Experimentelle Pathologie最新文献_第9页

Effects of serum concentrations on the clonal growth of Syrian golden hamster fetal lung cells 血清浓度对叙利亚金仓鼠胎肺细胞克隆生长的影响

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80049-6

M. Emura, H.-B. Richter-Reichhelm, S. Matthei, U. Mohr

引用次数: 6

Encephalitis congenita symptomatica toxica in experimental conditions 实验条件下先天性脑炎的症状毒性

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80028-9

M. Beskid

引用次数: 2

Comparison of protein and DNA synthesis assays of guinea pig spleen lymphocytes after stimulation with influenza virus antigen and phytohemagglutinin 流感病毒抗原和植物血凝素刺激豚鼠脾淋巴细胞后蛋白质和DNA合成的比较

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2012-01-23 DOI: 10.1016/S0014-4908(79)80070-8

J. Süss, A. Stelzner, K.-H. Vogt, J. Schmidt

{"title":"Comparison of protein and DNA synthesis assays of guinea pig spleen lymphocytes after stimulation with influenza virus antigen and phytohemagglutinin","authors":"J. Süss, A. Stelzner, K.-H. Vogt, J. Schmidt","doi":"10.1016/S0014-4908(79)80070-8","DOIUrl":"10.1016/S0014-4908(79)80070-8","url":null,"abstract":"<div>Two in vitro-methods for demonstration of cell-mediated immune response are compared: Protein and DNA synthesis for detection of in vitro influenza virus antigen- and mitogen-induced lymphocyte stimulation. Guinea pig spleen lymphocytes sensitized with influenza virus antigen were tested in a microadaptation of the lymphocyte transformation test using 14C- or 3H-leucine and 3H-thymidme. As a positive control for T-cell stimulation PHA-induced lymphocyte stimulation was measured.The following results were obtained:<ul><li>1.Kinetics of the incorporation of 14C-leucine and 3H-thymidine in lymphocytes incubated with optimal and suboptimal PHA-doses respectively are quantitatively similar but different in time.</li><li>2.The results of the protein- and DNA-synthesis stimulation assays were correlated against influenza virus antigens, this could not be described by the comparison of cellular and single humoral parameters.</li><li>3.The administration of influenza virus antigens in CFA induced a more intensive cell-mediated reaction than injections of antigens in aqueous suspensions, but the results of both methods of CMI were correlated.</li><li>4.The optimal CMI under the exeprimental conditions described is induced by an administration of 30 to 50 μg virus protein per animal and by a combined intramuscular — intraperitoneal immunization procedure.</li><li>5.The measurement of the early stimulation of protein synthesis in the PSS-test is substantially more rapid than for the classical LTT.</li></ul></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 7","pages":"Pages 498-512"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80070-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11714059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Studies on the quantification of local tissue injury following intramuscular injection of aqueous solutions VIII. The local lesion after application of TURIMYCIN in different preparations 肌内注射水溶液对局部组织损伤的定量研究[j]。不同制剂应用图里霉素后局部病变

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2012-01-23 DOI: 10.1016/S0014-4908(79)80071-X

O. Löw, H. Lemke, G. Reich, G. Machnik

引用次数: 1

Rat endo- and mesothelium lack Fc receptors 大鼠内皮和间皮缺乏Fc受体

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80025-3

D. Geiling, H.G. Geiling, K.J. Halbhuber, R. Fröber, G. Geyer

引用次数: 3

A morphological study in germfree mice (Salmonella infection) 无菌小鼠(沙门氏菌感染)形态学研究

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80023-X

Y. Shirai , K. Sunakawa , Y. Ichihashi , H. Yamaguchi

{"title":"A morphological study in germfree mice (Salmonella infection)","authors":"Y. Shirai , K. Sunakawa , Y. Ichihashi , H. Yamaguchi","doi":"10.1016/S0014-4908(79)80023-X","DOIUrl":"10.1016/S0014-4908(79)80023-X","url":null,"abstract":"<div>The morphological manifestation of the intestinal infections of Salmonella typhimurium by the intestine rolled method in both conventional DK1 and germfree mice have been investigated in our laboratory. In the conventional mice, the morphological manifestation of intestinal infection shows no difference from the general features of infection, while in the germfree mice, the manifestation is characterized by the so-called non-reactive necrotizing enteritis without cellular reaction. When infection in the germfree mice occurs, some state of immunological insufficiency should be taken into consideration. In infections of germfree mice it is difficult to consider the immunological or the allergic reaction which is expected in the conventional mice.In addition, the direct influences of bacteria such as endotoxin must be taken into consideration as another possibility, but the very limited localized lesions, as seen in this experiment cannot always be suggested to be due to the direct influence of bacteria or intoxication. Though there are many problems to be solved in the future, we are now able to state a kind of mechanism similar to that of Shwartzman's phenomenon cannot be ignored in the infection in newborns or in immunologically immature animals.</div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 3","pages":"Pages 158-166"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80023-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11590173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

The effects of short-term exposure to crowding stress on the pancreatic islets morphology and glycemia in mice 短期拥挤应激对小鼠胰岛形态和血糖的影响

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80042-3

T. Trandaburu , I. Mincu , A. Petrescu-Kaianu , V. Popescu

{"title":"The effects of short-term exposure to crowding stress on the pancreatic islets morphology and glycemia in mice","authors":"T. Trandaburu , I. Mincu , A. Petrescu-Kaianu , V. Popescu","doi":"10.1016/S0014-4908(79)80042-3","DOIUrl":"10.1016/S0014-4908(79)80042-3","url":null,"abstract":"<div>Behavior, pancreatic islets morphology and plasma glucose levels of male mice exposed for 2, 4, 24 and 48 hours to crowding stress were investigated. The crowding induced an intense turmoil state associated with enhanced irritability and aggressiveness among the specimens of all experimental groups. Violent fights occurred especially in the first 4–6 hours, generally with the death of 1–2 individuals from each group.The changes recorded in the pancreatic islets affected first (2 hours) exclusively the insulin-producing cells, and in subsequent intervals they progressively expanded over all cell types. The changes occurred during the experiment in all islet cell types; however the B-cells showed by far the most pronounced alterations irrespective of the studied time interval. Most changes suggested the stimulation of the entire gland secretory activity, but particularly of B-cells, which was also proved by low glycemia values recorded at 3 of the 4 crowding time intervals. On the other hand, some alterations, occurring first at 24 hours, were regarded as signs of a moderate B-cells secretory hypoactivity; they may partly support the slight hyperglycemia obtained at this time interval.The significance of the above short-term observations in the induction of glycoregulation disturbances, diabetes included, as well as the presumably mediation role of adrenal-cortex and -medulla hormones under stress conditions are discussed and correlated with findings reported in literature.</div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 5","pages":"Pages 280-292"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80042-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11590174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Endothelium-associated IgG in the post-capillary venules of the lymphatic tissues in mice bearing experimental neoplasia 实验性肿瘤小鼠淋巴组织毛细血管后小静脉内皮相关IgG的表达

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80040-X

K.J. Syrjänen

引用次数: 1

Image processing in pathology. IX. A new morphometry system and its application on gangliocytes of the nucleus olivaris 病理学中的图像处理。9一种新的形态测量系统及其在橄榄核神经节细胞上的应用

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2012-01-23 DOI: 10.1016/S0014-4908(79)80054-X

W.R. Herrmann, K. Voss, H. Barz

引用次数: 3

The influence of a permanent Isoproterenol (ISO) application on the dynamics of the Sephadex inflammation 永久性异丙肾上腺素(ISO)应用对葡聚糖炎症动力学的影响

Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80004-6

G. Egger, S. Porta

引用次数: 10