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Experimentelle Pathologie最新文献

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Influence of nicotinamide on mutagenic activity of N-nitrosomorpholine in the AMES/Salmonella microsome test 在AMES/沙门氏菌微粒体试验中，烟酰胺对n -亚硝基卟啉致突变活性的影响
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80038-X
R. Braun, J. Schöneich, D. Ziebarth
{"title":"Influence of nicotinamide on mutagenic activity of N-nitrosomorpholine in the AMES/Salmonella microsome test","authors":"R. Braun, J. Schöneich, D. Ziebarth","doi":"10.1016/S0014-4908(80)80038-X","DOIUrl":"10.1016/S0014-4908(80)80038-X","url":null,"abstract":"","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 5","pages":"Pages 314-319"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80038-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17505575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
The proliferation activity of the rat thymocytes after partial hepatectomy 肝部分切除后大鼠胸腺细胞的增殖活性
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80016-0
L. Desser-Wiest , H. Desser
{"title":"The proliferation activity of the rat thymocytes after partial hepatectomy","authors":"L. Desser-Wiest ,&nbsp;H. Desser","doi":"10.1016/S0014-4908(80)80016-0","DOIUrl":"10.1016/S0014-4908(80)80016-0","url":null,"abstract":"<div><p>The influence of partial hepatectomy, unilateral nephrectomy and shamoperation on thymocyte proliferation capacity in male rats was investigated. The wet weight and the cell number declines significantly after partial hepatectomy. A stimulation of mitotic activity and H<sup>3</sup>TdR incorporation on day 3 to day 6 was also observed in partially hepatectomized animals. The polyamine content of the thymocytes was transiently decreased 2 days post partial hepatectomy and shamoperation. Thereafter the amine concentrations increased and remained elevated in the case of partially hedatectomized animals. No significant changes in the content of histamine were observed.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 3","pages":"Pages 167-169"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80016-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18016282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effects of granulation-tissue extracts on collagen synthesis 肉芽组织提取物对胶原合成的影响
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80047-0
E. Kulonen, M. Potila
{"title":"Effects of granulation-tissue extracts on collagen synthesis","authors":"E. Kulonen,&nbsp;M. Potila","doi":"10.1016/S0014-4908(80)80047-0","DOIUrl":"10.1016/S0014-4908(80)80047-0","url":null,"abstract":"<div><p>The effect of granulation-tissue extract on the synthesis of collagen in embryonic-chick tendon cells was found to depend on (i) the developmental phase of the granulation tissue, (ii) the concentration of the extract and (iii) the presence of diffusible components in it. The suppressing effect was maximal with concentrated extracts from 2–3-week granulation tissue (where the collagen synthesis is also maximal). The suppressing factor could be enriched by gel filtration chromatography. Cultured human synovial cells were affected like the embryonic-chick cells. When the sponge implant was imbibed with granulation-tissue extract in advance, the developing granuloma contained less collagen than the control.</p><p>The stimulating effects with dilute extracts from granulation tissue were due to diffusible components. Blood serum and rheumatoid synovial fluid samples also stimulated collagen synthesis in granulation-tissue slices, less after dialysis.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 7","pages":"Pages 456-461"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80047-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18019048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Light microscopic study on the tumor cell-associated antigens in patients with breast cancer by immunoperoxidase technique 免疫过氧化物酶技术对乳腺癌患者肿瘤细胞相关抗原的光镜研究
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80005-6
I.K. Yantchev
{"title":"Light microscopic study on the tumor cell-associated antigens in patients with breast cancer by immunoperoxidase technique","authors":"I.K. Yantchev","doi":"10.1016/S0014-4908(80)80005-6","DOIUrl":"10.1016/S0014-4908(80)80005-6","url":null,"abstract":"<div><p>Tumors from patients with breast cancer were examined by light microscopy using immunoperoxidase techniques. The positive immunoperoxidase reaction was observed in 12 of 19 tumors treated with autologous serum. The percentage of the labeled tumor cells was from 10–15 to 60–70. It was established that tumor cell-associated antigen(s) was located mainly on both, the plasma and the nuclear membrane. More rarely it could be seen on the chromatin.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 9","pages":"Pages 492-495"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80005-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55384149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histochemical and histopathological changes in the skin of rats after manganese application 施用锰后大鼠皮肤组织化学及病理变化
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80007-X
D.K. Saxena, R.C. Murthy, S.V. Chandra
{"title":"Histochemical and histopathological changes in the skin of rats after manganese application","authors":"D.K. Saxena,&nbsp;R.C. Murthy,&nbsp;S.V. Chandra","doi":"10.1016/S0014-4908(80)80007-X","DOIUrl":"10.1016/S0014-4908(80)80007-X","url":null,"abstract":"<div><p>Histochemical and histopathological changes in the skin of rats, after the daily application of manganese chloride solution for a period of 90 days, are reported. These alterations consist of hyperkeratinization and marked proliferation of hair follicles. The application of manganese chloride solution produced marked inhibition in the activities of succinic dehydrogenase, glucose-6-phosphate dehydrogenase and cytochrome oxidase, however no effect was noticed in the activities of acid and alkaline phosphatases, melanin deposition and the contents of nucleic acids in the skin of rats. The intensity of staining reaction for sulfhydryl groups appeared markedly increased due to the proliferation of the hair follicles in the painted skin. The absence of any effect on the cutaneous melanin appears of significance since manganese has been found to reduce neuromelanin in rhesus monkeys. The implications of these findings are discussed.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 9","pages":"Pages 502-507"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80007-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55384172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The influence of “hylase” on the ultrastructure of ischaemic heart muscle changes “水解酶”对缺血心肌超微结构变化的影响
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80053-6
H. David, K.-F. Lindenau, D. Behrisch
{"title":"The influence of “hylase” on the ultrastructure of ischaemic heart muscle changes","authors":"H. David,&nbsp;K.-F. Lindenau,&nbsp;D. Behrisch","doi":"10.1016/S0014-4908(80)80053-6","DOIUrl":"10.1016/S0014-4908(80)80053-6","url":null,"abstract":"<div><p>A two-hour acute ischaemia of the myocardium was induced in dogs by ligature of the coronary arteries and the effect produced on the qualitative and quantitative ultrastructure of heart muscle cells by infusing “hylase”, a hyaluronidase preparation, was examined. The changes in both the central and peripheral ischaemic zones following hylase infusion are more severe than after ischaemia alone. Particularly the mitochondria showed an increased dissolution of the outer membrane. In the case of ischaemia the percentage of mitochondria in the peripheral zone is 29.6%, in the central zone 27.6%; after hylase infusion it is 25.9% in the peripheral zone and 32.3% in the central zone. After hylase infusion, the percentage of sarcoplasm in the central zone rises to 120.7 % and to 186.8 % in the peripheral zone.</p><p>In view of the fact that macroscopic, histological and histochemical findings also show negative effects, the infusion of hyaluronidase is not recommended.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 4","pages":"Pages 232-239"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80053-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18407795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Studies on the specificity of tissue supernatants on the proliferation of liver in baby-rats 组织上清液对幼鼠肝脏增殖特异性的研究
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80036-6
J. Mattern, K. Wayss, M. Volm
{"title":"Studies on the specificity of tissue supernatants on the proliferation of liver in baby-rats","authors":"J. Mattern,&nbsp;K. Wayss,&nbsp;M. Volm","doi":"10.1016/S0014-4908(80)80036-6","DOIUrl":"10.1016/S0014-4908(80)80036-6","url":null,"abstract":"<div><p>Supernatants (105,000 g) prepared from extracts of liver and kidney were injected at different concentrations into 10 day-old rats and the resulting effects on <sup>3</sup>H-thymidine incorporation in liver, kidney and lung were measured over a period of 24 hours. Incorporation in all three organs is inhibited by supernatants from both liver and kidney, with maximal activity between 12 and 18 hours after injection. Fractions prepared from liver supernatant by ultrafiltration and alcohol precipitation also showed no specific effect on liver cells. In order to test whether the activity of any factors in the supernatants is cell-cycle dependent, organs of baby rats were synchronized by two different procedures: a) injection of a 3.5% casein solution, b) injection of hydroxyurea (2×10 mg/kg body weight with an interval of one hour).</p><p>Inhibitory effects were only observed when the supernatants were injected during the G1-phase of the target cells. Supernatants prepared in a similar way from other organs such as spleen, lung or heart also inhibited thymidine incorporation in casein-stimulated liver from baby rats. All of our investigations have therefore failed to find any indication of tissue-specific activity in these extracts.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 5","pages":"Pages 302-309"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80036-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18044366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunosuppressive effects of rabbit anti- canine brain serum 兔抗犬血清的免疫抑制作用
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80037-8
A.R. Zander, A.D. Hess, R.B. Epstein
{"title":"Immunosuppressive effects of rabbit anti- canine brain serum","authors":"A.R. Zander,&nbsp;A.D. Hess,&nbsp;R.B. Epstein","doi":"10.1016/S0014-4908(80)80037-8","DOIUrl":"10.1016/S0014-4908(80)80037-8","url":null,"abstract":"<div><p>Liver absorbed rabbit anticanine brain serum (ABS) was tested for its immunosuppressive capacities in dogs. Single intravenous injection of ABS led to significant decrease in lymphocyte counts and functions after 24 hours, as measured by phytohemagglutinin stimulation and mixed lymphocyte culture. The immunosuppressive effectiveness of ABS could further be documented by prolongation of skin graft survival in unrelated dogs which were treated daily for 12 days with intramuscular ABS injections. The ABS was generally welltolerated. One dog died of pneumonia. All dogs showed moderate decrease in platelet counts after 10 days of ABS treatment. Autopsies showed normal cerebral histology, moderate lymphoid hypoplasia, and no changes in the bone marrow and liver. The results suggest that liver absorbed anti-canine brain serum is a potent immunosuppressant with limited toxicity.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 5","pages":"Pages 310-313"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80037-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18044367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Morphometric analysis of peroxisomes in the liver cells of male rats during postnatal development 雄性大鼠出生后发育过程中肝细胞过氧化物酶体的形态计量学分析
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80021-4
H. David
{"title":"Morphometric analysis of peroxisomes in the liver cells of male rats during postnatal development","authors":"H. David","doi":"10.1016/S0014-4908(80)80021-4","DOIUrl":"10.1016/S0014-4908(80)80021-4","url":null,"abstract":"<div><p>Quantitative changes in the cell components of male Wistar rats (Rehbrücke stock) were determined daily from birth to the 7th day, on the 14th, 21st and 28th day and monthly from the 2nd to the 6th month. At birth, peroxisomes have a volume density of 0.021 ± 0.001, which does not change substantially until the 6th month (0.022 ± 0.008). Numerical density increases from 0.0277 ± 0.0014 at birth to 0.0863 ± 0.0033 in the 6th month. The relative volume of peroxisomes increases in the same period from 98.9 ± 5.2 μm<sup>3</sup> to 221.4 ± 8.3 μm<sup>3</sup>. The number of peroxisomes per hepatocyte increases from 130.4 ± 6.8 to 868.5 ± 33.4. The volume of the individual peroxisome, on the other hand drops from 0.79 μm<sup>3</sup> to 0.25 μm<sup>3</sup>. Changes in peroxisomes vary in the sinusoidal zone, the lateral zone and the zone near the bile canaliculi.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 6","pages":"Pages 321-328"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80021-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18428332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
The histochemical behaviour of zinc-activated tartrate-resistant phosphatase (ZnTP) in early stages of experimental tumors in, the rat trigeminal nerve 锌活化酒石酸盐抗性磷酸酶(ZnTP)在大鼠三叉神经肿瘤早期的组织化学行为
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80068-8
F.-W. Rath, R. Grahl , D. Felicetti
{"title":"The histochemical behaviour of zinc-activated tartrate-resistant phosphatase (ZnTP) in early stages of experimental tumors in, the rat trigeminal nerve","authors":"F.-W. Rath,&nbsp;R. Grahl ,&nbsp;D. Felicetti","doi":"10.1016/S0014-4908(80)80068-8","DOIUrl":"10.1016/S0014-4908(80)80068-8","url":null,"abstract":"<div><p>The activity of the ZnTP (Felicetti und Rath 1975; Rath and Felicetti 1975) was investigated histo- and biochemically in neurinomas of trigeminal nerves of rats. The tumors were induced by a single transplacental pulse of 30 mg ENU/kg on the 17th day of gestation. The rats were killed at the age of 40 to 160 days. The activity of the ZnTP is demonstrated histochemically by a coupling azo dye technique with 1-naphthylphosphate after Rath and Felicetti (1975) as well as a lead nitrate method with 4-nitrophenyl phosphate at the age of 40 to 140 days. Biochemical investigations of the trigeminal nerves are performed at the age of 140 and 160 days only. The separation of ZnTP is carried out by isoelectrofocusing in polyacrylamide gels after Felicetti and Rath (1975).</p><p>Together 14 neurinomas are found in the trigeminal nerves of 53 rats. All neurinomas show a high activity of the ZnTP. The ZnTP activity is absent in normal Schwann cells. Three trigeminal nerves of rats subjected to the transplacental pulse of ENU harbour small foci of ZnTP activity without detectable neoplastic cell proliferation. Similar spots of enhanced ZnTP activity have never been found in control rats. This rises suspicion that the neoplastic proliferation of cells is preceded by the activation of ZnTP.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 1","pages":"Pages 25-30"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80068-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"17310051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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