American Journal of Hypertension最新文献_第8页

Response to Letter to the Editor entitled "2017 ACC/AHA BP Thresholds for Masked HTN Detection". 对题为“2017 ACC/AHA BP阈值用于屏蔽HTN检测”的致编辑的回复。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-08-12 DOI: 10.1093/ajh/hpaf151

Daichi Shimbo, Sophie Walsh, Eunhee Choi

引用次数: 0

Translating Guidelines, Protocols, and Care Pathways for Hypertension Into Effective Program Implementation. 将高血压指南、方案和护理途径转化为有效的项目实施。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-08-12 DOI: 10.1093/ajh/hpaf103

Pedro Ordunez, Sonia Y Angell, Donald J DiPette, Jeffrey Brettler, Norm R C Campbell, Marc G Jaffe, Niamh Chapman, Andres Rosende, Grace Marie Ku, Esteban Londoño, Daniel José Piñeiro, Paul K Whelton

{"title":"Translating Guidelines, Protocols, and Care Pathways for Hypertension Into Effective Program Implementation.","authors":"Pedro Ordunez, Sonia Y Angell, Donald J DiPette, Jeffrey Brettler, Norm R C Campbell, Marc G Jaffe, Niamh Chapman, Andres Rosende, Grace Marie Ku, Esteban Londoño, Daniel José Piñeiro, Paul K Whelton","doi":"10.1093/ajh/hpaf103","DOIUrl":"https://doi.org/10.1093/ajh/hpaf103","url":null,"abstract":"Background: Inconsistent terminology and conceptual overlap among clinical practice guidelines, treatment protocols, and care pathways can lead to confusion in program design and implementation.Methods: Drawing on the implementation experience of HEARTS in the Americas-the largest regional adaptation of the WHO Global HEARTS Initiative-this communication describes the characteristics, functions, and interrelationships of clinical practice guidelines, treatment protocols, and care pathways. It outlines their respective roles in development, approval, and execution to clarify their contributions to both health system organization and clinical practice.Results: Clinical practice guidelines are composed of evidence-based recommendations grounded in rigorous scientific evaluation to support clinical decision-making. Care pathways serve as implementation tools that translate guidelines into standardized, multidisciplinary plans that organize hypertension management, facilitate task-sharing, and engage patients. Embedded within pathways, treatment protocols offer a simplified, step-by-step approach tailored to most patients, specifying a limited set of medications and dosages to ensure timely blood pressure control, reduce therapeutic inertia, and promote consistent care delivery.Conclusions: Clarifying the distinctions and synergies among guidelines, protocols, and care pathways might enhance alignment between clinical guidance and service delivery, supporting effective implementation and scale-up of hypertension and chronic disease management programs.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with New-Onset Atrial Fibrillation in Thai Adults with Hypertension. 泰国成人高血压患者新发房颤的相关因素

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-08-09 DOI: 10.1093/ajh/hpaf149

Varisa Limpijankit, Thinnakrit Sasiprapha, Htun Teza, Anuchate Pattanateepapon, Sukanya Siriyotha, Suparee Boonmanunt, John Attia, Ammarin Thakkinstian

{"title":"Factors Associated with New-Onset Atrial Fibrillation in Thai Adults with Hypertension.","authors":"Varisa Limpijankit, Thinnakrit Sasiprapha, Htun Teza, Anuchate Pattanateepapon, Sukanya Siriyotha, Suparee Boonmanunt, John Attia, Ammarin Thakkinstian","doi":"10.1093/ajh/hpaf149","DOIUrl":"10.1093/ajh/hpaf149","url":null,"abstract":"Background: Data on risk factors for new-onset atrial fibrillation (NOAF) in hypertensive Asian populations are limited. This study aimed to identify predictors of NOAF in Thai adults with hypertension (HTN).Methods: We conducted a retrospective cohort study of adults (≥18 years) newly diagnosed with HTN at Ramathibodi Hospital, Bangkok, from 2010 to 2023. Patients with prior AF or predisposing conditions (e.g., valvular disease, hyperthyroidism) were excluded. Baseline demographics, comorbidities, and medication use were analyzed as time-varying covariates using multivariable Cox models.Results: Of 293,798 hypertensive patients, 168,441 met the criteria. Over a median follow-up of 3.7 years, 5,028 developed NOAF (5.7 per 1,000 person-years). A significant interaction between age and body mass index (BMI) was observed. In patients <60 years, low BMI increased NOAF risk (HR: 2.3; 95% CI: 1.4-3.6), while overweight and obesity did not. In those ≥60-79 years, NOAF risk increased 2- to 3-fold in underweight, overweight, and obese individuals compared to normal BMI. In patients ≥80 years, the risk was 3- to 4-fold higher across all BMI categories. Male sex and comorbidities (vascular disease, stroke, heart failure, chronic kidney disease, hyperuricemia) were associated with a 1.2-1.8-fold increased risk. Statin use reduced NOAF risk (HR: 0.8; 95% CI: 0.7-0.9), while SGLT2 inhibitors and GLP-1 receptor agonists showed a non-significant protective trend (HR: 0.8; 95% CI: 0.7-1.1).Conclusions: In Thai hypertensive patients, older age, male sex, abnormal BMI, and comorbidities predict NOAF, while statin use may be protective. Further prospective studies are needed to confirm these findings.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ventricular-Arterial Coupling and Hypertension: Integrating Vascular and Cardiac Indices. 心室-动脉耦合与高血压：整合血管和心脏指标。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-08-04 DOI: 10.1093/ajh/hpaf147

Sepiso K Masenga

引用次数: 0

Associations of Novel Triglyceride- and Triglyceride-Glucose-Derived Obesity Indices with Hypertension in Nonobese US Adults (NHANES 1999--2020). 新型甘油三酯和甘油三酯葡萄糖衍生的肥胖指数与非肥胖美国成年人高血压的关系（NHANES 1999- 2020）。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-08-01 DOI: 10.1093/ajh/hpaf146

Lingling Chen, Lixue Yin

{"title":"Associations of Novel Triglyceride- and Triglyceride-Glucose-Derived Obesity Indices with Hypertension in Nonobese US Adults (NHANES 1999--2020).","authors":"Lingling Chen, Lixue Yin","doi":"10.1093/ajh/hpaf146","DOIUrl":"https://doi.org/10.1093/ajh/hpaf146","url":null,"abstract":"Background: Visceral obesity, insulin resistance (IR), and glycolipid abnormalities are associated with an increased risk of hypertension (HTN). The study aimed to explore the correlation between novel triglyceride- and triglyceride‒glucose-derived obesity indices associated with these hypertension risk factors, and the prevalence of HTN among nonobese adults.Methods: We extracted data from 12,717 nonobese adults from NHANES between 1999-2020 and calculated triglyceride-derived obesity indices (lipid accumulation product (LAP), visceral adiposity index (VAI), and cardiometabolic index (CMI)), triglyceride-glucose-derived obesity indices (triglyceride glucose-body mass index (TyG-BMI), triglyceride glucose-waist circumference (TyG-WC), and triglyceride glucose-waist-to-height ratio (TyG-WHtR)) and traditional anthropometric indices. Logistic regression, curve fitting and subgroup analyses were employed to investigate the associations between these novel obesity indices and HTN prevalence. Receiver operating characteristic (ROC) curve analysis was performed to assess the predictive accuracy of all the above obesity parameters.Results: After weighted analysis of the data, the results of this study represented approximately 119.00 million nonobese U.S. adults. The prevalence of HTN was 49.74% (men 53.45%). The multivariate logistic regression analysis revealed that LAP, VAI, CMI, TyG-BMI, TyG-WC and TyG-WHtR were significantly associated with HTN. Smoothed curve-fitting analysis revealed that the LAP, VAI and CMI correlated nonlinearly with HTN.The area under the curve (AUC) for HTN was greater for all novel obesity indices compared to commonly used traditional anthropometric parameters such as BMI, WC, and WHtR.Conclusions: LAP, VAI, CMI, TyG-BMI, TyG-WC, and TyG-WHtR were significantly associated with HTN and demonstrated potentially better predictive capability than commonly used traditional anthropometric measures.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144758957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

2017 ACC/AHA BP Thresholds for Masked HTN Detection. 2017 ACC/AHA BP阈值屏蔽HTN检测。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-07-26 DOI: 10.1093/ajh/hpaf123

Paul Anthony Camacho López, German Camilo Giraldo-Gonzalez, Silvia Juliana Villabona-Flórez, Alberto Javier Vasquez-Cadena

引用次数: 0

Effect of sacubitril-valsartan on transcriptomic changes in lung tissue of spontaneously hypertensive rats: a multi-omics study based on RNA-Seq transcriptome analysis. 沙比替-缬沙坦对自发性高血压大鼠肺组织转录组变化的影响：基于RNA-Seq转录组分析的多组学研究。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-07-25 DOI: 10.1093/ajh/hpaf143

Zhengxiang Lv, Weiran Dai, Shunkang Rong, Jianlin Du

{"title":"Effect of sacubitril-valsartan on transcriptomic changes in lung tissue of spontaneously hypertensive rats: a multi-omics study based on RNA-Seq transcriptome analysis.","authors":"Zhengxiang Lv, Weiran Dai, Shunkang Rong, Jianlin Du","doi":"10.1093/ajh/hpaf143","DOIUrl":"https://doi.org/10.1093/ajh/hpaf143","url":null,"abstract":"Background: Hypertension, a prevalent cardiovascular disorder, exerts detrimental effects on the respiratory system. However, the underlying mechanisms remain incompletely elucidated.Methods: We conducted comparative transcriptomic profiling via RNA sequencing (RNA-seq) of lung tissues from spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto (WKY) controls. Additionally, we assessed the effects of angiotensin receptor blocker (ARB) and angiotensin receptor-neprilysin inhibitor (ARNI) interventions on mRNA and protein expression profiles in SHR pulmonary tissue using integrated omics approaches.Results: Core differentially expressed genes (DEGs) identified in SHR versus WKY comparisons included Nuf2 and Cenpa, with significant enrichment in the PI3K/AKT signaling pathway. In SHR versus ARB-treated cohorts, hub genes Ccnb2 and Mad2l1 demonstrated primary pathway enrichment in cell cycle regulation and human T-cell leukemia virus 1 infection. ARNI intervention yielded distinct hub genes (Gzma, Icam1) enriched in PI3K/AKT signaling and extracellular matrix (ECM)-receptor interactions. Proteomic analysis confirmed concordant expression patterns for EGFR and JUN proteins with transcriptomic findings.Conclusion: ARB and ARNI therapies mitigate hypertension-induced pulmonary damage through divergent molecular mechanisms, with PI3K/AKT signaling and ECM-receptor interactions serving as central regulatory hubs in this protective process.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Soluble Receptor for Advanced Glycation End Products and Incident Hypertension in REGARDS. 晚期糖基化终产物的可溶性受体和REGARDS中的高血压事件。

IF 3.2 3区医学

American Journal of Hypertension Pub Date : 2025-07-25 DOI: 10.1093/ajh/hpaf109

Sarah D R Krumholz, Mary Cushman, Nels C Olson, D Leann Long, Suzanne E Judd, Virginia J Howard, Timothy B Plante

{"title":"Soluble Receptor for Advanced Glycation End Products and Incident Hypertension in REGARDS.","authors":"Sarah D R Krumholz, Mary Cushman, Nels C Olson, D Leann Long, Suzanne E Judd, Virginia J Howard, Timothy B Plante","doi":"10.1093/ajh/hpaf109","DOIUrl":"https://doi.org/10.1093/ajh/hpaf109","url":null,"abstract":"Background: Black US adults experience a greater hypertension burden and have lower levels of soluble receptors for advanced glycation end products (sRAGE). sRAGE may reduce inflammation, which is itself a hypertension risk factor. We hypothesized that higher sRAGE levels are associated with a lower risk of incident hypertension in a cohort of Black and White adults.Methods: The REasons for Geographic and Racial Differences in Stroke (REGARDS) enrolled 30,239 Black and White adults from the contiguous United States in 2003-2007; a second visit occurred in 2013-2016. sRAGE was measured at baseline by ELISA in 4,400 participants attending both visits. Hypertension was defined as BP > 140/90 mm Hg or use of antihypertensive medications. Participants with baseline hypertension were excluded. Poisson regression estimated incident hypertension risk ratios (RR) by sRAGE levels, adjusting for confounders.Results: Among 1,799 participants without baseline hypertension (mean [SD] age 62 [8] years, 55% females, 25% Black), 46% of Black participants and 31% of White participants developed hypertension. Median sRAGE was lower in Black than White persons (P < 0.0001). Relative to quartile 1, White participants in quartile 4 of sRAGE had a 24% lower risk of incident hypertension (RR 0.76; 95% CI 0.59, 0.96) in a minimally adjusted model, but no differences in a fully adjusted model (0.81; 0.63 to 1.05). There was no association of sRAGE with hypertension in Black participants.Conclusions: Higher baseline sRAGE levels were not associated with lower risk of incident hypertension after adjusting for known confounders. Low sRAGE might represent adverse inflammation that drives hypertension rather than being a primary driver of hypertension development itself.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effect of SGLT2 inhibitors on blood pressure in relation to baseline kidney function: A systematic literature review and data analysis. SGLT2抑制剂对血压和基线肾功能的影响：系统的文献回顾和数据分析。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-07-24 DOI: 10.1093/ajh/hpaf130

Charlotte Agergaard Møller, Steffen Flindt Nielsen, Frank Holden Mose

{"title":"The effect of SGLT2 inhibitors on blood pressure in relation to baseline kidney function: A systematic literature review and data analysis.","authors":"Charlotte Agergaard Møller, Steffen Flindt Nielsen, Frank Holden Mose","doi":"10.1093/ajh/hpaf130","DOIUrl":"https://doi.org/10.1093/ajh/hpaf130","url":null,"abstract":"Background: Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce both systolic blood pressure (SBP) and diastolic blood pressure (DBP). The glucose-lowering effect of SGLT2i depends on baseline estimated glomerular filtration rate (eGFR), but whether the same is true for the blood pressure lowering effect is unknown.Methods: We performed a systematic literature review in PubMed (Study 1) and analysed data from a clinical study (Study 2) to investigate if the blood pressure lowering effect of SGLT2i depends on baseline eGFR. In the literature review, we performed a weighted regression analysis with mean change in SBP and DBP as dependent variables and mean eGFR as an independent variable. Furthermore, we analyzed data from a cohort of 48 patients with either type 2 diabtes mellitus with and without chronic kidney disease (CKD) or non-diabetic CKD with varying degrees of kidney function.Results: 2069 articles were identified of which 27 articles met the inclusion criteria. Analysis revealed a mean weighted reduction in SBP -4.7 mmHg compared to baseline and -3.5 mmHg compared to placebo. The weighted regression analysis showed no correlation between change in SBP and baseline eGFR. Data analysis of 48 patients revealed a SBP reduction of 5.5 mmHg and the simple linear regression revealed no correlation between the decrease in blood pressure and baseline eGFR.Conclusions: The blood pressure lowering effect of SGLT2i does not depend on baseline eGFR.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Time in Target Range for Systolic Blood Pressure on Left Ventricular Hypertrophy. 收缩压目标范围时间对左室肥厚的影响。

IF 3.1 3区医学

American Journal of Hypertension Pub Date : 2025-07-24 DOI: 10.1093/ajh/hpaf141

Jianjiao Wang, Wen Li, Gui Man, Yang Liu, Siyu Wang, Shouling Wu, Wei Huang

{"title":"The Impact of Time in Target Range for Systolic Blood Pressure on Left Ventricular Hypertrophy.","authors":"Jianjiao Wang, Wen Li, Gui Man, Yang Liu, Siyu Wang, Shouling Wu, Wei Huang","doi":"10.1093/ajh/hpaf141","DOIUrl":"10.1093/ajh/hpaf141","url":null,"abstract":"Background: We aimed to explore the association between systolic blood pressure time-in-target range (SBP-TTR) and left ventricular hypertrophy (LVH).Methods: A total of 33,818 participants of the Kailuan Study who underwent echocardiography and had participated in at least two health check-ups between 2006 and 2020. The target systolic blood pressure (SBP) ranges are defined as 120-140 mmHg and 110-130 mmHg, respectively. SBP-TTR was calculated by linear interpolation. Poisson regression models were used to assess relative risk (RR) and 95% confidence intervals (CIs) for the associations of 120-140 mmHg SBP-TTR and 110-130 mmHg SBP-TTR with LVH.Results: When the SBP target range was defined as 120-140mmHg, in multivariable-adjusted models, compared to the reference group (SBP-TTR ≤ 25%), LVH risk was significantly reduced in the 75% < SBP-TTR ≤ 100% group, (RR: 0.94, 95% CI: 0.89-0.99). When the SBP target range was defined as 110-130mmHg, compared to the reference group (SBP-TTR ≤ 25%),there was significantly reduced in LVH risk in the 25%<SBP-TTR≤50%（RR：0.89，95%CI：0.83-0.94）、50%<SBP-TTR≤75%（RR：0.85，95%CI：0.79-0.91） and 75%< SBP-TTR≤100%（RR：0.81，95%CI：0.76-0.86）groups. Analysis using restricted cubic splines revealed a linear, dose-response relationship between SBP-TTR and LVH risk.Conclusions: With increased SBP-TTR associated with a reduced risk of LVH, demonstrating a clear dose-response relationship. Compared to an SBP-TTR range of 120-140 mmHg, maintaining SBP-TTR at 110-130 mmHg more effectively reduces LVH risk.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144726493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0