American Journal of Hypertension最新文献_第6页

Debating coffee and hypertension: coffee may increase the risk for chronic hypertension. 争论咖啡和高血压：咖啡可能会增加患慢性高血压的风险。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-07-01 DOI: 10.1093/ajh/hpag017

Paolo Palatini

引用次数: 0

Hypertension and new-onset atrial fibrillation in participants with diabetes mellitus: a report from the population-based Kailuan study. 糖尿病患者高血压和新发房颤：一项基于人群的开滦研究报告

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-07-01 DOI: 10.1093/ajh/hpag011

Hongmin Liu, Tonglian Lyu, Yuntao Wu, Haiyan Zhao, Liming Lin, Gregory Y H Lip, Shouling Wu, Tong Liu

{"title":"Hypertension and new-onset atrial fibrillation in participants with diabetes mellitus: a report from the population-based Kailuan study.","authors":"Hongmin Liu, Tonglian Lyu, Yuntao Wu, Haiyan Zhao, Liming Lin, Gregory Y H Lip, Shouling Wu, Tong Liu","doi":"10.1093/ajh/hpag011","DOIUrl":"10.1093/ajh/hpag011","url":null,"abstract":"Background: Hypertension and diabetes mellitus are both known risk factors for atrial fibrillation (AF). Whether coexisting hypertension exacerbates AF risk among individuals with diabetes remains unclear. This study aims to investigate the association between hypertension and incident AF in this population.Methods: We studied participants in the prospective Kailuan Study, including 18,084 adults diagnosed with diabetes between 2006 and 2011 and free of AF at baseline. Hypertension was defined by a previous diagnosis, use of antihypertensive medications, or systolic/diastolic blood pressure ≥140/90 mm Hg. Incident AF was identified via biennial electrocardiograms and hospital records. Cox proportional hazards models adjusted for demographic, lifestyle, metabolic, and clinical covariates were used to estimate hazard ratios (HRs).Results: Over a median follow-up of 14.8 years (interquartile range 12.7-16.8), 275 participants with diabetes developed AF, and 5,265 died from any cause. Hypertension was associated with a higher risk of AF (adjusted HR, 1.48; 95% confidence interval [CI], 1.05-2.07) compared to those without hypertension. Compared to participants with normal blood pressure, the adjusted HRs for AF were 1.54 (95% CI, 1.11-2.13) for grade 1 hypertension and 1.61 (95% CI, 1.06-2.44) for grade 2 hypertension. Among those with hypertension, target organ damage-particularly prior myocardial infarction or ischemic stroke-further elevated AF risk (HR, 2.66; 95% CI, 1.26-5.60).Conclusions: Hypertension independently increases AF risk in individuals with diabetes, especially with higher blood pressure levels and target organ damage. Early hypertension control is crucial for the prevention of AF in this high-risk population.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"892-900"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146200052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Debating coffee and hypertension: coffee does not increase the risk of chronic hypertension. 争论咖啡和高血压：咖啡不会增加患慢性高血压的风险。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-07-01 DOI: 10.1093/ajh/hpag028

Guido Grassi

引用次数: 0

Innovative Device-Based Treatments for Hypertension. 创新设备治疗高血压。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-07-01 DOI: 10.1093/ajh/hpaf235

Min Zhang, Peng Li, Yanhui Sheng

引用次数: 0

Lorundrostat for Patients With Uncontrolled Hypertension: A Systematic Review With Meta-Analysis and Trial Sequential Analysis. Lorundrostat对不受控制的高血压患者的治疗：meta分析和试验序列分析的系统综述。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-07-01 DOI: 10.1093/ajh/hpaf246

Vicente Morales Ribeiro, Douglas Nunes Cavalcante, Hermes Estevam Torega Celkevicius, Giovanna Cristina Gonçalves Camacho, Henrique Alexsander Ferreira Neves, Kevlin de Souza, Rafael Henkes Machado, Lucca Moreira Lopes, Webster Donaldy, Luiz Aparecido Bortolotto, Jamil Cherem Schneider

{"title":"Lorundrostat for Patients With Uncontrolled Hypertension: A Systematic Review With Meta-Analysis and Trial Sequential Analysis.","authors":"Vicente Morales Ribeiro, Douglas Nunes Cavalcante, Hermes Estevam Torega Celkevicius, Giovanna Cristina Gonçalves Camacho, Henrique Alexsander Ferreira Neves, Kevlin de Souza, Rafael Henkes Machado, Lucca Moreira Lopes, Webster Donaldy, Luiz Aparecido Bortolotto, Jamil Cherem Schneider","doi":"10.1093/ajh/hpaf246","DOIUrl":"10.1093/ajh/hpaf246","url":null,"abstract":"Background: The efficacy and safety of lorundrostat, a selective aldosterone synthase inhibitor, in patients with uncontrolled hypertension remain unclear. This meta-analysis aimed to evaluate its effects on blood pressure and risk of hyperkalemia.Methods: PubMed, Embase, Cochrane Library, and ClinicalTrials.gov were systematically searched through July 2025 for randomized controlled trials comparing lorundrostat with placebo. Pooled mean differences (MD) and risk ratios (RR) with 95% CIs were estimated using a random-effects model with the Restricted Maximum Likelihood estimator. Trial sequential analysis (TSA) was conducted to assess the conclusiveness of safety evidence.Results: Three RCTs including 1060 patients were identified. Lorundrostat significantly reduced systolic blood pressure at 50 mg (MD, -9.08 mmHg; 95% CI, -13.14 to -5.03) and 100 mg (MD, -11.41 mmHg; 95% CI, -15.97 to -6.85), and diastolic blood pressure at 50 mg (MD, -3.48 mmHg; 95% CI, -5.98 to -0.98). However, lorundrostat increased the risk of hyperkalemia at 50 mg (RR, 6.56; 95% CI, 1.53-28.12; NNH = 71) and 100 mg (RR, 10.37; 95% CI, 2.44-44.03; NNH = 42). TSA confirmed hyperkalemia at 100 mg as the only conclusive harm signal, while other safety outcomes remained inconclusive.Conclusions: Lorundrostat effectively lowered blood pressure but increased dose-dependent risk of hyperkalemia. These findings support its potential as a novel therapy for uncontrolled hypertension, while emphasizing the need for longer-term cardiovascular outcome trials and direct comparisons with mineralocorticoid receptor antagonists concerning efficacy and safety.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"911-920"},"PeriodicalIF":2.9,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Validation and Subgroup Analysis of the Accuracy of the Photoplethysmography-based Microlife Cuffless Upper-arm Wearable Blood Pressure Monitor. 基于光电容积描记仪的Microlife无袖带上臂可穿戴式血压监测仪准确性的验证和亚组分析。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-06-01 DOI: 10.1093/ajh/hpaf238

Ching-Fu Wang, Han-Lin Wang, Pei-Hsin Kuo, Shih-Zhang Li, Bo-Wei Chen, Ssu-Ju Li, You-Yin Chen, Sheng-Huang Lin

{"title":"Validation and Subgroup Analysis of the Accuracy of the Photoplethysmography-based Microlife Cuffless Upper-arm Wearable Blood Pressure Monitor.","authors":"Ching-Fu Wang, Han-Lin Wang, Pei-Hsin Kuo, Shih-Zhang Li, Bo-Wei Chen, Ssu-Ju Li, You-Yin Chen, Sheng-Huang Lin","doi":"10.1093/ajh/hpaf238","DOIUrl":"10.1093/ajh/hpaf238","url":null,"abstract":"Background: This study (1) validates the accuracy of the photoplethysmography-based Microlife cuffless upper-arm wearable blood pressure (BP) monitor according to the AAMI/ESH/ISO 81060-2:2018/Amd 1:2020 standard; (2) investigates the device's performance across age groups and skin tone; and (3) evaluates the advantages of cuffless BP monitoring in terms of estimation variability, required time, and stability.Methods: A total of 120 participants aged ≥20 years were recruited from the general population, ensuring the representation of diverse age and skin tone groups. The device was calibrated against a clinically validated mercury sphygmomanometer. Sequential same-arm BP estimation were performed. Accuracy was analyzed according to the ISO criteria, and further subgroup analysis was conducted to compare results between participants aged ≥65 and <65 years, as well as between participants with lighter and darker skin tones (classified according to the Fitzpatrick system). Additionally, estimation stability and variability were evaluated using 3 averaged BP estimations.Results: The results demonstrated that the Microlife device met the AAMI/ESH/ISO accuracy criteria. Subgroup analysis revealed consistent accuracy across age and skin tone groups, with slight differences warranting further exploration. Notably, the cuffless design enabled faster estimations with reduced variation between the 3 averaged readings, showcasing its potential for home BP monitoring and frequent self-assessments.Conclusions: These findings support the clinical potential of photoplethysmography-based cuffless BP monitoring in diverse adult populations, particularly for facilitating rapid and stable BP estimations in elderly individuals and users with varying skin tones. Further large-scale studies are warranted to corroborate and build upon these observations.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"757-766"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145754770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing Optical Character Recognition of Home Blood Pressure Measurements, a Randomized Trial. 测试光学字符识别家庭血压测量，一个随机试验。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-06-01 DOI: 10.1093/ajh/hpaf227

Austin J Strom, Esra'a Khader, Philip M Polgreen, Shelby L Francis, Alberto M Segre, Ted Herman, Lisa M Antes, Amanda R Karanikolas, Linnea A Polgreen

{"title":"Testing Optical Character Recognition of Home Blood Pressure Measurements, a Randomized Trial.","authors":"Austin J Strom, Esra'a Khader, Philip M Polgreen, Shelby L Francis, Alberto M Segre, Ted Herman, Lisa M Antes, Amanda R Karanikolas, Linnea A Polgreen","doi":"10.1093/ajh/hpaf227","DOIUrl":"10.1093/ajh/hpaf227","url":null,"abstract":"Background: Diagnosing hypertension typically requires repeated blood pressure (BP) readings taken over multiple days, but obtaining accurate BP measurements from patients at home is known to be challenging, at least in part due to failure to accurately report those measurements. Here, we evaluate 2 low-cost electronic reporting strategies, text messaging, and a novel image-based alternative, for acceptability and accuracy.Methods: We developed and tested a 2-stage optical character recognition (OCR) model to \"read\" a BP monitor display from patient-provided cellphone photographs. We then conducted a crossover trial to test the accuracy and acceptability of image-based BP reporting with having patients report BP measurements by text messaging. We compared the response rates and values obtained from photo uploads to those from text messages.Results: The majority of the 50 respondents submitted most of the requested data. We received an average of 12/14 texted BP responses and 11.3/14 photo responses from participants. Only 4 participants sent neither text nor photo responses. In addition, our OCR model achieved 98.3% accuracy when \"reading\" BP values from images of sufficient quality (17.9% were rejected for quality issues), and the average BP reported by subjects did not differ between our text and image-based methods.Conclusion: We were able to successfully \"read\" BP values from photos of BP monitors sent by participants. Both text messaging and photo uploads of monitor displays appear to be accurate and acceptable approaches for collecting home BP readings.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"744-749"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13101530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145547673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigation on the clinical value and potential mechanism of miR-127-3p in preeclampsia. miR-127-3p在子痫前期的临床价值及可能机制探讨。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-06-01 DOI: 10.1093/ajh/hpag005

Maocheng Xiong, Lin Yang, Peng Hou

{"title":"Investigation on the clinical value and potential mechanism of miR-127-3p in preeclampsia.","authors":"Maocheng Xiong, Lin Yang, Peng Hou","doi":"10.1093/ajh/hpag005","DOIUrl":"10.1093/ajh/hpag005","url":null,"abstract":"Background: Preeclampsia (PE) is a pregnancy-specific condition characterized by hypertension and multiorgan dysfunction that can lead to severe maternal and perinatal complications. The miR-127-3p is downregulated in PE, but the mechanism of action in PE is not yet clear.Methods: The study enrolled 113 PE patients and 93 healthy controls. The expression level of miR-127-3p was evaluated by real-time quantitative polymerase chain reaction (RT-qPCR), its correlation with clinical indicators of PE was analyzed by correlation analysis, and the diagnostic value of miR-127-3p in PE was evaluated by the receiver operator characteristic (ROC) curve. In vitro, HTR8/SVneo cells were treated with hypoxia/reoxygenation (H/R) and transfected with miR-127-3p mimics/inhibitors. The regulatory effects of miR-127-3p on the H/R-induced HTR8/SVneo model were verified by cell counting kit-8, Transwell, and enzyme linked immunosorbent assay. The interaction between KIF3B and miR-574-3p was confirmed through dual-luciferase reporter assays.Results: The miR-127-3p expression was significantly downregulated in PE patients and correlated with the severity and outcomes of PE. ROC analysis showed that miR-127-3p had a significant diagnostic value in PE. In vitro, miR-127-3p overexpression could restore trophoblast proliferation and invasion ability, and suppress proinflammatory cytokines including tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β in HTR8/SVneo cells induced by H/R. KIF3B was confirmed as a downstream gene of miR-127-3p, and the regulatory relationship between miR-127-3p and KIF3B was confirmed.Conclusion: In PE, downregulated miR-127-3p expression correlating with PE severity and outcomes could be used as a biomarker for PE auxiliary diagnosis. In vitro, miR-127-3p overexpression enhances trophoblast function and inhibits the inflammatory responses.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"806-815"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146123438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Non-Insulin-Based Markers of Insulin Resistance With Hypertension in Type 2 Diabetes: An Age- and Gender-Matched Cross-Sectional Study. 非胰岛素基础的胰岛素抵抗标志物与2型糖尿病高血压的关联：一项年龄和性别匹配的横断面研究

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-06-01 DOI: 10.1093/ajh/hpaf237

Amirhossein Yadegar, Fatemeh Mohammadi, Seyedeh Nazanin Aghayan, Fatemeh Heydarzadeh, Sepideh Yadegar, Ali Mohammadi Naeini, Seyed Arsalan Seyedi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani

{"title":"Association of Non-Insulin-Based Markers of Insulin Resistance With Hypertension in Type 2 Diabetes: An Age- and Gender-Matched Cross-Sectional Study.","authors":"Amirhossein Yadegar, Fatemeh Mohammadi, Seyedeh Nazanin Aghayan, Fatemeh Heydarzadeh, Sepideh Yadegar, Ali Mohammadi Naeini, Seyed Arsalan Seyedi, Soghra Rabizadeh, Alireza Esteghamati, Manouchehr Nakhjavani","doi":"10.1093/ajh/hpaf237","DOIUrl":"10.1093/ajh/hpaf237","url":null,"abstract":"Background: This study investigated the association and discriminative ability of 6 surrogate insulin resistance (IR) indices-TyG, TyG-BMI, TyG-WC, TyG-WHtR, METS-IR, and the TG/HDL-C ratio-for hypertension (HTN) in patients with type 2 diabetes (T2D).Methods: This cross-sectional, age- and gender-matched case-control study included 4236 patients with T2D (2167 with HTN and 2069 without) who attended a diabetes clinic between January 2014 and December 2024. Associations between surrogate IR indices and HTN were assessed using RCS and multivariable logistic regression. Discriminative ability and calibration were evaluated using ROC and calibration plots. The net reclassification improvement and integrated discrimination improvement analyses quantified the incremental value beyond a basic model.Results: Each surrogate IR index showed a significant non-linear association with HTN. After adjusting for confounding factors, the ORs for HTN increased with higher values of each index. All indices demonstrated significant discriminative ability (AUCs ≥ 0.690), with TyG-BMI showing the highest AUC (0.698; 95% CI, 0.664-0.733). A TyG-BMI cutoff of 144.5 identified HTN with 61% sensitivity and 71% specificity (P < .001). Calibration was relatively good, and the addition of surrogate IR indices to the basic model (age, gender, diabetes duration, LDL-C, HbA1c, and eGFR) significantly improved HTN identification.Conclusions: These findings support the use of surrogate IR indices as practical tools for identifying and assessing the risk of HTN in patients with T2D and highlight the potential role of IR in the development of HTN.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"776-783"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145808910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ubiquitin-Specific Peptidase 8 Mediates Angiotensin-II-Induced Smooth Muscle Cell Phenotypic Transformation during Hypertension via Regulating LRRC8A. 泛素特异性肽酶8通过调节LRRC8A介导高血压患者血管紧张素ii诱导的平滑肌细胞表型转化。

IF 2.9 3区医学

American Journal of Hypertension Pub Date : 2026-06-01 DOI: 10.1093/ajh/hpaf250

Huiliang Zhou, Xiong Ge, Guangrui Feng, Liang Liu

{"title":"Ubiquitin-Specific Peptidase 8 Mediates Angiotensin-II-Induced Smooth Muscle Cell Phenotypic Transformation during Hypertension via Regulating LRRC8A.","authors":"Huiliang Zhou, Xiong Ge, Guangrui Feng, Liang Liu","doi":"10.1093/ajh/hpaf250","DOIUrl":"10.1093/ajh/hpaf250","url":null,"abstract":"Background: Leucine-rich repeat-containing protein 8 A (LRRC8A) has been uncovered to play a role in pulmonary vascular remodeling during hypertension. The present study aims to investigate a novel mechanism involving LRRC8A in smooth muscle cell (SMC) phenotypic transformation under the hypertension context.Methods: Angiotensin (Ang)-II-treated human aortic SMCs were established as the cell model under the hypertension context. Western blot and reverse-transcription quantitative polymerase chain reaction were used to detect the levels of target genes. Cell viability and proliferation were evaluated by cell counting kit 8 and 5-ethynyl-2'-deoxyuridine assays, and migration and invasion assays were applied to assess the abilities to migrate and invade of SMCs. The interaction between LRRC8A and ubiquitin-specific protein 8 (USP8) was predicted by the Ubibrowser database and verified by co-immunoprecipitation assay, respectively.Results: LRRC8A was upregulated in Ang-II-treated SMCs, the silence of which reduced cell proliferation, migration, and invasion and increased the expression of contractile proteins (α-SMA, alpha-smooth muscle actin; SM22α, SM22 alpha). USP8 modulated the ubiquitination-modifying levels on LRRC8A protein, and USP8 promoted SMC phenotypic transformation depending on its deubiquitination function. LRRC8A overexpression reversed the repressed cell phenotypic transformation mediated by USP8 silence, and USP8 might accelerate vascular remodeling partly by activating the LRRC8A/PI3K/AKT axis during hypertension.Conclusion: LRRC8A upregulation involves in SMC phenotypic transformation under the hypertension context; USP8 can modulate LRRC8A expression in a deubiquitination-dependent manner to further regulate the downstream PI3K/AKT axis during hypertension, which may provide novel therapeutic targets for hypertension management.","PeriodicalId":7578,"journal":{"name":"American Journal of Hypertension","volume":" ","pages":"767-775"},"PeriodicalIF":2.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145916548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0