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Light microscopic and ultrastructural changes of the exocrine pancreas in magnesium deficient rats 缺镁大鼠外分泌胰腺的光镜及超微结构变化
Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(80)80055-X
T.L. The, W.L. Maxwell, C. Thirumalai
{"title":"Light microscopic and ultrastructural changes of the exocrine pancreas in magnesium deficient rats","authors":"T.L. The,&nbsp;W.L. Maxwell,&nbsp;C. Thirumalai","doi":"10.1016/S0014-4908(80)80055-X","DOIUrl":"10.1016/S0014-4908(80)80055-X","url":null,"abstract":"<div><p>In magnesium deficient rats with a clinical picture of protein malnutrition, pancreatic changes typical of protein malnutrition were expected. However, in rats fed for four weeks on a low magnesium diet (protein content 25%), light and electron microscopic studies revealed that the acinar cells of the pancreas were packed with zymogen granules, suggesting a disturbance in the discharge (rather than in the production) of the pancreatic enzymes. The mitochondria and the lumina of the RER were swollen. The nuclei had an irregular outline, the chromatin was aggregated into irregular granules and the nucleolemma of the nucleolus was fibrillar. It was suggested that the disturbance in the release of pancreatic enzymes might cause a maldigestion of the dietary protein, which eventually would lead to the condition of protein malnutrition in the magnesium deficient rats.</p><p>The disturbance of exocytosis in the pancreas of magnesium deficient rats might be due to the preferential use of all the available magnesium for protein (enzymes) synthesis so that there were no magnesium ions left for the energy dependent discharge of the zymogen granules.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"18 4","pages":"Pages 245-253"},"PeriodicalIF":0.0,"publicationDate":"1980-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(80)80055-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"18407796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Organophosphate pesticide DDVP-induced alterations in the rat cerebellum and spinal cord — an electron microscopic study 有机磷农药ddvp诱导大鼠小脑和脊髓改变的电镜研究
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80032-0
M. Hasan, S.C. Maitra, S. Fatehyab Ali
{"title":"Organophosphate pesticide DDVP-induced alterations in the rat cerebellum and spinal cord — an electron microscopic study","authors":"M. Hasan,&nbsp;S.C. Maitra,&nbsp;S. Fatehyab Ali","doi":"10.1016/S0014-4908(79)80032-0","DOIUrl":"10.1016/S0014-4908(79)80032-0","url":null,"abstract":"<div><p>DDVP is an organophosphate pesticide whose neurotoxicity, in the form of cholinesterase inhibition, is well-known. Rats, weighing 200–225 g were given intraperitoneal injections of 3 mg/kg. DDYP daily for 10 days. Following perfusion-fixation, ultrathin sections of the cerebellum and spinal cord were examined with an electron microscope. A large number of electron-dense bodies exhibiting electron-lucid vacuoles were discernible in the perikarya of cerebellar neurons. Aggregations of mitochondria were also seen. Myelin-figures in dendrites and axons of the spinal cord were detected. Evidence of oedema was evident in the spinal cord.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 2","pages":"Pages 88-94"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80032-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11652718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Endotoxin-induced myeloid reactions in dogs 犬内毒素诱导的髓细胞反应
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80036-8
W. Hinterberger , H. Kinast , W. Paukovits , A. Keiler , P. Möschl
{"title":"Endotoxin-induced myeloid reactions in dogs","authors":"W. Hinterberger ,&nbsp;H. Kinast ,&nbsp;W. Paukovits ,&nbsp;A. Keiler ,&nbsp;P. Möschl","doi":"10.1016/S0014-4908(79)80036-8","DOIUrl":"10.1016/S0014-4908(79)80036-8","url":null,"abstract":"<div><p>The response to artificial endotoxinemia was studied in adult dogs. Granulocyte-macrophage colony stimulating activity (CSA) in lung tissue and blood was measured along with the number of circulating granulocytes and myeloid committed stem cells (colony forming units, CFUc). Acute endotoxinemia induced a measurable CSA increase in lung tissue before being detectable in blood. Granulocytes, rapidly removed from the circulation, showed no release of CSA during sequestration. These experiments demonstrate that the process of endotoxin recognition and subsequent transition into a myelopoietic stimulus is mediated by cells belonging to tissue; mature granulocytes, involved in the defence against bacterial infection, do not release activity that promotes growth of immature myeloid cells.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 2","pages":"Pages 113-118"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80036-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11584575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Effects of insulin on hepatic lipid synthesis in alloxan diabetic rats 胰岛素对四氧嘧啶型糖尿病大鼠肝脏脂质合成的影响
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80075-7
G. Mingrone , E. Peruzzi , F.M. Yecchio , A.Y. Greco
{"title":"Effects of insulin on hepatic lipid synthesis in alloxan diabetic rats","authors":"G. Mingrone ,&nbsp;E. Peruzzi ,&nbsp;F.M. Yecchio ,&nbsp;A.Y. Greco","doi":"10.1016/S0014-4908(79)80075-7","DOIUrl":"10.1016/S0014-4908(79)80075-7","url":null,"abstract":"<div><p><em>In vitro</em> hepatic synthesis of lipids starting from l-<sup>14</sup>C-acetate was studied in rats made diabetic by subcutaneous alloxan administration (175 mg/kg b.w.). A second group of diabetic rats was treated with lente insulin.</p><p>In the alloxan-treated rats, a decrease was observed in hepatic incorporation of l-<sup>14</sup>C-acetate into phospholipids, triglycerides and esterified cholesterol; there was an increased incorporation into nonesterified fatty acids (NEFA) and free cholesterol.</p><p>Insulin administration restored lipid synthesis values to normal.</p><p>On histologic examination, an intranuclear glycogenesis was observed in the hepatocytes of the alloxan-treated rats, along with severe hepatic necrosis; the latter however, only in rats sacrified on the 3rd day. Hepatic steatosis with small, medium and large droplets was present in the insulin-treated rats; signs of cellular degeneration were less evident.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 9","pages":"Pages 533-538"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80075-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11603472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Quantitative stereological studies on the mechanism of immuno-suppressive effect of nitrogen mustards of benzimidazole derivatives: the role of polymorphonuclear leukocytes and mononuclear phagocytes 苯并咪唑衍生物氮芥免疫抑制机制的定量体视学研究:多形核白细胞和单核吞噬细胞的作用
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2012-01-23 DOI: 10.1016/S0014-4908(79)80064-2
R.S. Fritsch
{"title":"Quantitative stereological studies on the mechanism of immuno-suppressive effect of nitrogen mustards of benzimidazole derivatives: the role of polymorphonuclear leukocytes and mononuclear phagocytes","authors":"R.S. Fritsch","doi":"10.1016/S0014-4908(79)80064-2","DOIUrl":"10.1016/S0014-4908(79)80064-2","url":null,"abstract":"<div><p>The effect on antigen uptake and digestion in macrophages and polymorphonuclear leukocytes (PMNL) of 2 compounds of a series of benzimidazole nitrogen mustard derivatives has been investigated by ultra structural quantitative stereological techniques in order to enlighten some mechanisms of the immunosuppressive effect of especially one of the chemicals. One compound, ZIMET 3393 (Cytostasan®), is a powerful cancerostatic with only moderate immunosuppressive side effects while ZIMET 3164 proved an effective immunosuppressant with low cytostatic action.</p><p>Results of a recent study (<span>Fritsch</span> and <span>Gothe</span> 1979) have lent support to the hypothesis that immunosuppression can be induced by an inhibition of antigen processing by macrophages through a membrane-stabilizing effect of the chemicals under investigation. It can be shown in the present study that in the case of ZIMET 3164 an increased competitive antigen phagocytosis and digestion takes place in PMNL. This alternative pathway of antigen processing is suggested to be ineffective with respect to enhancement of immune responses compared with that through macrophages, thus providing an additional possible mechanism of chemical immunosuppression.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 7","pages":"Pages 446-460"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80064-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11714194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Behaviour of normal and neoplastic cultured mouse cells on the chorioallantoic membrane of the chicken 正常和肿瘤培养小鼠细胞在鸡绒毛膜尿囊膜上的行为
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80005-8
B. Mauersberger, W. Jakob, J. Zipper
{"title":"Behaviour of normal and neoplastic cultured mouse cells on the chorioallantoic membrane of the chicken","authors":"B. Mauersberger,&nbsp;W. Jakob,&nbsp;J. Zipper","doi":"10.1016/S0014-4908(79)80005-8","DOIUrl":"10.1016/S0014-4908(79)80005-8","url":null,"abstract":"<div><p>Cultivated normal and transformed fibroblasts of the mouse (short-term cultures of lung fibroblasts and L-cells) have been implanted onto the chorioallantoic membrane of the chick embryo (CAM). Both cell types formed macroscopically visible nodules on the CAM where they induced a weak angiogenic reaction. Labelling of the cells with activated charcoal or 3H-thymidine gave evidence of their invasion into the CAM mesoderm, where they induced the formation of new capillaries. The successive multiplication of the cells led to the formation of tumours, resp. tumour-like cellular accumulations in the hypertrophied mesoderm of the CAM. Treatment of L-cells with the protease-inhibitor Contrykal reduced the invasive properties of the cells. The results presented clearly demonstrate invasive and angiogenic properties of the normal and malignantly transformed cell cultures of the mouse used in our experiments.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 1","pages":"Pages 18-24"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80005-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11635094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Renal cortical tubules in experimental malakoplakia. Phagocytic alteration of tubular epithelium 实验性斑疹的肾皮质小管。小管上皮的吞噬改变
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80003-4
J. Ormos, G. Mohácsi, E. Kuthy, Zs. Böti
{"title":"Renal cortical tubules in experimental malakoplakia. Phagocytic alteration of tubular epithelium","authors":"J. Ormos,&nbsp;G. Mohácsi,&nbsp;E. Kuthy,&nbsp;Zs. Böti","doi":"10.1016/S0014-4908(79)80003-4","DOIUrl":"10.1016/S0014-4908(79)80003-4","url":null,"abstract":"<div><p>Intrarenal injection of a crude E. coli extract (endotoxin-antigen-complex) induced malakoplakia in rats. Beside the granulation tissue the proximal tubular epithelium showed a strong phagolysosomal response — especially in two-three weeks —, thus becoming very similar to the Hansemann cells of the malakoplakia granulation tissue. This malakoplakia alteration of the epithelium if very severe sometimes led to necrosis or it was segregated inside the epithelial cells. Later on an atrophy of the tubules developed similar to the atrophy of different etiology, but the remaining cells often contained a striking number of residual bodies. It is suggested that the tubular granulated cells of megalocytic interstitial nephritis regarded as identical with renal cortical malakoplakia also have a tubular epithelial origin.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 1","pages":"Pages 3-11"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80003-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11635096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Morphologic study of the action of lymphoid tissue extracts in peroxidase arthritis 淋巴组织提取物对过氧化物酶关节炎作用的形态学研究
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80007-1
R. Ptašekas, V. Gražienė, V. Urmonas, D. Vaitkienė, N. Preikšaitė, G. Ignotienė
{"title":"Morphologic study of the action of lymphoid tissue extracts in peroxidase arthritis","authors":"R. Ptašekas,&nbsp;V. Gražienė,&nbsp;V. Urmonas,&nbsp;D. Vaitkienė,&nbsp;N. Preikšaitė,&nbsp;G. Ignotienė","doi":"10.1016/S0014-4908(79)80007-1","DOIUrl":"10.1016/S0014-4908(79)80007-1","url":null,"abstract":"<div><p>By means of modelling arthritis by horseradish peroxidase it was possible to reproduce a process corresponding to immune synovitis. A considerable reduction of immunomorphological phenomena in joints, lymphoid tissue, heart, liver and kidneys was favoured by application of lymphoid tissue extracts. Comparison between the extracts of spleen and lymph nodes showed a more pronounced effect of spleen extract.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 1","pages":"Pages 33-39"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80007-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55383416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Placental barrier against circulating immune complexes. A study in pregnant guinea pigs using maternal injection of horseradish peroxidase soluble immune complexes. 胎盘屏障对抗循环免疫复合物。妊娠豚鼠母体注射辣根过氧化物酶可溶性免疫复合物的研究。
Experimentelle Pathologie Pub Date : 1979-01-01
M Morisada, S Kawakami, H Yamaguchi, R Iizuka
{"title":"Placental barrier against circulating immune complexes. A study in pregnant guinea pigs using maternal injection of horseradish peroxidase soluble immune complexes.","authors":"M Morisada,&nbsp;S Kawakami,&nbsp;H Yamaguchi,&nbsp;R Iizuka","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>It is not rare that the so-called immune complex diseases (some of which were recently supposed to be induced by the biological effects of circulating antigen-antibody immune complexes) are concomitantly present in pregnant females. But there have been very few reports of congenital immune complex diseases.</p>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 4","pages":"200-7"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11375812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of adrenalin depletion in hypoglycaemic rats following permanent adrenalin application by depot capsule 长效肾上腺素胶囊对低血糖大鼠肾上腺素消耗的抑制作用
Experimentelle Pathologie Pub Date : 1979-01-01 Epub Date: 2011-11-08 DOI: 10.1016/S0014-4908(79)80022-8
S. Porta, G. Egger, R. Kubat, R. Sattelberger
{"title":"Inhibition of adrenalin depletion in hypoglycaemic rats following permanent adrenalin application by depot capsule","authors":"S. Porta,&nbsp;G. Egger,&nbsp;R. Kubat,&nbsp;R. Sattelberger","doi":"10.1016/S0014-4908(79)80022-8","DOIUrl":"10.1016/S0014-4908(79)80022-8","url":null,"abstract":"<div><p>Chronic treatment of rats with adrenalin by means of a subcutaneous depot capsule (cont. 40 mg dry adrenalin/HCl, Merck, ca. 10 mg ascorbic acid and ca. 0.4 ml 0.9 % NaCl, and sealed with a dialysis membrane to provide constant adrenalin output) leads after a primary hyperglycaemic phase to hypoglycaemia. At the onset of hypoglycaemia the adrenalin contents of the suprarenal glands decrease to levels of about one third of their normal state. Simultaneous glucose infusions by intraperitoneal depot capsules prevent hypoglycaemia as well as adrenalin depletion.</p><p>The fact that adrenalin depletion does not always correspond with blood sugar levels below 80 mg/dl and that this depletion could be prevented by glucose infusions altogether seems to provide a strong hint that the mentioned depletion is due to hypersecretion and not to the blocking of adrenalin synthesis.</p><p>If is true, then there must be no direct negative feed-back system between adrenalin secretion and its extraglandular level.</p></div>","PeriodicalId":75841,"journal":{"name":"Experimentelle Pathologie","volume":"17 3","pages":"Pages 152-157"},"PeriodicalIF":0.0,"publicationDate":"1979-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0014-4908(79)80022-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"11683516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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