American Journal of Hypertension最新文献

{"title":"The Interplay Between Time in Target Range for Blood Pressure and Left Ventricular Hypertrophy: A Tricky Exercise.","authors":"Ilektra Oikonomopoulou, Olga Kourti, Paparidou Rafaella, Elias Sanidas, Costas Thomopoulos","doi":"10.1093/ajh/hpaf157","DOIUrl":"https://doi.org/10.1093/ajh/hpaf157","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144939097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered amyloid-β42 and BACE-1 proteins in plasma astrocyte-derived exosomes in hypertensive patients with cerebral microbleeds.","authors":"Xiaoxiao Liu, Yuanyuan Liu, Ran Yao, Mengfan Li, Tengqun Shen, Bing Leng, Hairong Sun, Zhenguang Li, Jinbiao Zhang","doi":"10.1093/ajh/hpaf158","DOIUrl":"https://doi.org/10.1093/ajh/hpaf158","url":null,"abstract":"<p><strong>Background: </strong>Cerebral microbleeds (CMBs) have been found to promote Alzheimer's disease (AD) progression. Hypertension (HTN) is one of the major etiological factors for CMBs and an important risk factor for AD. However, the association between HTN-related CMBs and AD pathology remains undetermined. This study aims to identify the relationship between HTN-related CMBs and amyloid-β 42 (Aβ42) and β-site amyloid precursor protein cleaving enzyme 1 (BACE-1) levels in plasma astrocyte-derived exosomes (ADEs).</p><p><strong>Methods: </strong>In total, 88 HTN participants including 30 with deep/infratentorial (D/I) CMBs, 30 with mixed CMBs, and 28 without CMBs were analyzed. Susceptibility-weighted imaging was performed to assess the location, presence, and number of CMBs. ELISA kits for BACE-1 and Aβ42 were employed to evaluate the levels of astrocyte-derived exosomal proteins.</p><p><strong>Results: </strong>The results indicated that plasma ADE levels of Aβ42 were reduced in the HTN + D/I CMBs and HTN + Mixed CMBs groups relative to the HTN-CMBs group. Furthermore, the plasma ADE levels of Aβ42 were significantly associated with CMBs in patients with HTN. However, no significant differences were found in the plasma ADE levels of BACE-1 among the HTN + D/I CMBs, HTN + Mixed CMBs, and HTN-CMBs groups.</p><p><strong>Conclusions: </strong>The study revealed that reduced plasma ADE levels of Aβ42 were significantly associated with CMBs in HTN patients. This finding suggests a potential link between HTN-related CMBs and AD-related amyloid-β pathology, offering novel insights into the mechanisms by which HTN-related CMBs promote AD progression.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood Obesity Raises GDM Risk Through Adult Obesity: Evidence From Lifecourse Mendelian Randomization Study.","authors":"Yuying Zhang, Zikai Lin, Xuyu He, Jialin Lu, Peishan Tan, Qinyao Huang, Kunyi Zhang","doi":"10.1093/ajh/hpaf154","DOIUrl":"https://doi.org/10.1093/ajh/hpaf154","url":null,"abstract":"<p><strong>Background: </strong>The relationship between childhood and adulthood obesity and the risk of gestational diabetes mellitus (GDM) remains unclear. To clarify the independent and joint effects of childhood and adulthood body size on GDM risk, and explore inflammation's role.</p><p><strong>Methods: </strong>Using female-specific UK Biobank genome-wide association study data, genetic instruments for childhood/adult body size (\"thinner,\" \"about average,\" \"plumper\") and C-reactive protein (CRP) were identified. GDM variants came from FinnGen. Univariable and multivariable Mendelian randomization (MR) assessed causality and mediation.</p><p><strong>Results: </strong>Univariable MR analyses provided strong evidence for genetically predicted effects of both childhood body size (odds ratio [OR] per category = 1.72, 95% CI: 1.42-2.09, P < 0.001) and adulthood body size (OR = 1.59, 95% CI: 1.42-1.79, P < 0.001) on GDM risk. However, in multivariable MR analysis, the effect of childhood body size was attenuated and no longer significant after adjusting for adulthood body size (OR = 1.19, 95% CI: 0.91-1.48, P = 0.221), whereas the effect of adulthood body size remained significant even after controlling for birth weight, childhood body size, and age at menarche (OR = 1.42, 95% CI: 1.15-1.68, P = 0.011). Further analysis indicated that CRP partially mediated the effect of adulthood body size on GDM risk.</p><p><strong>Conclusions: </strong>Our findings suggest that childhood obesity increases the future risk of GDM primarily through its persistence into adulthood, and that inflammation, as indicated by elevated CRP levels, partially mediates the effect of adult obesity on GDM risk. These results highlight the importance of early obesity prevention and intervention, as well as inflammation control, to reduce the risk of GDM later in life.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":""},"PeriodicalIF":3.1,"publicationDate":"2025-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144999464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac Biomarkers in Pregnancies With and Without Hypertension.","authors":"Lara C Kovell, Mawulorm K I Denu, Julia Berkowitz, Sravya Shankara, Cassie Shao, Ekaterina Skaritanov, Gianna Wilkie, Tiffany A Moore Simas, Stephen P Juraschek","doi":"10.1093/ajh/hpaf061","DOIUrl":"10.1093/ajh/hpaf061","url":null,"abstract":"<p><strong>Background: </strong>Mechanisms of injury due to hypertension (HTN) in pregnancy remain poorly characterized. This study examined trends in markers of cardiac injury (high-sensitivity troponin I, hs-cTnI), strain (N-terminal pro-B-type natriuretic peptide, NT-proBNP), and inflammation (high-sensitivity C-reactive protein, hs-CRP) in pregnancies with and without HTN.</p><p><strong>Methods: </strong>This prospective, 1:1 case-control study enrolled pregnant women with and without HTN (24-32 weeks gestation) from 2019 to 2022. HTN was defined by a clinical diagnosis of HTN or baseline blood pressure (BP) ≥ 140/90 mm Hg. Serum was collected at baseline, predelivery, and postpartum day 1. Mixed effects tobit models compared log-transformed hs-cTnI, NT-proBNP, and hs-CRP across HTN groups and over time, adjusted for age and body mass index.</p><p><strong>Results: </strong>Mean baseline BP was 130.5 (17.5)/88.2 (13.5) mm Hg for the HTN group (n = 38, 86.8% chronic, 13.2% gestational HTN), and 112.0 (9.8)/70.9 (8.2) mm Hg for those without HTN (n = 38). Over pregnancy, the HTN group had higher hs-cTnI than those without HTN (2.12 [0.43] vs. 1.07 [0.25], Δ1.05 [95%CI: 0.07-2.03] ng/l). Compared to baseline, hs-cTnI increased at predelivery and postpartum for both groups. Overall, the two groups had similar NT-proBNP (HTN: 39.0 [4.5] vs. no HTN: 35.6 [4.3] pg/mL) and hs-CRP (HTN: 12.0 [1.7] vs. no HTN: 9.9 [1.5] mg/L). For both groups, NT-proBNP and hs-CRP increased from baseline to postpartum (NT-proBNP, HTN: 127% [58-227%], no HTN: 120% [51-219%]; hs-CRP: HTN: 550% [343-853%], no HTN: 664% [415-1,034%]).</p><p><strong>Conclusion: </strong>HTN was associated with markers of cardiac injury during pregnancy, while delivery alone led to increases in markers of strain and inflammation. These biomarker changes associated with HTN in pregnancy may represent potential mechanisms to explain adverse cardiovascular events.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"697-705"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Treatment of Primary Aldosteronism: Can We Compare Apples to Oranges?","authors":"John M Giacona, Wanpen Vongpatanasin","doi":"10.1093/ajh/hpaf094","DOIUrl":"10.1093/ajh/hpaf094","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"635-636"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144180719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances in Adrenal Ablation for Primary Aldosteronism.","authors":"Isaac Glassman, Gregory L Hundemer","doi":"10.1093/ajh/hpaf091","DOIUrl":"10.1093/ajh/hpaf091","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"637-639"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasmacytoid Dendritic Cell Content Is Associated With Plasma Aldosterone Concentration in Patients With Primary Aldosteronism.","authors":"Anna M Imiela, Tomasz P Mikołajczyk, Sylwia Kołodziejczyk-Kruk, Jacek Kądziela, Mateusz Spiewak, Magdalena Januszewicz, Marek Kabat, Ignacy Sterliński, Marcin Wąs, Aleksandra Wróbel, Dominik Skiba, Joanna Natorska, Tomasz J Guzik, Andrzej Januszewicz","doi":"10.1093/ajh/hpaf019","DOIUrl":"10.1093/ajh/hpaf019","url":null,"abstract":"<p><strong>Background: </strong>Inflammation plays a pivotal role in blood pressure regulation. Current data reflect the important role of T cells in primary hypertension. The role of dendritic cells (DC) in secondary hypertension-primary aldosteronism (PA) remains unknown. The aim of this study was to quantify peripheral blood T lymphocytes, plasmacytoid dendritic cells (pDCs), and inflammatory markers in individuals with PA compared to essential hypertension (HTN).</p><p><strong>Methods: </strong>Thirty-nine patients with PA and 15 patients with HTN were enrolled. Clinical data, serum aldosterone concentration, ambulatory blood pressure monitoring (ABPM), echocardiography, and phenotype of peripheral blood cells with the usage of flow cytometry were assessed.</p><p><strong>Results: </strong>No differences were found in terms of age, sex, and BMI between the groups. In both groups, similar levels of systolic and diastolic blood pressure on ABPM were noted. Both PA and HTN were associated with cardiac hypertrophy (LVMI). In comparison with HTN, PA patients had a notably higher percentage of pDC characterized by co-expression of CD123 and CD303. A positive correlation between aldosterone concentration and the percentage of CD123+ CD303+ pDC in the PA was observed. The PA group exhibited lower concentrations of RANTES, TNF-α, CD40L, and VEGF compared to the HTN group.</p><p><strong>Conclusions: </strong>Higher aldosterone concentration was connected with the increased numbers of plasmacytoid pDC.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"644-653"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143582162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Outcomes of Adrenalectomy, Mineralocorticoid Receptor Antagonist, and Percutaneous Adrenal Ablation for Primary Aldosteronism: A Systematic Review and Network Meta-Analysis.","authors":"Liyuan Yuan, Xinyi Li, Fang Sun, Yi Tang, Wuhao Wang, Wei Liu, Xiaona Sun, Yushuang Luo, Xiaona Bu, Zongshi Lu, Daoyan Liu, Qiang Li, Zhiming Zhu","doi":"10.1093/ajh/hpaf029","DOIUrl":"10.1093/ajh/hpaf029","url":null,"abstract":"<p><strong>Background: </strong>Percutaneous adrenal ablation (PAA) is an effective and safe therapy for treating patients with primary aldosteronism (PA). However, its effectiveness in comparison to that of adrenalectomy (ADX) and mineralocorticoid receptor antagonists (MRAs) remains unclear.</p><p><strong>Methods: </strong>Databases were searched including PubMed, Embase, and The Cochrane Library. Studies included patients with PA who received two of three different treatments (ADX, MRAs, or PAA) and reported our interested outcomes, including blood pressure, serum potassium, and the aldosterone-to-renin ratio (ARR).</p><p><strong>Results: </strong>In a total of 10,681 patients from 47 studies were identified. Both ADX and PAA showed superior clinical success (systolic blood pressure (BP): ADX: -4.69 (-6.4, -2.95), PAA: -3.96 (-9.05, 0.99); diastolic BP: ADX: -3.14 (-4.55, -1.85), PAA: -2.99 (-6.96, 0.98)) compared with MRAs. According to the Bayesian ranking curves (surface under the cumulative ranking values), ADX ranked first for all outcomes of interest (systolic BP: 81.02%, diastolic BP: 76.95%, serum potassium: 96.55%, and ARR: 88.03%), while PAA ranked second for all outcomes (systolic BP: 65.94%, diastolic BP: 69.66%, serum potassium: 50%, and ARR: 45.14%).</p><p><strong>Conclusions: </strong>The findings of this network meta-analysis suggest that PAA could be an alternative treatment for patients with PA who are unable to opt for surgery or MRA therapy, and its clinical and biochemical success falls between those of ADX and MRAs.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"654-665"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological Age as a Predictor of Arterial Stiffness in Young and Early Midlife Black and White Women.","authors":"Telisa A Spikes, Alvaro Alonso, Roland J Thorpe, Jordan Pelkmans, Melinda Higgins, Samaah Sullivan, Sandra B Dunbar, Vasiliki Michopoulos, Charles Searles, Tené T Lewis, Puja K Mehta, Priscilla Pemu, Herman Taylor, Arshed Quyyumi","doi":"10.1093/ajh/hpaf059","DOIUrl":"10.1093/ajh/hpaf059","url":null,"abstract":"<p><strong>Background: </strong>Chronological age (CA) is independently associated with arterial stiffness, but it is not a sufficient measure of aging or the disparities related to disease risk. While biological age (BA) is considered a more accurate indicator of disease risk, the relationships among BA, CA, and arterial stiffness remain inconclusive.</p><p><strong>Methods: </strong>In 222 women (n = 143 White, n = 79 Black) enrolled in the Predictive Health Institute cohort (age range 25-49), arterial stiffness was assessed using carotid-femoral pulse wave velocity (cfPWV), measured by applanation tonometry (SphygmoCor). BA was estimated using the Klemera-Doubal method from 11 different clinical biomarkers and CA. Accelerated age (AccA) was calculated as the difference between BA and CA. Overall and race-specific associations between BA and arterial stiffness adjusting for sociodemographics, health behaviors, and clinical factors were estimated using multiple linear regression.</p><p><strong>Results: </strong>Mean (SD) CA was 41.4 (6.3) years in Black women and 39.8 (6.0) years in White women, respectively. Mean (SD) BA, AccA, and cfPWV were 43 (13.1) and 1.6 (12.9) years, and 7.3 (1.1) m/s in Black women and 36 (10.8) and -3.2 (10.6) years, and 6.3 (0.8) m/s in White women (Black-White difference in BA: 6.4 years, P = <0.001). Higher BA was associated with a 0.015 m/s per year (95% CI: 0.002, 0.029, P = 0.028) higher cfPWV after adjustment for demographic and CVD risk factors, without evidence of an interaction by race (P = 0.65).</p><p><strong>Conclusions: </strong>BA was associated with arterial stiffness in the fully adjusted model. Targeting modifiable risk factors may promote healthy vascular aging and reduce subclinical CVD progression.</p>","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"706-713"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143953801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on \"Plasmacytoid Dendritic Cell Content Is Associated With Plasma Aldosterone Concentration in Patients With Primary Aldosteronism\".","authors":"Georgiana Constantinescu, Nicole Bechmann","doi":"10.1093/ajh/hpaf076","DOIUrl":"10.1093/ajh/hpaf076","url":null,"abstract":"","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"632-634"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}