American journal of obstetrics and gynecology最新文献

{"title":"Reducing the long-term impact of cesarean scar defects: a focus on prevention.","authors":"Sarah P Walker,Helena C Bartels,Davor Jurkovic,Eric Jauniaux","doi":"10.1016/j.ajog.2026.04.024","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.024","url":null,"abstract":"As cesarean delivery rates continue to rise worldwide, the long-term obstetric and gynecological complications associated with cesarean scar defects are becoming increasingly prevalent. These include cesarean scar ectopic pregnancies, placenta previa accreta, secondary subfertility, chronic pelvic pain, and intermenstrual bleeding. The objective of this review is to evaluate how the optimization of the hysterotomy location in relation to myometrial thickness and uterine vascularity, together with an appropriate uterine closure technique, could reduce the long-term impact of cesarean scar defects. A wide range of closure techniques have been described, with substantial heterogeneity in study design, outcome measures, and follow-up intervals, limiting definitive conclusions. Emerging evidence suggests that unlocked, interrupted, purse-string, and endometrium-free sutures, along with the use of monofilament or barbed sutures, may reduce cesarean scar formation and thus the risks of scar placentation in subsequent pregnancies. These approaches may promote better healing by reducing tissue compression and ischemia, unlike continuous, locked, endometrium-inclusive sutures, which may impair perfusion. Increasing attention to endometrium-free closure and precise anatomical realignment highlights the importance of meticulous surgical technique in contemporary obstetrics. Surgical repair of cesarean scar defects improves outcomes in patients with chronic gynecological symptoms and subfertility. However, evidence supporting its role in preventing obstetric complications in subsequent pregnancies remains limited, in part because such complications are rare. Moreover, cesarean scar defect repair requires removing the scar tissue and reconstruction using healthy myometrium, which may theoretically increase the risk of dehiscence or uterine rupture in subsequent pregnancies. A key knowledge gap in much of the existing literature is its focus on imaging-defined cesarean scar defects rather than on patient-centered long-term gynecological symptoms. Well-designed, multi-arm studies that incorporate standardized postpartum imaging to characterize uterine remodeling over time are essential for identifying best practices. While resource-intensive, advancing this field could improve long-term patient outcomes and reduce healthcare costs.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"1 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving Communication in Pregnancy: A Neurodivergent-Responsive Approach.","authors":"Amos Grünebaum,John H Coverdale,Mollie R Gordon,Renee McLeod-Sordjan,Susan L Pollet,Amanda Kirby,Frank A Chervenak","doi":"10.1016/j.ajog.2026.04.020","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.020","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"23 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Language Barriers in Medical Professional Liability Cases in Obstetrics and Gynecology.","authors":"Adam C Schaffer,Jonathan S Einbinder,Tarek Zawi,Luke Sato","doi":"10.1016/j.ajog.2026.04.021","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.021","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"9 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodevelopmental Disorders Following Fetal Reduction of Triplet Pregnancies: A Nationwide Cohort Study.","authors":"Mads L Larsen,Steffen E Kristensen,Maria K Rasmussen,Christina E Hoei-Hansen,Olav B Petersen","doi":"10.1016/j.ajog.2026.04.018","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.018","url":null,"abstract":"BACKGROUNDTriplet pregnancies carry high risks of prematurity and subsequent neurodevelopmental disorders. Fetal reduction from triplets to twins improves short-term obstetric outcomes, but long-term neurodevelopmental outcomes among surviving children remain uncertain.OBJECTIVESTo compare the long-term risk of neurodevelopmental disorders among liveborn children from trichorionic triamniotic (TCTA) triplet pregnancies managed with fetal reduction from 3 to 2 fetuses vs no reduction.STUDY DESIGNWe conducted a nationwide, population-based cohort study using the Danish Fetal Medicine Database, linked to national health registries and local prenatal records. We included all TCTA triplet pregnancies diagnosed at the routine first-trimester scan (11-14 weeks' gestation) with estimated due dates from January 1, 2008, through December 31, 2018. Liveborn children were then followed from birth until an outcome of interest, death, emigration, or the end of the study period (December 31, 2022). The outcomes of interest were neurodevelopmental disorders, defined by diagnoses of epilepsy, cerebral palsy, or intellectual disability, combined into a primary composite outcome of any of these disorders. Cumulative incidence through age 15 years was estimated in each group, with death as a competing risk. Moreover, cause-specific hazard ratios (HR) were estimated using multivariable Cox regression with robust variance to account for clustering within pregnancies, adjusted for maternal age, educational level, and assisted reproduction.RESULTSAmong 313 eligible TCTA pregnancies, 219 (70%) underwent 3-2 fetal reduction at a median gestational age of 11+6 weeks (IQR 11+5-12+1), and 87 (28%) did not. Overall, 625 liveborn children were included (399 (64%) from reduced pregnancies and 226 (36%) from nonreduced pregnancies). Over a median follow-up of 9.3 years (IQR 6.5-12.5), 34 children were diagnosed with at least one neurodevelopmental disorder (cumulative incidence at 15 years, 6.6% (95% CI 4.4-9.5%)). Neurodevelopmental disorders were diagnosed in 13 children after reduction and in 21 without. Thus, the cumulative incidence of neurodevelopmental disorders by age 15 was 4.2% (95% CI 2.1-7.5) after 3-2 fetal reduction and 10.7% (95% CI 6.5-16.2%) with no reduction (Gray test, P<0.001). Furthermore, fetal reduction was associated with a lower hazard of neurodevelopmental disorders (adjusted HR, 0.33 (95% CI 0.15-0.71)). For individual disorders, estimates were directionally similar but imprecise due to small numbers; for epilepsy, the adjusted HR was 0.37 (0.14-0.98) following fetal reduction. Among all pregnancies with at least one surviving child, the absolute risk of minimum one child being diagnosed with a neurodevelopmental disorder was 5.9% (12/202) following fetal reduction; however, 19,8% (17/86) without.CONCLUSIONAmong liveborn children from TCTA triplet pregnancies, fetal reduction from 3 to 2 fetuses was associated with a substantially lower long-term risk ","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"14 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147708536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Hypertensive Disorders of Pregnancy and Severe Maternal Morbidity.","authors":"Marion E Granger Howard,Berry A Campbell,Nansi S Boghossian","doi":"10.1016/j.ajog.2026.04.016","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.016","url":null,"abstract":"BACKGROUNDHypertensive disorders of pregnancy (HDP) are major contributors to both short- and long-term morbidity. Among the adverse outcomes associated with HDP is severe maternal morbidity (SMM).1-4 Although the various HDP subtypes differ in their timing of onset, clinical presentation, and severity, little is known about how this heterogeneity is associated with the risk of SMM. This study examines the association between subtypes of HDP and SMM.STUDY DESIGNWe examined hospital administrative data for pregnancies resulting in live or stillbirth ≥20 weeks' gestation at the Prisma Health Midlands and Upstate facilities in South Carolina from 2016 to 2024 (n = 96,161). We compared individuals with no hypertensive disorder vs. those with chronic hypertension with superimposed pre-eclampsia with or without severe features or with unspecified severity, chronic hypertension without superimposed pre-eclampsia, pre-eclampsia with and without severe features or with unspecified severity, and gestational hypertension. HDP were defined using International Classification of Disease codes.5 HDP were classified into mutually exclusive groups based on the highest severity level reached during the pregnancy. Adjusted Poisson regression models with robust error variance were used to determine the association between each HDP and non-transfusion SMM as defined by the Centers for Disease Control, as well as SMM including blood transfusions of ≥1200 mL. The primary adjusted models included maternal race/ethnicity, parity, smoking, marital status, insurance, plurality, and preexisting diabetes mellitus, and secondary adjusted models included maternal race/ethnicity, parity, smoking, marital status, insurance, and comorbidity index score as defined by the California Maternal Quality Care Collaborative.RESULTSOf 96,161 birthing individuals, 27,460 (28.6%) had HDP. HDP were more prevalent among Black birthing individuals, as well as those who smoked, were obese, delivered by cesarean, were unmarried, or had public insurance. Most comorbid conditions were more prevalent among individuals with HDP compared with those without and SMM indicators varied by HDP type. All HDP were associated with increased risk of non-transfusion SMM [chronic hypertension with superimposed pre-eclampsia with severe features adjusted risk ratio (aRR): 9.75 (95% CI: 8.04-11.83), chronic hypertension with superimposed pre-eclampsia without severe features aRR: 4.45 (95% CI: 2.30-8.59), chronic hypertension with pre-eclampsia of unspecified severity aRR: 5.32 (95% CI: 4.36-6.48), chronic hypertension without pre-eclampsia aRR: 2.20 (95% CI: 1.67-2.90), pre-eclampsia with severe features aRR: 6.24 (95% CI: 5.44-7.16), pre-eclampsia without severe features aRR: 3.57 (95% CI: 2.67-4.77), pre-eclampsia of unspecified severity aRR: 3.49 (95% CI: 2.73-4.46), gestational hypertension aRR: 1.72 (95% CI: 1.46-2.02)]. Results were similar for SMM including blood transfusions of ≥1200 mL. When the comorbi","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"19 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptomic Evidence of Remodeling in Postpartum Levator Ani Muscle Associated with Maternal Age and Recovery Time after First Vaginal Delivery.","authors":"Carolyn W Swenson,Nima Pouladi,Hannah A Zabriskie,Paul-Emile Bourrant,Jianrong Li,Liam S Wilson,Micah J Drummond,Yves A Lussier","doi":"10.1016/j.ajog.2026.04.013","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.013","url":null,"abstract":"BACKGROUNDOlder maternal age at first vaginal delivery, defined in some studies as ≥30 years old, confers a significant increased risk of pelvic organ prolapse. Age-related impairment of postpartum recovery of levator ani muscles may help explain this association; yet, little is known about the biomolecular changes that occur in the levator ani after vaginal delivery, or with aging.OBJECTIVETo evaluate the transcriptional signature of the levator ani immediately after vaginal delivery and 6-8 weeks postpartum among young primiparas (18-25 years) and older primiparas (≥35 years).STUDY DESIGNThis study is a prospective study in which nulliparous women were recruited in the third trimester of pregnancy. Levator ani muscle biopsies were obtained immediately after vaginal delivery and at 6-8 weeks postpartum. Clinical measures of pelvic floor support and levator ani muscle function were obtained at the 6-8 week postpartum visit. Biopsies were analyzed using RNA sequencing methods and differentially expressed genes were compared with those reported in prior studies of pelvic organ prolapse patients. We used a moderated t-test (false discovery rate <5%) to identify differentially expressed genes associated with postpartum delivery, maternal age, and the interaction between the two. Principal component analysis confirmed segregation of clinical phenotype variables based on gene expression.RESULTSEight women (3 young, 5 older) underwent levator ani biopsies at both time points and had sufficient tissue for analyses. A total of 58 differentially expressed genes were identified when evaluating the interaction of age and recovery interval, including TP53BP1 (upregulated), PRR12 (upregulated), ZNF316 (upregulated), and PLK3 (downregulated). Between age groups, 309 differentially expressed genes were identified, while 159 were identified between timepoints. Both age groups were enriched for core tissue-repair and homeostatic programs. Twenty of the differentially expressed genes identified in the separate analyses of age and time were previously identified in four case-control studies of pelvic organ prolapse. The correlation between the transcriptomic signature (principal component 3) and the overall clinical phenotype profile (principal component 1) was significant (ρ = 0.88, FDR < 0.05) while the correlation observed with maternal age alone was not (ρ = -0.72).CONCLUSIONSIn agreement with clinical evidence, the effects of maternal age on levator ani muscle recovery can be seen at the transcriptional level. Age and recovery time share similar biological processes that, when disrupted, may predispose the levator ani to altered recovery and long-term susceptibility to pelvic organ prolapse. Specifically, elevated TP53BP1 combined with reduced PLK3 suggests a pattern of disrupted p53-regulated checkpoint and elevated cellular senescence which would impair healing. Results from the principal component analysis indicate that the transcriptomic signature captures ","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"142 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In women with chronic hypertension, does fetal growth restriction increase progression to maternal preeclampsia?","authors":"Laura A Magee,Christos Chatzakis,Argyro Syngelaki,Ranjit Akolekar,Peter von Dadelszen,Kypros H Nicolaides","doi":"10.1016/j.ajog.2026.04.014","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.014","url":null,"abstract":"OBJECTIVESAmong women with chronic hypertension, it is unclear whether uteroplacental dysfunction should be classified as indicating superimposed preeclampsia, or be considered direct complications of chronic hypertension.STUDY DESIGNWe undertook a secondary analysis of a prospectively-evaluated cohort of women with chronic hypertension and singleton pregnancies, who underwent routine fetal ultrasound at 35+0-36+6 weeks' gestation. We compared the incidence of preeclampsia and other adverse pregnancy outcomes, between cases and propensity score-matched (PSM) controls; cases had estimated fetal weight (EFW) <10th percentile, with and without fetal growth restriction (FGR), defined as abnormal fetal Dopplers (uterine artery pulsatility index [PI] >95th centile, umbilical artery PI >95th centile, or middle cerebral artery PI <5th centile), and controls had EFW ≥10th percentile. Superimposed preeclampsia was defined by maternal criteria, either traditionally by development of new-onset proteinuria at ≥20 weeks', or by additional maternal criteria, by 2019 American College of Obstetricians and Gynecologists or 2021 International Society for the Study of Hypertension in Pregnancy guidance. Covariates included in PSM were: maternal race/ethnicity, mode of conception, smoking status, systemic lupus erythematosus, parity, history of preeclampsia, history of a baby with birthweight <10th centile, maternal age, body mass index, and gestational weight gain (kg). Matching was conducted using: a nearest-neighbor algorithm without replacement, a ratio of one case to two controls, and a caliper width of 0.2 SD of the logit of the propensity score. Balance between groups after matching was assessed using standardised mean differences, with values <0.1 considered indicative of adequate balance.RESULTSOf 1258 included pregnancies with chronic hypertension, there were 167 (13.3%) cases (64, 38.3% designated as FGR cases with abnormal fetal Dopplers), and 1091 (86.7%) controls. 234/1258 (18.6%) women went on to develop preeclampsia. After PSM analysis, there were no differences between the 167 cases and 334 PSM controls in baseline maternal or 35-36 weeks' characteristics. Cases with FGR (vs. PSM controls) more often: developed preeclampsia (regardless of definition), underwent labour induction, had Caesarean birth, and had a shorter ultrasound-to-birth interval by 1.8 weeks; they also delivered 1.7 weeks earlier, and more often had babies with birthweight <10th percentile for gestational age, or those admitted to the neonatal unit. There was no difference between groups in the composite neonatal outcome. Cases without FGR (vs. PSM controls) did not differ with regards to development of preeclampsia, but they did have a shorter ultrasound-to-birth interval (by 0.8 weeks), delivered 0.7 weeks earlier, and more often had babies with birthweight <10th percentile.CONCLUSIONSOur findings suggest that women with chronic hypertension who have evidence of FGR at 35-36 weeks'","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"1 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biallelic mutations in ANAPC13 cause female infertility characterized by oocyte maturation arrest both in humans and mice.","authors":"Yu Wang,Zhiming Ding,Xuemei Liu,Xu Liu,Hujia Tan,Na Zheng,Kexin Yu,Biaobang Chen,Fengsong Wang,Yunxia Cao,Lingli Huang,Qing Sang,Fuxi Zhu","doi":"10.1016/j.ajog.2026.04.017","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.017","url":null,"abstract":"BACKGROUNDOocyte maturation arrest is an intractable clinical problem, resulting in recurrent failure of assisted reproductive treatments (ARTs). The anaphase-promoting complex or cyclosome (APC/C) orchestrates a series of proteolytic events to ensure proper cell cycle progression of mitosis in somatic cell proliferation and meiosis during oocyte maturation. Defects in APC/C subunits, such as ANAPC8 and ANAPC12, have been demonstrated linked to oocyte maturation arrest. However, the roles of other APC/C subunits in oocyte maturation remain unclear.OBJECTIVEThis study aimed to reveal the causal relationship between ANAPC13 mutations and oocyte maturation arrest, while elucidating the pathogenic mechanism to provide a theoretical basis for clinical diagnosis and treatment.STUDY DESIGNPatients diagnosed with oocyte maturation arrest by morphological assessment during ARTs were recruited and underwent whole-exome sequencing. Mutations in ANAPC13 were identified in three patients and screened out as the candidate. The recurrent mutation c.6C>A was recapitulated in a knock-in mouse model (Anapc13M/M mice) to clarify its association with oocyte maturation arrest, with wild-type mice (Anapc13+/+ mice) serving as controls. Further phenotyping experiments with mouse oocytes, proteomic analysis of human oocytes, and molecular experiments with cell lines and plasmids were conducted to determine the role of ANAPC13 in oocyte maturation. Anapc13 mRNA microinjection was performed as an exploratory rescue treatment.RESULTSWe identified two biallelic ANAPC13 mutations (NM_001242374.1: c.6C>A; p.D2E and c.71T>G; p.L24R) in three infertile females with oocyte maturation arrest at metaphase I. Oocytes from the Anapc13M/M female mice similarly displayed an extremely low proportion of mature oocytes, whether obtained after superovulation (Anapc13+/+: 96.63% ± 3.40% vs. Anapc13M/M: 1.66% ± 3.34%, p < 0.001) or in vitro maturation (Anapc13+/+: 70.30% ± 1.10% vs. Anapc13M/M: 0.83% ± 1.66%, p < 0.001). An in-depth study of oocytes demonstrated that mutant ANAPC13 disrupts the protein composition of oocytes during metaphase I-to-anaphase I transition by impairing APC/C function, without changing the spindle assembly checkpoint dynamics. Furthermore, a molecular mechanistic study revealed that APC/C dysfunction resulted from abnormal subunit interaction. Moreover, Anapc13-mutant oocytes can be partially (49.20% ± 3.60%) rescued to extrude the first polar body by microinjection of Anapc13 mRNA.CONCLUSIONOur study demonstrated the critical role of ANAPC13 in human and mouse oocyte maturation, established a causal relationship between ANAPC13 mutations and oocyte maturation arrest, and further provided preliminary evidence that microinjection may serve as a potential treatment for these patients with ANAPC13 mutations.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"242 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147702255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SCREENING FOR LARGE-FOR-GESTATIONAL-AGE NEONATES AT TERM: EVIDENCE OF A LABELLING EFFECT AND INCREASED INTERVENTION WITHOUT NEONATAL BENEFIT","authors":"Miriam Lopian, Can Ozan Ulusoy, Doaa Mohamed, Ella Segal, Asma Khalil","doi":"10.1016/j.ajog.2026.04.015","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.015","url":null,"abstract":"To evaluate the diagnostic accuracy of routine third-trimester ultrasound for detecting large-for-gestational-age (LGA) and macrosomic neonates at term, and the impact of inaccurate prenatal diagnosis on obstetric management and perinatal outcomes.","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"193 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Questions about the RELAIS late third trimester scan trial (Letter-to-the-Editor).","authors":"Jim Thornton","doi":"10.1016/j.ajog.2026.04.008","DOIUrl":"https://doi.org/10.1016/j.ajog.2026.04.008","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"16 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}