The effect of methylnitrosourea intoxication on the fatty acid pattern of myelin lipids

Experimentelle Pathologie Pub Date : 1980-01-01 Epub Date: 2011-11-08 DOI:10.1016/S0014-4908(80)80046-9

M. Wender, Z. Adamczewska-Goncerzewicz, S. Żórawski

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Abstract

The effect of intravenous administration of methylnitrosourea (MNU), 60 mg/kg body weight to adult BD IX rats for 6 consecutive days, on the fatty acid composition of myelin lipids has been examined.

The results of our investigations show that the fatty acid spectrum of all myelin lipid components was significantly altered after MNU treatment.

The comparison of the fatty acid composition of the myelin phospholipids and the cholesterol esters formed MNU intoxication did not speak in favour of the hypothesis that enhanced lipolysis and thus the fatty acids liberated mainly from phospholipids are responsible for the increased esterification of cholesterol observed in toxic myelinopathies. It rather confirms the thesis that enhanced esterification of cholesterol is one of the early, independent events occurring in the lipid layer of the myelin sheath in the course of demyelination.

The observed changes in the fatty acyl spectrum of various myelin lipids may weaken the stability of the myelin lipid layer, and thus constitute another factor in the pathomechanism of toxic myelinopathies.

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甲基亚硝基脲中毒对髓磷脂脂肪酸模式的影响

研究了成年BD IX大鼠连续6天静脉注射60 mg/kg体重的甲基亚硝基脲(MNU)对髓磷脂脂质脂肪酸组成的影响。我们的研究结果表明，在MNU治疗后，所有髓磷脂脂质成分的脂肪酸谱都发生了显著改变。髓磷脂的脂肪酸组成与MNU中毒形成的胆固醇酯的比较并不支持脂肪分解增强的假设，因此主要从磷脂中释放的脂肪酸是中毒性髓鞘病中观察到的胆固醇酯化增加的原因。相反，它证实了胆固醇酯化的增强是脱髓鞘过程中髓鞘脂质层发生的早期独立事件之一。观察到的各种髓磷脂脂质脂肪酸酰基谱的变化可能会削弱髓磷脂脂质层的稳定性，从而构成中毒性髓鞘病发病机制的另一个因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Experimentelle Pathologie

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