American Journal of Hypertension最新文献

{"title":"Strategies for Success: Million Hearts Hypertension Control Champions.","authors":"Jessica Barnett, Adam S Vaughan, Judith Hannan, Haley Stolp, Janet S Wright, Fátima Coronado","doi":"10.1093/ajh/hpaf040","DOIUrl":"10.1093/ajh/hpaf040","url":null,"abstract":"<p><strong>Background: </strong>Among the 119.9 million US adults with hypertension, an estimated 92.9 million have systolic blood pressure ≥ 130 mm Hg or diastolic blood pressure ≥ 80 mm Hg. Million Hearts is an initiative co-led since 2011 by the Centers for Disease Control and Prevention and the Centers for Medicare and Medicaid Services. The program drives improvement in hypertension control by celebrating high-achieving clinicians, practices, and health systems each year as Million Hearts Hypertension Control Champions. Champions have validated control rates of 80% or higher.</p><p><strong>Methods: </strong>Using data from each Champion, we summarized their key characteristics and quantified their use of various evidence-based strategies. We calculated summary statistics for application data provided by Champions based on the initiative's 5-year cycles of operation (2012-2015; 2017-2020; and 2022-2024).</p><p><strong>Results: </strong>From 2012 to 2024, a total of 199 Hypertension Control Champions from 44 states were recognized; the mean prevalence of systolic blood pressure < 140 mm Hg and diastolic blood pressure < 90 mm Hg was 82%. Overall, Champions reported using multiple evidence-based strategies to help their patients achieve hypertension control. The top 3 strategies were use of electronic medical record IT tools, patient support including self-measured blood pressure monitoring and team-based care.</p><p><strong>Conclusions: </strong>The Million Hearts Hypertension Control Champions demonstrate that hypertension control may be achievable among patients across diverse settings through the implementation of evidence-based approaches.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"640-643"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coronary Artery Disease and Sudden Unexplained Death in Patients on Dialysis: A Propensity Score-Matched Cohort Study.","authors":"Jose Jayme G De Lima, Luis Henrique W Gowdak, José Otto Reusing, Elias David-Neto, Luiz A Bortolotto","doi":"10.1093/ajh/hpaf002","DOIUrl":"10.1093/ajh/hpaf002","url":null,"abstract":"<p><strong>Background: </strong>To investigate the link between coronary artery disease (CAD) and sudden unexplained death (SUD) in patients undergoing dialysis and coronary angiography.</p><p><strong>Methods: </strong>We performed coronary angiography in 1,883 out of 3,080 dialysis patients on the waitlist for transplant following a prespecified protocol and 1,044 were included in the study using a propensity-match analysis and estimated by logistic regression to adjust for potential confounding variables and match. Patients with significant CAD were selected for medical treatment or coronary intervention. Cumulative incidence curves were constructed using the Aalen-Johansen method and compared by using Gray's test.</p><p><strong>Results: </strong>A total of 1,044 patients were split into 2 equal groups, with 522 subjects in each group based on the presence of CAD. CAD was associated with a nonsignificant 37% increased risk of SUD (hazard ratio 1.37 [0.83-2.24], P = 0.21). Among the 277 patients who underwent coronary intervention, the risk of SUD was reduced by 59% (hazard ratio 0.41 [0.23-0.72], P = 0.002).</p><p><strong>Conclusions: </strong>In patients undergoing dialysis and coronary angiography, CAD was not related to SUD. In a group with more severe and widespread CAD, coronary intervention was found to be associated with a reduced incidence of SUD. The data suggest that an invasive assessment of CAD may be beneficial in select dialysis populations for identifying and treating individuals at increased risk of SUD.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"714-721"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Comparative Study of the Clinical Efficacy of Superselective Adrenal Artery Embolization for Patients with Primary Aldosteronism.","authors":"L Wang, R Xiang, J Chang, M Mao, R Feng, L Tao, P Tang, Y P Zhao, Z Zuo, D S Gao, P Pu, W Huang, X Li, J Chen, H Zhao, Q Y Shi, F J Lv, Y T He, N A Khan, Z X Xu","doi":"10.1093/ajh/hpaf083","DOIUrl":"10.1093/ajh/hpaf083","url":null,"abstract":"<p><strong>Background: </strong>Superselective adrenal artery embolization (SAAE) is a potential treatment option for patients with primary aldosteronism (PA).</p><p><strong>Methods: </strong>This retrospective study aimed to compare the clinical efficacy and impact on cardiorenal organs of SAAE with mineralocorticoid receptor antagonists (MRA) and adrenalectomy (ADX) in patients with PA. After a median follow-up of 19 (12.5-26.5) months, 148 patients with PA were included in the study. The study cohorts consisted of 58, 53, and 37 patients treated with SAAE, MRA, and ADX, respectively.</p><p><strong>Results: </strong>During follow-up, SAAE achieved a significantly greater level of complete clinical success in the treatment of PA compared to MRA (P < 0.05). Within the SAAE group (n = 58), 19 (32.8%) and 26 (44.8%) patients achieved complete and partial clinical success, respectively. However, there were no significant differences in the prognostic parameters of the cardiorenal organs between the two groups. In the comparison of patients with UPA treated with SAAE (n = 35) and ADX (n = 37), there was no significant difference in clinical efficacy between the two groups.</p><p><strong>Conclusions: </strong>The findings of this study suggest that for patients with PA who are not suitable for ADX, SAAE is a viable treatment option that significantly improves clinical outcomes compared to MRA treatment.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"666-674"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144075350","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Neck Circumference and Cardiac Electrical Remodeling in Chinese Hypertension Patients With Obesity: A Cross-Sectional Study.","authors":"Pengjie Gao, Danni Wang, Tingting Zheng, Xiyang Li, Chaodi Luo, Suining Xu, Gang Tian","doi":"10.1093/ajh/hpaf064","DOIUrl":"10.1093/ajh/hpaf064","url":null,"abstract":"<p><strong>Background: </strong>Hypertension and obesity promote cardiac electrical remodeling. Neck circumference (NC) was correlated with cardiometabolic diseases. This study investigated the association between NC and cardiac electrical remodeling among Chinese hypertensive adults with obesity.</p><p><strong>Methods: </strong>1,123 hospitalized hypertension patients were finally included after excluding patients with secondary hypertension, atrial fibrillation, severe hepatic or renal disorders, and cancers. They were classified into four groups according to obesity status and the median NC values. Atrial electrical remodeling was defined by P-wave dispersion (Pwd) and the maximum P-wave duration (Pmax). Increased transmural dispersion of ventricular repolarization (TDR) was defined by Tpeak-to-Tend interval (Tpe) and Tpe/QT. The correlations between NC and cardiac electrical remodeling were evaluated using restricted cubic spline (RCS), logistic regression, and receiver operating characteristic curve (ROC). Stratified analysis was applied to evaluate differences in different subgroups.</p><p><strong>Results: </strong>Total participants included 479 (42.7%) obesity patients, of which the median NC was 41 cm. RCS showed the risk of atrial electrical remodeling increased exponentially when NC exceeded 37.73 cm. In hypertension patients with obesity, NC was independently associated with atrial electrical remodeling after adjusting for confounding factors. Stratified analysis showed a strong correlation between NC and atrial electrical remodeling in males and snoring patients. ROC suggested that NC can identify atrial electrical remodeling. Regarding the ventricular electrical remodeling, NC was only correlated with TDR, but not associated with traditional ventricular remodeling parameters.</p><p><strong>Conclusions: </strong>Large NC is an independent risk factor for atrial electrical remodeling in Chinese hypertension patients with obesity, especially for males and snoring patients.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"722-732"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Augmentation Index With Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis.","authors":"Fotios Karachalias, Lazaros K Yofoglu, Nikolaos Kakaletsis, Konstantinos Grammatopoulos, Antonios A Argyris, Eleni Korompoki, Elpida Athanasopoulou, Theodoros G Papaioannou, Athanasios D Protogerou","doi":"10.1093/ajh/hpaf054","DOIUrl":"10.1093/ajh/hpaf054","url":null,"abstract":"<p><strong>Background: </strong>Augmentation index (Aix) is a widely used index of pressure wave reflections (PWRs) derived from noninvasive blood pressure waves recordings and pulse wave analysis. Cerebral small vessel disease (cSVD) comprises various pathological processes affecting the brain's microvasculature and is a major cause of vascular cognitive impairment, ischemic, and hemorrhagic stroke. This meta-analysis aimed to assess the association between PWRs, as measured by AIx, and cSVD as identified through neuroimaging biomarkers, and to explore potential differences based on arterial site of AIx measurement.</p><p><strong>Methods: </strong>Following a predefined protocol adhering to the Meta-Analysis of Observational Studies in Epidemiology guidelines, nine studies comprising a total of 6,774 participants were included. Pooled effect estimates were calculated to evaluate the relationship between AIx and cSVD markers, including white matter hyperintensities (WMH).</p><p><strong>Results: </strong>A marginal positive association was observed between AIx and cSVD [central (carotid and aortic) AIx: β=0.04 (95% CI: 0.01-0.07) per SD increase; carotid AIx: β=0.05 (95% CI: 0.00-0.09); aortic AIx: β=0.03 (95% CI: 0.00-0.06)]. Similar results were found for the association between AIx and WMH [central (carotid and aortic) AIx: β=0.05 (95% CI: 0.01-0.08); carotid AIx: β=0.05 (95% CI: 0.00-0.10); aortic AIx: β=0.05 (95% CI: 0.00-0.010)].</p><p><strong>Conclusions: </strong>AIx showed a marginal positive association with cSVD, but the clinical relevance remains unclear. Substantial heterogeneity across studies, along with the absence of data on other PWR indices, limits the robustness and generalizability of these findings. Future research should employ advanced methodologies capable of assessing local PWR coefficients to better elucidate the relationship between PWRs and brain microcirculation.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"686-696"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term Efficacy and Safety of Unilateral Adrenal Artery Embolization in Patients with Idiopathic Hyperaldosteronism: A 24-month Cohort Study.","authors":"Guo Ji, Sen Liu, Jindong Wan, Yaqiong Zhou, Changqiang Yang, Xinquan Wang, Gaomin He, Anping Zeng, Lingling Zhang, Tao Luo, Yi Yang, Dan Wang, Kaige Feng, Jixin Hou, Peijian Wang","doi":"10.1093/ajh/hpaf077","DOIUrl":"10.1093/ajh/hpaf077","url":null,"abstract":"<p><strong>Background: </strong>Adrenal artery embolization (AAE) has been shown to reduce blood pressure (BP) and correct biochemical abnormalities in patients with idiopathic hyperaldosteronism (IHA) during short-term 6-12-month follow-ups. This study aimed to evaluate the long-term efficacy and safety of unilateral AAE over a 24-month period.</p><p><strong>Methods: </strong>The prospective study included 109 IHA patients undergoing unilateral AAE, with 94 completing the 24-month follow-up. Evaluations included office, home and 24-hour ambulatory BP, biochemical markers, renal function, and cardiac function (echocardiography). Medication use and adverse events were documented.</p><p><strong>Results: </strong>At the 24-month follow-up, the office, home, and 24-hour ambulatory systolic BP values decreased by 17.3 ± 23.1, 16.4 ± 21.9, and 9.9 ± 18.6 mmHg, respectively (all P < 0.001), and the diastolic BP values decreased by 8.8 ± 16.1, 7.1 ± 15.8, and 6.4 ± 11.1 mmHg (all P < 0.001). The complete and partial clinical success rates were 14.9% and 50.0%, respectively, whereas those for biochemical success were 13.6% and 45.5%. Abnormal biochemical characteristics, including elevated plasma aldosterone levels, increased aldosterone‒renin ratios (ARRs), plasma renin suppression, and hypokalemia, were significantly improved (all P < 0.01). Improvements in cardiac remodeling and left ventricular (LV) diastolic function were observed, particularly in those with elevated LV mass index (P < 0.05). No evidence of renal impairment or long-term safety concerns was observed.</p><p><strong>Conclusion: </strong>Unilateral AAE in IHA patients promotes sustained BP reduction, biochemical correction, improved cardiac remodeling, and enhanced LV diastolic function over 24 months, with no significant long-term safety concerns.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"675-685"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Heart-to-Heart With ChatGPT: AI Applications in Hypertension.","authors":"Anita T Layton","doi":"10.1093/ajh/hpaf045","DOIUrl":"10.1093/ajh/hpaf045","url":null,"abstract":"<p><p>Hypertension is a major contributor to cardiovascular disease and premature mortality. Yet despite extensive research, aspects of the disease remain incompletely understood. Indeed, even with the availability of numerous medications, achieving optimal blood pressure control continues to be a challenge for some patients. These challenges may be attributable to the inherent heterogeneity in disease phenotype and to comorbidities. The recent explosion in healthcare data has presented an opportunity for progress: Artificial intelligence (AI), which is particularly adept in identifying patterns and regularity in a dataset, may facilitate a breakthrough in hypertension. This review summarizes the ways in which AI has transformed clinical practices, patient care, medical education, and research methodologies in hypertension. The focus of the review is on ChatGPT, an AI-powered conversational model that has enhanced data analysis, decision support, and patient education and has the potential to revolutionize hypertension research, diagnosis, and treatment.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"621-627"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354285/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adrenal Ablation for Primary Aldosteronism: A Novel Alternative or Complement to Traditional Treatments.","authors":"Zhiming Zhu, Hao Wu, Hongbo He","doi":"10.1093/ajh/hpaf067","DOIUrl":"10.1093/ajh/hpaf067","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"628-631"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compliance and Impact of a 5-minute Seated Rest Protocol on Home Blood Pressure Monitoring in Postpartum Women.","authors":"J Kim, B B Gibbs, K M Whitaker","doi":"10.1093/ajh/hpaf152","DOIUrl":"https://doi.org/10.1093/ajh/hpaf152","url":null,"abstract":"<p><strong>Background: </strong>Home blood pressure monitoring (HBPM) is an effective method for diagnosing and managing postpartum hypertension, a condition associated with increased health risks. A 5-minute seated rest before home blood pressure (BP) measurement is recommended; however, compliance to this recommendation and its impact on HBPM reading in postpartum women is unknown.</p><p><strong>Methods: </strong>A subset of participants enrolled in a pregnancy cohort were followed at 3 and 6 months postpartum. At each assessment, participants completed HBPM for seven days with an oscillometric device and concurrently wore an accelerometer on their thigh to assess postures. Mixed-effects models and intraclass correlation coefficients (ICC) were utilized to analyze BP differences and measurement reliability between 5-minute rest compliant and non-compliant readings, respectively.</p><p><strong>Results: </strong>45 participants (mean age: 30.5 years) provided HBPM data at 3 and/or 6 months postpartum, with 90.2% of requested BP measures taken. Approximately 33% of readings adhered to the 5-minute rest protocol. Compliant readings averaged lower systolic and diastolic BP values than non-compliant readings (SBP: 105.9 mmHg vs. 107.1 mmHg; DBP: 72.6 mmHg vs. 73.2 mmHg), but differences were not clinically relevant. Compliant DBP ICCs fell within the good reliability range (ICCs: 0.785 - 0.817), while other ICCs indicated moderate reliability.</p><p><strong>Conclusions: </strong>Despite low compliance with 5 minutes of seated rest prior to HBPM, the minimal impact on BP values suggests HBPM remains a useful monitoring strategy in postpartum women, even if the pre-measurement rest is not always possible. Future research could evaluate whether shorter pre-measurement rest recommendations produce similar findings.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Dietary Salt excess on DNA Methylation and Transcriptional Regulation of human Angiotensinogen (hAGT) Gene Expression.","authors":"Sravan Perla, Rolando Garcia-Milan, Brahmaraju Mopidevi, Sudhir Jain, Ashok Kumar","doi":"10.1093/ajh/hpaf150","DOIUrl":"10.1093/ajh/hpaf150","url":null,"abstract":"<p><strong>Background: </strong>Hypertension is caused by a combination of genetic and environmental factors. Angiotensinogen (AGT) is a component of renin-angiotensin-aldosterone system (RAAS), that regulates blood pressure. Genome-wide association studies (GWAS) have shown that two A/G polymorphisms (rs2493134 and rs2004776), located at +507 and +1164 in intron I of the human AGT (hAGT) gene, are linked to hypertension. AGT polymorphisms result in two haplotypes, Hap-I a pro-hypertensive, whereas Hap-II is normotensive. Previous studies support the role of epigenetics in blood pressure regulation. In this study we generated transgenic mice (TG) with hAGT containing Hap-I and Hap-II variants to investigate the effect of high salt diet (HSD) on epigenetics and transcriptional regulation.</p><p><strong>Methods: </strong>We treated Hap-I and Hap-II TG mice with 4% HSD and identified DNA methylation patterns. We measured hAGT mRNA and protein by qPCR and immunoblot respectively. ChIP assay and RNA sequencing were performed.</p><p><strong>Results: </strong>hAGT gene expression is increased by HSD in both Hap-I and Hap-II TG mice. In the liver and kidney, we observed significantly higher DNA demethylation (less CpG's) and stronger binding of transcription factors in the promoter of Hap-I TG mice as compared to Hap-II post HSD. RNA-Seq identified differentially expressed genes, novel target genes, canonical pathways, and upstream regulators associated with hypertension.</p><p><strong>Conclusions: </strong>Our findings identified a novel high salt-sensitive risk haplotype, novel CpG sites and DNA methylation patterns, potential gene targets, and pathways implicated in hypertension. Combining epigenetic and transcriptional analysis allows for a more holistic understanding of the regulatory mechanisms that govern the hAGT gene.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144843996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}