (MNU) n -甲基-n -亚硝基脲(MNU)诱导裸鼠胸腺外淋巴白血病的研究
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80023-8
W. Arnold, H. Naundorf, F. Fey
{"title":"Induction of extra-thymic lymphatic leukemias in nude mice by means of administration of N-methyl-N-nitrosourea (MNU)","authors":"W. Arnold,&nbsp;H. Naundorf,&nbsp;F. Fey","doi":"10.1016/S0014-4908(80)80023-8","DOIUrl":"10.1016/S0014-4908(80)80023-8","url":null,"abstract":"<div><p>Experiments concerning the chemical leukemogenesis in nude mice were performed. Following administration of N-methyl-N-nitrosourea (MNU) 4 out of 11 nude mice developed extra-thymic lymphatic leukemias. The findings are demonstrated by means of histological and histochemical methods. The successful cellular transplantation of an induced lymphatic leukemia is reported.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 6","pages":"Pages 336-340"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80023-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18428333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of brain fraction with fibroblast growth factor activity on regeneration and differentiation of articular cartilage 具有成纤维细胞生长因子活性的脑组织对关节软骨再生分化的影响
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80033-0
G. Wellmitz , E. Petzold , K.D. Jentzsch , G. Heder , P. Buntrock
{"title":"The effect of brain fraction with fibroblast growth factor activity on regeneration and differentiation of articular cartilage","authors":"G. Wellmitz ,&nbsp;E. Petzold ,&nbsp;K.D. Jentzsch ,&nbsp;G. Heder ,&nbsp;P. Buntrock","doi":"10.1016/S0014-4908(80)80033-0","DOIUrl":"10.1016/S0014-4908(80)80033-0","url":null,"abstract":"<div><p>From bovine brains a fraction with fibroblast growth factor activity was prepared according to the method given by <span>Gospodarowicz</span> et al. (1978) and tested regarding to its biological effectiveness on articular cartilage regeneration in rabbits the cartilage in one knee-joint of those had been injured in a defined manner. The intraarticular administration of the brain fraction supported the healing process of the intrachondral lesions by conspicuously increasing the chondrocyte proliferation starting from preexisting cartilage tissue. In the case of subchondral lesions the neodifferentiation of chondrocytes out of the simple connective tissue that primarily filled the defect was promoted significantly.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 5","pages":"Pages 282-287"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80033-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18419728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 15
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