Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection.

IF 3.2 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE
Xinchun Xu, Qiong Li, Qiuping Chen, Haibo Wang, Chuchu Wu, Xiaohu Chen, Fei Chen, Chaoyan Yue
{"title":"Elevated Blood Pressure: A Genetically Determined Risk Factor for Cerebral Artery Dissection.","authors":"Xinchun Xu, Qiong Li, Qiuping Chen, Haibo Wang, Chuchu Wu, Xiaohu Chen, Fei Chen, Chaoyan Yue","doi":"10.1093/ajh/hpae102","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk by employing a 2-sample Mendelian randomization (TSMR) framework.</p><p><strong>Methods: </strong>Utilizing large-scale genome-wide association studies-retrieved data, we employed various Mendelian randomization (MR) techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP's causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran's Q statistic.</p><p><strong>Results: </strong>The findings highlighted a significant association between elevated systolic BP (SBP; IVW: OR = 3.09, 95% CI: 1.11-8.61, P = 0.031) and increased diastolic BP (DBP; IVW: OR = 2.17, 95% CI: 1.14-6.21, P = 0.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results.</p><p><strong>Conclusions: </strong>The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, which provides genetic evidence for a reduced risk of CAD under BP control.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"970-977"},"PeriodicalIF":3.2000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"American Journal of Hypertension","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1093/ajh/hpae102","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PERIPHERAL VASCULAR DISEASE","Score":null,"Total":0}
引用次数: 0

Abstract

Background: We aim to investigate the potential causal link between blood pressure (BP) levels and cerebral artery dissection (CAD) risk by employing a 2-sample Mendelian randomization (TSMR) framework.

Methods: Utilizing large-scale genome-wide association studies-retrieved data, we employed various Mendelian randomization (MR) techniques, including inverse variance weighted (IVW), MR-Egger regression, weighted median, and weighted mode, to ascertain BP's causal impact on CAD. The MR-Egger intercept was calculated to assess pleiotropy presence, determining heterogeneity by Cochran's Q statistic.

Results: The findings highlighted a significant association between elevated systolic BP (SBP; IVW: OR = 3.09, 95% CI: 1.11-8.61, P = 0.031) and increased diastolic BP (DBP; IVW: OR = 2.17, 95% CI: 1.14-6.21, P = 0.023) with CAD risk. Sensitivity analyses reinforced the robustness and reliability of these results.

Conclusions: The results from this TSMR study suggest a causal link between high SBP and DBP and the increased likelihood of CAD, which provides genetic evidence for a reduced risk of CAD under BP control.

血压升高:由基因决定的脑动脉夹层风险因素。
背景:我们旨在采用双样本孟德尔随机化(TSMR)框架研究血压(BP)水平与脑动脉夹层(CAD)风险之间的潜在因果关系:利用大规模全基因组关联研究(GWAS)检索到的数据,我们采用了各种 MR 技术,包括反方差加权(IVW)、MR-Egger 回归、加权中位数和加权模式,以确定血压对 CAD 的因果影响。计算MR-Egger截距以评估是否存在多向性,并通过Cochran's Q统计量确定异质性:研究结果表明,收缩压升高(SBP;IVW:OR=3.09,95% CI:1.11-8.61,p=0.031)和舒张压升高(DBP;IVW:OR=2.17,95% CI:1.14-6.21,p=0.023)与 CAD 风险之间存在明显关联。敏感性分析加强了这些结果的稳健性和可靠性:这项 TSMR 研究的结果表明,高 SBP 和 DBP 与患 CAD 的可能性增加之间存在因果关系,这为控制血压可降低患 CAD 的风险提供了遗传学证据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
American Journal of Hypertension
American Journal of Hypertension 医学-外周血管病
CiteScore
6.90
自引率
6.20%
发文量
144
审稿时长
3-8 weeks
期刊介绍: The American Journal of Hypertension is a monthly, peer-reviewed journal that provides a forum for scientific inquiry of the highest standards in the field of hypertension and related cardiovascular disease. The journal publishes high-quality original research and review articles on basic sciences, molecular biology, clinical and experimental hypertension, cardiology, epidemiology, pediatric hypertension, endocrinology, neurophysiology, and nephrology.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信