{"title":"Robotic-assisted surgery for endometrial cancer: The need for further randomized trials.","authors":"Elina Kivekäs,Synnöve Staff,Minna M Mäenpää","doi":"10.1016/j.ajog.2025.04.062","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.04.062","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"13 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reassessing robot-assisted laparoscopic surgery in endometrial cancer: Generalizability and key confounding factors.","authors":"Ren Xu,Yanan Ren,Luyang Su","doi":"10.1016/j.ajog.2025.04.061","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.04.061","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"138 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Reducing Preventable Maternal Deaths by Strengthening Mental Health Support: A Call for Action.","authors":"Luyang Su,Zeqing Du","doi":"10.1016/j.ajog.2025.04.065","DOIUrl":"https://doi.org/10.1016/j.ajog.2025.04.065","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"24 1","pages":""},"PeriodicalIF":9.8,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143914789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Society for Maternal-Fetal Medicine Publications Committee, Vincenzo Berghella MD
{"title":"Corrigendum to ‘Progesterone and preterm birth prevention: translating clinical trials data into clinical practice’ American Journal of Obstetrics & Gynecology 206 (2012) 376-386","authors":"Society for Maternal-Fetal Medicine Publications Committee, Vincenzo Berghella MD","doi":"10.1016/j.ajog.2025.04.043","DOIUrl":"10.1016/j.ajog.2025.04.043","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"233 1","pages":"Page 77"},"PeriodicalIF":8.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Apolonia García-Patterson, Montserrat Balsells, Ivan Solà, Rosa Corcoy
{"title":"Detection and treatment of early gestational diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials.","authors":"Apolonia García-Patterson, Montserrat Balsells, Ivan Solà, Rosa Corcoy","doi":"10.1016/j.ajog.2025.04.059","DOIUrl":"10.1016/j.ajog.2025.04.059","url":null,"abstract":"<p><strong>Objective: </strong>To estimate the impact of detection and treatment of early gestational diabetes mellitus on short-term maternal, fetal, and neonatal outcomes. We defined 2 maternal (gestational diabetes prevalence and cesarean section) and 2 neonatal (preterm birth and macrosomia) primary outcomes. We also defined 5 maternal and 12 fetal-neonatal secondary outcomes.</p><p><strong>Data sources: </strong>Ovid Medline, Cochrane CENTRAL, and Embase since inception. The search was updated in November 2024.</p><p><strong>Study eligibility criteria: </strong>Inclusion criteria: randomized controlled trials addressing detection and treatment of early gestational diabetes (diagnosed before 20 completed weeks).</p><p><strong>Exclusion criteria: </strong>pregestational diabetes or overt diabetes in pregnancy.</p><p><strong>Study appraisal and synthesis methods: </strong>The Cochrane Handbook was used to guide data extraction and interpretation including risk of bias assessment (Risk of Bias 2 tool). Aggregation and comparison of results were performed with Revman 5.4.1. Pooled relative risk and mean differences were calculated with 95% confidence intervals using random-effects models. The quality of the evidence for primary outcomes was summarized using Grading of Recommendations Assessment, Development and Evaluation criteria.</p><p><strong>Results: </strong>We identified 1221 unique references. Seven articles addressing early gestational diabetes met the eligibility criteria with a total of 30,791 participants. These studies used 2 strategies: (1) treatment vs usual care of women with a diagnosis of early gestational diabetes and (2) population-based approaches, either performing screening (vs not) or using different cutoffs for diagnosis. In studies comparing treatment vs usual care, differences were observed only in secondary outcomes: more drug treatment, less maternal weight gain, lower birthweight, and less respiratory distress. In studies comparing different population-based strategies, primary outcomes differed for a higher rate of early and overall gestational diabetes (relative risk, 5.50; 95% confidence interval, 3.56-8.48 and 1.83; 95% confidence interval, 1.41-2.38, respectively) and a lower rate of primary cesarean section (relative risk, 0.88; 95% confidence interval, 0.84-0.93); as to secondary outcomes, differences were observed in terms of higher total pregnancy-induced hypertension and preeclampsia. The quality of evidence for most outcomes was low/very low.</p><p><strong>Conclusion: </strong>Detection and treatment of early gestational diabetes mellitus do not offer indisputable benefits either in treated women or at the population level. More studies are required to elucidate this issue.</p>","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Godwin Osei-Poku, Ronald Iverson, Nairi Kalpakian, Zev Morgan, Megan Carney, Alexandra Spadola, Kathaleen Barker, Jason Leonard, Christin Price, Melissa Schapero, Laura Federico, Kylie Bouley, Joan Pezzano, Jaime Vallejos, Alison Sekelsky, Julia Prentice
{"title":"Frontline clinician perspectives on clinical accuracy of severe maternal morbidity identified in administrative data.","authors":"Godwin Osei-Poku, Ronald Iverson, Nairi Kalpakian, Zev Morgan, Megan Carney, Alexandra Spadola, Kathaleen Barker, Jason Leonard, Christin Price, Melissa Schapero, Laura Federico, Kylie Bouley, Joan Pezzano, Jaime Vallejos, Alison Sekelsky, Julia Prentice","doi":"10.1016/j.ajog.2025.04.055","DOIUrl":"10.1016/j.ajog.2025.04.055","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren A King, Evelyn T Pan, Maria E Florian-Rodriguez, Cherine A Hamid, Patrick M Weix, Sunil Balgobin
{"title":"Vaginal colpotomy for traditional and natural orifice endoscopic surgery.","authors":"Lauren A King, Evelyn T Pan, Maria E Florian-Rodriguez, Cherine A Hamid, Patrick M Weix, Sunil Balgobin","doi":"10.1016/j.ajog.2025.04.058","DOIUrl":"10.1016/j.ajog.2025.04.058","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":" ","pages":""},"PeriodicalIF":8.7,"publicationDate":"2025-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Information for readers","authors":"","doi":"10.1016/S0002-9378(25)00187-5","DOIUrl":"10.1016/S0002-9378(25)00187-5","url":null,"abstract":"","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"232 5","pages":"Page A6"},"PeriodicalIF":8.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143916152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Maternal vascular-placental axis in the third trimester in women with gestational diabetes mellitus, hypertensive disorders, and unaffected pregnancies","authors":"Christos Chatzakis MD , Dimitra Papavasiliou MD , Tanvi Mansukhani MD , Kypros H. Nicolaides MD , Marietta Charakida MD","doi":"10.1016/j.ajog.2024.08.045","DOIUrl":"10.1016/j.ajog.2024.08.045","url":null,"abstract":"<div><h3>Background</h3><div>Hypertensive disorders of pregnancy and gestational diabetes mellitus are characterized by vascular dysfunction and are associated with long term cardiovascular risks.</div></div><div><h3>Objective</h3><div>This study aimed to compare different markers of maternal vascular function in women with gestational diabetes mellitus, preeclampsia, or gestational hypertension and in women whose pregnancies were unaffected by these complications and to assess the association between maternal vascular function and markers of placental perfusion and maternal vascular-placental axis in 4 groups of women.</div></div><div><h3>Study Design</h3><div>This was a prospective observational study of women who had routine hospital visits at 35 0/7 to 36 6/7 weeks of gestation at King’s College Hospital, London, United Kingdom. The routine hospital visit included recording of maternal demographic characteristics and medical history, ultrasound examination for fetal anatomy and growth, Doppler studies of the uterine arteries and ophthalmic arteries, carotid-femoral pulse wave velocity measurements, estimation of the augmentation index and total peripheral resistance, and measurements of serum placental growth factor and soluble fms-like tyrosine kinase 1. Linear regression analysis was performed for the outcomes of uterine artery pulsatility index multiple of the median, placental growth factor multiple of the median, and soluble fms-like tyrosine kinase 1 multiple of the median. The ophthalmic artery peak systolic velocity ratio, pulse wave velocity, augmentation index, and total peripheral vascular resistance were assessed as potential predictors. This analysis was performed on all women and separately in the different groups.</div></div><div><h3>Results</h3><div>The study population of 6502 women included 614 (9.4%) with gestational diabetes mellitus, 140 (2.1%) who subsequently developed preeclampsia, and 129 (2.0%) who developed gestational hypertension. Women with gestational diabetes mellitus had increased pulse wave velocity compared with those with pregnancies unaffected by gestational diabetes mellitus, preeclampsia, or gestational hypertension. Women with preeclampsia or gestational hypertension had lower placental growth factor multiple of the median and higher uterine artery pulsatility index multiple of the median, soluble fms-like tyrosine kinase 1 multiple of the median, augmentation index, pulse wave velocity, total peripheral resistance, and ophthalmic artery peak systolic velocity ratio than those with unaffected pregnancies. In women with unaffected pregnancies, the ophthalmic artery peak systolic velocity ratio was predictive of the uterine artery pulsatility index multiple of the median, and ophthalmic artery peak systolic velocity ratio, augmentation index, total peripheral resistance, and pulse wave velocity were predictive of the placental growth factor multiple of the median and the soluble fms-like tyrosine kinase 1","PeriodicalId":7574,"journal":{"name":"American journal of obstetrics and gynecology","volume":"232 5","pages":"Pages 489.e1-489.e11"},"PeriodicalIF":8.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142103527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}