Experimentelle Pathologie最新文献

Ultrastructural changes in hepatocytes of mice exposed to arsenic in drinking water 饮水中砷对小鼠肝细胞超微结构的影响

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80032-9

H. Mohelská , V. Bencko , K. Smetana , V. Hynčica

{"title":"Ultrastructural changes in hepatocytes of mice exposed to arsenic in drinking water","authors":"H. Mohelská , V. Bencko , K. Smetana , V. Hynčica","doi":"10.1016/S0014-4908(80)80032-9","DOIUrl":"10.1016/S0014-4908(80)80032-9","url":null,"abstract":"<div><p>Arsenic belongs to the important occupational and environmental agents which can cause damages to the liver by chronic exposure. In a long-term experiment (64 days) in mice the changes in liver cells due to arsenic were studied on the ultrastructural level. The qualitative and quantitative evaluation of the results obtained demonstrate two types of response. The first one was an acute reaction (maximum 4 days) characterized by enlargement of the surfaces of some inner membraneous structures of the hepatocytes (invaginations of the nuclear membrane and undulations of the mitochondrial surface) as well as by loss of glycogen. These changes receded gradually during the course of the experiment. The second type was characterized by a strikingly delayed change (maximum 32 days) represented by the occurrence of dense lamellar structures in the peroxisomes. Both types of response persisted till the termination of the experiment (64 days). The first type of response is considered to be a consequence of the direct toxic action of arsenic, the second one is interpreted as an expression of induced tolerance to arsenic of the organism.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 5","pages":"Pages 275-281"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80032-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18419727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The effects of cyclophosphamide, nitrosomethylurea and benzo(a)pyrene on the rat incisor 环磷酰胺、亚硝基甲基脲和苯并(a)芘对大鼠门牙的影响

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80034-2

P.A. Reichart , J. Althoff

引用次数: 2

Culture medium components modify the effects exerted by alpha-fetoprotein (AFP) on lymphocyte response 培养基成分改变甲胎蛋白(AFP)对淋巴细胞反应的影响

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80035-4

M. Czokalo, L. Wiśniewski

引用次数: 1

Influence of hirudin on endotoxin-induced disseminated intravascular coagulation (DIC) in weaned pigs 水蛭素对内毒素诱导的断奶仔猪弥散性血管内凝血(DIC)的影响

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80045-7

G. Nowak, F. Markwardt

引用次数: 23

Stimulatory effect of platelet homogenate on collagen biosynthesis in L-929 cells 血小板匀浆对L-929细胞胶原合成的刺激作用

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80048-2

E. Bańkowski, H.F. Nowak, K.J. Jodczyk

引用次数: 2

Calcium deposition in human pituitary adenomas studied by histology, electron microscopy, electron diffraction and X-ray spectrometry 用组织学、电镜、电子衍射和x射线光谱法研究人垂体腺瘤中钙沉积

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80039-1

G. Ilse , N. Ryan , K. Kovacs , D. Ilse

{"title":"Calcium deposition in human pituitary adenomas studied by histology, electron microscopy, electron diffraction and X-ray spectrometry","authors":"G. Ilse , N. Ryan , K. Kovacs , D. Ilse","doi":"10.1016/S0014-4908(80)80039-1","DOIUrl":"10.1016/S0014-4908(80)80039-1","url":null,"abstract":"<div><p>The incidence and morphogenesis of calcification were investigated by histology, electron microscopy, electron diffraction and X-ray spectrometry in 312 surgically removed human pituitary adenomas. By light microscopy the incidence of calcification was 9 %. The calcium deposits were evident in several adenoma types, but were most frequent and extensive in prolactin-producing adenomas. Histologically, calcium deposits represented amorphous precipitates and psarnmoma bodies staining with hematoxylin, the <span>von Kossa</span> technique and alizarin red. By electron microscopy, calcified deposits were noted in the cytoplasm of adenoma cells and extracellular space. Electron diffraction and X-ray spectrometry of intracellular precipitates as well as psammoma bodies showed the presence of phosphate, calcium and organically bound sulphur with a ratio of 3.5 : 5 : 2, indicating that they contained calcium hydroxyapatite. Present findings provide evidence that mitochondria with microcrystal deposition of calcium represent the primary sites of calcification.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 7","pages":"Pages 377-386"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80039-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18449474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Pathomorphological reactions of myocardium and intramural vessels of rats in the course of hypertension induced by depot angiotensin. Autoradiographic, light and electron microscopic investigations 储血血管紧张素致高血压大鼠心肌和壁内血管的病理形态学反应。射线自照相、光学和电子显微镜研究

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80070-6

E. Engler, D. Matthias, C.H. Becker

{"title":"Pathomorphological reactions of myocardium and intramural vessels of rats in the course of hypertension induced by depot angiotensin. Autoradiographic, light and electron microscopic investigations","authors":"E. Engler, D. Matthias, C.H. Becker","doi":"10.1016/S0014-4908(80)80070-6","DOIUrl":"10.1016/S0014-4908(80)80070-6","url":null,"abstract":"<div><p>Autoradiographic, light and electron microscopic investigations on the effect of depot angiotensin on the hearts of rats suggested that the myocardium and the intramural vessels reacted with an activation of the mesenchymal and DNA metabolism already 3 hrs, after the injection of depot angiotensin. The reactions in the capillaries and small arterioles were dominating. Degenerative alterations could be found in the cardiac muscle cells only 9 hrs. after inj ection and culminated in infarction-like necroses and intensive mesenchymal proliferation after the 4th A II injection. Despite further daily applications of A II the degenerative and necrotic myocardial alterations will extensively diminish until the 14th day of experiment, while the mesenchymal activation and the enhanced DNA synthesis in the vessels remained unchanged. Thus an initial stage with the development of disseminated muscle fibre necroses and infarction-like alterations and a stage of compensatory adaptation may be distinguished in the heart after depot angiotensin injections.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 1","pages":"Pages 37-51"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80070-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18392317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Lipid segregation from the maturing erythroid cell membrane 成熟红细胞膜的脂质分离

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80020-2

G. Geyer, W. Lösecke, W. Linss

引用次数: 0

Morphopharmacological analysis of the carcinogenic properties of N-methyl-N′-nitro-N-nitrosoguanidine n -甲基-n ' -硝基-n -亚硝基胍致癌性的形态药理学分析

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80026-3

V.K. Gurkalo, N.J. Volfson

引用次数: 21

Long-term tissue culture of human pheochromocytomas 人嗜铬细胞瘤的长期组织培养

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80043-3

R. Pfragner, V. Walser

引用次数: 11