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Experimentelle Pathologie最新文献

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The influence of nicotinamide on microsomal drug-metabolizing activity in vitro 烟酰胺对体外微粒体药物代谢活性的影响
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2012-01-23 DOI: 10.1016/S0014-4908(79)80066-6
D. Müller, W. Klinger (Head: Prof. Dr. sc. med.)
{"title":"The influence of nicotinamide on microsomal drug-metabolizing activity in vitro","authors":"D. Müller, W. Klinger (Head: Prof. Dr. sc. med.)","doi":"10.1016/S0014-4908(79)80066-6","DOIUrl":"10.1016/S0014-4908(79)80066-6","url":null,"abstract":"","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 7","pages":"Pages 474-478"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80066-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11377939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Characteristic chromosome markers and regularity of karyotype changes of continuous hematopoietic cell lines established from monkeys with malignant lymphoma. — Report IV 猴恶性淋巴瘤连续造血细胞系染色体特征标记及核型变化规律。-报告四
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80034-4
D.S. Markaryan, I.A. Gvaramija, V.Z. Agrba, V.A. Vasiljeva, I.A. Sangulija, V.V. Timanovskaja
{"title":"Characteristic chromosome markers and regularity of karyotype changes of continuous hematopoietic cell lines established from monkeys with malignant lymphoma. — Report IV","authors":"D.S. Markaryan,&nbsp;I.A. Gvaramija,&nbsp;V.Z. Agrba,&nbsp;V.A. Vasiljeva,&nbsp;I.A. Sangulija,&nbsp;V.V. Timanovskaja","doi":"10.1016/S0014-4908(79)80034-4","DOIUrl":"10.1016/S0014-4908(79)80034-4","url":null,"abstract":"<div><p>The dynamic karyotype studies of SU-1, SU-2, KMMA-2 (produce C-type oncorna virus) lines and KMPG-1, SPG-2 and SPG-3 (produce HYP) lines have been carried out. The lines have been established from hematopoietic cells of <em>Macaca arctoides</em> and <em>Papio hamadryas</em> monkeys with malignant lymphomas.</p><p>Some lines had peridiploid-pseudodiploid karyotype and the other ones were aneuploid. Selectivity of structural and numerical disturbances of chromosomes 1, 9, 10, 12, 13, 15, 17, 18, 20 has been revealed, which points out to a certain specificity of the karyotype changes in malignization and transformation. The number of chromosomes more or less being differentiated in aneuploidization was subjected to more changeability as compared with chromosomes being well differentiated. It has not yet been possible to observe some kind of parallelism between the character of karyotype changes and the virus being produced (C-type or HVP).</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 2","pages":"Pages 100-109"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80034-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11436204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on a new acute phase protein 一种新的急性期蛋白的研究
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80050-2
K. Thoss
{"title":"Studies on a new acute phase protein","authors":"K. Thoss","doi":"10.1016/S0014-4908(79)80050-2","DOIUrl":"10.1016/S0014-4908(79)80050-2","url":null,"abstract":"<div><p>Antisera against polymorphonuclear leukocytes of the rat and against an extract ot these cells heated at 100°C for 1 hr were produced in rabbits. By use of indirect fluorescent antibody technique both immune sera stained neutrophils of the rat. In double diffusion and immunoelectrophoresis the antisera reacted with the heated extract of granulocytes. The antisera exhibited a cross-reactivity with granulocytes of other species. The results indicate that the neutrophils of the rat contain a thermostable antigen. Using immunodiffusion the antigen is demonstrable in sera of rats with inflammatory diseases.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 6","pages":"Pages 347-353"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80050-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11337889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mononuclear cell infiltration of the aortic intima in domestic swine 家猪主动脉内膜单核细胞浸润
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80035-6
J. Massmann
{"title":"Mononuclear cell infiltration of the aortic intima in domestic swine","authors":"J. Massmann","doi":"10.1016/S0014-4908(79)80035-6","DOIUrl":"10.1016/S0014-4908(79)80035-6","url":null,"abstract":"<div><p>The preparation of thick endothelial “Häutchen” from microscopically lipid-free areas of the thoracic and abdominal aorta of 22 domestic pigs proved that there is a surprisingly frequent penetration of mononuclear blood cells into the subendothelial space. They are deposited on the intima in a diffuse or focal distribution as dense epi-, inter- and subendothelial cell infiltrates.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 2","pages":"Pages 110-112"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80035-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11651864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
Cytogenetic properties of Chinese hamster V79-E cells: G-banding, C-banding, nucleolar organizer regions, and sister chromatid exchanges 中国仓鼠V79-E细胞的细胞遗传学特性:g带、c带、核仁组织区和姐妹染色单体交换
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80033-2
R. Thust
{"title":"Cytogenetic properties of Chinese hamster V79-E cells: G-banding, C-banding, nucleolar organizer regions, and sister chromatid exchanges","authors":"R. Thust","doi":"10.1016/S0014-4908(79)80033-2","DOIUrl":"10.1016/S0014-4908(79)80033-2","url":null,"abstract":"<div><p>A line of the Chinese hamster V 79 strain, denominated as V 79-E, is cytogenetically characterized. It has a modal chromosome number of 22. Chromosome morphology, G- and C-banding reveal strong differences from the normal complement of the Chinese hamster presumably caused by rearrangements of chromosome segments during the past 20 years of <em>in vitro</em> culture. 4 chromosomes possess terminal nucleolar organizer regions. Spontaneous sister chromatid exchanges occur with a frequency of 0.38 sister chromatid exchanges per chromosome.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 2","pages":"Pages 95-99"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80033-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11652719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Influence of porcine corpus luteum extract on DNA synthesis and proliferation of cultivated fibroblasts and endothelial cells 猪黄体提取物对培养成纤维细胞和内皮细胞DNA合成和增殖的影响
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2012-01-23 DOI: 10.1016/S0014-4908(79)80069-1
G. Heder, W. Jakob, W. Halle, B. Mauersberger, G. Kambach, K.D. Jentzsch, P. Oehme
{"title":"Influence of porcine corpus luteum extract on DNA synthesis and proliferation of cultivated fibroblasts and endothelial cells","authors":"G. Heder,&nbsp;W. Jakob,&nbsp;W. Halle,&nbsp;B. Mauersberger,&nbsp;G. Kambach,&nbsp;K.D. Jentzsch,&nbsp;P. Oehme","doi":"10.1016/S0014-4908(79)80069-1","DOIUrl":"10.1016/S0014-4908(79)80069-1","url":null,"abstract":"<div><p>The angiogenic activity in corpus luteum (corpus luteum angiogenesis factor = CLAF) reported first by us in 1977 was enriched by ammonium sulfate precipitation and further purified by ion exchange chromatography. Extracts producedin this way from corpora lutea of cyclus synchronized pigs have proven effective to stimulate DNA synthesis and proliferation of both calf aorta endothelial cells and primary mouse embryo fibroblasts cultivated either under optimal or suboptimal (depletion) conditions. The mitogenic action of these extracts has been found to be dose-dependent and similar to that of bovine brain extract produced according to the preparation method published by <span>Gospodarowicz</span>.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 7","pages":"Pages 493-497"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80069-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11714058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 19
Cyclic AMP mediated activity stimulation by metronidazole in rat liver 甲硝唑对大鼠肝脏环磷酸腺苷介导的活性刺激
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80019-8
M. Beskid, J. Sadowski
{"title":"Cyclic AMP mediated activity stimulation by metronidazole in rat liver","authors":"M. Beskid,&nbsp;J. Sadowski","doi":"10.1016/S0014-4908(79)80019-8","DOIUrl":"10.1016/S0014-4908(79)80019-8","url":null,"abstract":"<div><p>In the homogenate of the liver biochemically examined 45 hrs after a single 250 mg dose of metronidazole administration, a 45% increase of c-AMP level was found as compared with controls. A marked proliferation of hepatic smooth endoplasmic reticulum was observed. In the light microscope numerous mitotic figures could be seen. No mitotic figures were present in the liver tissue of either treated or untreated animals examined 24, 72 and 120 hrs post administration of metronidazole. Two points seem of interest in the biologic properties of metronidazole: one is the participation of hepatic smooth endoplasmic reticulum in its metabolism, the other — the formation of active metabolites which may posses carcinogenous properties.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 3","pages":"Pages 128-133"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80019-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11439338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats and guinea pigs 化学诱导皮肤肿瘤在小鼠、大鼠和豚鼠的可移植性
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80018-6
O. Räsänen
{"title":"Transplantability of chemically induced skin tumors in syngeneic strains of mice, rats and guinea pigs","authors":"O. Räsänen","doi":"10.1016/S0014-4908(79)80018-6","DOIUrl":"10.1016/S0014-4908(79)80018-6","url":null,"abstract":"<div><p>Syngeneic tumour transplants to inbred female animal strains were carried out with basaliomas, squamous cell carcinomas and fibrosarcomas of the skin, induced by DMBA (9,10-dimethyl-1,2-benzanthracene) in the mouse, rat and guinea pig. A completely successful transplantation of all tumors was only achieved in the group of fibrosarcomas of the rat when a myocardial suspension of a young rat was used as a “supporting agent”. This may be a new immuno-biological aspect in tumor transplantation. In the other groups, five tumors developed in the host animals after a period of latency of 10 months or more. Therefore, it is discussed whether two of these tumors grown in the host rats should be considered spontaneous. In addition I have found no earlier reports in the literature with successful DMBA-induced epidermal tumors transplantations in homologous or syngeneic animal strains. Tumors were grafted on to altogether 100 animals.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 3","pages":"Pages 121-127"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80018-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11332821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Changes of cardiac and skeletal muscle in pigs following transport stress 猪在运输应激后心脏和骨骼肌的变化
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80038-1
V. Bergmann
{"title":"Changes of cardiac and skeletal muscle in pigs following transport stress","authors":"V. Bergmann","doi":"10.1016/S0014-4908(79)80038-1","DOIUrl":"10.1016/S0014-4908(79)80038-1","url":null,"abstract":"<div><p>After lorry transport (60–120 min), fattening pigs (100–120 kg living weight) with clinical signs of exhaustion and acute circulation insufficiency showed acute ultrastructural damage to the myocard and the skeletal muscle. These represent the morphological equivalent of a stress induced cardiomyopathy and are to be counted among the stress myopathies of the pig. These changes may be caused particularly by the high lactate production of the predominantly glycolytically operating skeletal muscles and by the effects of cardial catecholamine release following transport stress. Attention is drawn to the model character of these changes for similar processes in humans.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 5","pages":"Pages 243-248"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80038-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11683520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Autolytic changes in the rat adenohypophysis 大鼠垂体自溶的变化
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80011-3
G. Ilse, K. Kovacs, N. Ryan, E. Horvath, D. Ilse
{"title":"Autolytic changes in the rat adenohypophysis","authors":"G. Ilse,&nbsp;K. Kovacs,&nbsp;N. Ryan,&nbsp;E. Horvath,&nbsp;D. Ilse","doi":"10.1016/S0014-4908(79)80011-3","DOIUrl":"https://doi.org/10.1016/S0014-4908(79)80011-3","url":null,"abstract":"<div><p>Thirty-nine adult female Long Evans rats were decapitated and the heads stored at room temperature. The pituitaries were removed at intervals from 30 minutes to seven days, fixed, embedded and studied by histology, immunocytology and electron microscopy. Histologically, changes were noticeable after two hours postmortem. Immunoperoxidase staining showed positivity for growth hormone, prolactin, FSH, LH and TSH up to seven days after sacrifice, appearing even stronger in the advanced stages of autolysis. Fine structural alterations were evident at 30 minutes and more conspicuous later. Changes included dilation, partial degranulation and whorl formation of RER, swelling of Golgi complexes and mitochondria, chromatin clumping, lysis, rhexis and pyknosis of nuclei, cytosegresome formation and disruption of cell membranes. Secretory granules remained well preserved throughout, although some exhibited fusion or reduced electron density. Dilation of capillaries with accumulation of erythrocytes, platelets and fibrin fibers were prominent findings. The severity of changes varied considerably from cell to cell indicating that the rate of autolysis is not the same among different cell types and is possibly affected by the actual functional state of the cell. It appears that increased membrane permeability and disruption of plasmalemma represent important steps in the autolytic process.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 4","pages":"Pages 185-195"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80011-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91667056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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