American journal of obstetrics and gynecology最新文献

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Consensus and controversies of international guidelines for the diagnosis, surveillance and management of fetal growth restriction: an updated comparison. 胎儿生长受限诊断、监测和管理国际指南的共识和争议:最新比较。
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-10 DOI: 10.1016/j.ajog.2026.04.010
Daniele Di Mascio,Suneet P Chauhan,Tullio Ghi,Asma Khalil,Juliana G Martins,Sara Sorrenti,Tamara Stampalija,Fabrizio Zullo,Francesc Figueras
{"title":"Consensus and controversies of international guidelines for the diagnosis, surveillance and management of fetal growth restriction: an updated comparison.","authors":"Daniele Di Mascio,Suneet P Chauhan,Tullio Ghi,Asma Khalil,Juliana G Martins,Sara Sorrenti,Tamara Stampalija,Fabrizio Zullo,Francesc Figueras","doi":"10.1016/j.ajog.2026.04.010","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.010","url":null,"abstract":"OBJECTIVETo compare areas of consensus and disagreements across contemporary international and national guidelines on the diagnosis, surveillance, and management of fetal growth restriction (FGR).DATA SOURCESElectronic searches of MEDLINE from database inception up to March 2026 using MeSH terms and keywords related to FGR and guidelines.STUDY ELIGIBILITY CRITERIACritical, structured comparison of national or international guidelines on FGR published since 2010. Final inclusion required unanimous agreement from all authors.STUDY APPRAISAL AND SYNTHESIS METHODSPre-specified extraction across domains: definition; prediction/prevention; surveillance tools and frequency; delivery timing and mode; and labor induction methods. Dual data checking with consensus resolution. We focused mainly on areas of cross-guideline agreement and divergence in (1) definitions (FGR vs small-for-gestational age [SGA]; early vs late), (2) diagnostic/surveillance tools (biometry, Doppler, cardiotocography CTG (conventional or computerized), biophysical profile, biomarkers), and (3) management (aspirin/low-molecular weight heparin [LMWH], steroids, magnesium sulfate, induction methods, delivery timing/mode).RESULTSSix guidelines, three national (Canada, United Kingdom, France), one US society guideline (SMFM) and two international societies (ISUOG, FIGO) published predominantly between 2015 and 2024 were included. Broad agreement exists on the central role of Doppler-especially umbilical artery and, in early-onset cases, ductus venosus (except for SMFM) -for risk stratification and delivery timing. Other consensus points include antenatal corticosteroids, magnesium sulfate for anticipated preterm birth, early aspirin in high-risk pregnancies, and access to genetic counseling/testing in severe or early-onset FGR with structural anomalies. Universal third-trimester ultrasound is not recommended in low-risk pregnancies. Controversies remain on the definition of FGR versus SGA (SMFM biometric threshold vs Delphi criteria), routine use of angiogenic biomarkers, LMWH for prevention, choice of growth charts, the role of the biophysical profile, computerized CTG, and induction methods (mechanical generally favored but with limited evidence).CONCLUSIONSCurrent guidelines converge on Doppler-based surveillance and standard preterm interventions, but substantial heterogeneity persists in definitions and several management domains, reflecting variable evidence and resource contexts. Priorities include harmonizing definitions, validating surveillance algorithms (notably computerized CTG and DV), clarifying growth-chart selection, and rigorously testing the added value of angiogenic biomarkers and induction strategies to improve FGR outcomes.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"21 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prolapse phenotypes and 12-month post-operative prolapse recurrence after apical native tissue surgery: a combined analysis using multicenter randomized trials and registry data. 脱垂表型和根尖原生组织手术后12个月脱垂复发:多中心随机试验和注册数据的联合分析
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-10 DOI: 10.1016/j.ajog.2026.04.012
Katherine Weston,Kimberly A Kenne,Catherine S Bradley,Linder Wendt,Joseph T Kowalski
{"title":"Prolapse phenotypes and 12-month post-operative prolapse recurrence after apical native tissue surgery: a combined analysis using multicenter randomized trials and registry data.","authors":"Katherine Weston,Kimberly A Kenne,Catherine S Bradley,Linder Wendt,Joseph T Kowalski","doi":"10.1016/j.ajog.2026.04.012","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.012","url":null,"abstract":"BACKGROUNDRecurrence after pelvic organ prolapse surgery is not uncommon, and recurrence rates differ based on baseline prolapse characteristics such as genital hiatus size and prolapse stage. Better understanding the relationship between anatomic prolapse subgroups and surgical outcomes may allow surgeons to individualize treatment decisions and improve outcomes. We previously identified clinically relevant prolapse phenotypes (subgroups) defined using the pelvic organ prolapse quantification (POP-Q) system and now seek to study associations between these phenotypes and surgical outcomes in a large, prospectively collected dataset.OBJECTIVEThe primary aim was to determine the association between a novel system of phenotyping prolapse and prolapse symptom recurrence 12 months post-operatively in women undergoing vaginal native-tissue apical prolapse surgery. We hypothesized that different prolapse phenotypes would have different risks of prolapse recurrence. Secondary aims included determining associations between the phenotypes and anatomic prolapse recurrence and new onset stress urinary incontinence (SUI).STUDY DESIGNThis was a secondary analysis of data combined from three multicenter randomized trials and one prospective, multicenter patient registry. Participants from these studies who underwent uterosacral ligament suspension (USLS) or sacrospinous ligament fixation (SSLF) without mesh and had 12 month follow up data were included and categorized into one of 8 phenotypes based on the POP-Q system: (1) no prolapse (n=5, excluded), (2) isolated anterior, (3) isolated posterior, (4) isolated apical, (5) anterior and posterior, (6) anterior-predominant and apical, (7) posterior-predominant and apical, and (8) anterior and posterior and apical. The primary outcome was symptomatic recurrence 12 months after surgery defined as a positive response to the Pelvic Floor Distress Inventory \"bulge\" question with at least \"somewhat\" bother. Univariable and multivariable logistic regression analyses (adjusted for prolapse stage (stage II vs. stage III-IV) and prior hysterectomy) were developed for each outcome.RESULTSOf 704 participants, most (473 (67.2%)) had anterior-predominant and apical prolapse (used as reference group), followed by the anterior and posterior and apical (101 (14.3%)) and isolated apical (45 (6.4%)) phenotypes. Overall, 184 (26.1%) had sacrospinous ligament fixation, 520 (73.9%) uterosacral ligament suspension and most had midurethral slings (MUS) (454 (64.5%)). Symptomatic prolapse recurrence occurred in 65 (9.2%) overall, ranging from 0% to 29% across phenotype groups, and was particularly uncommon in the isolated posterior (0%) and isolated apical (2.2%: one participant) phenotypes. However, phenotype group was not significantly associated with symptomatic recurrence in univariable or multivariable analysis. Hispanic ethnicity (OR 2.25 [1.17-4.35], p=0.015, private insurance (OR 0.58 [0.35-0.98], p=0.042) and vaginal parity (OR 1","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"456 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Outcomes Following Oophorectomy During Benign Hysterectomy in Those Who Are in Post-menopausal Ages: A Population-based Study. 绝经后良性子宫切除术期间卵巢切除术后的健康结果:一项基于人群的研究
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-10 DOI: 10.1016/j.ajog.2026.04.011
Helena Abreu do Valle,Ali Salmanpour,Paramdeep Kaur,Lesa Dawson,Graham C Wong,Janice S Kwon,Gillian E Hanley
{"title":"Health Outcomes Following Oophorectomy During Benign Hysterectomy in Those Who Are in Post-menopausal Ages: A Population-based Study.","authors":"Helena Abreu do Valle,Ali Salmanpour,Paramdeep Kaur,Lesa Dawson,Graham C Wong,Janice S Kwon,Gillian E Hanley","doi":"10.1016/j.ajog.2026.04.011","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.011","url":null,"abstract":"OBJECTIVESWhile postmenopausal bilateral salpingo-oophorectomy during benign hysterectomy may reduce the likelihood of adnexal surgeries and the risk of ovarian cancer, more evidence is needed to evaluate the health impacts of this procedure. Given the role of residual hormone secretion by postmenopausal ovaries, we hypothesize that performing bilateral oophorectomy at the time of benign hysterectomy among postmenopausal people may impact the risk of cardiovascular diseases and accelerated bone loss, both of which can significantly affect the quality of life in aging women.STUDY DESIGNIn this retrospective population-based study, we used linked administrative data from British Columbia, Canada to evaluate cardiovascular and bone health outcomes in people aged 50-60 years old who did and did not undergo bilateral salpingo-oophorectomy at the time of hysterectomy due to benign gynecological conditions between January 01, 1996, and September 30, 2019, with follow-up until December 31, 2020. Multivariable Cox proportional hazards models were used, adjusting for age at surgery, year of surgery, systemic menopausal hormone therapy use after surgery, and presence of baseline cardiovascular or bone health conditions up to 5 years before surgery, indication and route of surgery. Subgroup analyses were conducted by stratifying individuals into early postmenopausal ages (50-55 years) and later postmenopausal ages (56-60 years). Statistical analyses were performed in R software version 4.0.3, STATA 16.1 (StataCorp) and SAS 9·4 (SAS Institute, Cary, NC) software.RESULTSOut of the 18,676 patients who remained in the study after applying exclusion criteria, 46.3% (n=8,653) had hysterectomy with bilateral salpingo-oophorectomy. We observed no statistically significant difference in cardiovascular composite event outcomes (congestive heart failure, myocardial infarction, cerebral vascular disease, ischemic heart disease) and cardiovascular procedures outcomes (percutaneous coronary intervention, coronary artery bypass, or cardiac catheterization) across the groups. Nevertheless, patients who had concurrent oophorectomy were at a higher risk of being diagnosed with conditions that predispose them to cardiovascular diseases, such as diabetes and hypertension (aHR =1.16, 95%CI = 1.08-1.25) and were also more likely to be prescribed cardiovascular medications (aHR = 1.07, 95%CI = 1.00-1.15). No significant differences were observed between the groups in terms of osteoporosis, fractures, or initiating osteoporosis medication after adjustment for covariates. The likelihood of starting menopausal hormone therapy after surgery was significantly higher for those who had hysterectomy with bilateral oophorectomy compared to hysterectomy with ovarian conservation (aHR = 2.04, 95%CI 1.92-2.17). Results mostly remained consistent in the subgroup analyses, especially among participants aged 50-55.CONCLUSIONOur study revealed that although removing postmenopausal ovaries at the ","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"21 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Methodological considerations in randomized trial of third trimester ultrasound screening (Reply to Letter-to-the-Editor). 妊娠晚期超声筛查随机试验的方法学考虑(回复编辑信)。
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-10 DOI: 10.1016/j.ajog.2026.04.009
Alessandra Familiari,Enrico Ferrazzi,Tullio Ghi
{"title":"Methodological considerations in randomized trial of third trimester ultrasound screening (Reply to Letter-to-the-Editor).","authors":"Alessandra Familiari,Enrico Ferrazzi,Tullio Ghi","doi":"10.1016/j.ajog.2026.04.009","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.009","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"25 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine surgery before pregnancy is associated with later preterm birth and stillbirth: a population-based record linkage study. 妊娠前子宫手术与后期早产和死产相关:一项基于人群的记录关联研究。
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-09 DOI: 10.1016/j.ajog.2026.04.001
E C Olive,C Li,W-Q He,M Davies-Tuck,A Gordon,N Nassar
{"title":"Uterine surgery before pregnancy is associated with later preterm birth and stillbirth: a population-based record linkage study.","authors":"E C Olive,C Li,W-Q He,M Davies-Tuck,A Gordon,N Nassar","doi":"10.1016/j.ajog.2026.04.001","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.001","url":null,"abstract":"BACKGROUNDUterine surgery in high income countries is provided for management of failed or unplanned pregnancies, for excision of polyps and fibroids, for correction of congenital anomaly, for investigation of subfertility and to facilitate use of an intrauterine contraceptive device. Many women have at least one procedure prior to their first birth.OBJECTIVEWe hypothesise that any uterine surgery requiring dilation of the cervix could weaken the cervix and lead to a higher risk of preterm birth in a later pregnancy. We also hypothesise that uterine surgery could leave endometrial scarring which might lead to later impaired placentation and increased risk of stillbirth. Thirdly we hypothesise that the strength of association will increase for those having repeated surgical procedures.STUDY DESIGNPopulation linked data study of all first births in NSW Australia between 2007 and 2019. Linkage between the NSW Admitted Patient Data Collection and the Perinatal Data Collection allowed assessment of uterine surgery exposure and subsequent obstetric outcomes for individuals. Logistic regression was used to assess the impact of surgery and known relevant covariates.RESULTSThere were 520050 women who had a first birth in NSW between 2007-2019 and 99659 uterine surgery procedures performed between 2001 and 2019. Uterine surgery occurred for 14.7% of the population. Uterine surgery prior to a first birth is associated with both later preterm birth (adjusted OR 1.51 CI=1.47-1.55) and stillbirth (adjusted OR 1.39 CI=1.26-1.53). The associations strengthened with repeated procedures and were most significant at earliest gestational age.CONCLUSIONThis hypothesis generating study suggests that uterine surgery before pregnancy should be carefully considered with reference to evidence of benefit and any available medical alternate treatment strategies. Further research is needed to understand potential confounding by indication, as the reason for surgery may independently increase pregnancy risks. Antenatal surveillance for risk of preterm birth may be considered when surgery is unavoidable.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"26 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Associations Between Psychological and Trauma-Related Factors and Urinary Incontinence Severity and Treatment Response Among Women Veterans. 心理和创伤相关因素与女性退伍军人尿失禁严重程度和治疗反应的关系
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-09 DOI: 10.1016/j.ajog.2026.04.005
Danielle Scharp,Karen M Goldstein,Ursula A Kelly,Kathryn L Burgio,Camille P Vaughan,Orna Intrator,Alayne D Markland
{"title":"Associations Between Psychological and Trauma-Related Factors and Urinary Incontinence Severity and Treatment Response Among Women Veterans.","authors":"Danielle Scharp,Karen M Goldstein,Ursula A Kelly,Kathryn L Burgio,Camille P Vaughan,Orna Intrator,Alayne D Markland","doi":"10.1016/j.ajog.2026.04.005","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.005","url":null,"abstract":"BACKGROUNDPsychological and trauma-related factors (i.e., stress, anxiety, post-traumatic stress disorder, and military sexual trauma) may induce physiological responses that contribute to UI. Women Veterans are disproportionately affected by psychological and trauma-related factors, which may influence urinary incontinence severity and response to behavioral urinary incontinence treatment.OBJECTIVESWe aimed to examine associations between psychological and trauma-related factors and both urinary incontinence severity and response to behavioral urinary incontinence treatment among women Veterans.STUDY DESIGNWe conducted a secondary analysis of data from a randomized controlled trial that evaluated the effectiveness of two remote urinary incontinence behavioral treatment modalities in three southeastern Veterans Healthcare Administration systems from April 2020 to September 2023. Urinary incontinence severity was measured with International Consultation on Incontinence-Urinary Incontinence Short Form scores to reflect urinary incontinence frequency and amount leaked. Treatment response was defined as a 2.52-point reduction in International Consultation on Incontinence-Urinary Incontinence Short Form scores and modeled as a binary outcome. Stress was assessed with the Perceived Stress Scale-10. Military sexual trauma was determined based on two validated Veterans Health Administration screening items. Post-traumatic stress disorder and anxiety were assessed with self-reported items indicating whether participants were ever diagnosed with these conditions. We performed bivariate analyses to examine differences in sample characteristics by treatment response status. We used linear regression models to examine associations between each psychological and trauma-related factor and urinary incontinence severity at baseline and reported β coefficients. We used logistic regression models to estimate the odds of treatment response by each psychological and trauma-related factor.RESULTSAmong 200 women Veterans (mean age=54 years, standard deviation=11), the most commonly reported psychological and trauma-related factors were anxiety (138/200, 69%), military sexual trauma (120/200, 60%), and post-traumatic stress disorder (101/200, 51%), and their mean perceived stress score was 17.9 (standard deviation=8.6) indicating moderate stress. Higher levels of perceived stress (β=0.18, 95% confidence interval [0.08, 0.27], p<.001), diagnosed anxiety (β=3.35, 95% confidence interval [1.73, 4.97], p<.001), post-traumatic stress disorder (β=1.96, 95% confidence interval [0.40, 3.51], p=.02), and reported military sexual trauma (β=1.80, 95% confidence interval [0.18, 3.41, p=.03) were significantly associated with greater urinary incontinence severity after adjusting for age, race, ethnicity, education level, body mass index, vaginal parity, menopausal status, medication for urinary incontinence, hysterectomy status, and randomization group. In total, 55% (109/200) of wo","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"40 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147655719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal antisepsis should not be routinely performed prior to cesarean delivery in developed countries (reply to letter to the editor). 在发达国家,剖宫产前不应常规进行阴道消毒(回复致编辑的信)。
IF 8.4 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-08 DOI: 10.1016/j.ajog.2026.04.003
Jordan A McKinney, Luis Sanchez-Ramos, Jose Duncan
{"title":"Vaginal antisepsis should not be routinely performed prior to cesarean delivery in developed countries (reply to letter to the editor).","authors":"Jordan A McKinney, Luis Sanchez-Ramos, Jose Duncan","doi":"10.1016/j.ajog.2026.04.003","DOIUrl":"10.1016/j.ajog.2026.04.003","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.4,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147653533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uterine Fibroids in Latinas: Findings from the Environment, Leiomyomas, Latinas, and Adiposity Study. 拉丁美洲人的子宫肌瘤:来自环境、平滑肌瘤、拉丁美洲人和肥胖研究的发现。
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-07 DOI: 10.1016/j.ajog.2026.04.006
Erica E Marsh,Danielle A Jean,Charley Jiang,Felix Valbuena,Sioban Harlow,Lisa Neff,Mercedes Carnethon,Ganesa Wegienka,Donna D Baird
{"title":"Uterine Fibroids in Latinas: Findings from the Environment, Leiomyomas, Latinas, and Adiposity Study.","authors":"Erica E Marsh,Danielle A Jean,Charley Jiang,Felix Valbuena,Sioban Harlow,Lisa Neff,Mercedes Carnethon,Ganesa Wegienka,Donna D Baird","doi":"10.1016/j.ajog.2026.04.006","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.006","url":null,"abstract":"BACKGROUNDLatinos are among the fastest growing populations in the United States. While previous work indicates racial/ethnic differences in fibroid prevalence, little is known about the prevalence of this condition among Latina females in the U.S.OBJECTIVETo determine the prevalence of fibroids among reproductive-aged Latina females and identify associated factors in this population.STUDY DESIGNELLAS is a prospective cohort study of Latina females, based in Southeast Michigan. Data were collected between October 2017 and October 2022, at both the Community Health and Social and Social Services Center (CHASS) in Detroit, MI, and the University of Michigan's Center for Reproductive Medicine in Ann Arbor, MI. Eligible participants self-identified as Hispanic or Latina; were assigned female sex at birth; were aged 21-50 years at enrollment; could speak, read, and write in either English or Spanish; were not currently pregnant; and did not have an implantable electrical device, history of malignancy, or other conditions requiring chemotherapy or radiation. Fibroid symptoms were not a requirement of participation. Fibroid prevalence was rigorously established via self-reported medical history and expert administration of transvaginal ultrasounds. Participant features - including demographics, health, acculturation level, and other factors of interest - were established via surveys, interviews, and in-person measurement.RESULTSAmong ELLAS participants who completed a vaginal ultrasound (N = 609 of 621 eligible), the mean age was 37.3 ± 7.0 years and 68 (11.2%, CI 8.6%-13.8%) presented with fibroids. The majority had a single fibroid (75.0%), while 25.0% had two or more. The mean size of the largest fibroid - most often intramural (80.9%) - was 2.9 ± 1.2 cm in diameter. Fibroid prevalence was found to be higher in older age groups, rising from 3.5% (CI 1.4% - 10.0%) among participants aged 21-30 years, to 8.3% (CI 4.9% - 11.7%) in those 31-40, and 18.7% (CI 13.3%- 24.1%) between 41-50 (P<0.001). Logistic regression models indicated that fibroid presence was associated with younger age at menarche (aOR 0.84, 95% CI 0.72-0.99) and increasing gravidity (aOR 0.80, CI 0.66-0.97). Findings indicated no significant association with parity (aOR 0.85 CI 0.68-1.07).CONCLUSIONSELLAS is among the first prospective studies of its size to use an ultrasound confirmation approach to establish fibroid prevalence among Latina females in the United States. Our findings suggest the prevalence of fibroids among Latina females is much lower than previously reported in the literature and significantly lower than in Black and White women. More research is needed to understand why burden may be lower in this population and how such findings can be used to benefit all women.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"8 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147641708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaginal Antisepsis Should Not be Routinely Performed Prior to Cesarean Delivery in Developed Countries (Letter-to-the-Editor 在发达国家,剖宫产前不应常规进行阴道消毒(致编辑的信)
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-07 DOI: 10.1016/j.ajog.2026.04.002
Harold C. Wiesenfeld MD CM
{"title":"Vaginal Antisepsis Should Not be Routinely Performed Prior to Cesarean Delivery in Developed Countries (Letter-to-the-Editor","authors":"Harold C. Wiesenfeld MD CM","doi":"10.1016/j.ajog.2026.04.002","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.002","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"216 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New biomarkers for the detection of fetal death derived from large-scale proteomic analysis of maternal plasma 从母体血浆大规模蛋白质组学分析中获得检测胎儿死亡的新生物标志物
IF 9.8 1区 医学
American journal of obstetrics and gynecology Pub Date : 2026-04-02 DOI: 10.1016/j.ajog.2026.03.029
Roberto ROMERO, Gaurav BHATTI, Tinnakorn CHAIWORAPONGSA, Nardhy GOMEZ-LOPEZ, Arun MEYYAZHAGAN, Piya CHAEMSAITHONG, Eunjung JUNG, Awoniyi O. AWONUGA, Yeon Mee Kim, Dereje W. Gudicha, Chong Jai KIM, David R. BRYANT, Sonia S. HASSAN, Adi L. TARCA
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