Macrophage electrophoretic mobility (MEM) test in immunodiagnostics of Papio hamadryas malignant lymphomas

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI:10.1016/S0014-4908(80)80006-8
L.V. Indzhiia , L.A. Yakovleva , B.A. Lapin (Director: Prof. Dr.) , T.N. Tsaturyan , M. Malkowsky , J. Bubenik
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引用次数: 0

Abstract

Reactivity of lymphocytes from P. hamadryas monkeys carrying malignant lymphomas directed against soluble antigens from allogeneic lymphomas was investigated using macrophage electrophoretic mobility (MEM) test. Twenty-three monkeys have been examined. 14 of them carried malignant lymphoma including those with initial manifestations of malignant lymphoma, animals with generalized processes and those in the period of spontaneous remission, and 9 control animals (8 healthy baboons and one animal with hepatoma). The macrophage electrophoretic mobility reduction higher than 10% was considered as positive. Positive reaction was observed in 78% of monkeys with malignant lymphoma. The MEM-test was positive already in the initial stage of the disease and remained positive in the period of spontaneous remission.

巨噬细胞电泳迁移率(MEM)试验在乳头状瘤恶性淋巴瘤免疫诊断中的应用
采用巨噬细胞电泳迁移率(MEM)试验研究了携带恶性淋巴瘤的hamadryas猴淋巴细胞对同种异体淋巴瘤可溶性抗原的反应性。已经对23只猴子进行了检查。其中14只携带恶性淋巴瘤,包括有恶性淋巴瘤初始表现的动物、有全身性进展的动物和处于自发缓解期的动物。对照动物9只(健康狒狒8只,肝癌动物1只)。巨噬细胞电泳迁移率降低10%以上为阳性。78%的恶性淋巴瘤猴子出现阳性反应。在疾病的初始阶段,memi测试已经呈阳性,并在自发缓解期保持阳性。
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